Mutational landscape and significance across 12 major cancer types von Kandoth, Cyriac, McLellan, Michael D., Vandin, Fabio, Ye, Kai, Niu, Beifang, Lu, Charles, Xie, Mingchao, Zhang, Qunyuan, McMichael, Joshua F., Wyczalkowski, Matthew A., Leiserson, Mark D. M., Miller, Christopher A., Welch, John S., Walter, Matthew J., Wendl, Michael C., Ley, Timothy J., Wilson, Richard K., Raphael, Benjamin J., Ding, Li

Volltext

Splicing factor gene mutations in hematologic malignancies von Saez, Borja, Walter, Matthew J., Graubert, Timothy A.

Volltext

Spliceosome Mutations Induce R Loop-Associated Sensitivity to ATR Inhibition in Myelodysplastic Syndromes von Nguyen, Hai Dang, Leong, Wan Yee, Li, Weiling, Reddy, Pavankumar N G, Sullivan, Jack D, Walter, Matthew J, Zou, Lee, Graubert, Timothy A

Volltext

Mutant U2AF1 Expression Alters Hematopoiesis and Pre-mRNA Splicing In Vivo von Shirai, Cara Lunn, Ley, James N., White, Brian S., Kim, Sanghyun, Tibbitts, Justin, Shao, Jin, Ndonwi, Matthew, Wadugu, Brian, Duncavage, Eric J., Okeyo-Owuor, Theresa, Liu, Tuoen, Griffith, Malachi, McGrath, Sean, Magrini, Vincent, Fulton, Robert S., Fronick, Catrina, O’Laughlin, Michelle, Graubert, Timothy A., Walter, Matthew J.

Volltext

Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia von Klco, Jeffery M., Spencer, David H., Miller, Christopher A., Griffith, Malachi, Lamprecht, Tamara L., O’Laughlin, Michelle, Fronick, Catrina, Magrini, Vincent, Demeter, Ryan T., Fulton, Robert S., Eades, William C., Link, Daniel C., Graubert, Timothy A., Walter, Matthew J., Mardis, Elaine R., Dipersio, John F., Wilson, Richard K., Ley, Timothy J.

Volltext

CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression von Spencer, David H., Russler-Germain, David A., Ketkar, Shamika, Helton, Nichole M., Lamprecht, Tamara L., Fulton, Robert S., Fronick, Catrina C., O’Laughlin, Michelle, Heath, Sharon E., Shinawi, Marwan, Westervelt, Peter, Payton, Jacqueline E., Wartman, Lukas D., Welch, John S., Wilson, Richard K., Walter, Matthew J., Link, Daniel C., DiPersio, John F., Ley, Timothy J.

Volltext

Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia von Churpek, Jane E., Pyrtel, Khateriaa, Kanchi, Krishna-Latha, Shao, Jin, Koboldt, Daniel, Miller, Christopher A., Shen, Dong, Fulton, Robert, O’Laughlin, Michelle, Fronick, Catrina, Pusic, Iskra, Uy, Geoffrey L., Braunstein, Evan M., Levis, Mark, Ross, Julie, Elliott, Kevin, Heath, Sharon, Jiang, Allan, Westervelt, Peter, DiPersio, John F., Link, Daniel C., Walter, Matthew J., Welch, John, Wilson, Richard, Ley, Timothy J., Godley, Lucy A., Graubert, Timothy A.

Volltext

Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome von Shirai, Cara Lunn, White, Brian S., Tripathi, Manorama, Tapia, Roberto, Ley, James N., Ndonwi, Matthew, Kim, Sanghyun, Shao, Jin, Carver, Alexa, Saez, Borja, Fulton, Robert S., Fronick, Catrina, O’Laughlin, Michelle, Lagisetti, Chandraiah, Webb, Thomas R., Graubert, Timothy A., Walter, Matthew J.

Volltext

Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling von Pollyea, Daniel A, Harris, Chelsea, Rabe, Jennifer L, Hedin, Brenna R, De Arras, Lesly, Katz, Sigrid, Wheeler, Emily, Bejar, Rafael, Walter, Matthew J, Jordan, Craig T, Pietras, Eric M, Alper, Scott

Volltext

Knockdown of HSPA9 induces TP53-dependent apoptosis in human hematopoietic progenitor cells von Liu, Tuoen, Krysiak, Kilannin, Shirai, Cara Lunn, Kim, Sanghyun, Shao, Jin, Ndonwi, Matthew, Walter, Matthew J

Volltext

Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML von Wong, Terrence N., Miller, Christopher A., Klco, Jeffery M., Petti, Allegra, Demeter, Ryan, Helton, Nichole M., Li, Tiandao, Fulton, Robert S., Heath, Sharon E., Mardis, Elaine R., Westervelt, Peter, DiPersio, John F., Walter, Matthew J., Welch, John S., Graubert, Timothy A., Wilson, Richard K., Ley, Timothy J., Link, Daniel C.

Volltext

Genetics of progression from MDS to secondary leukemia von Menssen, Andrew J., Walter, Matthew J.

Volltext

Genetics of myelodysplastic syndromes: new insights von Graubert, Timothy, Walter, Matthew J

Volltext

Discriminating a common somatic ASXL1 mutation (c.1934dup; p.G646Wfs12) from artifact in myeloid malignancies using NGS von Alberti, Michael O., Srivatsan, Sridhar Nonavinkere, Shao, Jin, McNulty, Samantha N., Chang, Gue Su, Miller, Christopher A., Dunlap, Jennifer B., Yang, Fei, Press, Richard D., Gao, Qingsong, Ding, Li, Heusel, Jonathan W., Duncavage, Eric J., Walter, Matthew J.

Volltext

Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers von Duncavage, Eric J, Schroeder, Molly C, O’Laughlin, Michele, Wilson, Roxanne, MacMillan, Sandra, Bohannon, Andrew, Kruchowski, Scott, Garza, John, Du, Feiyu, Hughes, Andrew E.O, Robinson, Josh, Hughes, Emma, Heath, Sharon E, Baty, Jack D, Neidich, Julie, Christopher, Matthew J, Jacoby, Meagan A, Uy, Geoffrey L, Fulton, Robert S, Miller, Christopher A, Payton, Jacqueline E, Link, Daniel C, Walter, Matthew J, Westervelt, Peter, DiPersio, John F, Ley, Timothy J, Spencer, David H

Volltext

Increased clonal hematopoiesis involving DNA damage response genes in patients undergoing lung transplantation von Tague, Laneshia K, Oetjen, Karolyn A, Mahadev, Anirudh, Walter, Matthew J, Anthony, Hephzibah, Kreisel, Daniel, Link, Daniel C, Gelman, Andrew E

Volltext

Knockdown of Hspa9, a del(5q31.2) gene, results in a decrease in hematopoietic progenitors in mice von Chen, Tim H.-P., Kambal, Amal, Krysiak, Kilannin, Walshauser, Mark A., Raju, Gagan, Tibbitts, Justin F., Walter, Matthew J.

Volltext

Age-related mutations associated with clonal hematopoietic expansion and malignancies von Xie, Mingchao, Lu, Charles, Wang, Jiayin, McLellan, Michael D, Johnson, Kimberly J, Wendl, Michael C, McMichael, Joshua F, Schmidt, Heather K, Yellapantula, Venkata, Miller, Christopher A, Ozenberger, Bradley A, Welch, John S, Link, Daniel C, Walter, Matthew J, Mardis, Elaine R, Dipersio, John F, Chen, Feng, Wilson, Richard K, Ley, Timothy J, Ding, Li

Volltext

Progressive, edematous plaques, mild pancytopenia, and inflammation von Compton, Leigh A., Jones, Heather A., Vinyard, Connor A., Lee, Yi-Shan, Walter, Matthew J., Yokoyama, Christine C.

Volltext

Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant von Jacoby, Meagan A, Duncavage, Eric J, Chang, Gue Su, Miller, Christopher A, Shao, Jin, Elliott, Kevin, Robinson, Joshua, Fulton, Robert S, Fronick, Catrina C, O'Laughlin, Michelle, Heath, Sharon E, Pusic, Iskra, Welch, John S, Link, Daniel C, DiPersio, John F, Westervelt, Peter, Ley, Timothy J, Graubert, Timothy A, Walter, Matthew J

Volltext