Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration von Boyarko, Ben, Hook, Vivian

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Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amy... von Hook, Vivian Y.H., Kindy, Mark, Hook, Gregory

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Cathepsin B Gene Knockout Improves Behavioral Deficits and Reduces Pathology in Models of Neurologic Disorders von Hook, Gregory, Reinheckel, Thomas, Ni, Junjun, Wu, Zhou, Kindy, Mark, Peters, Christoph, Hook, Vivian

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Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders von Hook, Vivian, Yoon, Michael, Mosier, Charles, Ito, Gen, Podvin, Sonia, Head, Brian P., Rissman, Robert, O'Donoghue, Anthony J., Hook, Gregory

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A Commensal Dipeptidyl Aminopeptidase with Specificity for N‑Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro von Xu, Janice H, Jiang, Zhenze, Solania, Angelo, Chatterjee, Sandip, Suzuki, Brian, Lietz, Christopher B, Hook, Vivian Y. H, O’Donoghue, Anthony J, Wolan, Dennis W

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Lysosomal Cathepsin Protease Gene Expression Profiles in the Human Brain During Normal Development von Hsu, Amy, Podvin, Sonia, Hook, Vivian

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Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling von Jiang, Muzhou, Meng, Jie, Zeng, Fan, Qing, Hong, Hook, Gregory, Hook, Vivian, Wu, Zhou, Ni, Junjun

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Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein von Hook, Vivian Y.H., Kindy, Mark, Reinheckel, Thomas, Peters, Christoph, Hook, Gregory

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Multi-omics of human plasma reveals molecular features of dysregulated inflammation and accelerated aging in schizophrenia von Campeau, Anaamika, Mills, Robert H., Stevens, Toer, Rossitto, Leigh-Ana, Meehan, Michael, Dorrestein, Pieter, Daly, Rebecca, Nguyen, Tanya T., Gonzalez, David J., Jeste, Dilip V., Hook, Vivian

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NeuroPedia: neuropeptide database and spectral library von Kim, Yoona, Bark, Steven, Hook, Vivian, Bandeira, Nuno

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Design of Gallinamide A Analogs as Potent Inhibitors of the Cysteine Proteases Human Cathepsin L and Trypanosoma cruzi Cruzain von Boudreau, Paul D, Miller, Bailey W, McCall, Laura-Isobel, Almaliti, Jehad, Reher, Raphael, Hirata, Ken, Le, Thu, Siqueira-Neto, Jair L, Hook, Vivian, Gerwick, William H

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Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry von Hook, Vivian, Lietz, Christopher B., Podvin, Sonia, Cajka, Tomas, Fiehn, Oliver

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Cathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug Candidate von Hook, Gregory, Jacobsen, J Steven, Grabstein, Kenneth, Kindy, Mark, Hook, Vivian

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Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions von Yoon, Michael C, Solania, Angelo, Jiang, Zhenze, Christy, Mitchell P, Podvin, Sonia, Mosier, Charles, Lietz, Christopher B, Ito, Gen, Gerwick, William H, Wolan, Dennis W, Hook, Gregory, O’Donoghue, Anthony J, Hook, Vivian

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The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury von Hook, Gregory R, Yu, Jin, Sipes, Nancy, Pierschbacher, Michael D, Hook, Vivian, Kindy, Mark S

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Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease von Hook, Vivian, Funkelstein, Lydiane, Wegrzyn, Jill, Bark, Steven, Kindy, Mark, Hook, Gregory

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Penetrating Traumatic Brain Injury Triggers Dysregulation of Cathepsin B Protein Levels Independent of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid von Boutté, Angela M, Hook, Vivian, Thangavelu, Bharani, Sarkis, George Anis, Abbatiello, Brittany N, Hook, Gregory, Jacobsen, J Steven, Robertson, Claudia S, Gilsdorf, Janice, Yang, Zhihui, Wang, Kevin K W, Shear, Deborah A

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The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight von Garrett-Bakelman, Francine E., Darshi, Manjula, Green, Stefan J., Gur, Ruben C., Lin, Ling, Macias, Brandon R., McKenna, Miles J., Meydan, Cem, Mishra, Tejaswini, Nasrini, Jad, Piening, Brian D., Rizzardi, Lindsay F., Sharma, Kumar, Siamwala, Jamila H., Taylor, Lynn, Vitaterna, Martha Hotz, Afkarian, Maryam, Afshinnekoo, Ebrahim, Ahadi, Sara, Ambati, Aditya, Arya, Maneesh, Bezdan, Daniela, Callahan, Colin M., Chen, Songjie, Choi, Augustine M. K., Chlipala, George E., Contrepois, Kévin, Covington, Marisa, Crucian, Brian E., De Vivo, Immaculata, Dinges, David F., Ebert, Douglas J., Feinberg, Jason I., Gandara, Jorge A., George, Kerry A., Goutsias, John, Grills, George S., Hargens, Alan R., Heer, Martina, Hillary, Ryan P., Hoofnagle, Andrew N., Hook, Vivian Y. H., Jenkinson, Garrett, Jiang, Peng, Keshavarzian, Ali, Laurie, Steven S., Lee-McMullen, Brittany, Lumpkins, Sarah B., MacKay, Matthew, Maienschein-Cline, Mark G., Melnick, Ari M., Moore, Tyler M., Nakahira, Kiichi, Patel, Hemal H., Pietrzyk, Robert, Rao, Varsha, Saito, Rintaro, Salins, Denis N., Schilling, Jan M., Sears, Dorothy D., Sheridan, Caroline K., Stenger, Michael B., Tryggvadottir, Rakel, Urban, Alexander E., Vaisar, Tomas, Van Espen, Benjamin, Zhang, Jing, Ziegler, Michael G., Zwart, Sara R., Charles, John B., Kundrot, Craig E., Scott, Graham B. I., Bailey, Susan M., Basner, Mathias, Feinberg, Andrew P., Lee, Stuart M. C., Mason, Christopher E., Mignot, Emmanuel, Rana, Brinda K., Smith, Scott M., Snyder, Michael P., Turek, Fred W.

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Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons von Hook, Vivian, Brennand, Kristen J., Kim, Yongsung, Toneff, Thomas, Funkelstein, Lydiane, Lee, Kelly C., Ziegler, Michael, Gage, Fred H.

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High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma von Maffioli, Elisa, Jiang, Zhenze, Nonnis, Simona, Negri, Armando, Romeo, Valentina, Lietz, Christopher B, Hook, Vivian, Ristagno, Giuseppe, Baselli, Giuseppe, Kistler, Erik B, Aletti, Federico, O'Donoghue, Anthony J, Tedeschi, Gabriella

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