Discovery of a Novel Chemotype of Histone Lysine Methyltransferase EHMT1/2 (GLP/G9a) Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Co-crystal Structure von Milite, Ciro, Feoli, Alessandra, Horton, John R, Rescigno, Donatella, Cipriano, Alessandra, Pisapia, Vincenzo, Viviano, Monica, Pepe, Giacomo, Amendola, Giorgio, Novellino, Ettore, Cosconati, Sandro, Cheng, Xiaodong, Castellano, Sabrina, Sbardella, Gianluca

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TSPO Radioligands for Neuroinflammation: An Overview von Salerno, Silvia, Viviano, Monica, Baglini, Emma, Poggetti, Valeria, Giorgini, Doralice, Castagnoli, Jacopo, Barresi, Elisabetta, Castellano, Sabrina, Da Settimo, Federico, Taliani, Sabrina

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Indol-3-ylglyoxylamide as Privileged Scaffold in Medicinal Chemistry von Barresi, Elisabetta, Robello, Marco, Baglini, Emma, Poggetti, Valeria, Viviano, Monica, Salerno, Silvia, Da Settimo, Federico, Taliani, Sabrina

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A Scalable Two-Step Continuous Flow Synthesis of Nabumetone and Related 4-Aryl-2-butanones von Viviano, Monica, Glasnov, Toma N, Reichart, Benedik, Tekautz, Guenter, Kappe, C. Oliver

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Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells von Stazi, Giulia, Battistelli, Cecilia, Piano, Valentina, Mazzone, Roberta, Marrocco, Biagina, Marchese, Sara, Louie, Sharon M., Zwergel, Clemens, Antonini, Lorenzo, Patsilinakos, Alexandros, Ragno, Rino, Viviano, Monica, Sbardella, Gianluca, Ciogli, Alessia, Fabrizi, Giancarlo, Cirilli, Roberto, Strippoli, Raffaele, Marchetti, Alessandra, Tripodi, Marco, Nomura, Daniel K., Mattevi, Andrea, Mai, Antonello, Valente, Sergio

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Tetrahydroquinazole-based secondary sulphonamides as carbonic anhydrase inhibitors: synthesis, biological evaluation against isoforms I, II, IV, and IX, and computational studies von Baglini, Emma, Ravichandran, Rahul, Berrino, Emanuela, Salerno, Silvia, Barresi, Elisabetta, Marini, Anna Maria, Viviano, Monica, Castellano, Sabrina, Da Settimo, Federico, Supuran, Claudiu T., Cosconati, Sandro, Taliani, Sabrina

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NADPH Oxidases: From Molecular Mechanisms to Current Inhibitors von Cipriano, Alessandra, Viviano, Monica, Feoli, Alessandra, Milite, Ciro, Sarno, Giuliana, Castellano, Sabrina, Sbardella, Gianluca

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Microwave-Assisted Aminoalkylation of Phenols via Mustard Carbonate Analogues von Viviano, Monica, Trapasso, Giacomo, Annatelli, Mattia, Milite, Ciro, Castellano, Sabrina, Aricò, Fabio

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Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–... von Iannelli, Giulia, Milite, Ciro, Marechal, Nils, Cura, Vincent, Bonnefond, Luc, Troffer-Charlier, Nathalie, Feoli, Alessandra, Rescigno, Donatella, Wang, Yalong, Cipriano, Alessandra, Viviano, Monica, Bedford, Mark T., Cavarelli, Jean, Castellano, Sabrina, Sbardella, Gianluca

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Lysine methyltransferase inhibitors: where we are now von Feoli, Alessandra, Viviano, Monica, Cipriano, Alessandra, Milite, Ciro, Castellano, Sabrina, Sbardella, Gianluca

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Synthesis and biochemical evaluation of δ(2)-isoxazoline derivatives as DNA methyltransferase 1 inhibitors von Castellano, Sabrina, Kuck, Dirk, Viviano, Monica, Yoo, Jakyung, López-Vallejo, Fabian, Conti, Paola, Tamborini, Lucia, Pinto, Andrea, Medina-Franco, José L, Sbardella, Gianluca

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Front Cover: Prodrug Approach to Exploit (S)‐Alanine Amide as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors (ChemMedChem 17/2024) von Milite, Ciro, Sarno, Giuliana, Pacilio, Ida, Cianciulli, Agostino, Viviano, Monica, Iannelli, Giulia, Gazzillo, Erica, Feoli, Alessandra, Cipriano, Alessandra, Giovanna Chini, Maria, Castellano, Sabrina, Bifulco, Giuseppe, Sbardella, Gianluca

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Developing Spindlin1 small-molecule inhibitors by using protein microarrays von Bae, Narkhyun, Viviano, Monica, Su, Xiaonan, Lv, Jie, Cheng, Donghang, Sagum, Cari, Castellano, Sabrina, Bai, Xue, Johnson, Claire, Khalil, Mahmoud Ibrahim, Shen, Jianjun, Chen, Kaifu, Li, Haitao, Sbardella, Gianluca, Bedford, Mark T

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Discovery of Benzo[d]imidazole‐6‐sulfonamides as Bromodomain and Extra‐Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain von Cipriano, Alessandra, Milite, Ciro, Feoli, Alessandra, Viviano, Monica, Pepe, Giacomo, Campiglia, Pietro, Sarno, Giuliana, Picaud, Sarah, Imaide, Satomi, Makukhin, Nikolai, Filippakopoulos, Panagis, Ciulli, Alessio, Castellano, Sabrina, Sbardella, Gianluca

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Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor von Feoli, Alessandra, Iannelli, Giulia, Cipriano, Alessandra, Milite, Ciro, Shen, Lei, Wang, Zhihao, Hadjikyriacou, Andrea, Lowe, Troy L., Safaeipour, Cyrus, Viviano, Monica, Sarno, Giuliana, Morretta, Elva, Monti, Maria Chiara, Yang, Yanzhong, Clarke, Steven G., Cosconati, Sandro, Castellano, Sabrina, Sbardella, Gianluca

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Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models von Menna, Martina, Fiorentino, Francesco, Marrocco, Biagina, Lucidi, Alessia, Tomassi, Stefano, Cilli, Domenica, Romanenghi, Mauro, Cassandri, Matteo, Pomella, Silvia, Pezzella, Michele, Del Bufalo, Donatella, Zeya Ansari, Mohammad Salik, Tomašević, Nevena, Mladenović, Milan, Viviano, Monica, Sbardella, Gianluca, Rota, Rossella, Trisciuoglio, Daniela, Minucci, Saverio, Mattevi, Andrea, Rotili, Dante, Mai, Antonello

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Prodrug Approach to Exploit (S)‐Alanine Amide as Arginine Mimic Moiety in the Development of Protein Arginine Methyltransferase 4 Inhibitors von Milite, Ciro, Sarno, Giuliana, Pacilio, Ida, Cianciulli, Agostino, Viviano, Monica, Iannelli, Giulia, Gazzillo, Erica, Feoli, Alessandra, Cipriano, Alessandra, Giovanna Chini, Maria, Castellano, Sabrina, Bifulco, Giuseppe, Sbardella, Gianluca

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Inhibition studies on carbonic anhydrase isoforms I, II, IV and IX with N-arylsubstituted secondary sulfonamides featuring a bicyclic tetrahydroindazole scaffold von Salerno, Silvia, Amendola, Giorgio, Angeli, Andrea, Baglini, Emma, Barresi, Elisabetta, Marini, Anna Maria, Ravichandran, Rahul, Viviano, Monica, Castellano, Sabrina, Novellino, Ettore, Da Settimo, Federico, Supuran, Claudiu T., Cosconati, Sandro, Taliani, Sabrina

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A continuous-flow synthesis of 1,4-benzodiazepin-5-ones, privileged scaffolds for drug discovery von Viviano, Monica, Milite, Ciro, Rescigno, Donatella, Castellano, Sabrina, Sbardella, Gianluca

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The emerging role of lysine methyltransferase SETD8 in human diseases von Milite, Ciro, Feoli, Alessandra, Viviano, Monica, Rescigno, Donatella, Cianciulli, Agostino, Balzano, Amodio Luca, Mai, Antonello, Castellano, Sabrina, Sbardella, Gianluca

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