Monitoring protease activity in biological tissues using antibody prodrugs as sensing probes von Vasiljeva, Olga, Menendez, Elizabeth, Nguyen, Margaret, Craik, Charles S., Michael Kavanaugh, W.

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Quantitative Systems Pharmacology Model of a Masked, Tumor‐Activated Antibody von Stroh, Mark, Sagert, Jason, Burke, John M., Apgar, Joshua F., Lin, Lin, Millard, Bjorn L., Michael Kavanaugh, W.

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Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome von Zhang, Hongbing, Pao, Lily I., Zhou, Aileen, Brace, Arthur D., Halenbeck, Robert, Hsu, Amy W., Bray, Thomas L., Hestir, Kevin, Bosch, Elizabeth, Lee, Ernestine, Wang, Gang, Liu, Haixia, Wong, Brian R., Kavanaugh, W. Michael, Williams, Lewis T.

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A Probody T Cell-Engaging Bispecific Antibody Targeting EGFR and CD3 Inhibits Colon Cancer Growth with Limited Toxicity von Boustany, Leila M, LaPorte, Sherry L, Wong, Laurie, White, Clayton, Vinod, Veena, Shen, Joel, Yu, Wendy, Koditek, David, Winter, Michael B, Moore, Stephen J, Mei, Li, Diep, Linnea, Huang, Yuanhui, Liu, Shouchun, Vasiljeva, Olga, West, Jim, Richardson, Jennifer, Irving, Bryan, Belvin, Marcia, Kavanaugh, W Michael

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An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins von Kavanaugh, W. Michael, Williams, Lewis T.

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Nonclinical Efficacy and Safety of CX-2029, an Anti-CD71 Probody-Drug Conjugate von Singh, Shweta, Serwer, Laura, DuPage, Amy, Elkins, Kristi, Chauhan, Niharika, Ravn, Matthew, Buchanan, Fritz, Wang, Leyu, Krimm, Michael, Wong, Ken, Sagert, Jason, Tipton, Kimberly, Moore, Stephen J, Huang, Yuanhui, Jang, Andrew, Ureno, Eric, Miller, Adam, Patrick, Sarah, Duvur, Shanti, Liu, Shouchun, Vasiljeva, Olga, Li, Yingchun, Henriques, Tracy, Badagnani, Ilaria, Jeffries, Shawn, Schleyer, Siew, Leanna, Rob, Krebber, Claus, Viswanathan, Sridhar, Desnoyers, Luc, Terrett, Jonathan, Belvin, Marcia, Morgan-Lappe, Susan, Kavanaugh, W Michael, Richardson, Jennifer

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Model‐Informed Drug Development of the Masked Anti‑PD‑L1 Antibody CX‐072 von Stroh, Mark, Green, Michelle, Millard, Bjorn L., Apgar, Joshua F., Burke, John M., Garner, Will, Lu, Hong, Lyman, Susan K., Desnoyers, Luc R., Richardson, Jennifer, Hannah, Alison, Kavanaugh, W. Michael

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In vivo imaging of protease activity by Probody therapeutic activation von Wong, Kenneth R., Menendez, Elizabeth, Craik, Charles S., Kavanaugh, W. Michael, Vasiljeva, Olga

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Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 Agents von Assi, Hikmat H, Wong, Chihunt, Tipton, Kimberly A, Mei, Li, Wong, Ken, Razo, Jennifer, Chan, Chanty, Howng, Bruce, Sagert, Jason, Krimm, Michael, Diep, Linnea, Jang, Andrew, Nguyen, Margaret T, Lapuyade, Nicole, Singson, Victoria, Villanueva, Ruth, Paidhungat, Madan, Liu, Shouchun, Rangan, Vangipuram, Vasiljeva, Olga, West, James W, Richardson, Jennifer H, Irving, Bryan, Daniel, Dylan, Belvin, Marcia, Kavanaugh, W Michael

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A Pilot Screen of a Novel Peptide Hormone Library Identified Candidate GPR83 Ligands von Sallee, Nathan A., Lee, Ernestine, Leffert, Atossa, Ramirez, Silvia, Brace, Arthur D., Halenbeck, Robert, Kavanaugh, W. Michael, Sullivan, Kathleen M. C.

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A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain von Klippel, Anke, Kavanaugh, W. Michael, Pot, David, Williams, Lewis T.

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Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways von Klippel, Anke, Reinhard, Christoph, Kavanaugh, W. Michael, Apell, Gerald, Escobedo, Maria-Amelia, Williams, Lewis T.

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Activation of Phosphatidylinositol 3-Kinase Is Sufficient for Cell Cycle Entry and Promotes Cellular Changes Characteristic of Oncogenic Transformation von Klippel, Anke, Escobedo, Maria-Amelia, Wachowicz, Matthew S., Apell, Gerald, Brown, Timothy W., Giedlin, Martin A., Kavanaugh, W. Michael, Williams, Lewis T.

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PTB Domain Binding to Signaling Proteins Through a Sequence Motif Containing Phosphotyrosine von Kavanaugh, W. Michael, Turck, Christoph W., Williams, Lewis T.

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An SH2 Domain-Containing 5′ Inositolphosphatase Inhibits Insulin-Induced GLUT4 Translocation and Growth Factor-Induced Actin Filament Rearrangement von Vollenweider, Peter, Clodi, Martin, Martin, Stuart S., Imamura, Takeshi, Kavanaugh, W. Michael, Olefsky, Jerrold M.

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Semirational design of a potent, artificial agonist of fibroblast growth factor receptors von Kavanaugh, W. Michael, Ballinger, Marcus D, Shyamala, Venkatakrishna, Forrest, Louise D, Deuter-Reinhard, Maja, Doyle, Laura V, Wang, Jian-xin, Panganiban-Lustan, Lootsee, Stratton, Jennifer R, Apell, Gerald, Winter, Jill A, Doyle, Michael V, Rosenberg, Steven

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Evidence of intratumoral localization, activation, and immunomodulatory effect of CX-072, a probody therapeutic targeting PD-L1, in a phase I/II trial von Lyman, Susan, Naing, Aung, Zein, Ivan Adiputra, Howng, Bruce, Winter, Michael B., Vasiljeva, Olga, Garner, William, Zheng, Beiyao, Stroh, Mark, Kavanaugh, W Michael, Desnoyers, Luc Roland

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Abstract A164: EGFR-CD3 bispecific Probody™ therapeutic induces tumor regressions and increases maximum tolerated dose >60-fold in preclinical studies von Boustany, Leila M., Wong, Laurie, White, Clayton W., Diep, Linnea, Huang, Yuanhui, Liu, Shouchun, Richardson, Jennifer H., Kavanaugh, W. Michael, Irving, Bryan A.

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Affinity, Specificity, and Kinetics of the Interaction of the SHC Phosphotyrosine Binding Domain with Asparagine-X-X-Phosphotyrosine Motifs of Growth Factor Receptors (∗) von Laminet, Axel A., Apell, Gerald, Conroy, Leah, Kavanaugh, W. Michael

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Abstract 2975: Development of a probody drug conjugate (PDC) targeting CD71 for the treatment of solid tumors and lymphomas von Singh, Shweta, DuPage, Amy, Yang Weaver, Annie, Sagert, Jason, White, Clayton, Krimm, Michael, Huang, Yuanhui, Diep, Linnea, Tipton, Kim, Liu, Shouchun, Richardson, Jennifer, Kavanaugh, W. Michael, Terrett, Jonathan A., Desnoyers, Luc R.

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