Chroman-4-one- and Chromone-Based Sirtuin 2 Inhibitors with Antiproliferative Properties in Cancer Cells von Seifert, Tina, Malo, Marcus, Kokkola, Tarja, Engen, Karin, Fridén-Saxin, Maria, Wallén, Erik A. A, Lahtela-Kakkonen, Maija, Jarho, Elina M, Luthman, Kristina

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The effect of prolyl oligopeptidase inhibitors on alpha-synuclein aggregation and autophagy cannot be predicted by their inhibitory efficacy von Kilpeläinen, Tommi P., Hellinen, Laura, Vrijdag, Johannes, Yan, Xu, Svarcbahs, Reinis, Vellonen, Kati-Sisko, Lambeir, Anne-Marie, Huttunen, Henri, Urtti, Arto, Wallen, Erik A.A, Myöhänen, Timo T.

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5‑Aminothiazoles Reveal a New Ligand-Binding Site on Prolyl Oligopeptidase Which is Important for Modulation of Its Protein–Protein Interaction-Derived Functions von Pätsi, Henri T., Kilpeläinen, Tommi P., Jumppanen, Mikael, Uhari-Väänänen, Johanna, Wielendaele, Pieter Van, De Lorenzo, Francesca, Cui, Hengjing, Auno, Samuli, Saharinen, Janne, Seppälä, Erin, Sipari, Nina, Savinainen, Juha, De Meester, Ingrid, Lambeir, Anne-Marie, Lahtela-Kakkonen, Maija, Myöhänen, Timo T., Wallén, Erik A. A.

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Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on α‑Synuclein Mouse Models of Parkinson’s Disease von Kilpeläinen, Tommi P., Pätsi, Henri T., Svarcbahs, Reinis, Julku, Ulrika H., Eteläinen, Tony S., Cui, Hengjing, Auno, Samuli, Sipari, Nina, Norrbacka, Susanna, Leino, Teppo O., Jäntti, Maria, Myöhänen, Timo T., Wallén, Erik A. A.

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Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 Inhibitors von Huhtiniemi, Tero, Suuronen, Tiina, Rinne, Valtteri M, Wittekindt, Carsten, Lahtela-Kakkonen, Maija, Jarho, Elina, Wallén, Erik A. A, Salminen, Antero, Poso, Antti, Leppänen, Jukka

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The azulene scaffold from a medicinal chemist's perspective: Physicochemical and in vitro parameters relevant for drug discovery von Leino, Teppo O., Sieger, Peter, Yli-Kauhaluoma, Jari, Wallén, Erik A.A., Kley, Jörg T.

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Azulene as a biphenyl mimetic in orexin/hypocretin receptor agonists von Leino, Teppo O., Turku, Ainoleena, Urvas, Lauri, Adhikari, Karuna, Oksanen, Jouni, Steynen, Yana, Yli-Kauhaluoma, Jari, Xhaard, Henri, Kukkonen, Jyrki P., Wallén, Erik A.A.

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2‑Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors von Pätsi, Henri T, Kilpeläinen, Tommi P, Auno, Samuli, Dillemuth, Pyry M. J, Arja, Khaled, Lahtela-Kakkonen, Maija K, Myöhänen, Timo T, Wallén, Erik A. A

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Tetrazole as a Replacement of the Electrophilic Group in Characteristic Prolyl Oligopeptidase Inhibitors von Kilpeläinen, Tommi P, Tyni, Jonna K, Lahtela-Kakkonen, Maija K, Eteläinen, Tony S, Myöhänen, Timo T, Wallén, Erik A. A

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Azulene-based compounds for targeting orexin receptors von Leino, Teppo O., Turku, Ainoleena, Yli-Kauhaluoma, Jari, Kukkonen, Jyrki P., Xhaard, Henri, Wallén, Erik A.A.

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A scaffold replacement approach towards new sirtuin 2 inhibitors von Seifert, Tina, Malo, Marcus, Kokkola, Tarja, Stéen, E. Johanna L., Meinander, Kristian, Wallén, Erik A.A., Jarho, Elina M., Luthman, Kristina

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Pharmacological characterization of the orexin/hypocretin receptor agonist Nag 26 von Rinne, Maiju K., Leino, Teppo O., Turku, Ainoleena, Turunen, Pauli M., Steynen, Yana, Xhaard, Henri, Wallén, Erik A.A., Kukkonen, Jyrki P.

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Synthesis of 2,3,6,8-Tetrasubstituted Chromone Scaffolds von Dahlén, Kristian, Wallén, Erik A. A, Grøtli, Morten, Luthman, Kristina

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Synthesis of Orthogonally Protected Disulfide Bridge Mimetics von Tadd, Andrew C, Meinander, Kristian, Luthman, Kristina, Wallén, Erik A. A

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Utilization of whole health services among veterans with spinal cord injuries and disorders (SCI/D): Early insights from the VA SCI/D system of care von Wallen, Erik S., Sippel, Jennifer L., Park, Meaghan E., Etingen, Bella, Weaver, Frances M., Hogan, Timothy P., Smith, Bridget M., Bokhour, Barbara G., Wickremasinghe, Itala M.

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Stapled truncated orexin peptides as orexin receptor agonists von Karhu, Lasse, Weisell, Janne, Turunen, Pauli M., Leino, Teppo O., Pätsi, Henri, Xhaard, Henri, Kukkonen, Jyrki P., Wallén, Erik A.A.

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N,N‘-Bisbenzylidenebenzene-1,4-diamines and N,N‘-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors von Kiviranta, Päivi H, Leppänen, Jukka, Kyrylenko, Sergiy, Salo, Heikki S, Lahtela-Kakkonen, Maija, Tervo, Anu J, Wittekindt, Carsten, Suuronen, Tiina, Kuusisto, Erkki, Järvinen, Tomi, Salminen, Antero, Poso, Antti, Wallén, Erik A. A

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Inhibitors and promoters of tubulin polymerization: Synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents von Dyrager, Christine, Wickström, Malin, Fridén-Saxin, Maria, Friberg, Annika, Dahlén, Kristian, Wallén, Erik A.A., Gullbo, Joachim, Grøtli, Morten, Luthman, Kristina

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Chroman-4-one and chromone based somatostatin β-turn mimetics von Fridén-Saxin, Maria, Seifert, Tina, Malo, Marcus, da Silva Andersson, Krystle, Pemberton, Nils, Dyrager, Christine, Friberg, Annika, Dahlén, Kristian, Wallén, Erik A.A., Grøtli, Morten, Luthman, Kristina

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Mimetics of the disulfide bridge between the N- and C-terminal cysteines of the KLK3-stimulating peptide B-2 von Pakkala, Miikka, Weisell, Janne, Hekim, Can, Vepsäläinen, Jouko, Wallen, Erik A. A, Stenman, Ulf-Håkan, Koistinen, Hannu, Närvänen, Ale

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