PAINS in the Assay: Chemical Mechanisms of Assay Interference and Promiscuous Enzymatic Inhibition Observed during a Sulfhydryl-Scavenging HTS von Dahlin, Jayme L, Nissink, J. Willem M, Strasser, Jessica M, Francis, Subhashree, Higgins, LeeAnn, Zhou, Hui, Zhang, Zhiguo, Walters, Michael A

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Chemical con artists foil drug discovery von Baell, Jonathan, Walters, Michael A

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Chemistry: Chemical con artists foil drug discovery von Baell, Jonathan, Walters, Michael A.

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Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors von Dahlin, Jayme L., Nelson, Kathryn M., Strasser, Jessica M., Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena M., Organ, Shawna, Cuellar, Matthew, Singh, Gurpreet, Shrimp, Jonathan H., Nguyen, Nghi, Meier, Jordan L., Arrowsmith, Cheryl H., Brown, Peter J., Baell, Jonathan B., Walters, Michael A.

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Reference compounds for characterizing cellular injury in high-content cellular morphology assays von Dahlin, Jayme L., Hua, Bruce K., Zucconi, Beth E., Nelson, Shawn D., Singh, Shantanu, Carpenter, Anne E., Shrimp, Jonathan H., Lima-Fernandes, Evelyne, Wawer, Mathias J., Chung, Lawrence P. W., Agrawal, Ayushi, O’Reilly, Mary, Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena, Li, Fengling, Lak, Parnian, Cuellar, Matthew, Cole, Philip A., Meier, Jordan L., Thomas, Tim, Baell, Jonathan B., Brown, Peter J., Walters, Michael A., Clemons, Paul A., Schreiber, Stuart L., Wagner, Bridget K.

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Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A von Kim, Jonggul, Li, Geoffrey, Walters, Michael A., Taylor, Susan S., Veglia, Gianluigi

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The Essential Medicinal Chemistry of Curcumin von Nelson, Kathryn M, Dahlin, Jayme L, Bisson, Jonathan, Graham, James, Pauli, Guido F, Walters, Michael A

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GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity von Menon, Deepthi, Innes, Ashlee, Oakley, Aaron J., Dahlstrom, Jane E., Jensen, Lora M., Brüstle, Anne, Tummala, Padmaja, Rooke, Melissa, Casarotto, Marco G., Baell, Jonathan B., Nguyen, Nghi, Xie, Yiyue, Cuellar, Matthew, Strasser, Jessica, Dahlin, Jayme L., Walters, Michael A., Burgio, Gaetan, O’Neill, Luke A. J., Board, Philip G.

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Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model von Pérez Ortiz, Judit M., Mollema, Nissa, Toker, Nicholas, Adamski, Carolyn J., O'Callaghan, Brennon, Duvick, Lisa, Friedrich, Jillian, Walters, Michael A., Strasser, Jessica, Hawkinson, Jon E., Zoghbi, Huda Y., Henzler, Christine, Orr, Harry T., Lagalwar, Sarita

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Assessing Synthetic Accessibility of Chemical Compounds Using Machine Learning Methods von Podolyan, Yevgeniy, Walters, Michael A, Karypis, George

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Mitigating risk in academic preclinical drug discovery von Dahlin, Jayme L., Inglese, James, Walters, Michael A.

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Transcriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen von Choi, Si Ho, Bosnakovski, Darko, Strasser, Jessica M., Toso, Erik A., Walters, Michael A., Kyba, Michael

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High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity von Bosnakovski, Darko, Choi, Si Ho, Strasser, Jessica M, Toso, Erik A, Walters, Michael A, Kyba, Michael

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A cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylation von Dahlin, Jayme L, Sinville, Rondedrick, Solberg, Jonathan, Zhou, Hui, Han, Junhong, Francis, Subhashree, Strasser, Jessica M, John, Kristen, Hook, Derek J, Walters, Michael A, Zhang, Zhiguo

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The Essential Medicinal Chemistry of Cannabidiol (CBD) von Nelson, Kathryn M, Bisson, Jonathan, Singh, Gurpreet, Graham, James G, Chen, Shao-Nong, Friesen, J. Brent, Dahlin, Jayme L, Niemitz, Matthias, Walters, Michael A, Pauli, Guido F

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Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast von Zhang, Yujian, Tian, Defeng, Matsuyama, Hironori, Hamazaki, Takashi, Shiratsuchi, Takayuki, Terada, Naohiro, Hook, Derek J., Walters, Michael A., Georg, Gunda I., Hawkinson, Jon E.

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Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementias von Pockes, Steffen, Walters, Michael A., Ashe, Karen H.

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Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway von Alverez, Celeste, Bulfer, Stacie L, Chakrasali, Ramappa, Chimenti, Michael. S, Deshaies, Raymond J, Green, Neal, Kelly, Mark, LaPorte, Matthew G, Lewis, Taber S, Liang, Mary, Moore, William J, Neitz, R. Jeffrey, Peshkov, Vsevolod A, Walters, Michael A, Zhang, Feng, Arkin, Michelle R, Wipf, Peter, Huryn, Donna M

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How to Triage PAINS-Full Research von Dahlin, Jayme L, Walters, Michael A

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Nuisance compounds in cellular assays von Dahlin, Jayme L., Auld, Douglas S., Rothenaigner, Ina, Haney, Steve, Sexton, Jonathan Z., Nissink, J. Willem M., Walsh, Jarrod, Lee, Jonathan A., Strelow, John M., Willard, Francis S., Ferrins, Lori, Baell, Jonathan B., Walters, Michael A., Hua, Bruce K., Hadian, Kamyar, Wagner, Bridget K.

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