3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration von Wang, Hongbing, Brown, Paul C., Chow, Edwin C.Y., Ewart, Lorna, Ferguson, Stephen S., Fitzpatrick, Suzanne, Freedman, Benjamin S., Guo, Grace L., Hedrich, William, Heyward, Scott, Hickman, James, Isoherranen, Nina, Li, Albert P., Liu, Qi, Mumenthaler, Shannon M., Polli, James, Proctor, William R., Ribeiro, Alexandre, Wang, Jian‐Ying, Wange, Ronald L., Huang, Shiew‐Mei

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FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluations von Ackley, David, Birkebak, Joanne, Blumel, Jorg, Bourcier, Todd, de Zafra, Christina, Goodwin, Andrew, Halpern, Wendy, Herzyk, Danuta, Kronenberg, Sven, Mauthe, Robert, Shenton, Jacintha, Shuey, Dana, Wange, Ronald L.

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Implementation of the principles of the 3Rs of animal testing at CDER: Past, present and future von Wange, Ronald L., Brown, Paul C., Davis-Bruno, Karen L.

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Deficiency of ADAP/Fyb/SLAP-130 Destabilizes SKAP55 in Jurkat T Cells von Huang, Yanping, Norton, Darrell D., Precht, Patricia, Martindale, Jennifer L., Burkhardt, Janis K., Wange, Ronald L.

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T cell receptor signaling: beyond complex complexes von Huang, Yanping, Wange, Ronald L

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PTEN permits acute increases in D3‐phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt von Seminario, Maria‐Cristina, Precht, Patricia, Bunnell, Stephen C., Warren, Sarah E., Morris, Christa M., Taub, Dennis, Wange, Ronald L.

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Kinase-Independent Functions for Itk in TCR-Induced Regulation of Vav and the Actin Cytoskeleton von Dombroski, Derek, Houghtling, Richard A, Labno, Christine M, Precht, Patricia, Takesono, Aya, Caplen, Natasha J, Billadeau, Daniel D, Wange, Ronald L, Burkhardt, Janis K, Schwartzberg, Pamela L

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ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists von Madrenas, Joaquín, Wange, Ronald L., Wang, Jennifer L., Isakov, Noah, Samelson, Lawrence E., Germain, Ronald N.

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Genetic Evidence for Differential Coupling of Syk Family Kinases to the T-Cell Receptor: Reconstitution Studies in a ZAP-70-Deficient Jurkat T-Cell Line von Williams, Brandi L., Schreiber, Kathy L., Zhang, Weiguo, Wange, Ronald L., Samelson, Lawrence E., Leibson, Paul J., Abraham, Robert T.

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TCR Signaling: Another Abl-Bodied Kinase Joins the Cascade von Wange, Ronald L

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Itk/Emt/Tsk Activation in Response to CD3 Cross-linking in Jurkat T Cells Requires ZAP-70 and Lat and Is Independent of Membrane Recruitment von Shan, Xiaochuan, Wange, Ronald L.

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Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial von Seminario, Maria-Cristina, Wange, Ronald L.

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PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression von SEMINARIO, Maria-Cristina, PRECHT, Patricia, WERSTO, Robert P, GOROSPE, Myriam, WANGE, Ronald L

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Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells von Freeley, Michael, Park, Jongsun, Yang, Keum-Jin, Wange, Ronald L., Volkov, Yuri, Kelleher, Dermot, Long, Aideen

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Activating and Inhibitory Mutations in Adjacent Tyrosines in the Kinase Domain of ZAP-70 (∗) von Wange, Ronald L., Guitián, Ramón, Isakov, Noah, Watts, Julian D., Aebersold, Ruedi, Samelson, Lawrence E.

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Involvement of Hematopoietic Progenitor Kinase 1 in T Cell Receptor Signaling von Ling, Pin, Meyer, Christian F., Redmond, Lisa P., Shui, Jr-Wen, Davis, Beckley, Rich, Robert R., Hu, Mickey C.-T., Wange, Ronald L., Tan, Tse-Hua

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Modulation of specific protein expression levels by PTEN: identification of AKAP121, DHFR, G3BP, Rap1, and RCC1 as potential targets of PTEN von YANPING HUANG, WERNYJ, Roman P, NORTON, Darrell D, PRECHT, Patricia, SEMINARIO, Maria-Cristina, WANGE, Ronald L

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The Missing Link(er): A Return to Symmetry in Antigen Receptor Signaling? von Wange, Ronald L

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Distinct Tyrosine Phosphorylation Sites in JAK3 Kinase Domain Positively and Negatively Regulate Its Enzymatic Activity von Zhou, Yong-Jie, Hanson, Eric P., Chen, Yi-Qing, Magnuson, Kelly, Chen, Min, Swann, Patrick G., Wange, Ronald L., Changelian, Paul S., O'Shea, John J.

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ZAP-70-Independent Ca2+ Mobilization and Erk Activation in Jurkat T Cells in Response to T-Cell Antigen Receptor Ligation von Shan, Xiaochuan, Balakir, Richard, Criado, Gabriel, Wood, Jason S., Seminario, Maria-Cristina, Madrenas, Joaquin, Wange, Ronald L.

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