Membrane-bound O-acyltransferase 7 (MBOAT7)-driven phosphatidylinositol remodeling in advanced liver disease von Varadharajan, Venkateshwari, Massey, William J., Brown, J. Mark

Volltext

Membrane-bound O -acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury von Varadharajan, Venkateshwari, Ramachandiran, Iyappan, Massey, William J, Jain, Raghav, Banerjee, Rakhee, Horak, Anthony J, McMullen, Megan R, Huang, Emily, Bellar, Annette, Lorkowski, Shuhui W, Gulshan, Kailash, Helsley, Robert N, James, Isabella, Pathak, Vai, Dasarathy, Jaividhya, Welch, Nicole, Dasarathy, Srinivasan, Streem, David, Reizes, Ofer, Allende, Daniela S, Smith, Jonathan D, Simcox, Judith, Nagy, Laura E, Brown, J Mark

Volltext

MBOAT7-driven lysophosphatidylinositol acylation in adipocytes contributes to systemic glucose homeostasis von Massey, William J., Varadharajan, Venkateshwari, Banerjee, Rakhee, Brown, Amanda L., Horak, Anthony J., Hohe, Rachel C., Jung, Bryan M., Qiu, Yunguang, Chan, E. Ricky, Pan, Calvin, Zhang, Renliang, Allende, Daniela S., Willard, Belinda, Cheng, Feixiong, Lusis, Aldons J., Brown, J. Mark

Volltext

MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis von Phadnis, Vaishnavi V., Snider, Jamie, Varadharajan, Venkateshwari, Ramachandiran, Iyappan, Deik, Amy A., Lai, Zon Weng, Kunchok, Tenzin, Eaton, Elinor Ng, Sebastiany, Carolin, Lyakisheva, Anna, Vaccaro, Kyle D., Allen, Juliet, Yao, Zhong, Wong, Victoria, Geng, Betty, Weiskopf, Kipp, Clish, Clary B., Brown, J. Mark, Stagljar, Igor, Weinberg, Robert A., Henry, Whitney S.

Volltext

The nonvesicular sterol transporter Aster-C plays a minor role in whole body cholesterol balance von Banerjee, Rakhee, Hohe, Rachel C, Cao, Shijie, Jung, Bryan M, Horak, Anthony J, Ramachandiran, Iyappan, Massey, William J, Varadharajan, Venkateshwari, Zajczenko, Natalie I, Burrows, Amy C, Dutta, Sumita, Goudarzi, Maryam, Mahen, Kala, Carter, Abigail, Helsley, Robert N, Gordon, Scott M, Morton, Richard E, Strauch, Christopher, Willard, Belinda, Gogonea, Camelia Baleanu, Gogonea, Valentin, Pedrelli, Matteo, Parini, Paolo, Brown, J Mark

Volltext

Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice von Zelows, Mikala M., Cady, Corissa, Dharanipragada, Nikitha, Mead, Anna E., Kipp, Zachary A., Bates, Evelyn A., Varadharajan, Venkateshwari, Banerjee, Rakhee, Park, Se-Hyung, Shelman, Nathan R., Clarke, Harrison A., Hawkinson, Tara R., Medina, Terrymar, Sun, Ramon C., Lydic, Todd A., Hinds, Terry D., Brown, J. Mark, Softic, Samir, Graf, Gregory A., Helsley, Robert N.

Volltext

MBOAT7-driven phosphatidylinositol remodeling promotes the progression of clear cell renal carcinoma von Neumann, Chase K.A., Silver, Daniel J., Venkateshwari, Varadharajan, Zhang, Renliang, Traughber, C. Alicia, Przybycin, Christopher, Bayik, Defne, Smith, Jonathan D., Lathia, Justin D., Rini, Brian I., Brown, J. Mark

Volltext

Circulating Gut Microbe-Derived Metabolites Are Associated with Hepatocellular Carcinoma von Banerjee, Rakhee, Wehrle, Chase J, Wang, Zeneng, Wilcox, Jennifer D, Uppin, Vinayak, Varadharajan, Venkateshwari, Mrdjen, Marko, Hershberger, Courtney, Reizes, Ofer, Yu, Jennifer S, Lathia, Justin D, Rotroff, Daniel M, Hazen, Stanley L, Tang, W H Wilson, Aucejo, Federico, Brown, J Mark

Volltext

Kinetics of imidazole propionate from orally delivered histidine in mice and humans von Warmbrunn, Moritz V., Attaye, Ilias, Horak, Anthony, Banerjee, Rakhee, Massey, William J., Varadharajan, Venkateshwari, Rampanelli, Elena, Hao, Youling, Dutta, Sumita, Nemet, Ina, Aron-Wisnewsky, Judith, Clément, Karine, Koopen, Annefleur, Wortelboer, Koen, Bergh, Per-Olof, Davids, Mark, Mohamed, Nadia, Kemper, E. Marleen, Hazen, Stanley, Groen, Albert K., van Raalte, Daniel H., Herrema, Hilde, Backhed, Fredrik, Brown, J. Mark, Nieuwdorp, Max

Volltext

Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice von Dalton, George D., Oh, Seh-Hoon, Tang, Linda, Zhang, Stephanie, Brown, Amanda L., Varadharajan, Venkateshwari, Baleanu-Gogonea, Camelia, Gogonea, Valentin, Pathak, Preeti, Brown, J. Mark, Diehl, Anna Mae

Volltext

Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome von Wang, Min, Osborn, Lucas J., Jain, Sunit, Meng, Xiandong, Weakley, Allison, Yan, Jia, Massey, William J., Varadharajan, Venkateshwari, Horak, Anthony, Banerjee, Rakhee, Allende, Daniela S., Chan, E. Ricky, Hajjar, Adeline M., Wang, Zeneng, Dimas, Alejandra, Zhao, Aishan, Nagashima, Kazuki, Cheng, Alice G., Higginbottom, Steven, Hazen, Stanley L., Brown, J. Mark, Fischbach, Michael A.

Volltext

A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis von Osborn, Lucas J., Schultz, Karlee, Massey, William, DeLucia, Beckey, Choucair, Ibrahim, Varadharajan, Venkateshwari, Banerjee, Rakhee, Fung, Kevin, Horak, Anthony J., Orabi, Danny, Nemet, Ina, Nagy, Laura E., Wang, Zeneng, Allende, Daniela S., Willard, Belinda B., Sangwan, Naseer, Hajjar, Adeline M., McDonald, Christine, Ahern, Philip P., Hazen, Stanley L., Brown, J. Mark, Claesen, Jan

Volltext

Obesity-linked suppression of membrane-bound O -acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease von Helsley, Robert N, Varadharajan, Venkateshwari, Brown, Amanda L, Gromovsky, Anthony D, Schugar, Rebecca C, Ramachandiran, Iyappan, Fung, Kevin, Kabbany, Mohammad Nasser, Banerjee, Rakhee, Neumann, Chase K, Finney, Chelsea, Pathak, Preeti, Orabi, Danny, Osborn, Lucas J, Massey, William, Zhang, Renliang, Kadam, Anagha, Sansbury, Brian E, Pan, Calvin, Sacks, Jessica, Lee, Richard G, Crooke, Rosanne M, Graham, Mark J, Lemieux, Madeleine E, Gogonea, Valentin, Kirwan, John P, Allende, Daniela S, Civelek, Mete, Fox, Paul L, Rudel, Lawrence L, Lusis, Aldons J, Spite, Matthew, Brown, J Mark

Volltext

CREEPING FAT-DERIVED FREE FATTY ACIDS INDUCE HYPERPLASIA OF INTESTINAL MUSCULARIS PROPRIA MUSCLE CELLS – A NOVEL LINK BETWEEN FAT AND INTESTINAL STRICTURE FORMATION IN CROHN’S DISE... von Liu, Weiwei, Mao, Ren, Nga Le, Thi Hong, West, Gail, Varadharajan, Venkateshwari, Banerjee, Rakhee, Doyon, Genevieve, Mukherjee, Pranab, Nguyen, Quang Tam, Mulya, Anny, Rennison, Julie H., Gordon, Ilyssa O., Cruise, Michael, Hu, Shaomin, Czarnecki, Doug, Plesec, Thomas, Chandra, Jyotsna, Banerjee, Suhanti, Wang, Jie, Massey, William J., Goren, Idan, Lin, Si-Nan, Kurada, Satya, Cohen, Benjamin L., Qazi, Taha, Holubar, Stefan D., Lipman, Jeremy, Kanters, Arielle, Gliniak, Christy M., Scherer, Philipp E., Chen, Min-Hu, Siegmund, Britta, Ivanov, Andrei I., Fiocchi, Claudio, Van Wagoner, David R., Brown, J. Mark, Rieder, Florian

Volltext

Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury von Varadharajan, Venkateshwari, Ramachandiran, Iyappan, Massey, William J, Jain, Raghav, Banerjee, Rakhee, Horak, Anthony J, McMullen, Megan R, Huang, Emily, Bellar, Annette, Lorkowski, Shuhui W, Gulshan, Kailash, Helsley, Robert N, James, Isabella, Pathak, Vai, Dasarathy, Jaividhya, Welch, Nicole, Dasarathy, Srinivasan, Streem, David, Reizes, Ofer, Allende, Daniela S, Smith, Jonathan D, Simcox, Judith, Nagy, Laura E, Brown, J Mark

Volltext

Gut microbial trimethylamine is elevated in alcohol-associated hepatitis and contributes to ethanol-induced liver injury in mice von Helsley, Robert N, Miyata, Tatsunori, Kadam, Anagha, Varadharajan, Venkateshwari, Sangwan, Naseer, Huang, Emily C, Banerjee, Rakhee, Brown, Amanda L, Fung, Kevin K, Massey, William J, Neumann, Chase, Orabi, Danny, Osborn, Lucas J, Schugar, Rebecca C, McMullen, Megan R, Bellar, Annette, Poulsen, Kyle L, Kim, Adam, Pathak, Vai, Mrdjen, Marko, Anderson, James T, Willard, Belinda, McClain, Craig J, Mitchell, Mack, McCullough, Arthur J, Radaeva, Svetlana, Barton, Bruce, Szabo, Gyongyi, Dasarathy, Srinivasan, Garcia-Garcia, Jose Carlos, Rotroff, Daniel M, Allende, Daniela S, Wang, Zeneng, Hazen, Stanley L, Nagy, Laura E, Brown, Jonathan Mark

Volltext

Lymphatic endothelial-like cells promote glioblastoma stem cell growth through cytokine-driven cholesterol metabolism von Zhao, Linjie, Qiu, Zhixin, Yang, Zhengnan, Xu, Lian, Pearce, Thomas M, Wu, Qiulian, Yang, Kailin, Li, FuLong, Saulnier, Olivier, Fei, Fan, Yu, Huaxu, Gimple, Ryan C, Varadharajan, Venkateshwari, Liu, Juxiu, Hendrikse, Liam D, Fong, Vernon, Wang, Wei, Zhang, Jiao, Lv, Deguan, Lee, Derrick, Lehrich, Brandon M, Jin, Chunyu, Ouyang, Liang, Dixit, Deobrat, Wu, Haoxing, Wang, Xiang, Sloan, Andrew E, Wang, Xiuxing, Huan, Tao, Mark Brown, J, Goldman, Steven A, Taylor, Michael D, Zhou, Shengtao, Rich, Jeremy N

Volltext