Deep phenotyping of the unselected COPSAC2010 birth cohort study von Bisgaard, H., Vissing, N. H., Carson, C. G., Bischoff, A. L., Følsgaard, N. V., Kreiner-Møller, E., Chawes, B. L. K., Stokholm, J., Pedersen, L., Bjarnadóttir, E., Thysen, A. H., Nilsson, E., Mortensen, L. J., Olsen, S. F., Schjørring, S., Krogfelt, K. A., Lauritzen, L., Brix, S., Bønnelykke, K.

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Treatable traits in the European U‐BIOPRED adult asthma cohorts von Simpson, Andrew J., Hekking, Pieter‐Paul, Shaw, Dominick E., Fleming, Louise J., Roberts, Graham, Riley, John H., Bates, Stewart, Sousa, Ana R., Bansal, Aruna T., Pandis, Ioannis, Sun, Kai, Bakke, Per S., Caruso, Massimo, Dahlén, Barbro, Dahlén, Sven‐Erik, Horvath, Ildiko, Krug, Norbert, Montuschi, Paolo, Sandstrom, Thomas, Singer, Florian, Adcock, Ian M., Wagers, Scott S., Djukanovic, Ratko, Chung, Kian Fan, Sterk, Peter J., Fowler, Stephen J., Ahmed, H, Auffray, C, Baribaud, F, Bel, E. H, Bisgaard, H, Bønnelykke, K, Brandsma, J, Brinkman, P, Bucchioni, E, Burg, D, Bush, A, Chaiboonchoe, A, Chanez, P, Compton, C. H, Corfield, J, D'Amico, A, De Meulder, B, Erpenbeck, V. J, Erzen, D, Fichtner, K, Fleming, L. J, Formaggio, E, Frey, U, Gahlemann, M, Geiser, T, Goss, V, Guo, Y, Hashimoto, S, Haughney, J, Hedlin, G, Hekking, P. W, Higenbottam, T, Hohlfeld, J. M, Holweg, C, Horváth, I, Howarth, P, James, A. J, Knowles, R, Knox, A. J, Lefaudeux, D, Lutter, R, Manta, A, Masefield, S, Matthews, J. G, Mazein, A, Meiser, A, Middelveld, R. J. M, Miralpeix, M, Mores, N, Murray, C. S, Myles, D, Pahus, L, Pavlidis, S, Postle, A, Powel, P, Praticò, G, Rao, N, Roberts, A, Roberts, G, Rowe, A, Sandström, T, Schofield, J. P. R, Selby, A, Sigmund, R, Skipp, P. J, Thornton, B, Aalderen, W. M, Geest, M, Vestbo, J, Vissing, N. H, Wagener, A. H, Weiszhart, Z, Wheelock, C. E, Wilson, S. J

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Domestic dog exposure at birth reduces the incidence of atopic dermatitis von Thorsteinsdottir, S., Thyssen, J. P., Stokholm, J., Vissing, N. H., Waage, J., Bisgaard, H.

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A single-source nosocomial outbreak of Aspergillus flavus uncovered by genotyping von Gewecke, A, Hare, R Krøger, Salgård, C, Kyndi, L, Høg, M, Petersen, G, Nahimana, D, Abou-Chakra, N, Knudsen, J D, Rosendahl, S, Vissing, N H, Arendrup, M C

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Systemic exposure to inhaled beclometasone/formoterol DPI is age and body size dependent von Chawes, B.L, Govoni, M, Kreiner-Møller, E, Vissing, N.H, Poorisrisak, P, Mortensen, L, Nilsson, E, Bisgaard, A, Dossing, A, Deleuran, M, Skytt, N.L, Samandari, N, Piccinno, A, Sergio, F, Ciurlia, G, Poli, G, Acerbi, D, Singh, D, Bisgaard, H

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Lipid phenotyping of lung epithelial lining fluid in healthy human volunteers von Brandsma, Joost, Goss, Victoria M., Yang, Xian, Bakke, Per S., Caruso, Massimo, Chanez, Pascal, Dahlén, Sven-Erik, Fowler, Stephen J., Horvath, Ildiko, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandström, Thomas, Shaw, Dominick E., Chung, Kian Fan, Singer, Florian, Fleming, Louise J., Sousa, Ana R., Pandis, Ioannis, Bansal, Aruna T., Sterk, Peter J., Djukanović, Ratko, Postle, Anthony D.

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VEGFA variants are associated with pre-school lung function, but not neonatal lung function von Kreiner-Møller, E., Chawes, B. L. K., Vissing, N. H., Koppelman, G. H., Postma, D. S., Madsen, J. S., Olsen, D. A., Baty, F., Vonk, J. M., Kerkhof, M., Sleiman, P., Hakonarsson, H., Mortensen, L. J., Poorisrisak, P., Bisgaard, H., Bønnelykke, K.

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Epithelial IL-6 trans-signaling defines a new asthma phenotype with increased airway inflammation von Östling, Jörgen, Ax, Elisabeth, Calvén, Jenny, Thörn, Kristofer, Israelsson, Elisabeth, Öberg, Lisa, Wilson, Susan J., Ward, Jonathan A., Chauhan, Anoop, Sousa, Ana R., De Meulder, Bertrand, Baribaud, Frédéric, Sterk, Peter J., Guo, Yike, Dahlen, Barbro, Chanez, Pascal, Shaw, Dominick E., Krug, Norbert, Hohlfeld, Jens M., Sandström, Thomas, James, Anna, Hinks, Timothy S.C., Howarth, Peter H., Vaarala, Outi, van Geest, Marleen, Olsson, Henric, Ahmed, H., Auffray, C., Bakke, P., Bansal, A.T., Bates, S., Bel, E.H., Bigler, J., Boedigheimer, M.J., Bønnelykke, K., Brandsma, J., Bucchioni, E., Bush, A., Caruso, M., Chaiboonchoe, A., Chanez, P., Chung, F.K., Corfield, J., D'Amico, A., De Meulder, B., Djukanovic, R., Fichtner, K., Fleming, L.J., Formaggio, E., Frey, U., Goss, V., Guo, Y., Hashimoto, S., Haughney, J., Hekking, P.W., Higenbottam, T., Hohlfeld, J.M., Holweg, C., Horváth, I., James, A.J., Knowles, R., Loza, M.J., Manta, A., Matthews, J.G., Mazein, A., Meiser, A., Middelveld, R.J.M., Miralpeix, M., Montuschi, P., Murray, C.S., Myles, D., Pahus, L., Pandis, I., Pavlidis, S., Postle, A., Powel, P., Praticò, G., Riley, J., Roberts, G., Rowe, A., Sandström, T., Schofield, J.P.R., Selby, A., Shaw, D.E., Sigmund, R., Singer, F., Skipp, P.J., Sousa, A.R., Sterk, P.J., Sun, K., Thornton, B., van Aalderen, W.M., van Geest, M., Vestbo, J., Vissing, N.H., Wagener, A.H., Wagers, S.S., Weiszhart, Z., Wheelock, C.E., Wilson, S.J.

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IL-17–high asthma with features of a psoriasis immunophenotype von Schofield, James P.R., Ward, Jonathan, Montuschi, Paolo, Auffray, Charles, Adcock, Ian M., Howarth, Peter, Vaarala, Outi, Bates, S., Bigler, J., Boedigheimer, M.J., Bønnelykke, K., Bucchioni, E., Burg, D., Compton, C.H., Corfield, J., D'Amico, A., Dahlen, S.E., Fichtner, K., Fitch, N., Fowler, S.J., Frey, U., Gahlemann, M., Hashimoto, S., Hedlin, G., Knox, A.J., Lutter, R., Middelveld, R.J.M., Mores, N., Myles, D., Pavlidis, S., Rao, M. Puig N., Rowe, A., Sandström, T., Sigmund, R., Singer, F., Sousa, A.R., Sun, K., Thornton, B., van Aalderen, W.M., Vestbo, J., Wilson, S.J., Badorrek, P., Barber, Clair, Batuwitage, Manohara Kanangana, Berton, A., Bochenek, Grazyna, Dahlén, B., De Alba, Jorge, Dekker, Tamara, Dennison, P., Dodson, Paul, Edwards, Jessica, Emma, Rosalia, Flood, Breda, Guillmant-Farry, E., Hewitt, Lorraine, Hu, X., Johnson, K., Klüglich, M., Kots, Maxim, Kuo, Scott, Lambrecht, Bart, Lantz, A.-S., Latzin, P., Lemonnier, N., Lone-Latif, Saeeda, Manta, Alexander, Martin, Jane, Metcalf, Leanne, Mikus, Maria, Monk, Philip, Nething, K., Nicholas, Ben, Niven, R., Nordlund, B., Nsubuga, S., Palkonen, Susanna, Pellet, J., Pennazza, Giorgio, Petrén, Anne, Pink, Sandy, Rahman-Amin, Malayka, Reynolds, Leanne, Robberechts, Martine, Russell, Kirsty, Rutgers, Michael, Santini, G., Saqi, M., Scott, S., Smith, Katherine M., Stephan, S., Strandberg, K., Szentkereszty, M., Tariq, K., Thorsen, Jonathan, van Drunen, C.M., Wetzel, Kristiane, Wiegman, Coen, Yeyasingham, Elizabeth, Zetterquist, W.

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Pathway discovery using transcriptomic profiles in adult-onset severe asthma von Hekking, Pieter-Paul, Loza, Matt J., Pavlidis, Stelios, de Meulder, Bertrand, Lefaudeux, Diane, Baribaud, Fred, Auffray, Charles, Brinkman, Paul, Lutter, Rene, Bansal, Aruna T., Sousa, Ana R., Bates, Steve A., Pandis, Yannis, Fleming, Louise J., Shaw, Dominique E., Fowler, Stephen J., Meiser, Andrea, Sun, Kai, Corfield, Julie, Howarth, Peter H., Bel, Elisabeth H., Adcock, Ian M., Chung, Kian Fan, Djukanovic, Ratko, Adcock, I.M., Auffray, C., Bakke, P., Bansal, A.T., Baribaud, F., Bates, S., Bel, E.H., Bigler, J., Bisgaard, H., Boedigheimer, M.J., Bønnelykke, K., Brandsma, J., Bucchioni, E., Burg, D., Caruso, M., Chanez, P., Chung, F.K., Compton, C.H., Corfield, J., D'Amico, A., Dahlen, S.E., De Meulder, B., Erpenbeck, V.J., Erzen, D., Fichtner, K., Fitch, N., Formaggio, E., Frey, U., Gahlemann, M., Geiser, T., Hashimoto, S., Haughney, J., Hedlin, G., Hohlfeld, J.M., Holweg, C., Horváth, I., Howarth, P., Knowles, R., Krug, N., Lefaudeux, D., Loza, M.J., Lutter, R., Manta, A., Matthews, J.G., Mazein, A., Middelveld, R.J.M., Mores, N., Myles, D., Pahus, L., Pandis, I., Pavlidis, S., Powel, P., Praticò, G., Valls, M Puig, Rao, N., Riley, J., Roberts, G., Rowe, A., Sandström, T., Seibold, W., Selby, A., Sigmund, R., Singer, F., Skipp, P.J., Sousa, A.R., Sterk, P.J., Sun, K., Thornton, B., van Geest, M., Vestbo, J., Vissing, N.H., Wagener, A.H., Wagers, S.S., Weiszhart, Z., Wheelock, C.E., Wilson, S.J.

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Haemophilus influenzae and Moraxella catarrhalis in sputum of severe asthma with inflammasome and neutrophil activation von Versi, Ali, Ivan, Fransiskus Xaverius, Abdel-Aziz, Mahmoud I, Bates, Stewart, Riley, John, Baribaud, Frederic, Kermani, Nazanin Zounemat, Montuschi, Paolo, Dahlen, Sven-Erik, Djukanovic, Ratko, Sterk, Peter, Maitland-Van Der Zee, Anke H, Chotirmall, Sanjay H, Howarth, Peter, Adcock, Ian M, Chung, Kian Fan

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The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts von Fleming, Louise, Murray, Clare, Bansal, Aruna T, Hashimoto, Simone, Bisgaard, Hans, Bush, Andrew, Frey, Urs, Hedlin, Gunilla, Singer, Florian, van Aalderen, Wim M, Vissing, Nadja H, Zolkipli, Zaraquiza, Selby, Anna, Fowler, Stephen, Shaw, Dominick, Chung, Kian Fan, Sousa, Ana R, Wagers, Scott, Corfield, Julie, Pandis, Ioannis, Rowe, Anthony, Formaggio, Elena, Sterk, Peter J, Roberts, Graham

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Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux von Perotin, Jeanne-Marie, Schofield, James P R, Wilson, Susan J, Ward, Jonathan, Brandsma, Joost, Strazzeri, Fabio, Bansal, Aruna, Yang, Xian, Rowe, Anthony, Corfield, Julie, Lutter, Rene, Shaw, Dominick E, Bakke, Per S, Caruso, Massimo, Dahlén, Barbro, Fowler, Stephen J, Horváth, Ildikó, Howarth, Peter, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Sandström, Thomas, Sun, Kai, Pandis, Ioannis, Auffray, Charles, De Meulder, Bertrand, Lefaudeux, Diane, Riley, John H, Sousa, Ana R, Dahlen, Sven-Erik, Adcock, Ian M, Chung, Kian Fan, Sterk, Peter J, Skipp, Paul J, Collins, Jane E, Davies, Donna E, Djukanović, Ratko

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Asthma similarities across ProAR (Brazil) and U-BIOPRED (Europe) adult cohorts of contrasting locations, ethnicity and socioeconomic status von Cruz, Alvaro A., Riley, John H., Bansal, Aruna T., Souza-Machado, Adelmir, Almeida, Paula C.A., Biao-Lima, Valmar, Bates, Stewart, Adcock, Ian M., Sterk, Peter J., Araujo, M.I., Barnes, K.C., Belitardo, E., Bião-Lima, V., Cardoso, L., Camargos, P.A., Chatkin, J.M., Costa, R.S., Coelho, A.C.C., Cooper, P.J., Cruz, A.A., Cruz, C.S., Cunha, J., de Jesus, J.V., Gomes-Filho, I., Lima-Matos, A., Figueiredo, C.A., Lessa, M.A., Muniz, I.S., Pinheiro, G.P., Ponte, E.V., Santana, C.V.N., Santos-Lima, G., Souza, T.M.O., Souza-Machado, A., Stelmach, R., Vasquez, V.S., Adcock, I.M., Ahmed, H., Bakke, P., Baribaud, F., Bel, E.H., Bigler, J., Boedigheimer, M.J., Bønnelykke, K., Brinkman, P., Bucchioni, E., Caruso, M., Chaiboonchoe, A., Chanez, P., Compton, C.H., D'Amico, A., Dahlén, S.E., De Meulder, B., Djukanovic, R., Erpenbeck, V.J., Fichtner, K., Fitch, N., Fleming, L.J., Formaggio, E., Frey, U., Gahlemann, M., Goss, V., Hedlin, G., Hekking, P.W., Higenbottam, T., Hohlfeld, J.M., Holweg, C., James, A.J., Knox, A.J., Krug, N., Lefaudeux, D., Loza, M.J., Lutter, R., Manta, A., Masefield, S., Matthews, J.G., Middelveld, R.J.M., Montuschi, P., Myles, D., Pahus, L., Pandis, I., Pavlidis, S., Powel, P., Puig Valls, M., Rao, N., Roberts, G., Rowe, A., Sandström, T., Schofield, J.P.R., Selby, A., Shaw, D.E., Sigmund, R., Singer, F., Sun, K., Thornton, B., van Aalderen, W.M., Wagener, A.H., Wagers, S.S., Weiszhart, Z., Wilson, S.J.

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Urinary Leukotriene E 4 and Prostaglandin D 2 Metabolites Increase in Adult and Childhood Severe Asthma Characterized by Type 2 Inflammation. A Clinical Observational Study von Kolmert, Johan, Gómez, Cristina, Balgoma, David, Sjödin, Marcus, Bood, Johan, Konradsen, Jon R, Ericsson, Magnus, Thörngren, John-Olof, James, Anna, Mikus, Maria, Sousa, Ana R, Riley, John H, Bates, Stewart, Bakke, Per S, Pandis, Ioannis, Caruso, Massimo, Chanez, Pascal, Fowler, Stephen J, Geiser, Thomas, Howarth, Peter, Horváth, Ildikó, Krug, Norbert, Montuschi, Paolo, Sanak, Marek, Behndig, Annelie, Shaw, Dominick E, Knowles, Richard G, Holweg, Cécile T J, Wheelock, Åsa M, Dahlén, Barbro, Nordlund, Björn, Alving, Kjell, Hedlin, Gunilla, Chung, Kian Fan, Adcock, Ian M, Sterk, Peter J, Djukanovic, Ratko, Dahlén, Sven-Erik, Wheelock, Craig E

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Oropharyngeal Microbiota Clusters in Children with Asthma or Wheeze Associate with Allergy, Blood Transcriptomic Immune Pathways, and Exacerbation Risk von Abdel-Aziz, Mahmoud I, Thorsen, Jonathan, Hashimoto, Simone, Vijverberg, Susanne J H, Neerincx, Anne H, Brinkman, Paul, van Aalderen, Wim, Stokholm, Jakob, Rasmussen, Morten Arendt, Roggenbuck-Wedemeyer, Michael, Vissing, Nadja H, Mortensen, Martin Steen, Brejnrod, Asker Daniel, Fleming, Louise J, Murray, Clare S, Fowler, Stephen J, Frey, Urs, Bush, Andrew, Singer, Florian, Hedlin, Gunilla, Nordlund, Björn, Shaw, Dominick E, Chung, Kian Fan, Adcock, Ian M, Djukanovic, Ratko, Auffray, Charles, Bansal, Aruna T, Sousa, Ana R, Wagers, Scott S, Chawes, Bo Lund, Bønnelykke, Klaus, Sørensen, Søren Johannes, Kraneveld, Aletta D, Sterk, Peter J, Roberts, Graham, Bisgaard, Hans, Maitland-van der Zee, Anke H

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Asthma and Wheeze Severity and the Oropharyngeal Microbiota in Children and Adolescents von Thorsen, Jonathan, Stokholm, Jakob, Rasmussen, Morten Arendt, Roggenbuck-Wedemeyer, Michael, Vissing, Nadja H, Mortensen, Martin S, Brejnrod, Asker D, Fleming, Louise, Bush, Andrew, Roberts, Graham, Singer, Florian, Frey, Urs, Hedlin, Gunilla, Nordlund, Björn, Murray, Clare S, Abdel-Aziz, Mahmoud I, Hashimoto, Simone, van Aalderen, Wim, Maitland-van der Zee, Anke H, Shaw, Dominick, Fowler, Stephen J, Sousa, Ana, Sterk, Peter J, Chung, Kian Fan, Adcock, Ian M, Djukanovic, Ratko, Auffray, Charles, Bansal, Aruna T, Wagers, Scott, Chawes, Bo, Bønnelykke, Klaus, Sørensen, Søren Johannes, Bisgaard, Hans

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C26 ASTHMA IN INFANTS AND CHILDREN: Clinical Phenotypes Of Asthma In Childhood And Adolescence: Clustering Analysis From The Paediatric U-Biopred Cohorts von Hashimoto, S, Brinkman, P, Lefaudeux, D, Bansal, A, De Meulder, B, Murray, C, Bush, A, Frey, U, Singer, F, Hedlin, G, Nordlund, B, Bisgaard, H, Van Aalderen, W, Vissing, N, Zolkipli, Z, Selby, A, Fowler, S, Shaw, D, Sousa, A, Wagers, S, Corfield, J, Pandis, I, Rowe, A, Valls, M Puig, Pratico, G, Auffray, C, Chung, K F, Bel, E, Sterk, P J, Fleming, L, Roberts, G

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Reply von Bønnelykke, K, Vissing, NH, Sevelsted, A, Johnston, SL, Bisgaard, H

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Oropharyngeal microbiota clusters in children with asthma or wheeze associate with allergy, blood transcriptomic immune pathways, and exacerbation risk von Abdel-Aziz, MI, Thorsen, J, Hashimoto, S, Vijverberg, SJH, Neerincx, AH, Brinkman, P, Van Aalderen, W, Stokholm, J, Rasmussen, MA, Roggenbuck-Wedemeyer, M, Vissing, NH, Mortensen, MS, Brejnrod, AD, Fleming, LJ, Murray, CS, Fowler, SJ, Frey, U, Bush, A, Singer, F, Hedlin, G, Nordlund, B, Shaw, DE, Chung, KF, Adcock, IM, Djukanovic, R, Auffray, C, Bansal, AT, Sousa, AR, Wagers, SS, Chawes, BL, Bonnelykke, K, Sorensen, SJ, Kraneveld, AD, Sterk, PJ, Roberts, G, Bisgaard, H, Maitland-van der Zee, AH

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