TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting β-CATENIN and AKT Signaling in Colorectal Cancer von Solberg, Nina T, Waaler, Jo, Lund, Kaja, Mygland, Line, Olsen, Petter A, Krauss, Stefan

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A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice von WAALER, Jo, MACHON, Ondrej, GRADL, Dietmar, VORONKOV, Andrey, VON FRIES, Jens Peter, KRAUSS, Stefan, TUMOVA, Lucie, DINH, Huyen, KORINEK, Vladimir, RAY WILSON, Steven, ERIK PAULSEN, Jan, PEDERSEN, Nina Marie, EIDE, Tor J, MACHONOVA, Olga

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A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation―Driven Colorectal Tumor Growth von LAU, Ted, CHAN, Emily, MACHON, Ondrej, KORINEK, Vladimir, CHOO, Edna, DIAZ, Dolores, MERCHANT, Mark, POLAKIS, Paul, HOLSWORTH, Daniel D, KRAUSS, Stefan, COSTA, Mike, CALLOW, Marinella, WAALER, Jo, BOGGS, Jason, BLAKE, Robert A, MAGNUSON, Steven, SAMBRONE, Amy, SCHUTTEN, Melissa, FIRESTEIN, Ron

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Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice von Wang, Hong, Kuusela, Sara, Rinnankoski-Tuikka, Rita, Dumont, Vincent, Bouslama, Rim, Ramadan, Usama Abo, Waaler, Jo, Linden, Anni-Maija, Chi, Nai-Wen, Krauss, Stefan, Pirinen, Eija, Lehtonen, Sanna

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Structural Basis and SAR for G007-LK, a Lead Stage 1,2,4-Triazole Based Specific Tankyrase 1/2 Inhibitor von Voronkov, Andrew, Holsworth, Daniel D, Waaler, Jo, Wilson, Steven R, Ekblad, Bie, Perdreau-Dahl, Harmonie, Dinh, Huyen, Drewes, Gerard, Hopf, Carsten, Morth, Jens P, Krauss, Stefan

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Novel Synthetic Antagonists of Canonical Wnt Signaling Inhibit Colorectal Cancer Cell Growth von WAALER, Jo, MACHON, Ondrej, DINH, Huyen, KRAUSS, Stefan, VON KRIES, Jens Peter, WILSON, Steven Ray, LUNDENES, Elsa, WEDLICH, Doris, GRADL, Dietmar, PAULSEN, Jan Erik, MACHONOVA, Olga, DEMBINSKI, Jennifer L

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Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach von Anumala, Upendra Rao, Waaler, Jo, Nkizinkiko, Yves, Ignatev, Alexander, Lazarow, Katina, Lindemann, Peter, Olsen, Petter Angell, Murthy, Sudarshan, Obaji, Ezeogo, Majouga, Alexander G, Leonov, Sergey, von Kries, Jens Peter, Lehtiö, Lari, Krauss, Stefan, Nazaré, Marc

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Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes von Thorvaldsen, Tor Espen, Pedersen, Nina Marie, Wenzel, Eva M, Schultz, Sebastian W, Brech, Andreas, Liestøl, Knut, Waaler, Jo, Krauss, Stefan, Stenmark, Harald

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The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice von Zhong, Linlin, Ding, Yun, Bandyopadhyay, Gautam, Waaler, Jo, Börgeson, Emma, Smith, Susan, Zhang, Mingchen, Phillips, Susan A., Mahooti, Sepi, Mahata, Sushil K., Shao, Jianhua, Krauss, Stefan, Chi, Nai-Wen

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The tankyrase inhibitor G007-LK inhibits small intestine LGR5 + stem cell proliferation without altering tissue morphology von Norum, Jens Henrik, Skarpen, Ellen, Brech, Andreas, Kuiper, Raoul, Waaler, Jo, Krauss, Stefan, Sørlie, Therese

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A Small-Molecule Tankyrase Inhibitor Reduces Glioma Stem Cell Proliferation and Sphere Formation von Kierulf-Vieira, Kirsten Strømme, Sandberg, Cecilie Jonsgar, Waaler, Jo, Lund, Kaja, Skaga, Erlend, Saberniak, Birthe Mikkelsen, Panagopoulos, Ioannis, Brandal, Petter, Krauss, Stefan, Langmoen, Iver Arne, Vik-Mo, Einar Osland

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A Mouse Model for the Rapid and Binomial Assessment of Putative WNT/β-Catenin Signalling Inhibitors von Tse, Janson, O’Keefe, Ryan, Rigopolous, Angela, Carli, Annalisa L. E, Waaler, Jo, Krauss, Stefan, Ernst, Matthias, Buchert, Michael

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Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models von Waaler, Jo, Mygland, Line, Tveita, Anders, Strand, Martin Frank, Solberg, Nina Therese, Olsen, Petter Angell, Aizenshtadt, Aleksandra, Fauskanger, Marte, Lund, Kaja, Brinch, Shoshy Alam, Lycke, Max, Dybing, Elisabeth, Nygaard, Vegard, Bøe, Sigurd Læines, Heintz, Karen-Marie, Hovig, Eivind, Hammarström, Clara, Corthay, Alexandre, Krauss, Stefan

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The tankyrase‐specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines von Wessel Stratford, Eva, Daffinrud, Jeanette, Munthe, Else, Castro, Russell, Waaler, Jo, Krauss, Stefan, Myklebost, Ola

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Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines von Mygland, Line, Brinch, Shoshy Alam, Strand, Martin Frank, Olsen, Petter Angell, Aizenshtadt, Aleksandra, Lund, Kaja, Solberg, Nina Therese, Lycke, Max, Thorvaldsen, Tor Espen, Espada, Sandra, Misaghian, Dorna, Page, Christian M., Agafonov, Oleg, Nygård, Ståle, Chi, Nai-Wen, Lin, Eva, Tan, Jenille, Yu, Yihong, Costa, Mike, Krauss, Stefan, Waaler, Jo

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Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1[alpha] PARylation in db/db mice von Wang, Hong, Kuusela, Sara, Rinnankoski-Tuikka, Rita, Dumont, Vincent, Bouslama, Rim, Ramadan, Usama Abo, Waaler, Jo

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Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor von Waaler, Jo, Leenders, Ruben G. G, Sowa, Sven T, Alam Brinch, Shoshy, Lycke, Max, Nieczypor, Piotr, Aertssen, Sjoerd, Murthy, Sudarshan, Galera-Prat, Albert, Damen, Eddy, Wegert, Anita, Nazaré, Marc, Lehtiö, Lari, Krauss, Stefan

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Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II von Leenders, Ruben G. G, Brinch, Shoshy Alam, Sowa, Sven T, Amundsen-Isaksen, Enya, Galera-Prat, Albert, Murthy, Sudarshan, Aertssen, Sjoerd, Smits, Johannes N, Nieczypor, Piotr, Damen, Eddy, Wegert, Anita, Nazaré, Marc, Lehtiö, Lari, Waaler, Jo, Krauss, Stefan

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Versatile, sensitive liquid chromatography mass spectrometry – Implementation of 10 μm OT columns suitable for small molecules, peptides and proteins von Vehus, T., Roberg-Larsen, H., Waaler, J., Aslaksen, S., Krauss, S., Wilson, S. R., Lundanes, E.

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Development and structural analysis of adenosine site binding tankyrase inhibitors von Haikarainen, Teemu, Waaler, Jo, Ignatev, Alexander, Nkizinkiko, Yves, Venkannagari, Harikanth, Obaji, Ezeogo, Krauss, Stefan, Lehtiö, Lari

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