The prognostic impact of non‐driver gene mutations and variant allele frequency in primary myelofibrosis von Hernández‐Sánchez, Alberto, Villaverde‐Ramiro, Ángela, Arellano‐Rodrigo, Eduardo, Garrote, Marta, Martín, Iván, Mosquera‐Orgueira, Adrián, Gómez‐Casares, María‐Teresa, Ferrer‐Marín, Francisca, Such, Esperanza, Velez, Patricia, Ayala, Rosa, Angona, Anna, Heras, Natalia, Magro, Elena, Mata‐Vázquez, María‐Isabel, Fox, María‐Laura, Villambrosía, Sonia González, Ramírez, María‐José, García, Ana, García‐Gutiérrez, Valentín, Cáceres, Amparo, Durán, María‐Antonia, Senín, Alicia, Raya, José‐María, González, José Antonio, Cuevas, Beatriz, Xicoy, Blanca, Pérez‐Encinas, Manuel, Bellosillo, Beatriz, Álvarez‐Larrán, Alberto, Hernández‐Rivas, Jesús María, Hernández‐Boluda, Juan Carlos

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Chronic lymphocytic leukemia patients with chromosome 6q deletion as the sole cytogenetic abnormality display a high frequency of RPS15 mutations and have a poor prognosis von Pérez Carretero, Claudia, González, Teresa, Quijada Álamo, Miguel, Rigolin, Gian Matteo, Dubuc, Adrian, Villaverde Ramiro, Ángela, Rodríguez‐Sánchez, Alberto, Rubio, Araceli, Dávila, Julio, Vidal, Mª. Jesús, González Gascón y Marín, Isabel, Hernández‐Rivas, José‐Ángel, Benito, Rocío, Volpe, Virginia, Davids, Matthew S., Abramson, Jeremy S., Cuneo, Antonio, Dal Cin, Paola, Rodríguez‐Vicente, Ana‐Eugenia, Hernández‐Rivas, Jesús‐María

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P714: DISSECTING THE CLINICAL HETEROGENEITY OF ISOLATED TRISOMY 8 MYELODYSPLASTIC SYNDROMES THROUGH MUTATIONAL PROFILE von María Toribio Castelló, Sofía, Castaño, Sandra, Villaverde‐Ramiro, Angela, Such, Esperanza, Arnan, Montserrat, Solé, Francesc, Díaz Beyá, Marina, Díez‐Campelo, María, Rey, Mónica, González, Teresa, Hernández Rivas, Jesus

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Mutational Profile Enables the Identification of a High-Risk Subgroup in Myelodysplastic Syndromes with Isolated Trisomy 8 von Toribio-Castelló, Sofía, Castaño, Sandra, Villaverde-Ramiro, Ángela, Such, Esperanza, Arnán, Montserrat, Solé, Francesc, Díaz-Beyá, Marina, Díez-Campelo, María, Del Rey, Mónica, González, Teresa, Hernández-Rivas, Jesús María

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Rearrangements involving 11q23.3/KMT2A in adult AML: mutational landscape and prognostic implications – a HARMONY study von Hernández-Sánchez, Alberto, González, Teresa, Sobas, Marta, Sträng, Eric, Castellani, Gastone, Abáigar, María, Valk, Peter J. M., Villaverde Ramiro, Ángela, Benner, Axel, Metzeler, Klaus H., Azibeiro, Raúl, Tettero, Jesse M., Martínez-López, Joaquín, Pratcorona, Marta, Martínez Elicegui, Javier, Mills, Ken I., Thiede, Christian, Sanz, Guillermo, Döhner, Konstanze, Heuser, Michael, Haferlach, Torsten, Turki, Amin T., Reinhardt, Dirk, Schulze-Rath, Renate, Barbus, Martje, Hernández-Rivas, Jesús María, Huntly, Brian, Ossenkoppele, Gert, Döhner, Hartmut, Bullinger, Lars

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Unraveling the Genetic Heterogeneity of Acute Lymphoblastic Leukemia Based on NGS Applications von Ramírez Maldonado, Valentina, Navas Acosta, Josgrey, Maldonado Marcos, Iván, Villaverde Ramiro, Ángela, Hernández-Sánchez, Alberto, Hernández Rivas, Jesús M., Benito Sánchez, Rocío

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Mutational Profile Enables the Identification of a High-Risk Subgroup in Myelodysplastic Syndromes with Isolated Trisomy 8 von Toribio Castelló, Sofía, Castaño, Sandra, Villaverde Ramiro, Ángela, Such, Esperanza, Arnán, Montserrat, Solé, Francesc, Díaz Beyà, Marina, Díez Campelo, María, Rey, Mónica del, González, Teresa, Hernández Rivas, Jesús María

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MDS-472 STAG2 and SRSF2 Mutations Might Define Prognosis of MDS Patients With Isolated Trisomy 8 von Toribio-Castelló, Sofía, Castaño-Díez, Sandra, Villaverde-Ramiro, Ángela, López-Cadenas, Félix, Díaz-Beyá, Marina, Rodríguez-Iglesias, Irene, González-Briones, Sara, Hernández-Rivas, Jesús María, González, Teresa, Rey, Mónica Del, Díez-Campelo, María

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Poster: MDS-472 STAG2 and SRSF2 Mutations Might Define Prognosis of MDS Patients With Isolated Trisomy 8 von Toribio-Castelló, Sofía, Castaño-Díez, Sandra, Villaverde-Ramiro, Ángela, López-Cadenas, Félix, Díaz-Beyá, Marina, Rodríguez-Iglesias, Irene, González-Briones, Sara, Hernández-Rivas, Jesús María, González, Teresa, Rey, Mónica Del, Díez-Campelo, María

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Machine Learning Improves Risk Stratification in Myelofibrosis: An Analysis of the Spanish Registry of Myelofibrosis von Mosquera‐Orgueira, Adrián, Pérez‐Encinas, Manuel, Hernández‐Sánchez, Alberto, González‐Martínez, Teresa, Arellano‐Rodrigo, Eduardo, Martínez‐Elicegui, Javier, Villaverde‐Ramiro, Ángela, Raya, José‐María, Ayala, Rosa, Ferrer‐Marín, Francisca, Fox, María‐Laura, Velez, Patricia, Mora, Elvira, Xicoy, Blanca, Mata‐Vázquez, María‐Isabel, García‐Fortes, María, Angona, Anna, Cuevas, Beatriz, Senín, María‐Alicia, Ramírez‐Payer, Angel, Ramírez, María‐José, Pérez‐López, Raúl, González de Villambrosía, Sonia, Martínez‐Valverde, Clara, Gómez‐Casares, María‐Teresa, García‐Hernández, Carmen, Gasior, Mercedes, Bellosillo, Beatriz, Steegmann, Juan‐Luis, Álvarez‐Larrán, Alberto, Hernández‐Rivas, Jesús María, Hernández‐Boluda, Juan Carlos

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ZMYM3 Mutations Cooperate with NOTCH1 Alterations, Reduce Histone H4 Acetylation and Promote Apoptosis Evasion in Chronic Lymphocytic Leukemia von Rodríguez-Sánchez, Alberto, Quijada Álamo, Miguel, Perez Carretero, Claudia, Corchete Sanchez, Luis Antonio, Villaverde Ramiro, Angela, Miguel-García, Cristina, Santos-Mínguez, Sandra, Valls, Julio Davila, Garcia de Coca, Alfonso, Olazabal, Julio, Benito Sanchez, Maria Rocio, Rodriguez, Ana E., Hernández-Rivas, Jesús María

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Long-Term Outcome of 1296 Patients with Newly Diagnosed with APL: A Harmony Alliance Study von Guarnera, Luca, Lehmann, Soren, Döhner, Konstanze, Döhner, Hartmut, Platzbecker, Uwe, Russell, Nigel H., Dillon, Richard, Thomas, Ian, Ossenkoppele, Gert, Vignetti, Marco, la Sala, Edoardo, Piciocchi, Alfonso, Villaverde Ramiro, Angela, Tur, Laura, Gurnari, Carmelo, Bullinger, Lars, Hernández-Rivas, Jesús María, Voso, Maria Teresa

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Mutually-Exclusive Pathways between IKZF1plus and RAS Mutations and TP53 double-Hit Alterations Lead Relapse in B-Other, Ph-like and Hyperdiploidy Genetic Groups in Adult B-Cell Ac... von Navas Acosta, Josgrey Del Valle Del Valle, González, Teresa, Serramito-Gómez, Inmaculada, Villaverde Ramiro, Angela, Miguel-García, Cristina, Santos-Mínguez, Sandra, Ribera, Jordi, Granada, Isabel, Morgades, Mireia, Sanchez, Ricardo, Such, Esperanza, Barrera, Susana, Ciudad, Juana, Orfao, Alberto, Valls, Julio Davila, De Las Heras, Natalia, Fuster, José, Garcia de Coca, Alfonso, Labrador, Jorge, Queizan Hernandez, Jose Antonio, Mendoza, María Carmen, Riesco, Susana, Martín, Sandra, Ribera, Josep-Maria, Benito Sanchez, Maria Rocio, Hernández-Rivas, Jesús María

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Mutually-Exclusive Pathways between IKZF1 plus and RAS Mutations and TP53 double-Hit Alterations Lead Relapse in B-Other, Ph-like and Hyperdiploidy Genetic Groups in Adult B-Cell A... von Navas Acosta, Josgrey Del Valle Del Valle, González, Teresa, Serramito-Gómez, Inmaculada, Villaverde Ramiro, Angela, Miguel-García, Cristina, Santos-Mínguez, Sandra, Ribera, Jordi, Granada, Isabel, Morgades, Mireia, Sanchez, Ricardo, Such, Esperanza, Barrera, Susana, Ciudad, Juana, Orfao, Alberto, Valls, Julio Davila, De Las Heras, Natalia, Fuster, José, Garcia de Coca, Alfonso, Labrador, Jorge, Queizan Hernandez, Jose Antonio, Mendoza, María Carmen, Riesco, Susana, Martín, Sandra, Ribera, Josep-Maria, Benito Sanchez, Maria Rocio, Hernández-Rivas, Jesús María

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Long-Term Evolution of Somatic Mutations in Patients with Del(5q) MDS Early Treated with Lenalidomide in the Sintra-Rev Clinical Trial: Safe and Effecitive Approach? von Toribio Castelló, Sofía M, Lopez-Cadenas, Felix, Preudhomme, Claude, Villaverde Ramiro, Angela, Fenwarth, Laurène, Lumbreras, Eva, González, Teresa, Del Rey, Mónica, Xicoy, Blanca, Renneville, Aline, Sánchez-Garcia, Joaquín, Coll, Rosa, Slama, Bohrane, Hernández-Rivas, José Ángel, Thepot, Sylvain, Bernal, Teresa, Guerci-Bresler, Agnès, Götze, Katharina, Hernández-Rivas, Jesús María, Fenaux, Pierre, Del Cañizo, Consuelo, Diez-Campelo, Maria

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Machine Learning Provides Individualized Prediction of Outcomes after First Complete Remission in Adult AML Patients - Results from the Harmony Platform von Hernández Sánchez, Alberto, Martínez Elicegui, Javier, Sobas, Marta, Sträng, Eric, Benner, Axel, Abáigar, María, Castellani, Gastone, Tur, Laura, Valk, Peter J. M., Villaverde Ramiro, Angela, Metzeler, Klaus H, Azibeiro Melchor, Raúl, Versluis, Jurjen, Dall'Olio, Daniele, González, Teresa, Tettero, Jesse M., Martinez-Lopez, Joaquin, Fidalgo, Helena, Sierra, Jorge, Damm, Frederik, Mills, Ken I, Lehmann, Soren, Thomas, Ian, Mayer, Jiří, Thiede, Christian, Voso, Maria Teresa, Sanz, Guillermo, Döhner, Konstanze, Heuser, Michael, Haferlach, Torsten, Turki, Amin T., Reinhardt, Dirk, van Speybroeck, Michel, Schulze-Rath, Renate, Barbus, Martje, Butler, John E, Hernández-Rivas, Jesús María, Huntly, Brian, Ossenkoppele, Gert, Döhner, Hartmut, Bullinger, Lars

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Rearrangements Involving 11q23/KMT2A: Mutational Landscape and Prognostic Implications - Results of the Harmony Alliance AML Database von Hernández Sánchez, Alberto, González, Teresa, Sobas, Marta Anna, Sträng, Eric, Gastone, Castellani, Abáigar, María, Valk, Peter JM, Villaverde Ramiro, Angela, Benner, Axel, Metzeler, Klaus H., Tettero, Jesse M., Martínez-López, Joaquín, Pratcorona, Marta, Martinez Elicegui, Javier, Mills, Ken I, Thiede, Christian, Sanz, Guillermo, Döhner, Konstanze, Heuser, Michael, Haferlach, Torsten, Turki, Amin T., Reinhardt, Dirk, Schulze-Rath, Renate, Barbus, Martje, Hernández-Rivas, Jesús María, Huntly, Brian James Patrick, Ossenkoppele, Gert, Döhner, Hartmut, Bullinger, Lars

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Outcomes with intensive treatment for acute myeloid leukemia: an analysis of two decades of data from the HARMONY Alliance von Sobas, Marta Anna, Turki, Amin T., Ramiro, Angela Villaverde, Sánchez, Alberto Hernández, Elicegui, Javier Martinez, González, Teresa, Melchor, Raúl Azibeiro, Abáigar, María, Tur, Laura, Dall'Olio, Daniele, Sträng, Eric, Tettero, Jesse M., Castellani, Gastone, Benner, Axel, Döhner, Konstanze, Thiede, Christian, Metzeler, Klaus H., Haferlach, Torsten, Damm, Frederik, Ayala, Rosa, Martínez-López, Joaquín, Mills, Ken I, Sierra, Jorge, Lehmann, Sören, Porta, Matteo G. Della, Mayer, Jiri, Reinhardt, Dirk, Medina, Rubén Villoria, Schulze-Rath, Renate, Barbus, Martje, Hernández-Rivas, Jesús María, Huntly, Brian J.P, Ossenkoppele, Gert, Döhner, Hartmut, Bullinger, Lars

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Machine Learning Improves Risk Stratification in Myelofibrosis: An Analysis of the Spanish Registry of Myelofibrosis von Mosquera Orgueira, Adrian, Perez Encinas, Manuel, Hernández Sánchez, Alberto, González, Teresa, Arellano-Rodrigo, Eduardo, Martínez Elicegui, Javier Martinez, Villaverde Ramiro, Angela, Raya Sanchez, Jose Maria, Ayala, Rosa, Ferrer Marin, Francisca, Fox, Maria Laura, Velez Tenza, Patricia, Mora Casterá, Elvira, Xicoy, Blanca, Mata Vazquez, Maria Isabel, García Fortes, María, Angona, Anna, Cuevas, Beatriz, Senin, María Alicia, Ramírez Payer, Angel, Ramírez, María José, Perez Lopez, Raul, González de Villambrosia, Sonia, Martínez, Clara, Gómez-Casares, María Teresa, Garcia-Hernandez, Carmen, Gasior Kabat, Mercedes, Bellosillo, Beatriz, Steegmann, Juan Luis, Alvarez-Larran, Alberto, Hernández Rivas, Jesús M, Hernandez Boluda, Juan Carlos

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Long-Term Follow-up of AML Patients Treated Intensively before the Era of Targeted Agents. a Big Data Analysis from the Harmony Collaboration von Sobas, Marta Anna, Villaverde Ramiro, Angela, Hernández Sánchez, Alberto, Martinez Elicegui, Javier, González, Teresa, Azibeiro Melchor, Raúl, Abáigar, María, Tur, Laura, Dall'Olio, Daniele, Sträng, Eric, Tettero, Jesse M., Gastone, Castellani, Benner, Axel, Döhner, Konstanze, Thiede, Christian, Turki, Amin T., Metzeler, Klaus H., Haferlach, Torsten, Damm, Frederick, Ayala, Rosa, Martínez-López, Joaquín, Mills, Ken I, Sierra, Jorge, Lehmann, Sören, Della Porta, Matteo G., Mayer, Jiri, Reinhardt, Dirk, Villoria Medina, Rubén, Schulze-Rath, Renate, Barbus, Martje, Hernández-Rivas, Jesús María, Huntly, Brian James Patrick, Ossenkoppele, Gert, Dohner, Hartmut, Bullinger, Lars

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