Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man von Dragovic, Sanja, Vermeulen, Nico P. E., Gerets, Helga H., Hewitt, Philip G., Ingelman‐Sundberg, Magnus, Park, B. Kevin, Juhila, Satu, Snoeys, Jan, Weaver, Richard J.

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Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates von Koenderink, Jan B., van den Heuvel, Jeroen J. M. W., Bilos, Ab, Vredenburg, Galvin, Vermeulen, Nico P. E., Russel, Frans G. M.

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A Comparative Linear Interaction Energy and MM/PBSA Study on SIRT1–Ligand Binding Free Energy Calculation von Rifai, Eko Aditya, van Dijk, Marc, Vermeulen, Nico P. E, Yanuar, Arry, Geerke, Daan P

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Linear Interaction Energy Based Prediction of Cytochrome P450 1A2 Binding Affinities with Reliability Estimation von Capoferri, Luigi, Verkade-Vreeker, Marlies C A, Buitenhuis, Danny, Commandeur, Jan N M, Pastor, Manuel, Vermeulen, Nico P E, Geerke, Daan P

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The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae von Huseinovic, Angelina, van Leeuwen, Jolanda S, van Welsem, Tibor, Stulemeijer, Iris, van Leeuwen, Fred, Vermeulen, Nico P E, Kooter, Jan M, Vos, J Chris

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Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity von Reinen, Jelle, Postma, Geert, Tump, Cornelis, Bloemberg, Tom, Engel, Jasper, Vermeulen, Nico P. E, Commandeur, Jan N. M, Honing, Maarten

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Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations von den Braver-Sewradj, Shalenie P, den Braver, Michiel W, Toorneman, Robin M, van Leeuwen, Stephanie, Zhang, Yongjie, Dekker, Stefan J, Vermeulen, Nico P. E, Commandeur, Jan N. M, Vos, J. Chris

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Human NAD(P)H:quinone Oxidoreductase 1 (NQO1)-Mediated Inactivation of Reactive Quinoneimine Metabolites of Diclofenac and Mefenamic Acid von Vredenburg, Galvin, Elias, Naura S, Venkataraman, Harini, Hendriks, Delilah F. G, Vermeulen, Nico P. E, Commandeur, Jan N. M, Vos, J. Chris

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Diclofenac inhibits tumor necrosis factor‐α‐induced nuclear factor‐κB activation causing synergistic hepatocyte apoptosis von Fredriksson, Lisa, Herpers, Bram, Benedetti, Giulia, Matadin, Quraisha, Puigvert, Jordi C., de Bont, Hans, Dragovic, Sanja, Vermeulen, Nico P.E., Commandeur, Jan N.M., Danen, Erik, de Graauw, Marjo, van de Water, Bob

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Classification of Cytochrome P450 1A2 Inhibitors and Noninhibitors by Machine Learning Techniques von VASANTHANATHAN, Poongavanam, TABOUREAU, Olivier, OOSTENBRINK, Chris, VERMEULEN, Nico P. E, OLSEN, Lars, JORGENSEN, Flemming Steen

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Cytochrome P450-Mediated Bioactivation of Mefenamic Acid to Quinoneimine Intermediates and Inactivation by Human Glutathione S‑Transferases von Venkataraman, Harini, den Braver, Michiel W, Vermeulen, Nico P. E, Commandeur, Jan N. M

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Catalytic Site Prediction and Virtual Screening of Cytochrome P450 2D6 Substrates by Consideration of Water and Rescoring in Automated Docking von de Graaf, Chris, Oostenbrink, Chris, Keizers, Peter H. J., van der Wijst, Tushar, Jongejan, Aldo, Vermeulen, Nico P. E.

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Virtual Screening and Prediction of Site of Metabolism for Cytochrome P450 1A2 Ligands von Vasanthanathan, Poongavanam, Hritz, Jozef, Taboureau, Olivier, Olsen, Lars, Steen Jørgensen, Flemming, Vermeulen, Nico P. E, Oostenbrink, Chris

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Binding Mode Prediction of Cytochrome P450 and Thymidine Kinase Protein−Ligand Complexes by Consideration of Water and Rescoring in Automated Docking von de Graaf, Chris, Pospisil, Pavel, Pos, Wouter, Folkers, Gerd, Vermeulen, Nico P. E

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Effect of Human Glutathione S‑Transferases on Glutathione-Dependent Inactivation of Cytochrome P450-Dependent Reactive Intermediates of Diclofenac von Dragovic, Sanja, Boerma, Jan Simon, Vermeulen, Nico P. E, Commandeur, Jan N. M

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Mass Spectrometric Characterization of Protein Adducts of Multiple P450-Dependent Reactive Intermediates of Diclofenac to Human Glutathione‑S‑transferase P1‑1 von Boerma, Jan Simon, Dragovic, Sanja, Vermeulen, Nico P. E, Commandeur, Jan N. M

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Characterization of Human Cytochrome P450s Involved in the Bioactivation of Tri-ortho-cresyl Phosphate (ToCP) von Reinen, Jelle, Nematollahi, Leyla, Fidder, Alex, Vermeulen, Nico P. E, Noort, Daan, Commandeur, Jan N. M

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Metabolism related toxicity of diclofenac in yeast as model system von van Leeuwen, Jolanda S., Vredenburg, Galvin, Dragovic, Sanja, Tjong, T.F. Jennifer, Vos, J. Chris, Vermeulen, Nico P.E.

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Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners von Ortega Ugalde, Sandra, de Koning, Coen P., Wallraven, Kerstin, Bruyneel, Ben, Vermeulen, Nico P. E., Grossmann, Tom N., Bitter, Wilbert, Commandeur, Jan N. M., Vos, J. Chris

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Involvement of the Pleiotropic Drug Resistance Response, Protein Kinase C Signaling, and Altered Zinc Homeostasis in Resistance of Saccharomyces cerevisiae to Diclofenac von VAN LEEUWEN, Jolanda S, VERMEULEN, Nico P. E, VOS, J. Chris

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