A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models von Singh, Dharaminder, Deosarkar, Sudhir P, Cadogan, Elaine, Flemington, Vikki, Bray, Alysha, Zhang, Jingwen, Reiserer, Ronald S, Schaffer, David K, Gerken, Gregory B, Britt, Clayton M, Werner, Erik M, Gibbons, Francis D, Kostrzewski, Tomasz, Chambers, Christopher E, Davies, Emma J, Montoya, Antonio Ramos, Fok, Jacqueline H L, Hughes, David, Fabre, Kristin, Wagoner, Matthew P, Wikswo, John P, Scott, Clay W

Volltext

A REST derived gene signature stratifies glioblastomas into chemotherapy resistant and responsive disease von Wagoner, Matthew P, Roopra, Avtar

Volltext

The transcription factor REST is lost in aggressive breast cancer von Wagoner, Matthew P, Gunsalus, Kearney T W, Schoenike, Barry, Richardson, Andrea L, Friedl, Andreas, Roopra, Avtar

Volltext

Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity von Bajaj, Piyush, Chung, Git, Pye, Keith, Yukawa, Tomoya, Imanishi, Akio, Takai, Yuichi, Brown, Colin, Wagoner, Matthew P.

Volltext

A Conspicuous Connection: Structure Defines Function for the Phosphatidylinositol-Phosphate Kinase Family von Heck, Jessica N., Mellman, David L., Ling, Kun, Sun, Yue, Wagoner, Matthew P., Schill, Nicholas J., Anderson, Richard A.

Volltext

Induction of the RNA regulator LIN28A is required for the growth and pathogenesis of RESTless breast tumors von Gunsalus, Kearney T W, Wagoner, Matthew P, Meyer, Kassondra, Potter, Wyatt B, Schoenike, Barry, Kim, Soyoung, Alexander, Caroline M, Friedl, Andreas, Roopra, Avtar

Volltext

Human 3D Gastrointestinal Microtissue Barrier Function As a Predictor of Drug-Induced Diarrhea von Peters, Matthew F, Landry, Tim, Pin, Carmen, Maratea, Kim, Dick, Cortni, Wagoner, Matthew P, Choy, Allison L, Barthlow, Herb, Snow, Deb, Stevens, Zachary, Armento, Alex, Scott, Clay W, Ayehunie, Seyoum

Volltext

New phenotypic cytotoxicity assay for ROS-inducing compounds using rat renal epithelial cells von Uchiyama, Noriko, Yukawa, Tomoya, Dragan, Yvonne P., Wagoner, Matthew P., Naven, Russell T.

Volltext

Early prediction of polymyxin-induced nephrotoxicity with next-generation urinary kidney injury biomarkers von Keirstead, Natalie D, Wagoner, Matthew P, Bentley, Patricia, Blais, Marie, Brown, Crystal, Cheatham, Letitia, Ciaccio, Paul, Dragan, Yvonne, Ferguson, Douglas, Fikes, Jim, Galvin, Melanie, Gupta, Anshul, Hale, Michael, Johnson, Nakpangi, Luo, Wenli, McGrath, Frank, Pietras, Mark, Price, Sally, Sathe, Abhishek G, Sasaki, Jennifer C, Snow, Debra, Walsky, Robert L, Kern, Gunther

Volltext

Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate) von Baran, Szczepan W, Brown, Paul C, Baudy, Andreas R, Fitzpatrick, Suzanne C, Frantz, Christopher, Fullerton, Aaron, Gan, Jinping, Hardwick, Rhiannon N, Hillgren, Kathleen M, Kopec, Anna K, Liras, Jennifer L, Mendrick, Donna L, Nagao, Ryan, Proctor, William R, Ramsden, Diane, Ribeiro, Alexandre J.S, Stresser, David, Sung, Kyung E, Sura, Radhakrishna, Tetsuka, Kazuhiro, Tomlinson, Lindsay, Van Vleet, Terry, Wagoner, Matthew P, Wang, Qin, Arslan, Sevim Yildiz, Yoder, Gorm, Ekert, Jason E

Volltext

Movin' on up: the role of PtdIns(4,5)P2 in cell migration von Ling, Kun, Schill, Nicholas J., Wagoner, Matthew P., Sun, Yue, Anderson, Richard A.

Volltext

Type Iγ phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration von Sun, Yue, Ling, Kun, Wagoner, Matthew P, Anderson, Richard A

Volltext

Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity von Wang, Qin, Cohen, Jennifer D, Yukawa, Tomoya, Estrella, Heather, Leonard, Chris, Nunes, Jairo, Choi, Colin, Mishra, Nibha, Lewis, Lauren, Baker, Kevin S, Kuga, Kazuhiro, Dragan, Yvonne P, Wagoner, Matthew P

Volltext

A microfluidic system that replicates pharmacokinetic von Singh, Dharaminder, Deosarkar, Sudhir P, Cadogan, Elaine, Flemington, Vikki, Bray, Alysha, Zhang, Jingwen, Reiserer, Ronald S, Schaffer, David K, Gerken, Gregory B, Britt, Clayton M, Werner, Erik M, Gibbons, Francis D, Kostrzewski, Tomasz, Chambers, Christopher E, Davies, Emma J, Montoya, Antonio Ramos, Fok, Jacqueline H. L, Hughes, David, Fabre, Kristin, Wagoner, Matthew P, Wikswo, John P, Scott, Clay W

Volltext

Identification of FOXI1 as a potential regulator of Kidney Injury Molecule‐1 in Cisplatin‐Induced Kidney Injury von Wagoner, Matthew P, Milano, Joseph, Jeffy, Brandon, Thurman, Dale, Brott, David, Dragan, Yvonne, Kinter, Lewis

Volltext

Abstract LB-271: Loss of the transcription factor REST promotes breast cancer tumorigenicity in a LIN28-dependent manner von Gunsalus, Kearney T. W., Wagoner, Matthew P., Meyer, Kassondra M., Potter, Wyatt B., Kim, Soyoung, Schoenike, Barry, Alexander, Caroline M., Freidl, Andreas, Roopra, Avtar

Volltext

Abstract 5020: Role of LIN28 in aggressive breast cancers lacking REST von Gunsalus, Kearney T.W., Wagoner, Matthew P., Potter, Wyatt B., Schoenike, Barry, Roopra, Avtar

Volltext

Induction of the RNA Regulator LIN28A Is Required for the Growth and Pathogenesis of RESTIess Breast Tumors von GUNSALUS, Kearney T. W, WAGONER, Matthew P, MEYE, Kassondra, POTTER, Wyatt B, SCHOENIKE, Barry, KIM, Soyoung, ALEXANDER, Caroline M, FRIEDL, Andreas, ROOPRA, Avtar

Volltext

Type Igamma PIP Kinase is Required for EGF‐Stimulated Directional Cell Migration von Sun, Yue, Ling, Kun, Wagoner, Matthew P., Anderson, Richard A.

Volltext

Type I¿ phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration von Sun, Yue, Ling, Kun, Wagoner, Matthew P, Anderson, Richard A

Volltext