Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus von Bentham, James, Morris, David L, Cunninghame Graham, Deborah S, Pinder, Christopher L, Tombleson, Philip, Behrens, Timothy W, Martín, Javier, Fairfax, Benjamin P, Knight, Julian C, Chen, Lingyan, Replogle, Joseph, Syvänen, Ann-Christine, Rönnblom, Lars, Graham, Robert R, Wither, Joan E, Rioux, John D, Alarcón-Riquelme, Marta E, Vyse, Timothy J

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Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases von Acosta-Herrera, M, Kerick, M, Gonzalez-Serna, D, Wijmenga, C, Franke, A, Gregersen, PK, Padyukov, L, Worthington, J, Vyse, TJ, Alarcon-Riquelme, ME, Mayes, MD, Martin, J, Miller, FW, Chen, W, O'Hanlon, TP, Cooper, RG, Vencovsky, J, Rider, LG, Danko, K, Wedderburn, LR, Lundberg, IE, Pachman, LM, Reed, AM, Ytterberg, SR, Selva-O'Callaghan, A, Radstake, TR, Isenberg, DA, Chinoy, H, Ollier, WER, Scheet, P, Peng, B, Lee, A, Lamb, JA, Amos, CI, Denton, C, Hilton-Jones, D, Plotz, PH, Varsani, H, Radstake, TRDJ, Gorlova, O, Rueda, B, Martin, JE, Alizadeh, BZ, Palomino-Morales, R, Coenen, MJ, Vonk, MC, Voskuyl, AE, Scheurwegh, AJ, Broen, JC, van Riel, PLCM, van 't Slot, R, Italiaander, A, Ophoff, RA, Riemekasten, G, Hunzelmann, N, Simeon, CP, Ortego-Centeno, N, Gonzalez-Gay, MA, Gonzalez-Escribano, MF, Airo, P, van Laar, J, Herrick, A, Hesselstrand, R, Smith, V, de Keyser, F, Houssiau, F, Chee, MM, Madhok, R, Shiels, P, Westhovens, R, Kreuter, A, Kiener, H, de Baere, E, Witte, T, Klareskog, L, Beretta, L, Scorza, R, Lie, BA, Hoffman-Vold, AM, Carreira, P, Varga, J, Hinchcliff, M, Lee, AT, Ying, J, Han, Y, Weng, SF, Wigley, FM, Hummers, L, Nelson, JL, Agarwal, SK, Assassi, S, Gourh, P, Tan, FK, Koeleman, BPC, Arnett, FC

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The genetics of lupus: a functional perspective von Guerra, Sandra G, Vyse, Timothy J, Cunninghame Graham, Deborah S

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High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus von Reid, Sarah, Alexsson, Andrei, Frodlund, Martina, Morris, David, Sandling, Johanna K., Bolin, Karin, Svenungsson, Elisabet, Jönsen, Andreas, Bengtsson, Christine, Gunnarsson, Iva, Rodriguez, Vera Illescas, Bengtsson, Anders, Arve, Sabine, Rantapää-Dahlqvist, Solbritt, Eloranta, Maija-Leena, Syvänen, Ann-Christine, Sjöwall, Christopher, Vyse, Timothy James, Rönnblom, Lars, Leonard, Dag

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HLA Has Strongest Association with IgA Nephropathy in Genome-Wide Analysis von FEEHALLY, John, FARRALL, Martin, PADMANABHAN, Sandosh, VYSE, Timothy J, ZAWADZKA, Anna, REES, Andrew J, LATHROP, Mark, RATCLIFFET, Peter J, BOLAND, Anne, GALE, Daniel P, GUT, Ivo, HEATH, Simon, KUMAR, Ashish, PEDEN, John F, MAXWELL, Patrick H, MORRIS, David L

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Large-Scale Identification of Common Trait and Disease Variants Affecting Gene Expression von Hauberg, Mads Engel, Zhang, Wen, Giambartolomei, Claudia, Franzén, Oscar, Morris, David L., Vyse, Timothy J., Ruusalepp, Arno, Fromer, Menachem, Sieberts, Solveig K., Johnson, Jessica S., Ruderfer, Douglas M., Shah, Hardik R., Klei, Lambertus L., Dang, Kristen K., Perumal, Thanneer M., Logsdon, Benjamin A., Mahajan, Milind C., Mangravite, Lara M., Essioux, Laurent, Toyoshiba, Hiroyoshi, Gur, Raquel E., Hahn, Chang-Gyu, Lewis, David A., Haroutunian, Vahram, Peters, Mette A., Lipska, Barbara K., Buxbaum, Joseph D., Hirai, Keisuke, Domenici, Enrico, Devlin, Bernie, Sklar, Pamela, Schadt, Eric E., Björkegren, Johan L.M., Roussos, Panos

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Mutations in the gene encoding the 3′-5′ DNA exonuclease TREX1 are associated with systemic lupus erythematosus von Gong, Maolian, Lee, Young-Ae, Wong, Andrew, Hollis, Thomas, Lieberman, Judy, Pfeiffer, Christiane, Schmidt, Reinhold E, Koskenmies, Sari, Engel, Kerstin, Lee-Kirsch, Min Ae, Rohde, Klaus, Hübner, Norbert, Hummel, Oliver, Harvey, Scott, Dominiczak, Anna F, Perrino, Fred W, Chowdhury, Dipanjan, Vyse, Timothy J, Bailey, Suzanna L, Senenko, Lydia, de Silva, Udesh, Gahr, Manfred, Kere, Juha, Witte, Torsten

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Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans von Domin, Jan, Mangion, Jonathan, Cook, H. Terence, Petretto, Enrico, Vyse, Timothy J, Flint, Jonathan, Johnson, Michelle D, Patel, Sheetal G, Pusey, Charles D, Cook, Paul R, Evans, David J, Duda, Mark, Smith, Jennifer, Dong, Rong, Bhangal, Gurjeet, Aitman, Timothy J, Roberton-Lowe, Cheri, Sheehan-Rooney, Kelly, Marshall, Amy J, Boyle, Joseph J, Norsworthy, Penny J, Hodges, Matthew D

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Defective removal of ribonucleotides from DNA promotes systemic lupus erythematosus von Günther, C, Kind, B, Reijns, MAM, Berndt, N, Martinez-Bueno, M, Wolf, C, Tüngler, V, Chara, O, Lee, YA, Hübner, N, Bicknell, L, Blum, S, Krug, C, Schmidt, F, Kretschmer, S, Koss, S, Astell, KR, Ramantani, G, Bauerfeind, A, Morris, DL, Graham, DS Cunninghame, Bubeck, D, Leitch, A, Ralston, SH, Blackburn, EA, Gahr, M, Witte, T, Vyse, TJ, Melchers, I, Mangold, E, Nöthen, MM, Aringer, M, Kuhn, A, Lüthke, K, Unger, L, Bley, A, Lorenzi, A, Isaacs, JD, Alexopoulou, D, Conrad, K, Dahl, A, Roers, A, Alarcon-Riquelme, ME, Jackson, AP, Lee-Kirsch, MA

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Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort von Namjou, B, Kothari, P H, Kelly, J A, Glenn, S B, Ojwang, J O, Adler, A, Alarcón-Riquelme, M E, Gallant, C J, Boackle, S A, Criswell, L A, Kimberly, R P, Brown, E, Edberg, J, Stevens, A M, Jacob, C O, Tsao, B P, Gilkeson, G S, Kamen, D L, Merrill, J T, Petri, M, Goldman, R R, Vila, L M, Anaya, J-M, Niewold, T B, Martin, J, Pons-Estel, B A, Sabio, J M, Callejas, J L, Vyse, T J, Bae, S-C, Perrino, F W, Freedman, B I, Scofield, R H, Moser, K L, Gaffney, P M, James, J A, Langefeld, C D, Kaufman, K M, Harley, J B, Atkinson, J P

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Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus von Graham, Robert R, Kyogoku, Chieko, Sigurdsson, Snaevar, Vlasova, Irina A, Davies, Leela R.L, Baechler, Emily C, Plenge, Robert M, Koeuth, Thearith, Ortmann, Ward A, Hom, Geoffrey, Bauer, Jason W, Gillett, Clarence, Burtt, Noel, Cunninghame Graham, Deborah S, Onofrio, Robert, Petri, Michelle, Gunnarsson, Iva, Svenungsson, Elisabet, Rönnblom, Lars, Nordmark, Gunnel, Gregersen, Peter K, Moser, Kathy, Gaffney, Patrick M, Criswell, Lindsey A, Vyse, Timothy J, Syvänen, Ann-Christine, Bohjanen, Paul R, Daly, Mark J, Behrens, Timothy W, Altshuler, David

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Tartrate‐Resistant Acid Phosphatase Deficiency in the Predisposition to Systemic Lupus Erythematosus von An, Jie, Briggs, Tracy A., Dumax‐Vorzet, Audrey, Alarcón‐Riquelme, Marta E., Belot, Alexandre, Beresford, Michael, Bruce, Ian N., Carvalho, Claudia, Chaperot, Laurence, Frostegård, Johan, Plumas, Joel, Rice, Gillian I., Vyse, Timothy J., Wiedeman, Alice, Crow, Yanick J., Elkon, Keith B.

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Genetic mapping across autoimmune diseases reveals shared associations and mechanisms von Lincoln, Matthew R., Connally, Noah, Axisa, Pierre-Paul, Gasperi, Christiane, Mitrovic, Mitja, van Heel, David, Wijmenga, Cisca, Withoff, Sebo, Jonkers, Iris H., Padyukov, Leonid, Rich, Stephen S., Graham, Robert R., Gaffney, Patrick M., Langefeld, Carl D., Vyse, Timothy J., Hafler, David A., Chun, Sung, Sunyaev, Shamil R., Cotsapas, Chris

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Unraveling Multiple MHC Gene Associations with Systemic Lupus Erythematosus: Model Choice Indicates a Role for HLA Alleles and Non-HLA Genes in Europeans von MORRIS, David L, TAYLOR, Kimberly E, PONS-ESTEL, Bernardo A, GREGERSEN, Peter K, HARLEY, John B, HAUSER, Stephen L, HOM, Geoffrey, LANGEFELD, Carl D, NOBLE, Janelle A, RIOUX, John D, SELDIN, Michael F, CRISWELL, Lindsey A, FERNANDO, Michelle M. A, VYSE, Timothy J, NITITHAM, Joanne, ALARCON-RIQUELME, Marta E, BARCELLOS, Lisa F, BEHRENS, Timothy W, COTSAPAS, Chris, GAFFNEY, Patrick M, GRAHAM, Robert R

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Selective IgA deficiency in autoimmune diseases von Wang, Ning, Shen, Nan, Vyse, Timothy J, Anand, Vidya, Gunnarson, Iva, Sturfelt, Gunnar, Rantapää-Dahlqvist, Solbritt, Elvin, Kerstin, Truedsson, Lennart, Andersson, Bengt A, Dahle, Charlotte, Ortqvist, Eva, Gregersen, Peter K, Behrens, Timothy W, Hammarström, Lennart

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CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation von Manjarrez-Orduño, Nataly, Marasco, Emiliano, Chung, Sharon A, Katz, Matthew S, Kiridly, Jenna F, Simpfendorfer, Kim R, Freudenberg, Jan, Ballard, David H, Nashi, Emil, Hopkins, Thomas J, Cunninghame Graham, Deborah S, Lee, Annette T, Coenen, Marieke J H, Franke, Barbara, Swinkels, Dorine W, Graham, Robert R, Kimberly, Robert P, Gaffney, Patrick M, Vyse, Timothy J, Behrens, Timothy W, Criswell, Lindsey A, Diamond, Betty, Gregersen, Peter K

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Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility von Zhao, Jian, Wu, Hui, Khosravi, Melanie, Cui, Huijuan, Qian, Xiaoxia, Kelly, Jennifer A, Kaufman, Kenneth M, Langefeld, Carl D, Williams, Adrienne H, Comeau, Mary E, Ziegler, Julie T, Marion, Miranda C, Adler, Adam, Glenn, Stuart B, Alarcón-Riquelme, Marta E, Pons-Estel, Bernardo A, Harley, John B, Bae, Sang-Cheol, Bang, So-Young, Cho, Soo-Kyung, Jacob, Chaim O, Vyse, Timothy J, Niewold, Timothy B, Gaffney, Patrick M, Moser, Kathy L, Kimberly, Robert P, Edberg, Jeffrey C, Brown, Elizabeth E, Alarcon, Graciela S, Petri, Michelle A, Ramsey-Goldman, Rosalind, Vilá, Luis M, Reveille, John D, James, Judith A, Gilkeson, Gary S, Kamen, Diane L, Freedman, Barry I, Anaya, Juan-Manuel, Merrill, Joan T, Criswell, Lindsey A, Scofield, R Hal, Stevens, Anne M, Guthridge, Joel M, Chang, Deh-Ming, Song, Yeong Wook, Park, Ji Ah, Lee, Eun Young, Boackle, Susan A, Grossman, Jennifer M, Hahn, Bevra H, Goodship, Timothy H J, Cantor, Rita M, Yu, Chack-Yung, Shen, Nan, Tsao, Betty P

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MHC associations with clinical and autoantibody manifestations in European SLE von Morris, D L, Fernando, M M A, Taylor, K E, Chung, S A, Nititham, J, Alarcón-Riquelme, M E, Barcellos, L F, Behrens, T W, Cotsapas, C, Gaffney, P M, Graham, R R, Pons-Estel, B A, Gregersen, P K, Harley, J B, Hauser, S L, Hom, G, Langefeld, C D, Noble, J A, Rioux, J D, Seldin, M F, Vyse, T J, Criswell, L A

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The development of genome-wide association studies and their application to complex diseases, including lupus von Bentham, J, Vyse, TJ

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A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus von Patel, Zubin H, Lu, Xiaoming, Miller, Daniel, Forney, Carmy R, Lee, Joshua, Lynch, Arthur, Schroeder, Connor, Parks, Lois, Magnusen, Albert F, Chen, Xiaoting, Pujato, Mario, Maddox, Avery, Zoller, Erin E, Namjou, Bahram, Brunner, Hermine I, Henrickson, Michael, Huggins, Jennifer L, Williams, Adrienne H, Ziegler, Julie T, Comeau, Mary E, Marion, Miranda C, Glenn, Stuart B, Adler, Adam, Shen, Nan, Nath, Swapan K, Stevens, Anne M, Freedman, Barry I, Pons-Estel, Bernardo A, Tsao, Betty P, Jacob, Chaim O, Kamen, Diane L, Brown, Elizabeth E, Gilkeson, Gary S, Alarcón, Graciela S, Martin, Javier, Reveille, John D, Anaya, Juan-Manuel, James, Judith A, Sivils, Kathy L, Criswell, Lindsey A, Vilá, Luis M, Petri, Michelle, Scofield, R Hal, Kimberly, Robert P, Edberg, Jeffrey C, Ramsey-Goldman, Rosalind, Bang, So-Young, Lee, Hye-Soon, Bae, Sang-Cheol, Boackle, Susan A, Cunninghame Graham, Deborah, Vyse, Timothy J, Merrill, Joan T, Niewold, Timothy B, Ainsworth, Hannah C, Silverman, Earl D, Weisman, Michael H, Wallace, Daniel J, Raj, Prithvi, Guthridge, Joel M, Gaffney, Patrick M, Kelly, Jennifer A, Alarcón-Riquelme, Marta E, Langefeld, Carl D, Wakeland, Edward K, Kaufman, Kenneth M, Weirauch, Matthew T, Harley, John B, Kottyan, Leah C

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