Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity von Schenkel, Laurie B, Olivieri, Philip R, Boezio, Alessandro A, Deak, Holly L, Emkey, Renee, Graceffa, Russell F, Gunaydin, Hakan, Guzman-Perez, Angel, Lee, Josie H, Teffera, Yohannes, Wang, Weiya, Youngblood, Beth D, Yu, Violeta L, Zhang, Maosheng, Gavva, Narender R, Lehto, Sonya G, Geuns-Meyer, Stephanie

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Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors von Schenkel, Laurie B., DiMauro, Erin F., Nguyen, Hanh N., Chakka, Nagasree, Du, Bingfan, Foti, Robert S., Guzman-Perez, Angel, Jarosh, Michael, La, Daniel S., Ligutti, Joseph, Milgram, Benjamin C., Moyer, Bryan D., Peterson, Emily A., Roberts, John, Yu, Violeta L., Weiss, Matthew M.

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Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis von Nicholson, Donald W, Ali, Ambereen, Thornberry, Nancy A, Vaillancourt, John P, Ding, Connie K, Gallant, Michel, Gareau, Yves, Griffin, Patrick R, Labelle, Marc, Lazebnik, Yuri A, Munday, Neil A, Raju, Sayyaparaju M, Smulson, Mark E, Yamin, Ting-Ting, Yu, Violeta L, Miller, Douglas K

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The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment o... von Lewis, Richard T, Bode, Christiane M, Choquette, Deborah M, Potashman, Michele, Romero, Karina, Stellwagen, John C, Teffera, Yohannes, Moore, Earl, Whittington, Douglas A, Chen, Hao, Epstein, Linda F, Emkey, Renee, Andrews, Paul S, Yu, Violeta L, Saffran, Douglas C, Xu, Man, Drew, Allison, Merkel, Patricia, Szilvassy, Steven, Brake, Rachael L

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Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases (∗) von Munday, Neil A., Vaillancourt, John P., Ali, Ambereen, Casano, Francesca J., Miller, Douglas K., Molineaux, Susan M., Yamin, Ting-Ting, Yu, Violeta L., Nicholson, Donald W.

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The Discovery and Optimization of a Novel Class of Potent, Selective, and Orally Bioavailable Anaplastic Lymphoma Kinase (ALK) Inhibitors with Potential Utility for the Treatment o... von Lewis, Richard T., Bode, Christiane M., Choquette, Deborah M., Potashman, Michele, Romero, Karina, Stellwagen, John C., Teffera, Yohannes, Moore, Earl, Whittington, Douglas A., Chen, Hao, Epstein, Linda F., Emkey, Renee, Andrews, Paul S., Yu, Violeta L., Saffran, Douglas C., Xu, Man, Drew, Allison, Merkel, Patricia, Szilvassy, Steven, Brake, Rachael L.

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Discovery of a biarylamide series of potent, state-dependent Na V 1.7 inhibitors von Schenkel, Laurie B, DiMauro, Erin F, Nguyen, Hanh N, Chakka, Nagasree, Du, Bingfan, Foti, Robert S, Guzman-Perez, Angel, Jarosh, Michael, La, Daniel S, Ligutti, Joseph, Milgram, Benjamin C, Moyer, Bryan D, Peterson, Emily A, Roberts, John, Yu, Violeta L, Weiss, Matthew M

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Epitope-labeled Soluble Human Interleukin-5 (IL-5) Receptors von Brown, Pamela M., Tagari, Philip, Rowan, Kevin R., Yu, Violeta L., O'Neill, Gary P., Middaugh, C. Russell, Sanyal, Gautam, Ford-Hutchinson, Anthony W., Nicholson, Donald W.

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Epitope-labeled soluble human interleukin-5 (IL-5) receptors. Affinity cross-link labeling, IL-5 binding, and biological activity von Brown, P M, Tagari, P, Rowan, K R, Yu, V L, O'Neill, G P, Middaugh, C R, Sanyal, G, Ford-Hutchinson, A W, Nicholson, D W

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Molecular Cloning and Pro-apoptotic Activity of ICEII and ICEIII, Members of the ICE/CED-3 Family of Cysteine Proteases von Neil A. Munday, John P. Vaillancourt, Ambereen Ali, Francesca J. Casano, Douglas K. Miller, Susan M. Molineaux, Ting-Ting Yamin, Violeta L. Yu, Donald W. Nicholson

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Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apop... von Chen, Min‐Yu, Liao, Warren S.‐L., Lu, Zhen, Bornmann, William G., Hennessey, Violeta, Washington, Michele N., Rosner, Gary L., Yu, Yinhua, Ahmed, Ahmed Ashour, Bast, Robert C.

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A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer von FOX, Emily M, MILLER, Todd W, SHYR, Yu, MANNING, H. Charles, BUCK, Elizabeth, ARTEAGA, Carlos L, BALKO, Justin M, KUBA, Maria G, SANCHEZ, Violeta, ADAM SMITH, R, SHUYING LIU, GONZALEZ-ANGULO, Ana Maria, MILLS, Gordon B, FEI YE

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Safety and Antitumor Activity of α-PD-L1 Antibody as Monotherapy or in Combination with α-TIM-3 Antibody in Patients with Microsatellite Instability-High/Mismatch Repair-Deficient... von Hollebecque, Antoine, Chung, Hyun C, de Miguel, Maria J, Italiano, Antoine, Machiels, Jean-Pascal, Lin, Chia-Chi, Dhani, Neesha C, Peeters, Marc, Moreno, Victor, Su, Wu-Chou, Chow, Kay Hoong, Galvao, Violeta R, Carlsen, Michelle, Yu, Danni, Szpurka, Anna M, Zhao, Yumin, Schmidt, Shelly L, Gandhi, Leena, Xu, Xiaojian, Bang, Yung-Jue

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Single‐cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions von Kuboki, Yuko, Fischer, Catherine G, Beleva Guthrie, Violeta, Huang, Wenjie, Yu, Jun, Chianchiano, Peter, Hosoda, Waki, Zhang, Hao, Zheng, Lily, Shao, Xiaoshan, Thompson, Elizabeth D, Waters, Kevin, Poling, Justin, He, Jin, Weiss, Matthew J, Wolfgang, Christopher L, Goggins, Michael G, Hruban, Ralph H, Roberts, Nicholas J, Karchin, Rachel, Wood, Laura D

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TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR + Metastatic Triple-Negative Breast Cancer von Lehmann, Brian D, Abramson, Vandana G, Sanders, Melinda E, Mayer, Erica L, Haddad, Tufia C, Nanda, Rita, Van Poznak, Catherine, Storniolo, Anna Maria, Nangia, Julie R, Gonzalez-Ericsson, Paula I, Sanchez, Violeta, Johnson, Kimberly N, Abramson, Richard G, Chen, Sheau-Chiann, Shyr, Yu, Arteaga, Carlos L, Wolff, Antonio C, Pietenpol, Jennifer A

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A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-t... von Jovanović, Bojana, Mayer, Ingrid A, Mayer, Erica L, Abramson, Vandana G, Bardia, Aditya, Sanders, Melinda E, Kuba, M Gabriela, Estrada, Monica V, Beeler, J Scott, Shaver, Timothy M, Johnson, Kimberly C, Sanchez, Violeta, Rosenbluth, Jennifer M, Dillon, Patrick M, Forero-Torres, Andres, Chang, Jenny C, Meszoely, Ingrid M, Grau, Ana M, Lehmann, Brian D, Shyr, Yu, Sheng, Quanhu, Chen, Sheau-Chiann, Arteaga, Carlos L, Pietenpol, Jennifer A

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Polycomb repressor complex 2 suppresses interferon-responsive MHC-II expression in melanoma cells and is associated with anti-PD-1 resistance von James, Jamaal L, Taylor, Brandie C, Axelrod, Margaret L, Sun, Xiaopeng, Guerin, Lindsey N, Gonzalez-Ericsson, Paula I, Wang, Yu, Sanchez, Violeta, Fahey, Catherine C, Sanders, Melinda E, Xu, Yaomin, Hodges, Emily, Johnson, Douglas B, Balko, Justin M

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Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease von Grosse, Johannes, Chitu, Violeta, Marquardt, Andreas, Hanke, Petra, Schmittwolf, Carolin, Zeitlmann, Lutz, Schropp, Patricia, Barth, Bettina, Yu, Philipp, Paffenholz, Rainer, Stumm, Gabriele, Nehls, Michael, Stanley, E. Richard

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Tumor-specific MHC-II expression drives a unique pattern of resistance to immunotherapy via LAG-3/FCRL6 engagement von Johnson, Douglas B, Nixon, Mellissa J, Wang, Yu, Wang, Daniel Y, Castellanos, Emily, Estrada, Monica V, Ericsson-Gonzalez, Paula I, Cote, Candace H, Salgado, Roberto, Sanchez, Violeta, Dean, Phillip T, Opalenik, Susan R, Schreeder, Daniel M, Rimm, David L, Kim, Ju Young, Bordeaux, Jennifer, Loi, Sherene, Horn, Leora, Sanders, Melinda E, Ferrell, Jr, P Brent, Xu, Yaomin, Sosman, Jeffrey A, Davis, Randall S, Balko, Justin M

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Short Preoperative Treatment With Erlotinib Inhibits Tumor Cell Proliferation in Hormone Receptor–Positive Breast Cancers von GUIX, Marta, DE MATOS GRANJA, Nara, PESTANO, Gary, SHYR, Yu, MUTHUSWAMY, Senthil, CALVO, Benjamin, KRONTIRAS, Helen, KROP, Ian E, KELLEY, Mark C, ARTEAGA, Carlos L, MESZOELY, Ingrid, ADKINS, Theresa B, WIEMAN, Bobbye M, FRIERSON, Kerek E, SANCHEZ, Violeta, SANDERS, Melinda E, GRAU, Ana M, MAYER, Ingrid A

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