Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors von Kosinski, Cynthia, Li, Vivian S.W, Chan, Annie S.Y, Zhang, Ji, Ho, Coral, Tsui, Wai Yin, Chan, Tsun Leung, Mifflin, Randy C, Powell, Don W, Yuen, Siu Tsan, Leung, Suet Yi, Chen, Xin

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A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening von Yan, Helen H.N., Siu, Hoi Cheong, Law, Simon, Ho, Siu Lun, Yue, Sarah S.K., Tsui, Wai Yin, Chan, Dessy, Chan, April S., Ma, Stephanie, Lam, Ka On, Bartfeld, Sina, Man, Alice H.Y., Lee, Bernard C.H., Chan, Annie S.Y., Wong, Jason W.H., Cheng, Priscilla S.W., Chan, Anthony K.W., Zhang, Jiangwen, Shi, Jue, Fan, Xiaodan, Kwong, Dora L.W., Mak, Tak W., Yuen, Siu Tsan, Clevers, Hans, Leung, Suet Yi

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RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation von Yan, Helen H N, Lai, Jeffrey C W, Ho, Siu Lun, Leung, Wai Keung, Law, Wai Lun, Lee, Janet F Y, Chan, Anthony K W, Tsui, Wai Yin, Chan, Annie S Y, Lee, Bernard C H, Yue, Sarah S K, Man, Alice H Y, Clevers, Hans, Yuen, Siu Tsan, Leung, Suet Yi

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Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer von Wang, Kai, Kan, Junsuo, Yuen, Siu Tsan, Shi, Stephanie T, Chu, Kent Man, Law, Simon, Chan, Tsun Leung, Kan, Zhengyan, Chan, Annie S Y, Tsui, Wai Yin, Lee, Siu Po, Ho, Siu Lun, Chan, Anthony K W, Cheng, Grace H W, Roberts, Peter C, Rejto, Paul A, Gibson, Neil W, Pocalyko, David J, Mao, Mao, Xu, Jiangchun, Leung, Suet Yi

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Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles von Yan, Helen H N, Siu, Hoi Cheong, Ho, Siu Lun, Yue, Sarah S K, Gao, Yang, Tsui, Wai Yin, Chan, Dessy, Chan, April S, Wong, Jason W H, Man, Alice H Y, Lee, Bernard C H, Chan, Annie S Y, Chan, Anthony K W, Hui, Ho Sang, Cheung, Arthur K L, Law, Wai Lun, Lo, Oswens S H, Yuen, Siu Tsan, Clevers, Hans, Leung, Suet Yi

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Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1 von van Kessel, Ad Geurts, Hoenselaar, Eveline, Voorendt, Marsha, Kuiper, Roland P, Lee, Tracy Y H, Hendriks-Cornelissen, Sandra J B, Yuen, Siu Tsan, van Krieken, J Han J M, Leung, Suet Yi, Hoogerbrugge, Nicoline, Chan, Tsun Leung, Bodmer, Danielle, Ligtenberg, Marjolijn J L, Goossens, Monique, Hebeda, Konnie M, Tsui, Wai Yin, Brunner, Han G, Kong, Chi Kwan

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Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models von Tong, Yin, Cheng, Priscilla S W, Or, Chung Sze, Yue, Sarah S K, Siu, Hoi Cheong, Ho, Siu Lun, Law, Simon Y K, Tsui, Wai Yin, Chan, Dessy, Ma, Stephanie, Lee, Siu Po, Chan, Annie S Y, Chan, April S, Yun, Shui Wa, Hui, Ho Sang, Yuen, Siu Tsan, Leung, Suet Yi, Yan, Helen H N

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Mutational landscape of normal epithelial cells in Lynch Syndrome patients von Lee, Bernard C. H., Robinson, Philip S., Coorens, Tim H. H., Yan, Helen H. N., Olafsson, Sigurgeir, Lee-Six, Henry, Sanders, Mathijs A., Siu, Hoi Cheong, Hewinson, James, Yue, Sarah S. K., Tsui, Wai Yin, Chan, Annie S. Y., Chan, Anthony K. W., Ho, Siu Lun, Campbell, Peter J., Martincorena, Inigo, Buczacki, Simon J. A., Yuen, Siu Tsan, Leung, Suet Yi, Stratton, Michael R.

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Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer von Yuen, Siu Tsan, Leung, Suet Yi, Chan, Tsun Leung, Kong, Chi Kwan, Chan, Yee Wai, Chan, Annie SY, Ng, Wai Fu, Tsui, Wai Yin, Lo, Michelle WS, Tam, Wing Yip, Li, Vivian SW

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Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumours von Guo, Dong Li, Zhang, Ji, Yuen, Siu Tsan, Tsui, Wai Yin, Chan, Annie S.Y., Ho, Coral, Ji, Jiafu, Leung, Suet Yi, Chen, Xin

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Frequent Inactivation of Axon Guidance Molecule RGMA in Human Colon Cancer Through Genetic and Epigenetic Mechanisms von Li, Vivian S.W, Yuen, Siu Tsan, Chan, Tsun Leung, Yan, Helen H.N, Law, Wai Lun, Yeung, Bonnie H.Y, Chan, Annie S.Y, Tsui, Wai Yin, So, Samuel, Chen, Xin, Leung, Suet Yi

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Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma von SZE WAH CHAN, Agnes, WAI YIN TSUI, XIN CHEN, MAN CHU, Kent, TSUN LEUNG CHAN, SHUK YEE CHAN, Annie, RUI LI, SO, Samuel, SIU TSAN YUEN, SUET YI LEUNG

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Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer von Wang, Kai, Yuen, Siu Tsan, Xu, Jiangchun, Lee, Siu Po, Yan, Helen H N, Shi, Stephanie T, Siu, Hoi Cheong, Deng, Shibing, Chu, Kent Man, Law, Simon, Chan, Kok Hoe, Chan, Annie S Y, Tsui, Wai Yin, Ho, Siu Lun, Chan, Anthony K W, Man, Jonathan L K, Foglizzo, Valentina, Ng, Man Kin, Chan, April S, Ching, Yick Pang, Cheng, Grace H W, Xie, Tao, Fernandez, Julio, Li, Vivian S W, Clevers, Hans, Rejto, Paul A, Mao, Mao, Leung, Suet Yi

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Abstract 1448: Unraveling the oncogenic pathway of serrated polyposis syndrome driven by RNF43 germline mutation von Yan, Helen Hoi Ning, Lai, Jeffrey C W, Ho, Siu Lun, Chan, Anthony K W, Tsui, Wai Yin, Chan, Annie S Y, Yuen, Siu Tsan, Leung, Suet Yi

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Abstract 4378: Gastric cancer organoid culture shows preserved genomic stability in long-term passage von Yue, Sarah Siu Kuen, Yan, Helen Hoi Ning, Siu, Hoi Cheong, Ho, Siu Lun, Tsui, Wai Yin, Chan, Dessy, Chan, Annie Shuk Yee, Lee, Bernard Chi Hang, Chan, Anthony Kin Wang, Leung, Suet Yi

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Abstract 179: Regulation of stromal miR-125b on normal colonic epithelial cell renewal and its putative role in tumorigenesis von Yan, Helen H N, Lau, Jackie K Y, Chan, Annie S Y, Tsui, Wai Yin, Chan, Tsun Leung, Leung, Suet Yi

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Abstract 5016: Retinoic acid receptor responder 3 expression suppresses colorectal cancer cell growth in vitro and is a stage-independent prognostic marker in colorectal cancer pat... von Yan, Helen Hoi Ning, Li, Vivian S. W., Chan, Tsun Leung, Yuen, Siu Tsan, Yeung, Bonnie H. Y., Chan, Annie S. Y., Tsui, Wai Yin, Law, Wai Lun, Au, Gordon K. H., Kwong, Dora L. W., Leung, Suet Yi

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Abstract 4909: The role of CpG island methylator phenotype 2 (CIMP2) in early onset colorectal cancer patients von Li, Carmen, Yuen, Siu Tsan, Anthony, Chan, Kin Wang, Tsui, Wendy Wai Yin, Chan, Annie Suk Yee, Leung, Suet Yi, Chan, Tsun Leung

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Mutational landscape of normal epithelial cells in Lynch Syndrome patients von Lee, Bernard CH, Robinson, Philip S, Coorens, Tim HH, Yan, Helen HN, Olafsson, Sigurgeir, Lee-Six, Henry, Sanders, Mathijs A, Siu, Hoi Cheong, Hewinson, James, Yue, Sarah SK, Tsui, Wai Yin, Chan, Annie SY, Chan, Anthony KW, Ho, Siu Lun, Campbell, Peter J, Martincorena, Inigo, Buczacki, Simon JA, Yuen, Siu Tsan, Leung, Suet Yi, Stratton, Michael R

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Mutational landscape of normal epithelial cells in Lynch Syndrome patients von Lee, Bernard CH, Robinson, Philip S, Coorens, Tim HH, Yan, Helen HN, Olafsson, Sigurgeir, Lee-Six, Henry, Sanders, Mathijs A, Siu, Hoi Cheong, Hewinson, James, Yue, Sarah SK, Tsui, Wai Yin, Chan, Annie SY, Chan, Anthony KW, Ho, Siu Lun, Campbell, Peter J, Martincorena, Inigo, Buczacki, Simon JA, Yuen, Siu Tsan, Leung, Suet Yi, Stratton, Michael R

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