A Diverse Array of Large Capsules Transform in Response to Stimuli von Wu, Kai, Ronson, Tanya K., Goh, Leonard, Xue, Weichao, Heard, Andrew W., Su, Pingru, Li, Xiaopeng, Vinković, Mladen, Nitschke, Jonathan R.

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Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity von Howard, Steven, Berdini, Valerio, Boulstridge, John A, Carr, Maria G, Cross, David M, Curry, Jayne, Devine, Lindsay A, Early, Theresa R, Fazal, Lynsey, Gill, Adrian L, Heathcote, Michelle, Maman, Sarita, Matthews, Julia E, McMenamin, Rachel L, Navarro, Eva F, O’Brien, Michael A, O’Reilly, Marc, Rees, David C, Reule, Matthias, Tisi, Dominic, Williams, Glyn, Vinković, Mladen, Wyatt, Paul G

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Systematic construction of progressively larger capsules from a fivefold linking pyrrole-based subcomponent von Wu, Kai, Ronson, Tanya K., Su, Pingru, Chen, Zhi, Goh, Leonard, Heard, Andrew W., Li, Xiaopeng, Klautzsch, Fabian, Schalley, Christoph A., Vinković, Mladen, Nitschke, Jonathan R.

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Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by... von Woodhead, Andrew J, Angove, Hayley, Carr, Maria G, Chessari, Gianni, Congreve, Miles, Coyle, Joseph E, Cosme, Jose, Graham, Brent, Day, Philip J, Downham, Robert, Fazal, Lynsey, Feltell, Ruth, Figueroa, Eva, Frederickson, Martyn, Lewis, Jonathan, McMenamin, Rachel, Murray, Christopher W, O’Brien, M. Alistair, Parra, Lina, Patel, Sahil, Phillips, Theresa, Rees, David C, Rich, Sharna, Smith, Donna-Michelle, Trewartha, Gary, Vinkovic, Mladen, Williams, Brian, Woolford, Alison J.-A

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Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator von Frederickson, Martyn, Callaghan, Owen, Chessari, Gianni, Congreve, Miles, Cowan, Suzanna R, Matthews, Julia E, McMenamin, Rachel, Smith, Donna-Michelle, Vinković, Mladen, Wallis, Nicola G

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Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction von Chessari, Gianni, Hardcastle, Ian R, Ahn, Jong Sook, Anil, Burcu, Anscombe, Elizabeth, Bawn, Ruth H, Bevan, Luke D, Blackburn, Timothy J, Buck, Ildiko, Cano, Celine, Carbain, Benoit, Castro, Juan, Cons, Ben, Cully, Sarah J, Endicott, Jane A, Fazal, Lynsey, Golding, Bernard T, Griffin, Roger J, Haggerty, Karen, Harnor, Suzannah J, Hearn, Keisha, Hobson, Stephen, Holvey, Rhian S, Howard, Steven, Jennings, Claire E, Johnson, Christopher N, Lunec, John, Miller, Duncan C, Newell, David R, Noble, Martin E. M, Reeks, Judith, Revill, Charlotte H, Riedinger, Christiane, St. Denis, Jeffrey D, Tamanini, Emiliano, Thomas, Huw, Thompson, Neil T, Vinković, Mladen, Wedge, Stephen R, Williams, Pamela A, Wilsher, Nicola E, Zhang, Bian, Zhao, Yan

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High-throughput protein crystallography and drug discovery von Tickle, Ian, Sharff, Andrew, Vinkovic, Mladen, Yon, Jeff, Jhoti, Harren

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Abstract A143: Coupling fragment-based screening with targeted protein degradation and genetic rescue to identify and explore the function of a non-canonical pocket on eIF4E von Sharp, Swee Y, Martella, Marianna, Milton, Christopher I, Ward, George, Vinkovic, Mladen, Richardson, Caroline, Woodhead, Andrew, Clarke, Paul A

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Crystal Structure of Human Soluble Adenylate Cyclase Reveals a Distinct, Highly Flexible Allosteric Bicarbonate Binding Pocket von Saalau-Bethell, Susanne M., Berdini, Valerio, Cleasby, Anne, Congreve, Miles, Coyle, Joseph E., Lock, Victoria, Murray, Christopher W., O'Brien, M. Alistair, Rich, Sharna J., Sambrook, Tracey, Vinkovic, Mladen, Yon, Jeff R., Jhoti, Harren

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Structural constraints on protein self-processing in L-aspartate-α-decarboxylase von Schmitzberger, Florian, Kilkenny, Mairi L., Lobley, Carina M. C., Webb, Michael E., Vinkovic, Mladen, Matak-Vinkovic, Dijana, Witty, Michael, Chirgadze, Dimitri Y., Smith, Alison G., Abell, Chris, Blundell, Tom L.

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Identification of novel allosteric inhibitors through fragment-based drug discovery and X-ray crystallography von Pathuri, Puja, Saalau-Bethell, Susanne M., Woodhead, Andrew J., Berdini, Valerio, Carr, Maria G., Chessari, Gianni, Cleasby, Anne, Congreve, Miles, Coyle, Joseph E., Graham, Brent, Hiscock, Steven D., Lock, Victoria, Murray, Christopher W., O'Brien, M. Alistair, Rich, Sharna J., Richardson, Caroline J., Sambrook, Tracey, Vinkovic, Mladen, Williams, Pamela A., Yon, Jeff R., Jhoti, Harren

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Abstract A1: The physiological form of MetAP2 can be inhibited through binding to either of the two active-site metals von Wallis, Nicola G., Berdini, Valerio, Besong, Gilbert, Chessari, Gianni, Coyle, Joe, Graham, Brent, Madin, Andrew, O'Brien, Alistair, Richardson, Caroline J., Smith, Kirsten, Thompson, Neil T., Vinkovic, Mladen, Williams, Pamela A.

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Structural constraints on protein self-processing in L-aspartate- -decarboxylase von Schmitzberger, F.

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4-(2,6-DICHLOROBENZOYLAMINO)-1H-PYRAZOLE-3-CARBOXYLIC ACID PIPERIDIN-4-YLAMIDE ACID ADDITION SALTS AS KINASE INHIBITORS von TREWARTHA, Gary, VINKOVIC, Mladen, REES, David, Charles, WYATT, Paul, Graham

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O EKONOMIJI GAŠENJA POŽARA RASLINJA IZ ZRAKA NA PRIMJERU CANADAIR CL-415 von Regent, A, Szabo, N, Vinković, M

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Farmasøytiske forbindelser von Wyatt, Paul Graham, Vinkovic, Mladen, Trewartha, Gary, Rees, David Charles

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HYDROBENZAMIDE DERIVATIVES AS INHIBITORS OF HSP90 von Vinkovic, Mladen, Thompson, Neil, Woolford, Alison, Frederickson, Martyn, Williams, Brian, Woodhead, Andrew, Lyons, John

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Crystal Structure of Escherichia coli Ketopantoate Reductase at 1.7 Å Resolution and Insight into the Enzyme Mechanism von Matak-Vinković, Dijana, Vinković, Mladen, Saldanha, S. Adrian, Ashurst, Jennifer L, von Delft, Frank, Inoue, Tsuyoshi, Miguel, Ricardo Nunez, Smith, Alison G, Blundell, Tom L, Abell, Chris

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HYDROBENZAMIDE DERIVATIVES AS INHIBITORS OF HSP90 von Frederickson Martyn, Lyons John Francis, Woodhead Andrew James, Woolford Alison Jo-Anne, Williams Brian, Thompson Neil Thomas, Vinkovic Mladen

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HYDROBENZAMIDE DERIVATIVES AS INHIBITORS OF HSP90 von Woolford, Alison Jo-Anne, Lyons, John Francis, Vinkovic, Mladen, Woodhead, Andrew James, Frederickson, Martyn, Thompson, Neil Thomas, Williams, Brian

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