The Discovery of N‑[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]‑N′‑propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor Ant... von Bolli, Martin H, Boss, Christoph, Binkert, Christoph, Buchmann, Stephan, Bur, Daniel, Hess, Patrick, Iglarz, Marc, Meyer, Solange, Rein, Josiane, Rey, Markus, Treiber, Alexander, Clozel, Martine, Fischli, Walter, Weller, Thomas

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Promotion of sleep by targeting the orexin system in rats, dogs and humans von Jenck, François, Brisbare-Roch, Catherine, Dingemanse, Jasper, Koberstein, Ralf, Hoever, Petra, Aissaoui, Hamed, Flores, Susan, Mueller, Celia, Nayler, Oliver, van Gerven, Joop, de Haas, Sanne L, Hess, Patrick, Qiu, Changbin, Buchmann, Stephan, Scherz, Michael, Weller, Thomas, Fischli, Walter, Clozel, Martine

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Design and Preparation of Potent, Nonpeptidic, Bioavailable Renin Inhibitors von Bezençon, Olivier, Bur, Daniel, Weller, Thomas, Richard-Bildstein, Sylvia, Remeň, Luboš, Sifferlen, Thierry, Corminboeuf, Olivier, Grisostomi, Corinna, Boss, Christoph, Prade, Lars, Delahaye, Stéphane, Treiber, Alexander, Strickner, Panja, Binkert, Christoph, Hess, Patrick, Steiner, Beat, Fischli, Walter

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Functional and Biochemical Analysis of Angiotensin II-Forming Pathways in the Human Heart von Wolny, Arlene, Clozel, Jean-Paul, Rein, Josiane, Mory, Paul, Vogt, Paul, Turino, Marko, Kiowski, Wolfgang, Fischli, Walter

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Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist von Clozel, Martine, Breu, Volker, Burri, Kaspar, Cassal, Jean-Marie, Fischli, Walter, Gray, Gillian A, Hirth, Georges, Löffier, Bernd-Michael, Müller, Marcel, Neidhart, Werner, Ramuz, Henri

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Achiral, Cheap, and Potent Inhibitors of Plasmepsins I, II, and IV von Boss, Christoph, Corminboeuf, Olivier, Grisostomi, Corinna, Meyer, Solange, Jones, Andrew F., Prade, Lars, Binkert, Christoph, Fischli, Walter, Weller, Thomas, Bur, Daniel

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Substituted piperidines - highly potent renin inhibitors due to induced fit adaptation of the active site von Vieira, Eric, Binggeli, Alfred, Breu, Volker, Bur, Daniel, Fischli, Walter, Güller, Rolf, Hirth, Georges, Märki, Hans Peter, Müller, Marcel, Oefner, Christian, Scalone, Michelangelo, Stadler, Heinz, Wihelm, Maurice, Wostl, Wolfgang

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Endothelin-1/Endothelin-3 Ratio von Montani, David, Souza, Rogerio, Binkert, Christoph, Fischli, Walter, Simonneau, Gerald, Clozel, Martine, Humbert, Marc

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Identification of non-peptidic neuromedin U receptor modulators by a robust homogeneous screening assay von Meng, Tao, Su, Hao-ran, Binkert, Christoph, Fischli, Walter, Zhou, Ling, Shen, Jing-kang, Wang, Ming-wei

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Chymase: a multifunctional player in pulmonary hypertension associated with lung fibrosis von Kosanovic, Djuro, Luitel, Himal, Dahal, Bhola Kumar, Cornitescu, Teodora, Janssen, Wiebke, Danser, A H Jan, Garrelds, Ingrid M, De Mey, Jo G R, Fazzi, Gregorio, Schiffers, Paul, Iglarz, Marc, Fischli, Walter, Ghofrani, Hossein Ardeschir, Weissmann, Norbert, Grimminger, Friedrich, Seeger, Werner, Reiss, Irwin, Schermuly, Ralph Theo

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Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling von Le Bihan, Amélie, de Kanter, Ruben, Angulo-Barturen, Iñigo, Binkert, Christoph, Boss, Christoph, Brun, Reto, Brunner, Ralf, Buchmann, Stephan, Burrows, Jeremy, Dechering, Koen J, Delves, Michael, Ewerling, Sonja, Ferrer, Santiago, Fischli, Christoph, Gamo-Benito, Francisco Javier, Gnädig, Nina F, Heidmann, Bibia, Jiménez-Díaz, María Belén, Leroy, Didier, Martínez, Maria Santos, Meyer, Solange, Moehrle, Joerg J, Ng, Caroline L, Noviyanti, Rintis, Ruecker, Andrea, Sanz, Laura María, Sauerwein, Robert W, Scheurer, Christian, Schleiferboeck, Sarah, Sinden, Robert, Snyder, Christopher, Straimer, Judith, Wirjanata, Grennady, Marfurt, Jutta, Price, Ric N, Weller, Thomas, Fischli, Walter, Fidock, David A, Clozel, Martine, Wittlin, Sergio

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Endothelin-1/endothelin-3 ratio: A potential prognostic factor of Pulmonary arterial hypertension von MONTANI, David, SOUZA, Rogerio, BINKERT, Christoph, FISCHLI, Walter, SIMONNEAU, Gerald, CLOZEL, Martine, HUMBERT, Marc

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Tetrahydroisoquinolines as Orexin Receptor Antagonists: Strategies for Lead Optimization by Solution-Phase Chemistry von Koberstein, Ralf, Treiber, Alexander, Sifferlen, Thierry, Nayler, Oliver, Mueller, Celia, Jenck, François, Fischli, Walter, Clozel, Martine, Bur, Daniel, Aissaoui, Hamed, Weller, Thomas

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Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action von Boss, Christoph, Aissaoui, Hamed, Amaral, Nathalie, Bauer, Aude, Bazire, Stephanie, Binkert, Christoph, Brun, Reto, Bürki, Cédric, Ciana, Claire-Lise, Corminboeuf, Olivier, Delahaye, Stephane, Dollinger, Claire, Fischli, Christoph, Fischli, Walter, Flock, Alexandre, Frantz, Marie-Céline, Girault, Malory, Grisostomi, Corinna, Friedli, Astrid, Heidmann, Bibia, Hinder, Claire, Jacob, Gael, Le Bihan, Amelie, Malrieu, Sophie, Mamzed, Saskia, Merot, Aurelien, Meyer, Solange, Peixoto, Sabrina, Petit, Nolwenn, Siegrist, Romain, Trollux, Julien, Weller, Thomas, Wittlin, Sergio

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Temporal evolution of endothelial dysfunction in a rat model of chronic heart failure von Teerlink, John R., Clozel, Martine, Fischli, Walter, Clozel, Jean-Paul

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Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling von Le Bihan, Amélie, de Kanter, Ruben, Angulo-Barturen, Iñigo, Binkert, Christoph, Boss, Christoph, Brun, Reto, Brunner, Ralf, Buchmann, Stephan, Burrows, Jeremy, Dechering, Koen J, Delves, Michael, Ewerling, Sonja, Ferrer, Santiago, Fischli, Christoph, Gamo-Benito, Francisco Javier, Gnädig, Nina F, Heidmann, Bibia, Jiménez-Díaz, María Belén, Leroy, Didier, Martínez, Maria Santos, Meyer, Solange, Moehrle, Joerg J, Ng, Caroline L, Noviyanti, Rintis, Ruecker, Andrea, Sanz, Laura María, Sauerwein, Robert W, Scheurer, Christian, Schleiferboeck, Sarah, Sinden, Robert, Snyder, Christopher, Straimer, Judith, Wirjanata, Grennady, Marfurt, Jutta, Price, Ric N, Weller, Thomas, Fischli, Walter, Fidock, David A, Clozel, Martine, Wittlin, Sergio

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Back Cover: Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action (ChemMedChem 18/2016) von Boss, Christoph, Aissaoui, Hamed, Amaral, Nathalie, Bauer, Aude, Bazire, Stephanie, Binkert, Christoph, Brun, Reto, Bürki, Cédric, Ciana, Claire-Lise, Corminboeuf, Olivier, Delahaye, Stephane, Dollinger, Claire, Fischli, Christoph, Fischli, Walter, Flock, Alexandre, Frantz, Marie-Céline, Girault, Malory, Grisostomi, Corinna, Friedli, Astrid, Heidmann, Bibia, Hinder, Claire, Jacob, Gael, Le Bihan, Amelie, Malrieu, Sophie, Mamzed, Saskia, Merot, Aurelien, Meyer, Solange, Peixoto, Sabrina, Petit, Nolwenn, Siegrist, Romain, Trollux, Julien, Weller, Thomas, Wittlin, Sergio

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Inhibitors of Plasmepsin II – Potential Antimalarial Agents von Boss, Christoph, Brun, Reto, Fischli, Walter, Binkert, Christoph, Meyer, Solange, Prade, Lars, Harris, Luke, Coppex, Lionel, Grisostomi, Corinna, Corminboeuf, Olivier, Bourgeois, Jean-Marc, Furnari, Rocco, Richard-Bildstein, Sylvia, Weller, Thomas

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Piperidine-based renin inhibitors: Upper chain optimization von Corminboeuf, Olivier, Bezençon, Olivier, Remeň, Ľuboš, Grisostomi, Corinna, Richard-Bildstein, Sylvia, Bur, Daniel, Prade, Lars, Strickner, Panja, Hess, Patrick, Fischli, Walter, Steiner, Beat, Treiber, Alexander

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Novel Benzo[1,4]diazepin-2-one Derivatives as Endothelin Receptor Antagonists von Bolli, Martin H, Marfurt, Judith, Grisostomi, Corinna, Boss, Christoph, Binkert, Christoph, Hess, Patrick, Treiber, Alexander, Thorin, Eric, Morrison, Keith, Buchmann, Stephan, Bur, Daniel, Ramuz, Henri, Clozel, Martine, Fischli, Walter, Weller, Thomas

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