Population-Based Penetrance of Deleterious Clinical Variants von Forrest, Iain S, Chaudhary, Kumardeep, Vy, Ha My T, Petrazzini, Ben O, Bafna, Shantanu, Jordan, Daniel M, Rocheleau, Ghislain, Loos, Ruth J. F, Nadkarni, Girish N, Cho, Judy H, Do, Ron

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Probing the aggregated effects of purifying selection per individual on 1,380 medical phenotypes in the UK biobank von Vy, Ha My T., Jordan, Daniel M., Balick, Daniel J., Do, Ron

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Genetic pleiotropy of ERCC6 loss‐of‐function and deleterious missense variants links retinal dystrophy, arrhythmia, and immunodeficiency in diverse ancestries von Forrest, Iain S., Chaudhary, Kumardeep, Vy, Ha My T., Bafna, Shantanu, Kim, Soyeon, Won, Hong‐Hee, Loos, Ruth J.F., Cho, Judy, Pasquale, Louis R., Nadkarni, Girish N., Rocheleau, Ghislain, Do, Ron

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Machine Learning Identifies Plasma Metabolites Associated With Heart Failure in Underrepresented Populations With the TTR V122I Variant von Park, Joshua K, Petrazzini, Ben O, Saha, Aparna, Vaid, Akhil, Vy, Ha My T, Márquez-Luna, Carla, Chan, Lili, Nadkarni, Girish N, Do, Ron

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Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease von Liu, Hongbo, Doke, Tomohito, Guo, Dong, Sheng, Xin, Ma, Ziyuan, Park, Joseph, Vy, Ha My T., Nadkarni, Girish N., Abedini, Amin, Miao, Zhen, Palmer, Matthew, Voight, Benjamin F., Li, Hongzhe, Brown, Christopher D., Ritchie, Marylyn D., Shu, Yan, Susztak, Katalin

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Multimodal fusion learning for long QT syndrome pathogenic genotypes in a racially diverse population von Jiang, Joy, Thi Vy, Ha My, Charney, Alexander, Kovatch, Patricia, Reddy, Vivek, Jayaraman, Pushkala, Do, Ron, Khera, Rohan, Chugh, Sumeet, Bhatt, Deepak L., Vaid, Akhil, Lampert, Joshua, Nadkarni, Girish Nitin

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A Composite-Likelihood Method for Detecting Incomplete Selective Sweep from Population Genomic Data von Vy, Ha My T, Kim, Yuseob

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Molecular Analysis of the Kidney From a Patient With COVID-19–Associated Collapsing Glomerulopathy von Meliambro, Kristin, Li, Xuezhu, Salem, Fadi, Yi, Zhengzi, Sun, Zeguo, Chan, Lili, Chung, Miriam, Chancay, Jorge, Vy, Ha My T., Nadkarni, Girish, Wong, Jenny S., Fu, Jia, Lee, Kyung, Zhang, Weijia, He, John C., Campbell, Kirk N.

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Multiple Modes of Positive Selection Shaping the Patterns of Incomplete Selective Sweeps over African Populations of Drosophila melanogaster von Vy, Ha My T, Won, Yong-Jin, Kim, Yuseob

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Genetically Downregulated Interleukin-6 Signaling Is Associated With a Favorable Cardiometabolic Profile: A Phenome-Wide Association Study von Georgakis, Marios K., Malik, Rainer, Li, Xue, Gill, Dipender, Levin, Michael G., Vy, Ha My T., Judy, Renae, Ritchie, Marylyn, Verma, Shefali S., Nadkarni, Girish N., Damrauer, Scott M., Theodoratou, Evropi, Dichgans, Martin

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Use of Diagnostic Codes for Primary Open-Angle Glaucoma Polygenic Risk Score Construction in Electronic Health Record–Linked Biobanks von Tran, Jessica H., Kang, Joyce, Han, Elaine, Gupta, Urvi, Seresirikachorn, Kasem, Vy, Ha My T., Zhao, Yan, Rocheleau, Ghislain, Luo, Yuyang, Lee, Rachel, Do, Ron, Friedman, David S., Kang, Jae H., Wiggs, Janey L., Pasquale, Louis R., Segrè, Ayellet V., Zebardast, Nazlee

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Polygenic prediction of preeclampsia and gestational hypertension von Honigberg, Michael C., Truong, Buu, Khan, Raiyan R., Xiao, Brenda, Bhatta, Laxmi, Vy, Ha My T., Guerrero, Rafael F., Schuermans, Art, Selvaraj, Margaret Sunitha, Patel, Aniruddh P., Koyama, Satoshi, Cho, So Mi Jemma, Vellarikkal, Shamsudheen Karuthedath, Trinder, Mark, Urbut, Sarah M., Gray, Kathryn J., Brumpton, Ben M., Patil, Snehal, Zöllner, Sebastian, Antopia, Mariah C., Saxena, Richa, Nadkarni, Girish N., Do, Ron, Yan, Qi, Pe’er, Itsik, Verma, Shefali Setia, Gupta, Rajat M., Haas, David M., Martin, Hilary C., van Heel, David A., Laisk, Triin, Natarajan, Pradeep

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Exome sequence analysis identifies rare coding variants associated with a machine learning-based marker for coronary artery disease von Petrazzini, Ben Omega, Forrest, Iain S., Rocheleau, Ghislain, Vy, Ha My T., Márquez-Luna, Carla, Duffy, Áine, Chen, Robert, Park, Joshua K., Gibson, Kyle, Goonewardena, Sascha N., Malick, Waqas A., Rosenson, Robert S., Jordan, Daniel M., Do, Ron

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Genome-wide polygenic risk score for retinopathy of type 2 diabetes von Forrest, Iain S, Chaudhary, Kumardeep, Paranjpe, Ishan, Vy, Ha My T, Marquez-Luna, Carla, Rocheleau, Ghislain, Saha, Aparna, Chan, Lili, Van Vleck, Tielman, Loos, Ruth J F, Cho, Judy, Pasquale, Louis R, Nadkarni, Girish N, Do, Ron

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Expanding drug targets for 112 chronic diseases using a machine learning-assisted genetic priority score von Chen, Robert, Duffy, Áine, Petrazzini, Ben O., Vy, Ha My, Stein, David, Mort, Matthew, Park, Joshua K., Schlessinger, Avner, Itan, Yuval, Cooper, David N., Jordan, Daniel M., Rocheleau, Ghislain, Do, Ron

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Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program von Klarin, Derek, Devineni, Poornima, Sendamarai, Anoop K., Angueira, Anthony R., Graham, Sarah E., Shen, Ying H., Levin, Michael G., Pirruccello, James P., Surakka, Ida, Karnam, Purushotham R., Roychowdhury, Tanmoy, Li, Yanming, Wang, Minxian, Aragam, Krishna G., Paruchuri, Kaavya, Zuber, Verena, Shakt, Gabrielle E., Tsao, Noah L., Judy, Renae L., Vy, Ha My T., Verma, Shefali S., Rader, Daniel J., Do, Ron, Bavaria, Joseph E., Nadkarni, Girish N., Ritchie, Marylyn D., Burgess, Stephen, Guo, Dong-chuan, Ellinor, Patrick T., LeMaire, Scott A., Milewicz, Dianna M., Willer, Cristen J., Natarajan, Pradeep, Tsao, Philip S., Pyarajan, Saiju, Damrauer, Scott M.

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Genome-first evaluation with exome sequence and clinical data uncovers underdiagnosed genetic disorders in a large healthcare system von Forrest, Iain S., Duffy, Áine, Park, Joshua K., Vy, Ha My T., Pasquale, Louis R., Nadkarni, Girish N., Cho, Judy H., Do, Ron

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Genome-Wide Epistatic Interaction between DEF1B and APOL1 High-Risk Genotypes for Chronic Kidney Disease von Vy, Ha My T, Lin, Bridget M, Gulamali, Faris F, Kooperberg, Charles, Graff, Mariaelisa, Wong, Jenny, Campbell, Kirk N, Matise, Tara C, Coresh, Josef, Thomas, Fridtjof, Reiner, Alexander P, Nassir, Rami, Schnatz, Peter F, Johns, Tanya, Buyske, Steven, Haiman, Christopher, Cooper, Richard, Loos, Ruth J F, Horowitz, Carol R, Gutierrez, Orlando M, Do, Ron, Franceschini, Nora, Nadkarni, Girish N

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Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits von Park, Joshua K, Bafna, Shantanu, Forrest, Iain S, Duffy, Áine, Marquez-Luna, Carla, Petrazzini, Ben O, Vy, Ha My, Jordan, Daniel M, Verbanck, Marie, Narula, Jagat, Rosenson, Robert S, Rocheleau, Ghislain, Do, Ron

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Short-term prediction of coronary artery disease using serum metabolomic patterns von Petrazzini, Ben Omega, Vaid, Akhil, Park, Joshua K., Marquez-Luna, Carla, Vy, Ha My, Saha, Aparna, Chaudhary, Kumardeep, Cho, Judy, Chan, Lili, Argulian, Edgar, Narula, Jagat, Nadkarni, Girish, Do, Ron

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