Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes von Saleem, Umber, van Meer, Berend J, Katili, Puspita A, Mohd Yusof, Nurul A N, Mannhardt, Ingra, Garcia, Ana Krotenberg, Tertoolen, Leon, de Korte, Tessa, Vlaming, Maria L H, McGlynn, Karen, Nebel, Jessica, Bahinski, Anthony, Harris, Kate, Rossman, Eric, Xu, Xiaoping, Burton, Francis L, Smith, Godfrey L, Clements, Peter, Mummery, Christine L, Eschenhagen, Thomas, Hansen, Arne, Denning, Chris

Volltext

Impact of Abcc2 [Multidrug Resistance-Associated Protein (Mrp) 2], Abcc3 (Mrp3), and Abcg2 (Breast Cancer Resistance Protein) on the Oral Pharmacokinetics of Methotrexate and Its M... von Vlaming, Maria LH, van Esch, Anita, van de Steeg, Evita, Pala, Zeliha, Wagenaar, Els, van Tellingen, Olaf, Schinkel, Alfred H.

Volltext

Intensity of mental health treatment of cancer-related psychopathology: the predictive role of Early Maladaptive Schemas von de Vlaming, Irene H., Schellekens, Melanie P. J., van der Lee, Marije L.

Volltext

Evaluation of 3D Human Intestinal Organoids as a Platform for EV-A71 Antiviral Drug Discovery von Masmoudi, Fatma, Santos-Ferreira, Nanci, Pajkrt, Dasja, Wolthers, Katja C, DeGroot, Jeroen, Vlaming, Maria L H, Rocha-Pereira, Joana, Buti, Ludovico

Volltext

Hepatic transport mechanisms of cholyl-L-lysyl-fluorescein von de Waart, Dirk R, Häusler, Stephanie, Vlaming, Maria L H, Kunne, Cindy, Hänggi, Emanuel, Gruss, Hans-Jurgen, Oude Elferink, Ronald P J, Stieger, Bruno

Volltext

Multidrug Resistance Proteins 2 and 3 Provide Alternative Routes for Hepatic Excretion of Morphine-Glucuronides von van de Wetering, Koen, Zelcer, Noam, Kuil, Annemieke, Feddema, Wouter, Hillebrand, Michel, Vlaming, Maria L H, Schinkel, Alfred H, Beijnen, Jos H, Borst, Piet

Volltext

Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo von Vlaming, Maria L H, van Esch, Anita, Pala, Zeliha, Wagenaar, Els, van de Wetering, Koen, van Tellingen, Olaf, Schinkel, Alfred H

Volltext

Bcrp1;Mdr1a/b;Mrp2 Combination Knockout Mice: Altered Disposition of the Dietary Carcinogen PhIP (2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine) and Its Genotoxic Metabolites von Vlaming, Maria L.H., Teunissen, Sebastiaan F., van de Steeg, Evita, van Esch, Anita, Wagenaar, Els, Brunsveld, Luc, de Greef, Tom F.A., Rosing, Hilde, Schellens, Jan H.M., Beijnen, Jos H., Schinkel, Alfred H.

Volltext

Complex Pharmacokinetic Behavior of Ezetimibe Depends on Abcc2, Abcc3, and Abcg2 von de Waart, Dirk R., Vlaming, Maria L.H., Kunne, Cindy, Schinkel, Alfred H., Elferink, Ronald P.J. Oude

Volltext

P-glycoprotein (P-gp/Abcb1), Abcc2, and Abcc3 Determine the Pharmacokinetics of Etoposide von LAGAS, Jurjen S, LIN FAN, WAGENAAR, Els, VLAMING, Maria L. H, VAN TELLINGEN, Olaf, BEIJNEN, Jos H, SCHINKEL, Alfred H

Volltext

Liquid chromatography–tandem mass spectrometric assay for sorafenib and sorafenib–glucuronide in mouse plasma and liver homogenate and identification of the glucuronide metabolite... von Sparidans, Rolf W., Vlaming, Maria L.H., Lagas, Jurjen S., Schinkel, Afred H., Schellens, Jan H.M., Beijnen, Jos H.

Volltext

Development and validation of a liquid chromatography–tandem mass spectrometry assay for the analysis of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and its metabolite... von Teunissen, S.F., Vlaming, M.L.H., Rosing, H., Schellens, J.H.M., Schinkel, A.H., Beijnen, J.H.

Volltext

Breast cancer resistance protein (Bcrp1/Abcg2) is expressed in the harderian gland and mediates transport of conjugated protoporphyrin IX von Jonker, Johan W, Musters, Sandra, Vlaming, Maria L. H, Plosch, Torsten, Gooijert, Karin E. R, Hillebrand, Michel J, Rosing, Hilde, Beijnen, Jos H, Verkade, Henkjan J, Schinkel, Alfred H

Volltext

Physiological and pharmacological roles of ABCG2 (BCRP): Recent findings in Abcg2 knockout mice von Vlaming, Maria L.H., Lagas, Jurjen S., Schinkel, Alfred H.

Volltext

Comparison of 10 Control hPSC Lines for Drug Screening in an Engineered Heart Tissue Format von Mannhardt, Ingra, Saleem, Umber, Mosqueira, Diogo, Loos, Malte F., Ulmer, Bärbel M., Lemoine, Marc D., Larsson, Camilla, Améen, Caroline, de Korte, Tessa, Vlaming, Maria L.H., Harris, Kate, Clements, Peter, Denning, Chris, Hansen, Arne, Eschenhagen, Thomas

Volltext

Feasibility of SPECT-CT Imaging to Study the Pharmacokinetics of Antisense Oligonucleotides in a Mouse Model of Duchenne Muscular Dystrophy von van de Steeg, Evita, Läppchen, Tilman, Aguilera, Begoña, Jansen, Harm T., Muilwijk, Daan, Vermue, Rick, van der Hoorn, José W., Donato, Katia, Rossin, Raffaella, de Visser, Peter C., Vlaming, Maria L.H.

Volltext

To Apply Microdosing or Not? Recommendations to Single Out Compounds with Non-Linear Pharmacokinetics von Bosgra, Sieto, Vlaming, Maria L. H., Vaes, Wouter H. J.

Volltext

PET imaging of disease progression and treatment effects in the experimental autoimmune encephalomyelitis rat model von de Paula Faria, Daniele, Vlaming, Maria L H, Copray, Sjef C V M, Tielen, Frans, Anthonijsz, Herma J A, Sijbesma, Jurgen W A, Buchpiguel, Carlos A, Dierckx, Rudi A J O, van der Hoorn, José W A, de Vries, Erik F J

Volltext

Differential, strain-specific cellular and subcellular distribution of multidrug transporters in murine choroid plexus and blood–brain barrier von Soontornmalai, A., Vlaming, M.L.H., Fritschy, J.-M.

Volltext

Predicting cardiac safety using human induced pluripotent stem cell-derived cardiomyocytes combined with multi-electrode array (MEA) technology: A conference report von Mulder, Petra, de Korte, Tessa, Dragicevic, Elena, Kraushaar, Udo, Printemps, Richard, Vlaming, Maria L.H., Braam, Stefan R., Valentin, Jean-Pierre

Volltext