Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5′-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compou... von Venkatesan, Aranapakam M, Dehnhardt, Christoph M, Delos Santos, Efren, Chen, Zecheng, Dos Santos, Osvaldo, Ayral-Kaloustian, Semiramis, Khafizova, Gulnaz, Brooijmans, Natasja, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Gibbons, James, Abraham, Robert T, Chaudhary, Inder, Mansour, Tarek S

Volltext

Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine von Stork, Gilbert, Yamashita, Ayako, Hanson, Robert M, Phan, Ly, Phillips, Eifion, Dubé, Daniel, Bos, Pieter H, Clark, Andrew J, Gough, Maxwell, Greenlee, Mark L, Jiang, Yimin, Jones, Keith, Kitamura, Masato, Leonard, John, Liu, Tongzhu, Parsons, Philip J, Venkatesan, Aranapakam M

Volltext

Ultrasmall Folate Receptor Alpha Targeted Enzymatically Cleavable Silica Nanoparticle Drug Conjugates Augment Penetration and Therapeutic Efficacy in Models of Cancer von Wu, Fei, Chen, Pei-Ming, Gardinier, Thomas C., Turker, Melik Z., Venkatesan, Aranapakam M., Patel, Vaibhav, Khor, Tin, Bradbury, Michelle S., Wiesner, Ulrich B., Adams, Gregory P., Germano, Geno, Chen, Feng, Ma, Kai

Volltext

Efficacy of Piperacillin Combined with the Penem β-Lactamase Inhibitor BLI-489 in Murine Models of Systemic Infection von PETERSEN, Peter J, HAL JONES, C, VENKATESAN, Aranapakam M, BRADFORD, Patricia A

Volltext

Stereoselective Synthesis of an Active Metabolite of the Potent PI3 Kinase Inhibitor PKI-179 von Chen, Zecheng, Venkatesan, Aranapakam M, Dos Santos, Osvaldo, Delos Santos, Efren, Dehnhardt, Christoph M, Ayral-Kaloustian, Semiramis, Ashcroft, Joseph, McDonald, Leonard A, Mansour, Tarek S

Volltext

Establishment of In Vitro Susceptibility Testing Methodologies and Comparative Activities of Piperacillin in Combination with the Penem β-Lactamase Inhibitor BLI-489 von PETERSEN, Peter J, HAL JONES, C, VENKATESAN, Aranapakam M, MANSOUR, Tarek S, PROJAN, Steven J, BRADFORD, Patricia A

Volltext

Inhibition of OXA-1 β-Lactamase by Penems von BETHEL, Christopher R, DISTLER, Anne M, ANDERSON, Vernon E, LEONARD, David A, HUJER, Kristine M, ABE, Takao, VENKATESAN, Aranapakam M, MANSOUR, Tarek S, BONOMO, Robert A, RUSZCZYCKY, Mark W, CAREY, Marianne P, CAREY, Paul R, HUJER, Andrea M, TARACILA, Magda, HELFAND, Marion S, THOMSON, Jodi M, KALP, Matthew

Volltext

In Vitro and In Vivo Activities of Novel 6-Methylidene Penems as β-Lactamase Inhibitors von WEISS, William J, PETERSEN, Peter J, USHIROGOCHI, Hideki, TAKASAKE, Tsuyoshi, PROJAN, Steve, O'CONNELL, John, MANSOUR, Tarek S, MURPHY, Timothy M, TARDIO, Luanna, YOUJUN YANG, BRADFORD, Patricia A, VENKATESAN, Aranapakam M, ABE, Takao, ISODA, Takeshi, MIHIRA, Ado

Volltext

Synthesis and SAR of Novel 4-Morpholinopyrrolopyrimidine Derivatives as Potent Phosphatidylinositol 3-Kinase Inhibitors von Chen, Zecheng, Venkatesan, Aranapakam M, Dehnhardt, Christoph M, Ayral-Kaloustian, Semiramis, Brooijmans, Natasja, Mallon, Robert, Feldberg, Larry, Hollander, Irwin, Lucas, Judy, Yu, Ker, Kong, Fangming, Mansour, Tarek S

Volltext

Lead Optimization of N-3-Substituted 7-Morpholinotriazolopyrimidines as Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of PKI-402 von Dehnhardt, Christoph M, Venkatesan, Aranapakam M, Delos Santos, Efren, Chen, Zecheng, Santos, Osvaldo, Ayral-Kaloustian, Semiramis, Brooijmans, Natasja, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Chaudhary, Inder, Yu, Ker, Gibbons, Jay, Abraham, Robert, Mansour, Tarek S

Volltext

PKI-179: An orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor von Venkatesan, Aranapakam M., Chen, Zecheng, Santos, Osvaldo Dos, Dehnhardt, Christoph, Santos, Efren Delos, Ayral-Kaloustian, Semiramis, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Chaudhary, Inder, Mansour, Tarek S.

Volltext

2,4-Diamino-quinazolines as inhibitors of β-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer von Chen, Zecheng, Venkatesan, Aranapakam M., Dehnhardt, Christoph M., Santos, Osvaldo Dos, Santos, Efren Delos, Ayral-Kaloustian, Semiramis, Chen, Lei, Geng, Yi, Arndt, Kim T., Lucas, Judy, Chaudhary, Inder, Mansour, Tarek S.

Volltext

Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors von Dehnhardt, Christoph M., Venkatesan, Aranapakam M., Chen, Zecheng, Delos-Santos, Efren, Ayral-Kaloustian, Semiramis, Brooijmans, Natasja, Yu, Ker, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Mallon, Robert

Volltext

5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of β-lactamases von Venkatesan, Aranapakam M., Agarwal, Atul, Abe, Takao, Ushirogochi, Hideki, Ado, Mihira, Tsuyoshi, Takasaki, Dos Santos, Osvaldo, Li, Zhong, Francisco, Gerry, Lin, Yang I., Petersen, Peter J., Yang, Youjun, Weiss, William J., Shlaes, David M., Mansour, Tarek S.

Volltext

5-Ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-α and mTOR for the treatment of breast cancer von Zhang, Nan, Ayral-Kaloustian, Semiramis, Anderson, James T., Nguyen, Thai, Das, Sasmita, Venkatesan, Aranapakam M., Brooijmans, Natasja, Lucas, Judy, Yu, Ker, Hollander, Irwin, Mallon, Robert

Volltext

Novel purine and pyrazolo[3,4- d]pyrimidine inhibitors of PI3 kinase-α: Hit to lead studies von Gilbert, Adam M., Nowak, Pawel, Brooijmans, Natasja, Bursavich, Matthew G., Dehnhardt, Christoph, Santos, Efren Delos, Feldberg, Larry R., Hollander, Irwin, Kim, Stephen, Lombardi, Sabrina, Park, Kaapjoo, Venkatesan, Aranapakam M., Mallon, Robert

Volltext

Design and Synthesis of Novel Diaminoquinazolines with in Vivo Efficacy for β-Catenin/T-Cell Transcriptional Factor 4 Pathway Inhibition von Dehnhardt, Christoph M, Venkatesan, Aranapakam M, Chen, Zecheng, Ayral-Kaloustian, Semiramis, Dos Santos, Osvaldo, Delos Santos, Efren, Curran, Kevin, Follettie, Max T, Diesl, Veronica, Lucas, Judy, Geng, Yi, DeJoy, Susan Quinn, Petersen, Rosanne, Chaudhary, Inder, Brooijmans, Natasja, Mansour, Tarek S, Arndt, Kim, Chen, Lei

Volltext

Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors von Venkatesan, Aranapakam M., Dehnhardt, Christoph M., Chen, Zecheng, Santos, Efren Delos, Dos Santos, Osvaldo, Bursavich, Matthew, Gilbert, Adam M., Ellingboe, John W., Ayral-Kaloustian, Semiramis, Khafizova, Gulnaz, Brooijmans, Natasja, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Gibbons, Jay, Abraham, Robert, Mansour, Tarek S.

Volltext

A Novel, Mild, and Facile Method To Prepare 6-Methylidene Penem Derivatives von Abe, Takao, Sato, Chisato, Ushirogochi, Hideki, Sato, Koichi, Takasaki, Tsuyoshi, Isoda, Takeshi, Mihira, Ado, Yamamura, Itsuki, Hayashi, Kazuhiko, Kumagai, Toshio, Tamai, Satoshi, Shiro, Motoo, Venkatesan, Aranapakam M, Mansour, Tarek S

Volltext

Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity von Venkatesan, Aranapakam M, Dos Santos, O, Ellingboe, John, Evrard, Deborah A, Harrison, Boyd L, Smith, Deborah L, Scerni, Rosemary, Hornby, Geoffrey A, Schechter, Lee E, Andree, Terrence H

Volltext