Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9) von Mussari, Christopher P, Dodd, Dharmpal S, Sreekantha, Ratna Kumar, Pasunoori, Laxman, Wan, Honghe, Posy, Shana L, Critton, David, Ruepp, Stefan, Subramanian, Murali, Watson, Andrew, Davies, Paul, Schieven, Gary L, Salter-Cid, Luisa M, Srivastava, Ratika, Tagore, Debarati Mazumder, Dudhgaonkar, Shailesh, Poss, Michael A, Carter, Percy H, Dyckman, Alaric J

Volltext

Improved conditions for converting sterically hindered amides to 1,5-disubstituted tetrazoles von Schroeder, Gretchen M., Marshall, Sydney, Wan, Honghe, Purandare, Ashok V.

Volltext

Benzo[ d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)—Hit to Lead studies von Wan, Honghe, Huynh, Tram, Pang, Suhong, Geng, Jieping, Vaccaro, Wayne, Poss, Michael A., Trainor, George L., Lorenzi, Matthew V., Gottardis, Marco, Jayaraman, Lata, Purandare, Ashok V.

Volltext

Chiral Nonracemic α-Alkylidene and α-Silylidene Cyclopentenones from Chiral Allenes Using an Intramolecular Allenic Pauson−Khand-Type Cycloaddition von Brummond, Kay M, Kerekes, Angela D, Wan, Honghe

Volltext

Identification of chemokine receptor CCR4 antagonist von Purandare, Ashok V., Gao, Aiming, Wan, Honghe, Somerville, John, Burke, Christine, Seachord, Carrie, Vaccaro, Wayne, Wityak, John, Poss, Michael A.

Volltext

Core exploration in optimization of chemokine receptor CCR4 antagonists von Purandare, Ashok V., Wan, Honghe, Somerville, John E., Burke, Christine, Vaccaro, Wayne, Yang, XiaoXia, McIntyre, Kim W., Poss, Michael A.

Volltext

Pyrrolo[1,2- f]triazines as JAK2 inhibitors: Achieving potency and selectivity for JAK2 over JAK3 von Harikrishnan, Lalgudi S., Kamau, Muthoni G., Wan, Honghe, Inghrim, Jennifer A., Zimmermann, Kurt, Sang, Xiaopeng, Mastalerz, Harold A., Johnson, Walter L., Zhang, Guifen, Lombardo, Louis J., Poss, Michael A., Trainor, George L., Tokarski, John S., Lorenzi, Matthew V., You, Dan, Gottardis, Marco M., Baldwin, Kathy F., Lippy, Jonathan, Nirschl, David S., Qiu, Ruhui, Miller, Arthur V., Khan, Javed, Sack, John S., Purandare, Ashok V.

Volltext

Optimization of CCR4 antagonists: Side-chain exploration von Purandare, Ashok V., Wan, Honghe, Gao, Aiming, Somerville, John, Burke, Christine, Vaccaro, Wayne, Yang, XiaoXia, McIntyre, Kim W., Poss, Michael A.

Volltext

Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor von Zhang, Yong, Parrish, Karen E, Tortolani, David R, Poss, Michael A, Huang, Audris, Wan, Honghe, Purandare, Ashok V, Donnell, Andrew F, Kempson, James, Hou, Xiaoping, Pawluczyk, Joseph, Yip, Shiuhang, Luk, Emily, Raghavan, Nimmi, Swanson, Jesse, Smalley, James, Murtaza, Anwar, Yang, Zheng, Augustine-Rauch, Karen, Lombardo, Louis J, Borzilleri, Robert

Volltext

Identification of a potent and rapidly reversible inhibitor of the 20S-proteasome von Purandare, Ashok V., Wan, Honghe, Laing, Naomi, Benbatoul, Khalid, Vaccaro, Wayne, Poss, Michael A.

Volltext

Substituted diaryl ether compounds as retinoic acid-related orphan Receptor-γt (RORγt) agonists von Ruan, Zheming, Park, Peter K., Wei, Donna, Purandare, Ashok, Wan, Honghe, O'Malley, Daniel, Stachura, Sylwia, Perez, Heidi, Cavallaro, Cullen L., Weigelt, Carolyn A., Sack, John S., Ruzanov, Max, Khan, Javed, Gururajan, Murali, Wong, Jessica J., Huang, Yanling, Yarde, Melissa, Li, Zhuyin, Chen, Cliff, Sun, Huadong, Borowski, Virna, Xie, Jenny H., Anthony, Monique, Agler, Michele, Fink, Brian E., Harikrishnan, Lalgudi S.

Volltext

Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms von Wan, Honghe, Schroeder, Gretchen M, Hart, Amy C, Inghrim, Jennifer, Grebinski, James, Tokarski, John S, Lorenzi, Matthew V, You, Dan, Mcdevitt, Theresa, Penhallow, Becky, Vuppugalla, Ragini, Zhang, Yueping, Gu, Xiaomei, Iyer, Ramaswamy, Lombardo, Louis J, Trainor, George L, Ruepp, Stefan, Lippy, Jonathan, Blat, Yuval, Sack, John S, Khan, Javed A, Stefanski, Kevin, Sleczka, Bogdan, Mathur, Arvind, Sun, Jung-Hui, Wong, Michael K, Wu, Dauh-Rurng, Li, Peng, Gupta, Anuradha, Arunachalam, P. N, Pragalathan, Bala, Narayanan, Sankara, K.C, Nanjundaswamy, Kuppusamy, Prakasam, Purandare, Ashok V

Volltext

Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5‑d]pyrrolo[2,3‑b]pyridine Inhibitors von Hart, Amy C, Schroeder, Gretchen M, Wan, Honghe, Grebinski, James, Inghrim, Jennifer, Kempson, James, Guo, Junqing, Pitts, William J, Tokarski, John S, Sack, John S, Khan, Javed A, Lippy, Jonathan, Lorenzi, Matthew V, You, Dan, McDevitt, Theresa, Vuppugalla, Ragini, Zhang, Yueping, Lombardo, Louis J, Trainor, George L, Purandare, Ashok V

Volltext

Abstract DDT01-03: Discovery of BMS-911543, a highly selective JAK2 inhibitor, as a clinical candidate for the treatment of myeloproliferative disease and other malignancies von Purandare, Ashok V., Wan, Honghe, Schroeder, Gretchen, Hart, Amy, Grebinski, James, Inghrim, Jennifer, Tokarski, John, You, Dan, Penhallow, Becky, McDevitt, Theresa, Vuppugalla, Ragini, Zhang, Yueping, Ruepp, Stefan, Trainor, George, Han, Xia, Lombardo, Louis, Lee, Francis Y., Gottardis, Marco, Hosbach, Jennifer, Fitzpatrick, Elizabeth, Emanuel, Stuart, Pardanani, Animesh, Lasho, Terra L., Tefferi, Ayalew, Lorenzi, Matthew V.

Volltext

An Intramolecular Allenic [2 + 2 + 1] Cycloaddition von Brummond, Kay M, Wan, Honghe, Kent, Joseph L

Volltext

Pyrrolo[1,2-f]triazines as JAK2 inhibitors: Achieving potency and selectivity for JAK2 over JAK3 Purandare von Harikrishnan, Lalgudi S, Kamau, Muthoni G, Wan, Honghe, Inghrim, Jennifer A, Zimmermann, Kurt, Sang, Xiaopeng, Mastalerz, Harold A, Johnson, Walter L, Zhang, Guifen, Lombardo, Louis J, Poss, Michael A, Trainor, George L, Tokarski, John S, Lorenzi, Matthew V, You, Dan, Gottardis, Marco M, Baldwin, Kathy F, Lippy, Jonathan, Nirschl, David S, Qiu, Ruhui

Volltext

The allenic Pauson-Khand cycloaddition. Dependence in π-bond selectivity on substrate structure von Brummond, Kay M., Wan, Honghe

Volltext

A new allenic Pauson-Khand cycloaddition for the preparation of α-methylene cyclopentenones von Kent, Joseph L., Wan, Honghe, Brummond, Kay M.

Volltext

Prodrugs of imidazotriazine compounds as CK2 inhibitors von Zimmermann, Kurt, Wan, Honghe, Purandare, Ashok Vinayak

Volltext bestellen

Crystalline forms of N,N-dicyclopropyl-4-(1,5-dimethyl-1H-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide for the treatment of mye... von Wan Honghe, Purandare Ashok Vinayak

Volltext bestellen