Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality von Ishizawa, Jo, Zarabi, Sarah F., Davis, R. Eric, Halgas, Ondrej, Nii, Takenobu, Jitkova, Yulia, Zhao, Ran, St-Germain, Jonathan, Heese, Lauren E., Egan, Grace, Ruvolo, Vivian R., Barghout, Samir H., Nishida, Yuki, Hurren, Rose, Ma, Wencai, Gronda, Marcela, Link, Todd, Wong, Keith, Mabanglo, Mark, Kojima, Kensuke, Borthakur, Gautam, MacLean, Neil, Ma, Man Chun John, Leber, Andrew B., Minden, Mark D., Houry, Walid, Kantarjian, Hagop, Stogniew, Martin, Raught, Brian, Pai, Emil F., Schimmer, Aaron D., Andreeff, Michael

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LGALS1 acts as a pro-survival molecule in AML von Ruvolo, Peter P., Ma, Huaxian, Ruvolo, Vivian R., Zhang, Xiaorui, Post, Sean M., Andreeff, Michael

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Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models von Han, Lina, Zhang, Qi, Dail, Monique, Shi, Ce, Cavazos, Antonio, Ruvolo, Vivian R., Zhao, Yang, Kim, Eugene, Rahmani, Mohamed, Mak, Duncan H., Jin, Sha S., Chen, Jun, Phillips, Darren C., Koller, Paul Bottecelli, Jacamo, Rodrigo, Burks, Jared K., DiNardo, Courtney, Daver, Naval, Jabbour, Elias, Wang, Jing, Kantarjian, Hagop M., Andreeff, Michael, Grant, Steven, Leverson, Joel D., Sampath, Deepak, Konopleva, Marina

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia von Konopleva, Marina, Contractor, Rooha, Tsao, Twee, Samudio, Ismael, Ruvolo, Peter P., Kitada, Shinichi, Deng, Xingming, Zhai, Dayong, Shi, Yue-Xi, Sneed, Thomas, Verhaegen, Monique, Soengas, Maria, Ruvolo, Vivian R., McQueen, Teresa, Schober, Wendy D., Watt, Julie C., Jiffar, Tilahun, Ling, Xiaoyang, Marini, Frank C., Harris, David, Dietrich, Martin, Estrov, Zeev, McCubrey, James, May, W. Stratford, Reed, John C., Andreeff, Michael

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AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3 -ITD acute myeloid leukemia von Post, Sean M, Ma, Huaxian, Malaney, Prerna, Zhang, Xiaorui, Aitken, Marisa J L, Mak, Po Yee, Ruvolo, Vivian R, Yasuhiro, Tomoko, Kozaki, Ryohei, Chan, Lauren E, Ostermann, Lauren B, Konopleva, Marina, Carter, Bing Z, DiNardo, Courtney, Andreeff, Michael D, Khoury, Joseph D, Ruvolo, Peter P

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The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations von Zhang, Weiguo, Borthakur, Gautam, Gao, Chen, Chen, Ye, Mu, Hong, Ruvolo, Vivian R, Nomoto, Kenichi, Zhao, Nanding, Konopleva, Marina, Andreeff, Michael

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Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival von Kornblau, Steven M, Ruvolo, Peter P, Wang, Rui-Yu, Battula, V Lokesh, Shpall, Elizabeth J, Ruvolo, Vivian R, McQueen, Teresa, Qui, YiHua, Zeng, Zhihong, Pierce, Sherry, Jacamo, Rodrigo, Yoo, Suk-Young, Le, Phuong M, Sun, Jeffrey, Hail, Jr, Numsen, Konopleva, Marina, Andreeff, Michael

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Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells von Ruvolo, Peter P., Ruvolo, Vivian R., Benton, Christopher B., AlRawi, Ahmed, Burks, Jared K., Schober, Wendy, Rolke, James, Tidmarsh, George, Hail, Numsen, Eric Davis, R., Andreeff, Michael

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Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML von Nishida, Yuki, Zhao, Ran, Heese, Lauren E., Akiyama, Hiroki, Patel, Shreya, Jaeger, Alex M., Jacamo, Rodrigo O., Kojima, Kensuke, Ma, Man Chun John, Ruvolo, Vivian R., Chachad, Dhruv, Devine, William, Lindquist, Susan, Davis, R. Eric, Porco, John A., Whitesell, Luke, Andreeff, Michael, Ishizawa, Jo

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Inhibition of Mcl-1 with the pan–Bcl-2 family inhibitor (–)BI97D6 overcomes ABT-737 resistance in acute myeloid leukemia von Pan, Rongqing, Ruvolo, Vivian R., Wei, Jun, Konopleva, Marina, Reed, John C., Pellecchia, Maurizio, Andreeff, Michael, Ruvolo, Peter P.

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Targeting PKC-mediated signal transduction pathways using enzastaurin to promote apoptosis in acute myeloid leukemia-derived cell lines and blast cells von Ruvolo, Peter P., Zhou, Liran, Watt, Julie C., Ruvolo, Vivian R., Burks, Jared K., Jiffar, Tilahun, Kornblau, Steven, Konopleva, Marina, Andreeff, Michael

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Atg7 suppression enhances chemotherapeutic agent sensitivity and overcomes stroma-mediated chemoresistance in acute myeloid leukemia von Piya, Sujan, Kornblau, Steven M., Ruvolo, Vivian R., Mu, Hong, Ruvolo, Peter P., McQueen, Teresa, Davis, R.Eric, Hail, Numsen, Kantarjian, Hagop, Andreeff, Michael, Borthakur, Gautam

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Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mec... von Ruvolo, Peter P, Ma, Huaxian, Ruvolo, Vivian R, Zhang, Xiaorui, Mu, Hong, Schober, Wendy, Hernandez, Ivonne, Gallardo, Miguel, Khoury, Joseph D, Cortes, Jorge, Andreeff, Michael, Post, Sean M

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Mitochondrial regulation of GPX4 inhibition–mediated ferroptosis in acute myeloid leukemia von Akiyama, Hiroki, Zhao, Ran, Ostermann, Lauren B., Li, Ziyi, Tcheng, Matthew, Yazdani, Samar J., Moayed, Arman, Pryor, Malcolm L., Slngh, Sandeep, Baran, Natalia, Ayoub, Edward, Nishida, Yuki, Mak, Po Yee, Ruvolo, Vivian R., Carter, Bing Z., Schimmer, Aaron D., Andreeff, Michael, Ishizawa, Jo

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Correction: Mitochondrial regulation of GPX4 inhibition–mediated ferroptosis in acute myeloid leukemia von Akiyama, Hiroki, Zhao, Ran, Ostermann, Lauren B., Li, Ziyi, Tcheng, Matthew, Yazdani, Samar J., Moayed, Arman, Pryor, Malcolm L., Slngh, Sandeep, Baran, Natalia, Ayoub, Edward, Nishida, Yuki, Mak, Po Yee, Ruvolo, Vivian R., Carter, Bing Z., Schimmer, Aaron D., Andreeff, Michael, Ishizawa, Jo

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Targeting Unc51-like Autophagy Activating Kinase 1 (ULK1) Overcomes Adaptive Drug Resistance in Acute Myelogenous Leukemia von Bhattacharya, Seemana, Piya, Sujan, Ma, Huaxian, Sharma, Priyanka, Zhang, Qi, Baran, Natalia, Ruvolo, Vivian R, McQueen, Teresa, Davis, R Eric, Pourebrahim, Rasoul, Konopleva, Marina, Kantarjian, Hagop, Cosford, Nicholas D P, Andreeff, Michael, Borthakur, Gautam

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Focal Adhesion Kinase as a Potential Target in AML and MDS von Carter, Bing Z, Mak, Po Yee, Wang, Xiangmeng, Yang, Hui, Garcia-Manero, Guillermo, Mak, Duncan H, Mu, Hong, Ruvolo, Vivian R, Qiu, Yihua, Coombes, Kevin, Zhang, Nianxiang, Ragon, Brittany, Weaver, David T, Pachter, Jonathan A, Kornblau, Steven, Andreeff, Michael

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Role of MSC-derived galectin 3 in the AML microenvironment von Ruvolo, Peter P., Ruvolo, Vivian R., Burks, Jared K., Qiu, YiHua, Wang, Rui-Yu, Shpall, Elizabeth J., Mirandola, Leonardo, Hail, Numsen, Zeng, Zhihong, McQueen, Teresa, Daver, Naval, Post, Sean M., Chiriva-Internati, Maurizio, Kornblau, Steven M., Andreeff, Michael

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Human Glycolipid Transfer Protein Gene (GLTP) Expression Is Regulated by Sp1 and Sp3 von Zou, Xianqiong, Gao, Yongguang, Ruvolo, Vivian R., Gardner, Tawnya L., Ruvolo, Peter P., Brown, Rhoderick E.

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The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells von Ruvolo, Peter P., Ruvolo, Vivian R., Jacamo, Rodrigo, Burks, Jared K., Zeng, Zhihong, Duvvuri, Seshagiri R., Zhou, Liran, Qiu, Yihua, Coombes, Kevin R., Zhang, Nianxiang, Yoo, Suk Y., Pan, Rongqing, Hail, Numsen, Konopleva, Marina, Calin, George, Kornblau, Steven M., Andreeff, Michael

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