Base editors: development and applications in biomedicine von Liang, Yanhui, Chen, Fangbing, Wang, Kepin, Lai, Liangxue

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Efficient base editing for multiple genes and loci in pigs using base editors von Xie, Jingke, Ge, Weikai, Li, Nan, Liu, Qishuai, Chen, Fangbing, Yang, Xiaoyu, Huang, Xingyun, Ouyang, Zhen, Zhang, Quanjun, Zhao, Yu, Liu, Zhaoming, Gou, Shixue, Wu, Han, Lai, Chengdan, Fan, Nana, Jin, Qin, Shi, Hui, Liang, Yanhui, Lan, Ting, Quan, Longquan, Li, Xiaoping, Wang, Kepin, Lai, Liangxue

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Enhancing prime editor flexibility with coiled-coil heterodimers von Mu, Shuangshuang, Chen, Huangyao, Li, Qianru, Gou, Shixue, Liu, Xiaoyi, Wang, Junwei, Zheng, Wei, Chen, Menglong, Jin, Qin, Lai, Liangxue, Wang, Kepin, Shi, Hui

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ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems von Xie, Jingke, Huang, Xingyun, Wang, Xia, Gou, Shixue, Liang, Yanhui, Chen, Fangbing, Li, Nan, Ouyang, Zhen, Zhang, Quanjun, Ge, Weikai, Jin, Qin, Shi, Hui, Zhuang, Zhenpeng, Zhao, Xiaozhu, Lian, Meng, Wang, Jiaowei, Ye, Yinghua, Quan, Longquan, Wu, Han, Wang, Kepin, Lai, Liangxue

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Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing von Wang, Kepin, Jin, Qin, Ruan, Degong, Yang, Yi, Liu, Qishuai, Wu, Han, Zhou, Zhiwei, Ouyang, Zhen, Liu, Zhaoming, Zhao, Yu, Zhao, Bentian, Zhang, Quanjun, Peng, Jiangyun, Lai, Chengdan, Fan, Nana, Liang, Yanhui, Lan, Ting, Li, Nan, Wang, Xiaoshan, Wang, Xinlu, Fan, Yong, Doevendans, Pieter A, Sluijter, Joost P G, Liu, Pentao, Li, Xiaoping, Lai, Liangxue

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Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation von Jin, Qin, Liu, Xiaoyi, Zhuang, Zhenpeng, Huang, Jiayuan, Gou, Shixue, Shi, Hui, Zhao, Yu, Ouyang, Zhen, Liu, Zhaoming, Li, Lei, Mao, Junjie, Ge, Weikai, Chen, Fangbing, Yu, Manya, Guan, Yezhi, Ye, Yinghua, Tang, Chengcheng, Huang, Ren, Wang, Kepin, Lai, Liangxue

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Exonuclease editor promotes precision of gene editing in mammalian cells von Shi, Hui, Li, Lei, Mu, Shuangshuang, Gou, Shixue, Liu, Xiaoyi, Chen, Fangbing, Chen, Menglong, Jin, Qin, Lai, Liangxue, Wang, Kepin

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Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses von Li, Wenjing, Shi, Lei, Zhuang, Zhenpeng, Wu, Han, Lian, Meng, Chen, Yihui, Li, Lei, Ge, Weikai, Jin, Qin, Zhang, Quanjun, Zhao, Yu, Liu, Zhaoming, Ouyang, Zhen, Ye, Yinghua, Li, Yingying, Wang, Hai, Liao, Yuan, Quan, Longquan, Xiao, Lei, Lai, Liangxue, Meng, Guangxun, Wang, Kepin

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Genome editing pig models with elements for controllable gene expression von Jin, Qin, Shi, Hui, Liu, Xiaoyi, Ju, Jialu, Wang, Kepin, Lai, Liangxue

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XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer von Ruan, Degong, Peng, Jiangyun, Wang, Xiaoshan, Ouyang, Zhen, Zou, Qingjian, Yang, Yi, Chen, Fangbing, Ge, Weikai, Wu, Han, Liu, Zhaoming, Zhao, Yu, Zhao, Bentian, Zhang, Quanjun, Lai, Chengdan, Fan, Nana, Zhou, Zhiwei, Liu, Qishuai, Li, Nan, Jin, Qin, Shi, Hui, Xie, Jingke, Song, Hong, Yang, Xiaoyu, Chen, Jiekai, Wang, Kepin, Li, Xiaoping, Lai, Liangxue

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Evaluation of guide-free Cas9-induced genomic damage and transcriptome changes in pig embryos von Ge, Weikai, Zhao, Xiaozhu, Gou, Shixue, Jin, Qin, Chen, Fangbing, Ouyang, Zhen, Lai, Chengdan, Cui, Tao, Mai, Baoyi, Lu, Sijia, Zhong, Kexin, Liang, Yanhui, Chen, Tao, Wu, Han, Li, Nan, Ye, Yinghua, Lai, Liangxue, Wang, Kepin

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Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression von Jin, Qin, Yang, Xiaoyu, Gou, Shixue, Liu, Xiaoyi, Zhuang, Zhenpeng, Liang, Yanhui, Shi, Hui, Huang, Jiayuan, Wu, Han, Zhao, Yu, Ouyang, Zhen, Zhang, Quanjun, Liu, Zhaoming, Chen, Fangbing, Ge, Weikai, Xie, Jingke, Li, Nan, Lai, Chengdan, Zhao, Xiaozhu, Wang, Jiaowei, Lian, Meng, Li, Lei, Quan, Longquan, Ye, Yinghua, Lai, Liangxue, Wang, Kepin

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In vivo evaluation of guide-free Cas9-induced safety risks in a pig model von Ge, Weikai, Gou, Shixue, Zhao, Xiaozhu, Jin, Qin, Zhuang, Zhenpeng, Zhao, Yu, Liang, Yanhui, Ouyang, Zhen, Liu, Xiaoyi, Chen, Fangbing, Shi, Hui, Yan, Haizhao, Wu, Han, Lai, Liangxue, Wang, Kepin

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Multiplexed base editing through Cas12a variant-mediated cytosine and adenine base editors von Chen, Fangbing, Lian, Meng, Ma, Bingxiu, Gou, Shixue, Luo, Xian, Yang, Kaiming, Shi, Hui, Xie, Jingke, Ge, Weika, Ouyang, Zhen, Lai, Chengdan, Li, Nan, Zhang, Quanjun, Jin, Qin, Liang, Yanhui, Chen, Tao, Wang, Jiaowei, Zhao, Xiaozhu, Li, Lei, Yu, Manya, Ye, Yinghua, Wang, Kepin, Wu, Han, Lai, Liangxue

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Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering von Yang, Yi, Wang, Kepin, Wu, Han, Jin, Qin, Ruan, Degong, Ouyang, Zhen, Zhao, Bentian, Liu, Zhaoming, Zhao, Yu, Zhang, Quanjun, Fan, Nana, Liu, Qishuai, Guo, Shimei, Bu, Lei, Fan, Yong, Sun, Xiaofang, Li, Xiaoping, Lai, Liangxue

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Genome-Wide CRISPR/Cas9 Screen Reveals a Role for SLC35A1 in the Adsorption of Porcine Deltacoronavirus von Wang, Xunlei, Jin, Qin, Xiao, Wenwen, Fang, Puxian, Lai, Liangxue, Xiao, Shaobo, Wang, Kepin, Fang, Liurong

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Generation of an ASGR1 homozygous mutant human embryonic stem cell line WAe001-A-6 using CRISPR/Cas9 von Xu, Yingying, Wu, Yuhang, Guo, Dongsheng, Gao, Ge, Lai, Keyu, Yang, Fan, Wang, Kepin, Wu, Han, Lai, Liangxue, Li, Jialiang, Xu, Kecheng, Li, Yin-xiong

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Generation of three miR-122 knockout lines from a human embryonic stem cell line von Liu, Yanli, Wu, Feima, Zhuang, Yuanqi, Guo, Dongsheng, Abbas, Nasir, Wei, Ruzi, Wang, Kepin, Chen, Yan, Tao, Jiawang, Wu, Yuhang, Yuan, Fang, Pan, Tingcai, Yang, Fan, Lai, Keyu, Lai, Liangxue, Li, Yin-xiong

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AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns von Liang, Yanhui, Xie, Jingke, Zhang, Quanjun, Wang, Xiaomin, Gou, Shixue, Lin, Lihui, Chen, Tao, Ge, Weikai, Zhuang, Zhenpeng, Lian, Meng, Chen, Fangbing, Li, Nan, Ouyang, Zhen, Lai, Chengdan, Liu, Xiaoyi, Li, Lei, Ye, Yinghua, Wu, Han, Wang, Kepin, Lai, Liangxue

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Precise genome editing of the Kozak sequence enables bidirectional and quantitative modulation of protein translation to anticipated levels without affecting transcription von Xie, Jingke, Zhuang, Zhenpeng, Gou, Shixue, Zhang, Quanjun, Wang, Xia, Lan, Ting, Lian, Meng, Li, Nan, Liang, Yanhui, Ouyang, Zhen, Ye, Yinghua, Wu, Han, Lai, Liangxue, Wang, Kepin

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