Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research? von De Vos, Kurt J, Hafezparast, Majid

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The role of mitochondria in amyotrophic lateral sclerosis von Smith, Emma F., Shaw, Pamela J., De Vos, Kurt J.

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Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish von Chapman, Anna L, Bennett, Ellen J, Ramesh, Tennore M, De Vos, Kurt J, Grierson, Andrew J

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ER–mitochondria associations are regulated by the VAPB–PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43 von Stoica, Radu, De Vos, Kurt J., Paillusson, Sébastien, Mueller, Sarah, Sancho, Rosa M., Lau, Kwok-Fai, Vizcay-Barrena, Gema, Lin, Wen-Lang, Xu, Ya-Fei, Lewis, Jada, Dickson, Dennis W., Petrucelli, Leonard, Mitchell, Jacqueline C., Shaw, Christopher E., Miller, Christopher C. J.

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Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations von Godena, Vinay K., Brookes-Hocking, Nicholas, Moller, Annekathrin, Shaw, Gary, Oswald, Matthew, Sancho, Rosa M., Miller, Christopher C. J., Whitworth, Alexander J., De Vos, Kurt J.

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Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels von Moller, Annekathrin, Bauer, Claudia S, Cohen, Rebecca N, Webster, Christopher P, De Vos, Kurt J

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C9orf72 expansion disrupts ATM-mediated chromosomal break repair von Walker, Callum, Herranz-Martin, Saul, Karyka, Evangelia, Liao, Chunyan, Lewis, Katherine, Elsayed, Waheba, Lukashchuk, Vera, Chiang, Shih-Chieh, Ray, Swagat, Mulcahy, Padraig J, Jurga, Mateusz, Tsagakis, Ioannis, Iannitti, Tommaso, Chandran, Jayanth, Coldicott, Ian, De Vos, Kurt J, Hassan, Mohamed K, Higginbottom, Adrian, Shaw, Pamela J, Hautbergue, Guillaume M, Azzouz, Mimoun, El-Khamisy, Sherif F

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Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6 von Vance, Caroline, Rogelj, Boris, Hortobágyi, Tibor, De Vos, Kurt J, Nishimura, Agnes Lumi, Sreedharan, Jemeen, Hu, Xun, Smith, Bradley, Ruddy, Deborah, Wright, Paul, Ganesalingam, Jeban, Williams, Kelly L, Tripathi, Vineeta, Al-Saraj, Safa, Al-Chalabi, Ammar, Leigh, P. Nigel, Blair, Ian P, Nicholson, Garth, de Belleroche, Jackie, Gallo, Jean-Marc, Miller, Christopher C, Shaw, Christopher E

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Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities? von Webster, Christopher P, Smith, Emma F, Shaw, Pamela J, De Vos, Kurt J

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Role of Axonal Transport in Neurodegenerative Diseases von DE VOS, Kurt J, GRIERSON, Andrew J, ACKERLEY, Steven, MILLER, Christopher C. J

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Reduced number of axonal mitochondria and tau hypophosphorylation in mouse P301L tau knockin neurons von Rodríguez-Martín, Teresa, Pooler, Amy M, Lau, Dawn H.W, Mórotz, Gábor M, De Vos, Kurt J, Gilley, Jonathan, Coleman, Michael P, Hanger, Diane P

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Mitochondrial Function and Actin Regulate Dynamin-Related Protein 1-Dependent Mitochondrial Fission von De Vos, Kurt J., Allan, Victoria J., Grierson, Andrew J., Sheetz, Michael P.

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C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten von Stopford, Matthew J, Higginbottom, Adrian, Hautbergue, Guillaume M, Cooper-Knock, Johnathan, Mulcahy, Padraig J, De Vos, Kurt J, Renton, Alan E, Pliner, Hannah, Calvo, Andrea, Chio, Adriano, Traynor, Bryan J, Azzouz, Mimoun, Heath, Paul R, Kirby, Janine, Shaw, Pamela J

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Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1 von Vagnoni, Alessio, Rodriguez, Lilia, Manser, Catherine, De Vos, Kurt J, Miller, Christopher C J

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Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content von De Vos, Kurt J., Chapman, Anna L., Tennant, Maria E., Manser, Catherine, Tudor, Elizabeth L., Lau, Kwok-Fai, Brownlees, Janet, Ackerley, Steven, Shaw, Pamela J., McLoughlin, Declan M., Shaw, Christopher E., Leigh, P. Nigel, Miller, Christopher C.J., Grierson, Andrew J.

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Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation von Bauer, Claudia S, Webster, Christopher P, Shaw, Allan C, Kok, Jannigje R, Castelli, Lydia M, Lin, Ya-Hui, Smith, Emma F, Illanes-Álvarez, Francisco, Higginbottom, Adrian, Shaw, Pamela J, Azzouz, Mimoun, Ferraiuolo, Laura, Hautbergue, Guillaume M, Grierson, Andrew J, De Vos, Kurt J

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Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients von Kasher, Paul R, De Vos, Kurt J, Wharton, Stephen B, Manser, Catherine, Bennett, Ellen J, Bingley, Megan, Wood, Jonathan D, Milner, Roy, McDermott, Christopher J, Miller, Christopher C.J, Shaw, Pamela J, Grierson, Andrew J

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The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy von Webster, Christopher P, Smith, Emma F, Bauer, Claudia S, Moller, Annekathrin, Hautbergue, Guillaume M, Ferraiuolo, Laura, Myszczynska, Monika A, Higginbottom, Adrian, Walsh, Matthew J, Whitworth, Alexander J, Kaspar, Brian K, Meyer, Kathrin, Shaw, Pamela J, Grierson, Andrew J, De Vos, Kurt J

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ALS/FTD-associated FUS activates GSK-3β to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations von Stoica, Radu, Paillusson, Sébastien, Gomez-Suaga, Patricia, Mitchell, Jacqueline C, Lau, Dawn HW, Gray, Emma H, Sancho, Rosa M, Vizcay-Barrena, Gema, De Vos, Kurt J, Shaw, Christopher E, Hanger, Diane P, Noble, Wendy, Miller, Christopher CJ

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ALS/FTD-associated FUS activates GSK-3[beta] to disrupt the VAPB-PTPIP51 interaction and ER-mitochondria associations von Stoica, Radu, Paillusson, Sébastien, Gomez-Suaga, Patricia, Mitchell, Jacqueline C, Lau, Dawn HW, Gray, Emma H, Sancho, Rosa M, Vizcay-Barrena, Gema, De Vos, Kurt J, Shaw, Christopher E, Hanger, Diane P, Noble, Wendy, Miller, Christopher CJ

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