Modeling and simulation in pediatric drug therapy: Application of pharmacometrics to define the right dose for children von Vinks, AA, Emoto, C, Fukuda, T

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP3A5 Genotype and Tacrolimus Dosing von Birdwell, KA, Decker, B, Barbarino, JM, Peterson, JF, Stein, CM, Sadee, W, Wang, D, Vinks, AA, He, Y, Swen, JJ, Leeder, JS, van Schaik, RHN, Thummel, KE, Klein, TE, Caudle, KE, MacPhee, IAM

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Precision Medicine—Nobody Is Average von Vinks, AA

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Efficacy and Safety of Sirolimus in the Treatment of Complicated Vascular Anomalies von Adams, Denise M, Trenor, 3rd, Cameron C, Hammill, Adrienne M, Vinks, Alexander A, Patel, Manish N, Chaudry, Gulraiz, Wentzel, Mary Sue, Mobberley-Schuman, Paula S, Campbell, Lisa M, Brookbank, Christine, Gupta, Anita, Chute, Carol, Eile, Jennifer, McKenna, Jesse, Merrow, Arnold C, Fei, Lin, Hornung, Lindsey, Seid, Michael, Dasgupta, A Roshni, Dickie, Belinda H, Elluru, Ravindhra G, Lucky, Anne W, Weiss, Brian, Azizkhan, Richard G

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Review article: applying pharmacokinetics to optimise dosing of anti‐TNF biologics in acute severe ulcerative colitis von Rosen, M. J., Minar, P., Vinks, A. A.

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Influence of OCT1 Ontogeny and Genetic Variation on Morphine Disposition in Critically Ill Neonates: Lessons From PBPK Modeling and Clinical Study von Hahn, David, Emoto, Chie, Euteneuer, Joshua C., Mizuno, Tomoyuki, Vinks, Alexander A., Fukuda, Tsuyoshi

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Antibodies‐to‐infliximab accelerate clearance while dose intensification reverses immunogenicity and recaptures clinical response in paediatric Crohn’s disease von Colman, Ruben J., Xiong, Ye, Mizuno, Tomoyuki, Hyams, Jeffrey S., Noe, Joshua D., Boyle, Brendan, D’Haens, Geert R., Limbergen, Johan, Chun, Kelly, Yang, Jane, Rosen, Michael J., Denson, Lee A., Vinks, Alexander A., Minar, Phillip

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Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions von Roberts, Jason A, Prof, Abdul-Aziz, Mohd H, BPharm, Lipman, Jeffrey, Prof, Mouton, Johan W, Prof, Vinks, Alexander A, Prof, Felton, Timothy W, Dr, Hope, William W, Prof, Farkas, Andras, Dr, Neely, Michael N, MD, Schentag, Jerome J, Dr, Drusano, George, Prof, Frey, Otto R, Dr, Theuretzbacher, Ursula, Dr, Kuti, Joseph L, Dr

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A Pilot Randomized, Controlled, Double‐Blind Trial of Bumetanide to Treat Neonatal Seizures von Soul, Janet S., Bergin, Ann M., Stopp, Christian, Hayes, Breda, Singh, Avantika, Fortuno, Carmen R., O'Reilly, Deirdre, Krishnamoorthy, Kalpathy, Jensen, Frances E., Rofeberg, Valerie, Dong, Min, Vinks, Alexander A., Wypij, David, Staley, Kevin J.

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MTXPK.org: A Clinical Decision Support Tool Evaluating High‐Dose Methotrexate Pharmacokinetics to Inform Post‐Infusion Care and Use of Glucarpidase von Taylor, Zachary L., Mizuno, Tomoyuki, Punt, Nieko C., Baskaran, Balaji, Navarro Sainz, Adriana, Shuman, William, Felicelli, Nicholas, Vinks, Alexander A., Heldrup, Jesper, Ramsey, Laura B.

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Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial von Alloway, Rita R, Vinks, Alexander A, Fukuda, Tsuyoshi, Mizuno, Tomoyuki, King, Eileen C, Zou, Yuanshu, Jiang, Wenlei, Woodle, E Steve, Tremblay, Simon, Klawitter, Jelena, Klawitter, Jost, Christians, Uwe

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Learning Health Systems as Facilitators of Precision Medicine von Ramsey, LB, Mizuno, T, Vinks, AA, Margolis, PA

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Why Has Model‐Informed Precision Dosing Not Yet Become Common Clinical Reality? Lessons From the Past and a Roadmap for the Future von Darwich, A S, Ogungbenro, K, Vinks, A A, Powell, J R, Reny, J‐L, Marsousi, N, Daali, Y, Fairman, D, Cook, J, Lesko, L J, McCune, J S, Knibbe, C A J, Wildt, S N, Leeder, J S, Neely, M, Zuppa, A F, Vicini, P, Aarons, L, Johnson, T N, Boiani, J, Rostami‐Hodjegan, A

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Population Pharmacokinetic Modeling of Total and Free Ceftriaxone in Critically Ill Children and Young Adults and Monte Carlo Simulations Support Twice Daily Dosing for Target Atta... von Tang Girdwood, Sonya, Dong, Min, Tang, Peter, Stoneman, Erin, Jones, Rhonda, Yunger, Toni, Ostermeier, Austin, Curry, Calise, Forton, Melissa, Hail, Traci, Mullaney, Randi, Lahni, Patrick, Punt, Nieko, Kaplan, Jennifer, Vinks, Alexander A

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Precise infliximab exposure and pharmacodynamic control to achieve deep remission in paediatric Crohn’s disease (REMODEL-CD): study protocol for a multicentre, open-label, pragmati... von Minar, Phillip Paul, Colman, Ruben J, Zhang, Nanhua, Mizuno, Tomoyuki, Vinks, Alexander A

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Suggestions for Model‐Informed Precision Dosing to Optimize Neonatal Drug Therapy von Euteneuer, Joshua C., Kamatkar, Suyog, Fukuda, Tsuyoshi, Vinks, Alexander A., Akinbi, Henry T.

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β-lactam precision dosing in critically ill children: Current state and knowledge gaps von Tang Girdwood, Sonya, Pavia, Kathryn, Paice, Kelli, Hambrick, H Rhodes, Kaplan, Jennifer, Vinks, Alexander A

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Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children von Hahn, David, Emoto, Chie, Vinks, Alexander A., Fukuda, Tsuyoshi

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Does intranasal dexmedetomidine provide adequate plasma concentrations for sedation in children: a pharmacokinetic study von Miller, J.W., Balyan, R., Dong, M., Mahmoud, M., Lam, J.E., Pratap, J.N., Paquin, J.R., Li, B.L., Spaeth, J.P., Vinks, A., Loepke, A.W.

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Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study von Weiss, Brian, Widemann, Brigitte C, Wolters, Pamela, Dombi, Eva, Vinks, Alexander, Cantor, Alan, Perentesis, John, Schorry, Elizabeth, Ullrich, Nicole, Gutmann, David H, Tonsgard, James, Viskochil, David, Korf, Bruce, Packer, Roger J, Fisher, Michael J

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