Synthesis of P1′-Functionalized Macrocyclic Transition-State Mimicking HIV‑1 Protease Inhibitors Encompassing a Tertiary Alcohol von De Rosa, Maria, Unge, Johan, Motwani, Hitesh V, Rosenquist, Åsa, Vrang, Lotta, Wallberg, Hans, Larhed, Mats

Volltext

Design and Synthesis of P1–P3 Macrocyclic Tertiary-Alcohol-Comprising HIV‑1 Protease Inhibitors von Joshi, Advait, Véron, Jean-Baptiste, Unge, Johan, Rosenquist, Åsa, Wallberg, Hans, Samuelsson, Bertil, Hallberg, Anders, Larhed, Mats

Volltext

Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors von Wu, Xiongyu, Öhrngren, Per, Joshi, Advait A, Trejos, Alejandro, Persson, Magnus, Arvela, Riina K, Wallberg, Hans, Vrang, Lotta, Rosenquist, Åsa, Samuelsson, Bertil B, Unge, Johan, Larhed, Mats

Volltext

Studies of the reactions between indole-2,3-diones (isatins) and 2-aminobenzylamine von Bergman, Jan, Engqvist, Robert, Stålhandske, Claes, Wallberg, Hans

Volltext

Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application von Kesteleyn, Bart, Amssoms, Katie, Schepens, Wim, Hache, Geerwin, Verschueren, Wim, Van De Vreken, Wim, Rombauts, Klara, Meurs, Greet, Sterkens, Patrick, Stoops, Bart, Baert, Lieven, Austin, Nigel, Wegner, Jörg, Masungi, Chantal, Dierynck, Inge, Lundgren, Stina, Jönsson, Daniel, Parkes, Kevin, Kalayanov, Genadiy, Wallberg, Hans, Rosenquist, Åsa, Samuelsson, Bertil, Van Emelen, Kristof, Thuring, Jan Willem

Volltext

Microwave-Accelerated Synthesis of P1‘-Extended HIV-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-State Mimicking Scaffold von Ekegren, Jenny K, Ginman, Nina, Johansson, Åsa, Wallberg, Hans, Larhed, Mats, Samuelsson, Bertil, Unge, Torsten, Hallberg, Anders

Volltext

Variations of the P2 group in HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimicking scaffold von Ekegren, Jenny K, Gising, Johan, Wallberg, Hans, Larhed, Mats, Samuelsson, Bertil, Hallberg, Anders

Volltext

Abstract 2691: A triple combination of fostrox (MIV-818) with immune checkpoint and kinase inhibition shows increased anti-tumor efficacy in vivo von Oberg, Fredrik G., Bhoi, Sujata, Jensen, Malene, Tunblad, Karin, Wallberg, Hans

Volltext

455 Fostrox (MIV-818) in combination with anti-PD-1 shows increased efficacy in nonclinical tumor models in vivo von Oberg, Fredrik, Bhoi, Sujata, Jensen, Malene, Morris, Tom, Tunblad, Karin, Wallberg, Hans

Volltext

A Phase 1a/1b Study of Fostroxacitabine Bralpamide (Fostrox) Monotherapy in Hepatocellular Carcinoma and Solid Tumor Liver Metastases von Plummer, Ruth, Greystoke, Alastair, Naylor, Gregory, Sarker, Debashis, Anam, A N M Kaiser, Prenen, Hans, Teuwen, Laure-Anne, Van Cutsem, Eric, Dekervel, Jeroen, Haugk, Beate, Ness, Thomas, Bhoi, Sujata, Jensen, Malene, Morris, Tom, Baumann, Pia, Sjögren, Niclas, Tunblad, Karin, Wallberg, Hans, Öberg, Fredrik, Evans, Thomas R Jeffry

Volltext

A Phase 1a/1b Study of Fostroxacitabine Bralpamide (Fostrox) Monotherapy in Hepatocellular Carcinoma and Solid Tumor Liver Metastases von Plummer, Ruth, Greystoke, Alastair, Naylor, Gregory, Sarker, Debashis, Anam, A.N.M. Kaiser, Prenen, Hans, Teuwen, Laure-Anne, Van Cutsem, Eric, Dekervel, Jeroen, Haugk, Beate, Ness, Thomas, Bhoi, Sujata, Jensen, Malene, Morris, Tom, Baumann, Pia, Sjogren, Niclas, Tunblad, Karin, Wallberg, Hans, Oberg, Fredrik, Evans, Thomas R. Jeffry

Volltext

Identification of MMP-12 Inhibitors by Using Biosensor-Based Screening of a Fragment Library von Nordström, Helena, Gossas, Thomas, Hämäläinen, Markku, Källblad, Per, Nyström, Susanne, Wallberg, Hans, Danielson, U. Helena

Volltext

HIV-1 Protease Inhibitors with a Transition-State Mimic Comprising a Tertiary Alcohol: Improved Antiviral Activity in Cells von Mahalingam, A.K, Axelsson, Linda, Ekegren, Jenny K, Wannberg, Johan, Kihlström, Jacob, Unge, Torsten, Wallberg, Hans, Samuelsson, Bertil, Larhed, Mats, Hallberg, Anders

Volltext

Two-Carbon-Elongated HIV-1 Protease Inhibitors with a Tertiary-Alcohol-Containing Transition-State Mimic von Wu, Xiongyu, Öhrngren, Per, Ekegren, Jenny K, Unge, Johan, Unge, Torsten, Wallberg, Hans, Samuelsson, Bertil, Hallberg, Anders, Larhed, Mats

Volltext

Design and synthesis of novel P2 substituents in diol-based HIV protease inhibitors von Adrian Meredith, Jenny, Wallberg, Hans, Vrang, Lotta, Oscarson, Stefan, Parkes, Kevin, Hallberg, Anders, Samuelsson, Bertil

Volltext

A New Class of HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimicking Scaffold von Ekegren, Jenny K, Unge, Torsten, Safa, Mayada Zreik, Wallberg, Hans, Samuelsson, Bertil, Hallberg, Anders

Volltext

Synthesis of the Hepatitis B Nucleoside Analogue Lagociclovir Valactate von Brodszki, Martin, Bäckström, Birthe, Horvath, Karol, Larsson, Torbjörn, Malmgren, Håkan, Pelcman, Mikael, Wähling, Horst, Wallberg, Hans, Wennerberg, Johan

Volltext

Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? A Case Study of... von Isaksson, Johan, Nyström, Susanne, Derbyshire, Dean, Wallberg, Hans, Agback, Tatiana, Kovacs, Helena, Bertini, Ivano, Giachetti, Andrea, Luchinat, Claudio

Volltext

Novel potent macrocyclic inhibitors of the hepatitis C virus NS3 protease: Use of cyclopentane and cyclopentene P2-motifs von Bäck, Marcus, Johansson, Per-Ola, Wångsell, Fredrik, Thorstensson, Fredrik, Kvarnström, Ingemar, Ayesa, Susana, Wähling, Horst, Pelcman, Mikael, Jansson, Katarina, Lindström, Stefan, Wallberg, Hans, Classon, Björn, Rydergård, Christina, Vrang, Lotta, Hamelink, Elizabeth, Hallberg, Anders, Rosenquist, Åsa, Samuelsson, Bertil

Volltext

HIV-1 protease inhibitors with a tertiary alcohol containing transition-state mimic and various P2 and P1′ substituents von Öhrngren, Per, Wu, Xiongyu, Persson, Magnus, Ekegren, Jenny K., Wallberg, Hans, Vrang, Lotta, Rosenquist, Åsa, Samuelsson, Bertil, Unge, Torsten, Larhed, Mats

Volltext