Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors von Mulcahy Levy, Jean M, Zahedi, Shadi, Griesinger, Andrea M, Morin, Andrew, Davies, Kurtis D, Aisner, Dara L, Kleinschmidt-DeMasters, B K, Fitzwalter, Brent E, Goodall, Megan L, Thorburn, Jacqueline, Amani, Vladimir, Donson, Andrew M, Birks, Diane K, Mirsky, David M, Hankinson, Todd C, Handler, Michael H, Green, Adam L, Vibhakar, Rajeev, Foreman, Nicholas K, Thorburn, Andrew

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Advancing biology-based therapeutic approaches for atypical teratoid rhabdoid tumors von Hoffman, Lindsey M, Richardson, Elizabeth Anne, Ho, Ben, Margol, Ashley, Reddy, Alyssa, Lafay-Cousin, Lucie, Chi, Susan, Slavc, Irene, Judkins, Alexander, Hasselblatt, Martin, Bourdeaut, Franck, Frühwald, Michael C, Vibhakar, Rajeev, Bouffet, Eric, Huang, Annie

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MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence von Venkataraman, Sujatha, Alimova, Irina, Fan, Rong, Harris, Peter, Foreman, Nicholas, Vibhakar, Rajeev

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scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy von Ocasio, Jennifer Karin, Babcock, Benjamin, Malawsky, Daniel, Weir, Seth J., Loo, Lipin, Simon, Jeremy M., Zylka, Mark J., Hwang, Duhyeong, Dismuke, Taylor, Sokolsky, Marina, Rosen, Elias P., Vibhakar, Rajeev, Zhang, Jiao, Saulnier, Olivier, Vladoiu, Maria, El-Hamamy, Ibrahim, Stein, Lincoln D., Taylor, Michael D., Smith, Kyle S., Northcott, Paul A., Colaneri, Alejandro, Wilhelmsen, Kirk, Gershon, Timothy R.

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Inhibition of MYC attenuates tumor cell self‐renewal and promotes senescence in SMARCB1‐deficient Group 2 atypical teratoid rhabdoid tumors to suppress tumor growth in vivo von Alimova, Irina, Pierce, Angela, Danis, Etienne, Donson, Andrew, Birks, Diane K., Griesinger, Andrea, Foreman, Nicholas K., Santi, Mariarita, Soucek, Laura, Venkataraman, Sujatha, Vibhakar, Rajeev

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A Small-Molecule Inhibitor of WEE1, AZD1775, Synergizes with Olaparib by Impairing Homologous Recombination and Enhancing DNA Damage and Apoptosis in Acute Leukemia von Garcia, Tamara B, Snedeker, Jonathan C, Baturin, Dmitry, Gardner, Lori, Fosmire, Susan P, Zhou, Chengjing, Jordan, Craig T, Venkataraman, Sujatha, Vibhakar, Rajeev, Porter, Christopher C

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Subgroup and subtype-specific outcomes in adult medulloblastoma von Coltin, Hallie, Sundaresan, Lakshmikirupa, Smith, Kyle S., Skowron, Patryk, Massimi, Luca, Eberhart, Charles G., Schreck, Karisa C., Gupta, Nalin, Weiss, William A., Tirapelli, Daniela, Carlotti, Carlos, Li, Kay K. W., Ryzhova, Marina, Golanov, Andrey, Zheludkova, Olga, Absalyamova, Oksana, Okonechnikov, Konstantin, Stichel, Damian, von Deimling, Andreas, Giannini, Caterina, Raskin, Scott, Van Meir, Erwin G., Chan, Jennifer A., Fults, Daniel, Chambless, Lola B., Kim, Seung-Ki, Vasiljevic, Alexandre, Faure-Conter, Cecile, Vibhakar, Rajeev, Jung, Shin, Leary, Sarah, Mora, Jaume, McLendon, Roger E., Pollack, Ian F., Hauser, Peter, Grajkowska, Wieslawa A., Rubin, Joshua B., van Veelen, Marie-Lise C., French, Pim J., Kros, Johan M., Liau, Linda M., Pfister, Stefan M., Kool, Marcel, Kijima, Noriyuki, Taylor, Michael D., Packer, Roger J., Northcott, Paul A., Korshunov, Andrey, Ramaswamy, Vijay

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Single-Cell RNA Sequencing of Childhood Ependymoma Reveals Neoplastic Cell Subpopulations That Impact Molecular Classification and Etiology von Gillen, Austin E., Riemondy, Kent A., Amani, Vladimir, Griesinger, Andrea M., Gilani, Ahmed, Venkataraman, Sujatha, Madhavan, Krishna, Prince, Eric, Sanford, Bridget, Hankinson, Todd C., Handler, Michael H., Vibhakar, Rajeev, Jones, Ken L., Mitra, Siddhartha, Hesselberth, Jay R., Foreman, Nicholas K., Donson, Andrew M.

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Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma von DeSisto, John, Lucas, John T., Xu, Ke, Donson, Andrew, Lin, Tong, Sanford, Bridget, Wu, Gang, Tran, Quynh T., Hedges, Dale, Hsu, Chih-Yang, Armstrong, Gregory T., Arnold, Michael, Bhatia, Smita, Flannery, Patrick, Lemma, Rakeb, Hardie, Lakotah, Schüller, Ulrich, Venkataraman, Sujatha, Hoffman, Lindsey M., Dorris, Kathleen, Mulcahy Levy, Jean M., Hankinson, Todd C., Handler, Michael, Liu, Arthur K., Foreman, Nicholas, Vibhakar, Rajeev, Jones, Kenneth, Allen, Sariah, Zhang, Jinghui, Baker, Suzanne J., Merchant, Thomas E., Orr, Brent A., Green, Adam L.

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Rapid P-TEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy von Walker, Faye M., Sobral, Lays Martin, Danis, Etienne, Sanford, Bridget, Donthula, Sahiti, Balakrishnan, Ilango, Wang, Dong, Pierce, Angela, Karam, Sana D., Kargar, Soudabeh, Serkova, Natalie J., Foreman, Nicholas K., Venkataraman, Sujatha, Dowell, Robin, Vibhakar, Rajeev, Dahl, Nathan A.

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BPTF regulates growth of adult and pediatric high-grade glioma through the MYC pathway von Green, Adam L., DeSisto, John, Flannery, Patrick, Lemma, Rakeb, Knox, Aaron, Lemieux, Madeleine, Sanford, Bridget, O’Rourke, Rebecca, Ramkissoon, Shakti, Jones, Kristen, Perry, Jennifer, Hui, Xu, Moroze, Erin, Balakrishnan, Ilango, O’Neill, Allison F., Dunn, Katherine, DeRyckere, Deborah, Danis, Etienne, Safadi, Aaron, Gilani, Ahmed, Hubbell-Engler, Benjamin, Nuss, Zachary, Levy, Jean M. Mulcahy, Serkova, Natalie, Venkataraman, Sujatha, Graham, Douglas K., Foreman, Nicholas, Ligon, Keith, Jones, Ken, Kung, Andrew L., Vibhakar, Rajeev

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Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG von Balakrishnan, Ilango, Danis, Etienne, Pierce, Angela, Madhavan, Krishna, Wang, Dong, Dahl, Nathan, Sanford, Bridget, Birks, Diane K., Davidson, Nate, Metselaar, Dennis S., Meel, Michaël Hananja, Lemma, Rakeb, Donson, Andrew, Vijmasi, Trinka, Katagi, Hiroaki, Sola, Ismail, Fosmire, Susan, Alimova, Irina, Steiner, Jenna, Gilani, Ahmed, Hulleman, Esther, Serkova, Natalie J., Hashizume, Rintaro, Hawkins, Cynthia, Carcaboso, Angel M., Gupta, Nalin, Monje, Michelle, Jabado, Nada, Jones, Kenneth, Foreman, Nicholas, Green, Adam, Vibhakar, Rajeev, Venkataraman, Sujatha

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MicroRNA 218 Acts as a Tumor Suppressor by Targeting Multiple Cancer Phenotype-associated Genes in Medulloblastoma von Venkataraman, Sujatha, Birks, Diane K., Balakrishnan, Ilango, Alimova, Irina, Harris, Peter S., Patel, Purvi R., Handler, Michael H., Dubuc, Adrian, Taylor, Michael D., Foreman, Nicholas K., Vibhakar, Rajeev

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Targeted fusion analysis can aid in the classification and treatment of pediatric glioma, ependymoma, and glioneuronal tumors von Lake, Jessica A., Donson, Andrew M., Prince, Eric, Davies, Kurtis D., Nellan, Anandani, Green, Adam L., Mulcahy Levy, Jean, Dorris, Kathleen, Vibhakar, Rajeev, Hankinson, Todd C., Foreman, Nicholas K., Ewalt, Mark D., Kleinschmidt‐DeMasters, Bette K., Hoffman, Lindsey M., Gilani, Ahmed

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Inhibition of EZH2 suppresses self-renewal and induces radiation sensitivity in atypical rhabdoid teratoid tumor cells von Alimova, Irina, Birks, Diane K, Harris, Peter S, Knipstein, Jeffrey A, Venkataraman, Sujatha, Marquez, Victor E, Foreman, Nicholas K, Vibhakar, Rajeev

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Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma von Dahl, Nathan A., Danis, Etienne, Balakrishnan, Ilango, Wang, Dong, Pierce, Angela, Walker, Faye M., Gilani, Ahmed, Serkova, Natalie J., Madhavan, Krishna, Fosmire, Susan, Green, Adam L., Foreman, Nicholas K., Venkataraman, Sujatha, Vibhakar, Rajeev

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B7-H3, a potential therapeutic target, is expressed in diffuse intrinsic pontine glioma von Zhou, Zhiping, Luther, Neal, Ibrahim, George M., Hawkins, Cynthia, Vibhakar, Rajeev, Handler, Michael H., Souweidane, Mark M.

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Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells von Harris, Peter S, Venkataraman, Sujatha, Alimova, Irina, Birks, Diane K, Donson, Andrew M, Knipstein, Jeffrey, Dubuc, Adrian, Taylor, Michael D, Handler, Michael H, Foreman, Nicholas K, Vibhakar, Rajeev

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Targeting MYC-driven replication stress in medulloblastoma with AZD1775 and gemcitabine von Moreira, Daniel C., Venkataraman, Sujatha, Subramanian, Apurva, Desisto, John, Balakrishnan, Ilango, Prince, Eric, Pierce, Angela, Griesinger, Andrea, Green, Adam, Eberhardt, Charles G., Foreman, Nicholas K., Vibhakar, Rajeev

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Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma von Dubuc, Adrian M., Remke, Marc, Korshunov, Andrey, Northcott, Paul A., Zhan, Shing H., Mendez-Lago, Maria, Kool, Marcel, Jones, David T. W., Unterberger, Alexander, Morrissy, A. Sorana, Shih, David, Peacock, John, Ramaswamy, Vijay, Rolider, Adi, Wang, Xin, Witt, Hendrik, Hielscher, Thomas, Hawkins, Cynthia, Vibhakar, Rajeev, Croul, Sidney, Rutka, James T., Weiss, William A., Jones, Steven J. M., Eberhart, Charles G., Marra, Marco A., Pfister, Stefan M., Taylor, Michael D.

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