Cell-Based Assays for High-Throughput Screening von An, W. Frank, Tolliday, Nicola

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Identification of Regulators of Polyploidization Presents Therapeutic Targets for Treatment of AMKL von Wen, Qiang, Goldenson, Benjamin, Silver, Serena J., Schenone, Monica, Dancik, Vlado, Huang, Zan, Wang, Ling-Zhi, Lewis, Timothy A., An, W. Frank, Li, Xiaoyu, Bray, Mark-Anthony, Thiollier, Clarisse, Diebold, Lauren, Gilles, Laure, Vokes, Martha S., Moore, Christopher B., Bliss-Moreau, Meghan, VerPlank, Lynn, Tolliday, Nicola J., Mishra, Rama, Vemula, Sasidhar, Shi, Jianjian, Wei, Lei, Kapur, Reuben, Lopez, Cécile K., Gerby, Bastien, Ballerini, Paola, Pflumio, Francoise, Gilliland, D. Gary, Goldberg, Liat, Birger, Yehudit, Izraeli, Shai, Gamis, Alan S., Smith, Franklin O., Woods, William G., Taub, Jeffrey, Scherer, Christina A., Bradner, James E., Goh, Boon-Cher, Mercher, Thomas, Carpenter, Anne E., Gould, Robert J., Clemons, Paul A., Carr, Steven A., Root, David E., Schreiber, Stuart L., Stern, Andrew M., Crispino, John D.

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Modulation of A-type potassium channels by a family of calcium sensors von Rhodes, Kenneth J, An, W. Frank, Bowlby, Mark R, Betty, Maria, Cao, Jie, Ling, Huai-Ping, Mendoza, Grace, Hinson, Joseph W, Mattsson, Karen I, Strassle, Brian W, Trimmer, James S

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Identification of antifungal compounds active against Candida albicans using an improved high-throughput Caenorhabditis elegans assay von Okoli, Ikechukwu, Coleman, Jeffrey J, Tampakakis, Emmanouil, Tempakakis, Emmanouil, An, W Frank, Holson, Edward, Wagner, Florence, Conery, Annie L, Larkins-Ford, Jonah, Wu, Gang, Stern, Andy, Ausubel, Frederick M, Mylonakis, Eleftherios

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1163 A novel bispecific antibody-drug conjugate targeting PTK7 and TROP2, BCG033, demonstrates preclinical efficacy against triple-negative breast cancer xenografts von Yao, Sufei, Shang, Chengzhang, An, Gao, Frank An, W, Guo, Chaoshe, Yang, Yi

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1152 DM001: A novel bispecific ADC targeting TROP2 and EGFR with potent anti-tumor efficacy in PDX models von Li, Zhuolin, Shang, Chengzhang, Guan, Xuewa, An, Gao, Guo, Yuming, Frank An, W, Guo, Chaoshe, Yang, Yi

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1153 BCG022: a HER3×MET bispecific antibody-drug conjugate (BsADC) targeting key mechanisms of bypass resistance in multiple tumor types von Li, Zhuolin, Shang, Chengzhang, Han, Zhenyan, An, Gao, Frank An, W, Guo, Chaoshe, Yang, Yi

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1165 Preclinical evaluation of fully human bispecific antibody-drug candidates targeting HER3 and the juxtamembrane region of MUC1 von Zhang, Yifu, Shang, Chengzhang, Wang, Nannan, Frank An, W, Guo, Chaoshe, An, Gao, Yang, Yi

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479 Fc-competent fully human anti-TIGIT blocking monoclonal antibodies demonstrated potent anti-tumor efficacy in preclinical models von Lan, Weiqiu, Liu, Baihong, Chen, Yang, Zhang, Xin, Zhang, Jing, Frank An, W, Guo, Chaoshe, Yang, Yi

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1175 YH006, a fully human Treg-depleting CTLA-4×OX40 bispecific antibody, demonstrates superior preclinical efficacy and favorable developability von Liu, Baihong, Guo, Xiang, Han, Yanfei, Zhang, Jing, Frank An, W, Guo, Chaoshe, Zhang, Lei, Yang, Yi

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1168 Identification of fully human TCR-mimic antibodies targeting the KRAS G12V/HLA complex generated in HLA-transgenic RenMabTM mice von Du, Jun, Tang, Wanbo, Jiao, Xin, Zhao, Limin, Du, Pengfei, Zhang, Yuqi, Zhang, Yue, Chen, Han, Bao, Jian, Niu, Aijing, Frank An, W, Guo, Chaoshe, Liu, Baihong, Yang, Yi

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356 Preclinical application of a fully human TCR-mimic antibody developed to target NY-ESO-1/HLA-A02 von Du, Jun, Zhang, Yue, Jiao, Xin, Zhao, Limin, Du, Pengfei, Zhang, Yuqi, Tang, Wanbo, Lv, Ruili, Du, Jichao, Frank An, W, Guo, Chaoshe, Yang, Yi

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1164 BSA01, a bispecific antibody-drug conjugate targeting EGFR and membrane-bound MUC-1-C, exhibits anti-tumor efficacy in vivo von Zhang, Yifu, Shang, Chengzhang, Wang, Anqi, Zhang, Jia, Liu, Yuji, Li, Hao, Li, Xiaopeng, An, Gao, Frank An, W, Guo, Chaoshe, Yang, Yi

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1150 DM005, an EGFR × MET bispecific antibody-drug conjugate, showed robust anti-tumor activity in PDX models von Han, Yanfei, Dai, Wenjuan, Shang, Chengzhang, Li, Zhuolin, Han, Zhenyan, Li, Jun, Cui, Zixu, An, Gao, Hao, Wanjun, Liu, Yujie, Li, Hao, Liu, Baihong, Frank An, W, Guo, Chaoshe, Yang, Yi, Shen, Yuelei

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Introduction: Cell-Based Assays for High-Throughput Screening von An, W. Frank, Tolliday, Nicola J.

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The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning von Alexander, Jon C, McDermott, Carmel M, Tunur, Tumay, Rands, Vicky, Stelly, Claire, Karhson, Debra, Bowlby, Mark R, An, W Frank, Sweatt, J David, Schrader, Laura A

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Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1 von Maben, Zachary, Arya, Richa, Rane, Digamber, An, W. Frank, Metkar, Shailesh, Hickey, Marc, Bender, Samantha, Ali, Akbar, Nguyen, Tina T, Evnouchidou, Irini, Schilling, Roger, Stratikos, Efstratios, Golden, Jennifer, Stern, Lawrence J

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AR Inhibitors Identified by High-Throughput Microscopy Detection of Conformational Change and Subcellular Localization von Jones, Jeremy O, An, W. Frank, Diamond, Marc I

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Remodelling inactivation gating of Kv4 channels by KChIP1, a small-molecular-weight calcium-binding protein von Beck, Edward J., Bowlby, Mark, An, W. Frank, Rhodes, Kenneth J., Covarrubias, Manuel

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Targeting BRCA1- and BRCA2-deficient cells with RAD52 small molecule inhibitors von Huang, Fei, Goyal, Nadish, Sullivan, Katherine, Hanamshet, Kritika, Patel, Mikir, Mazina, Olga M, Wang, Charles X, An, W Frank, Spoonamore, James, Metkar, Shailesh, Emmitte, Kyle A, Cocklin, Simon, Skorski, Tomasz, Mazin, Alexander V

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