Take the Torch von Waddell, Ian

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Inhibition of Glucose-6-Phosphate Dehydrogenase Activity Attenuates Right Ventricle Pressure and Hypertrophy Elicited by VEGFR Inhibitor + Hypoxia von Kitagawa, Atsushi, Jacob, Christina, Jordan, Allan, Waddell, Ian, McMurtry, Ivan F, Gupte, Sachin A

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First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib von James, Dominic I, Smith, Kate M, Jordan, Allan M, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, Jones, Stuart, Kelly, Paul, McGonagle, Alison E, Small, Helen, Stowell, Alexandra I. J, Tucker, Julie, Waddell, Ian D, Waszkowycz, Bohdan, Ogilvie, Donald J

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Small-Molecule Inhibition of UBE2T/FANCL-Mediated Ubiquitylation in the Fanconi Anemia Pathway von Cornwell, Matthew J, Thomson, Graeme J, Coates, Julia, Belotserkovskaya, Rimma, Waddell, Ian D, Jackson, Stephen P, Galanty, Yaron

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Regulation of ALT-associated homology-directed repair by polyADP-ribosylation von Hoang, Song My, Kaminski, Nicole, Bhargava, Ragini, Barroso-González, Jonathan, Lynskey, Michelle L., García-Expósito, Laura, Roncaioli, Justin L., Wondisford, Anne R., Wallace, Callen T., Watkins, Simon C., James, Dominic I., Waddell, Ian D., Ogilvie, Donald, Smith, Kate M., da Veiga Leprevost, Felipe, Mellacharevu, Dattatreya, Nesvizhskii, Alexey I., Li, Jianfeng, Ray-Gallet, Dominique, Sobol, Robert W., Almouzni, Genevieve, O’Sullivan, Roderick J.

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Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methyl... von Joshi, Sachindra Raj, Kitagawa, Atsushi, Jacob, Christina, Hashimoto, Ryota, Dhagia, Vidhi, Ramesh, Amrit, Zheng, Connie, Zhang, Hui, Jordan, Allan, Waddell, Ian, Leopold, Jane, Hu, Cheng-Jun, McMurtry, Ivan F, D'Alessandro, Angelo, Stenmark, Kurt R, Gupte, Sachin A

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Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sul... von Waszkowycz, Bohdan, Smith, Kate M, McGonagle, Alison E, Jordan, Allan M, Acton, Ben, Fairweather, Emma E, Griffiths, Louise A, Hamilton, Niall M, Hamilton, Nicola S, Hitchin, James R, Hutton, Colin P, James, Dominic I, Jones, Clifford D, Jones, Stuart, Mould, Daniel P, Small, Helen F, Stowell, Alexandra I. J, Tucker, Julie A, Waddell, Ian D, Ogilvie, Donald J

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In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor von Gilmartin, Aidan G, Groy, Arthur, Gore, Elizabeth R, Atkins, Charity, Long, Edward R, Montoute, Monica N, Wu, Zining, Halsey, Wendy, McNulty, Dean E, Ennulat, Daniela, Rueda, Lourdes, Pappalardi, Melissa, Kruger, Ryan G, McCabe, Michael T, Raoof, Ali, Butlin, Roger, Stowell, Alexandra, Cockerill, Mark, Waddell, Ian, Ogilvie, Donald, Luengo, Juan, Jordan, Allan, Benowitz, Andrew B

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Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer von Jain, Aditi, Agostini, Lebaron C, McCarthy, Grace A, Chand, Saswati N, Ramirez, AnnJosette, Nevler, Avinoam, Cozzitorto, Joseph, Schultz, Christopher W, Lowder, Cinthya Yabar, Smith, Kate M, Waddell, Ian D, Raitses-Gurevich, Maria, Stossel, Chani, Gorman, Yulia Glick, Atias, Dikla, Yeo, Charles J, Winter, Jordan M, Olive, Kenneth P, Golan, Talia, Pishvaian, Michael J, Ogilvie, Donald, James, Dominic I, Jordan, Allan M, Brody, Jonathan R

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Heat inactivation of clinical COVID-19 samples on an industrial scale for low risk and efficient high-throughput qRT-PCR diagnostic testing von Delpuech, Oona, Douthwaite, Julie A., Hill, Thomas, Niranjan, Dhevahi, Malintan, Nancy T., Duvoisin, Hannah, Elliott, Jane, Goodfellow, Ian, Hosmillo, Myra, Orton, Alexandra L., Taylor, Molly A., Brankin, Christopher, Pitt, Haidee, Ross-Thriepland, Douglas, Siek, Magdalena, Cuthbert, Anna, Richards, Ian, Ferdinand, John R., Barker, Colin, Shaw, Robert, Ariani, Cristina, Waddell, Ian, Rees, Steve, Green, Clive, Clark, Roger, Upadhyay, Abhishek, Howes, Rob

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Androgen Receptor and Poly(ADP-ribose) Glycohydrolase Inhibition Increases Efficiency of Androgen Ablation in Prostate Cancer Cells von Zhang, Manqi, Lai, Yanhao, Vasquez, Judy L., James, Dominic I., Smith, Kate M., Waddell, Ian D., Ogilvie, Donald J., Liu, Yuan, Agoulnik, Irina U.

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Studying Catabolism of Protein ADP-Ribosylation von Palazzo, Luca, James, Dominic I., Waddell, Ian D., Ahel, Ivan

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Toxoflavins and Deazaflavins as the First Reported Selective Small Molecule Inhibitors of Tyrosyl-DNA Phosphodiesterase II von Raoof, Ali, Depledge, Paul, Hamilton, Niall M, Hamilton, Nicola S, Hitchin, James R, Hopkins, Gemma V, Jordan, Allan M, Maguire, Laura A, McGonagle, Alison E, Mould, Daniel P, Rushbrooke, Mathew, Small, Helen F, Smith, Kate M, Thomson, Graeme J, Turlais, Fabrice, Waddell, Ian D, Waszkowycz, Bohdan, Watson, Amanda J, Ogilvie, Donald J

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A high-throughput screening-compatible homogeneous time-resolved fluorescence assay measuring the glycohydrolase activity of human poly(ADP-ribose) glycohydrolase von Stowell, Alexandra I.J., James, Dominic I., Waddell, Ian D., Bennett, Neil, Truman, Caroline, Hardern, Ian M., Ogilvie, Donald J.

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Rethinking ‘academic’ drug discovery: the Manchester Institute perspective von Jordan, Allan M., Waddell, Ian D., Ogilvie, Donald J.

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The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity von Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.

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Novel Steroid Inhibitors of Glucose 6-Phosphate Dehydrogenase von Hamilton, Niall M, Dawson, Martin, Fairweather, Emma E, Hamilton, Nicola S, Hitchin, James R, James, Dominic I, Jones, Stuart D, Jordan, Allan M, Lyons, Amanda J, Small, Helen F, Thomson, Graeme J, Waddell, Ian D, Ogilvie, Donald J

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Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores – A cautionary disclosure von Acton, Ben, Small, Helen F., Smith, Kate M., McGonagle, Alison, Stowell, Alexandra I.J., James, Dominic I., Hamilton, Niall M., Hamilton, Nicola, Hitchin, James R., Hutton, Colin P., Waddell, Ian D., Ogilvie, Donald J., Jordan, Allan M.

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Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators von BROCKLEHURST, Katy J, PAYNE, Victoria A, AGIUS, Loranne, DAVIES, Rick A, CARROLL, Debra, VERTIGAN, Helen L, WIGHTMAN, Heather J, ALSTON, Susan, WADDELL, Ian D, LEIGHTON, Brendan, COGHLAN, Matthew P

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TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k von Li, Yi-Ping, Lecker, Stewart H., Chen, Yuling, Waddell, Ian D., Goldberg, Alfred L., Reid, Michael B.

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