RIPK1 suppresses a TRAF2-dependent pathway to liver cancer von Schneider, A.T, Gautheron, J, Feoktistova, M, Roderburg, C, Loosen, S.H, Schemmer, P, Büchler, M.W, Neumann, U.P, Tacke, F, Trautwein, C, Longerich, T, Vucur, M, Luedde, T

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IKKALPHA/Beta Regulate Hepatocarcinogenesis and Biliary Homeostasis by Controlling RIPK1 Activity von Koppe, C, Reisinger, F, Verheugd, P, Gautheron, J, Roderburg, C, Tacke, F, Preisinger, C, Lüscher, B, Vucur, M, Trautwein, C, Heikenwälder, M, Luedde, T

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P236 RIP3-DEPENDENT NECROPTOSIS CONTROLS NON-ALCOHOLIC STEATOHEPATITIS INDUCED LIVER FIBROSIS VIA JNK von Gautheron, J, Vucur, M, Reisinger, F, Roderburg, C, Trautwein, C, Tacke, F, Heikenwalder, M, Luedde, T

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590 MICRO-RNA PROFILING IN HUMAN SERUM REVEALS ETIOLOGY-INDEPENDENT, COMPARTMENT-SPECIFIC ROLES OF MIR-571 AND MIR-652 IN LIVER CIRRHOSIS von Roderburg, C, Cardenas, D. Vargas, Vucur, M, Trautwein, C, Tacke, F, Luedde, T

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73 TAK1 SUPPRESSES A NEMO-DEPENDENT, BUT NF-KAPPAB-INDEPENDENT PATHWAY TO LIVER CANCER von Bettermann, K, Vucur, M, Haybaeck, J, Liedtke, C, Tacke, F, Heikenwalder, M, Trautwein, C, Luedde, T

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THU-122 - RIPK1 suppresses a TRAF2-dependent pathway to liver cancer von Schneider, A.T., Gautheron, J., Feoktistova, M., Roderburg, C., Loosen, S.H., Schemmer, P., Büchler, M.W., Neumann, U.P., Tacke, F., Trautwein, C., Longerich, T., Vucur, M., Luedde, T.

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THU-415 - IKKALPHA/Beta Regulate Hepatocarcinogenesis and Biliary Homeostasis by Controlling RIPK1 Activity von Koppe, C., Reisinger, F., Verheugd, P., Gautheron, J., Roderburg, C., Tacke, F., Preisinger, C., Lüscher, B., Vucur, M., Trautwein, C., Heikenwälder, M., Luedde, T.

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Spontaneous cholemia in C57BL/6 mice predisposes to liver cancer in NASH von Gallage, S, Ali, A, Barragan Avila, JE, Herebian, D, Karimi, MM, Irvine, EE, McHugh, D, Schneider, AT, Vucur, M, Keitel, V, Gil, J, Withers, DJ, Luedde, T, Heikenwalder, M

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Low molecular weight plant extract induces metabolic changes and the secretion of extracellular enzymes, but has a negative effect on the expression of the type-III secretion syste... von Watt, Tony Francis, Vucur, Mihael, Baumgarth, Birgit, Watt, Steven Alexander, Niehaus, Karsten

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Serum concentrations of A Proliferation-Inducing Ligand (APRIL) are elevated in sepsis and predict mortality in critically ill patients von Roderburg, Christoph, MD, Koch, Alexander, MD, Tacke, Frank, MD, PhD, Nieuwenhuijsen, Lukas, MD, Bruensing, Jan, MD, Vargas Cardenas, David, BSc, Kreggenwinkel, Karina, BSc, Vucur, Mihael, MSc, Koppe, Christiane, MSc, Jungebluth, Philipp, MD, Seikrit, Claudia, MD, Luedde, Mark, MD, Trautwein, Christian, MD, Luedde, Tom, MD, PhD

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Mesenchymal Stem Cells Restore Lung Function by Recruiting Resident and Nonresident Proteins von Jungebluth, Philipp, Luedde, Mark, Ferrer, Elisabet, Luedde, Tom, Vucur, Mihael, Peinado, Victor I., Go, Tetsuhiko, Schreiber, Catharina, Von Richthofen, Maximilian, Bader, Augustinus, Haag, Johannes, Darsow, Kai H., Bartel, Sebastian J., Lange, Harald A., Furlani, Dario, Steinhoff, Gustav, Macchiarini, Paolo

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TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer von Bettermann, K, Vucur, M, Haybaeck, J, Koppe, C, Janssen, J, Heymann, F, Weber, A, Weiskirchen, R, Liedtke, C, Gassler, N, Müller, M, de Vos, R, Wolf, M J, Boege, Y, Seleznik, G M, Zeller, N, Erny, D, Fuchs, T, Zoller, S, Cairo, S, Buendia, M A, Prinz, M, Akira, S, Tacke, F, Heikenwalder, M, Trautwein, C, Luedde, T

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TAK1 suppresses a NEMO-dependent but NF-kB-independent pathway to liver cancer von Bettermann, K, Vucur, M, Haybaeck, J, Koppe, C, Janssen, J, Heymann, F, Weber, A, Weiskirchen, R, Liedtke, C, Gassler, N, Müller, M.R, Vos, R., de, Wolf, M.J, Boege, Y, Seleznik, G.M, Zeller, N, Erny, D, Fuchs, T, Zoller, S, Cairo, S, Buendia, M.A, Prinz, M, Akira, S, Tacke, F, Heikenwalder, M, Trautwein, C, Luedde, T

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A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development von Boege, Y, Malehmir, M, Healy, ME, Bettermann, K, Lorentzen, A, Vucur, M, Ahuja, AK, Böhm, F, Mertens, JC, Shimizu, Y, Frick, L, Remouchamps, C, Mutreja, K, Kähne, T, Sundaravinayagam, D, Wolf, MJ, Rehrauer, H, Koppe, C, Speicher, T, Padrissa-Altés, S, Maire, R, Schattenberg, JRM, Jeong, J-S, Liu, L, Zwirner, S, Boger, R, Hüser, N, Davis, RJ, Müllhaupt, B, Moch, H, Schulze-Bergkamen, H, Clavien, P-A, Werner, S, Borsig, L, Luther, SA, Jost, PJ, Weinlich, R, Unger, K, Behrens, A, Hillert, L, Dillon, C, Di Virgilio, M, Wallach, D, Dejardin, E, Zender, L, Naumann, M, Walczak, H, Green, DR, Lopes, M, Lavrik, I, Luedde, T, Heikenwalder, M, Weber, A

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TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation von Labiano, Ibone, Agirre-Lizaso, Aloña, Olaizola, Paula, Echebarria, Anne, Huici-Izagirre, Maider, Olaizola, Irene, Esparza-Baquer, Aitor, Sharif, Omar, Hijona, Elizabeth, Milkiewicz, Piotr, Milkiewicz, Malgorzata, González-Romero, Francisco, Aspichueta, Patricia, Monte, Maria J., Marin, Jose J.G., Vucur, Mihael, Luedde, Tom, Marzioni, Marco, Mann, Derek A., Bujanda, Luis, Rodrigues, Pedro M., Banales, Jesus M., Perugorria, Maria J.

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Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity von Ghallab, Ahmed, Hassan, Reham, Hofmann, Ute, Friebel, Adrian, Hobloss, Zaynab, Brackhagen, Lisa, Begher-Tibbe, Brigitte, Myllys, Maiju, Reinders, Joerg, Overbeck, Nina, Sezgin, Selahaddin, Zühlke, Sebastian, Seddek, Abdel-latif, Murad, Walaa, Brecklinghaus, Tim, Kappenberg, Franziska, Rahnenführer, Jörg, González, Daniela, Goldring, Christopher, Copple, Ian M., Marchan, Rosemarie, Longerich, Thomas, Vucur, Mihael, Luedde, Tom, Urban, Stephan, Canbay, Ali, Schreiter, Thomas, Trauner, Michael, Akakpo, Jephte Y., Olyaee, Mojtaba, Curry, Steven C., Sowa, Jan-Peter, Jaeschke, Hartmut, Hoehme, Stefan, Hengstler, Jan G.

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Levels of Circulating PD-L1 Are Decreased in Patients with Resectable Cholangiocarcinoma von Roderburg, Christoph, Loosen, Sven H., Bednarsch, Jan, Alizai, Patrick H., Roeth, Anjali A., Schmitz, Sophia M., Vucur, Mihael, Luedde, Mark, Paffenholz, Pia, Tacke, Frank, Trautwein, Christian, Ulmer, Tom F., Neumann, Ulf Peter, Luedde, Tom

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Sublethal necroptosis signaling promotes inflammation and liver cancer von Vucur, Mihael, Ghallab, Ahmed, Schneider, Anne T., Adili, Arlind, Cheng, Mingbo, Castoldi, Mirco, Singer, Michael T., Büttner, Veronika, Keysberg, Leonie S., Küsgens, Lena, Kohlhepp, Marlene, Görg, Boris, Gallage, Suchira, Barragan Avila, Jose Efren, Unger, Kristian, Kordes, Claus, Leblond, Anne-Laure, Albrecht, Wiebke, Loosen, Sven H., Lohr, Carolin, Jördens, Markus S., Babler, Anne, Hayat, Sikander, Schumacher, David, Koenen, Maria T., Govaere, Olivier, Boekschoten, Mark V., Jörs, Simone, Villacorta-Martin, Carlos, Mazzaferro, Vincenzo, Llovet, Josep M., Weiskirchen, Ralf, Kather, Jakob N., Starlinger, Patrick, Trauner, Michael, Luedde, Mark, Heij, Lara R., Neumann, Ulf P., Keitel, Verena, Bode, Johannes G., Schneider, Rebekka K., Tacke, Frank, Levkau, Bodo, Lammers, Twan, Fluegen, Georg, Alexandrov, Theodore, Collins, Amy L., Nelson, Glyn, Oakley, Fiona, Mann, Derek A., Roderburg, Christoph, Longerich, Thomas, Weber, Achim, Villanueva, Augusto, Samson, Andre L., Murphy, James M., Kramann, Rafael, Geisler, Fabian, Costa, Ivan G., Hengstler, Jan G., Heikenwalder, Mathias, Luedde, Tom

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A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development von Boege, Yannick, Malehmir, Mohsen, Healy, Marc E., Bettermann, Kira, Lorentzen, Anna, Vucur, Mihael, Ahuja, Akshay K., Böhm, Friederike, Mertens, Joachim C., Shimizu, Yutaka, Frick, Lukas, Remouchamps, Caroline, Mutreja, Karun, Kähne, Thilo, Sundaravinayagam, Devakumar, Wolf, Monika J., Rehrauer, Hubert, Koppe, Christiane, Speicher, Tobias, Padrissa-Altés, Susagna, Maire, Renaud, Schattenberg, Jörn M., Jeong, Ju-Seong, Liu, Lei, Zwirner, Stefan, Boger, Regina, Hüser, Norbert, Davis, Roger J., Müllhaupt, Beat, Moch, Holger, Schulze-Bergkamen, Henning, Clavien, Pierre-Alain, Werner, Sabine, Borsig, Lubor, Luther, Sanjiv A., Jost, Philipp J., Weinlich, Ricardo, Unger, Kristian, Behrens, Axel, Hillert, Laura, Dillon, Christopher, Di Virgilio, Michela, Wallach, David, Dejardin, Emmanuel, Zender, Lars, Naumann, Michael, Walczak, Henning, Green, Douglas R., Lopes, Massimo, Lavrik, Inna, Luedde, Tom, Heikenwalder, Mathias, Weber, Achim

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Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling von Kotsiliti, Elena, Leone, Valentina, Schuehle, Svenja, Govaere, Olivier, Li, Hai, Wolf, Monika J., Horvatic, Helena, Bierwirth, Sandra, Hundertmark, Jana, Inverso, Donato, Zizmare, Laimdota, Sarusi-Portuguez, Avital, Gupta, Revant, O’Connor, Tracy, Giannou, Anastasios D., Shiri, Ahmad Mustafa, Schlesinger, Yehuda, Beccaria, Maria Garcia, Rennert, Charlotte, Pfister, Dominik, Öllinger, Rupert, Gadjalova, Iana, Ramadori, Pierluigi, Rahbari, Mohammad, Rahbari, Nuh, Healy, Marc E., Fernández-Vaquero, Mirian, Yahoo, Neda, Janzen, Jakob, Singh, Indrabahadur, Fan, Chaofan, Liu, Xinyuan, Rau, Monika, Feuchtenberger, Martin, Schwaneck, Eva, Wallace, Sebastian J., Cockell, Simon, Wilson-Kanamori, John, Ramachandran, Prakash, Kho, Celia, Kendall, Timothy J., Leblond, Anne-Laure, Keppler, Selina J., Bielecki, Piotr, Steiger, Katja, Hofmann, Maike, Rippe, Karsten, Zitzelsberger, Horst, Weber, Achim, Malek, Nisar, Luedde, Tom, Vucur, Mihael, Augustin, Hellmut G., Flavell, Richard, Parnas, Oren, Rad, Roland, Pabst, Olivier, Henderson, Neil C., Huber, Samuel, Macpherson, Andrew, Knolle, Percy, Claassen, Manfred, Geier, Andreas, Trautwein, Christoph, Unger, Kristian, Elinav, Eran, Waisman, Ari, Abdullah, Zeinab, Haller, Dirk, Tacke, Frank, Anstee, Quentin M., Heikenwalder, Mathias

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