LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition von Baron, Riccardo, Vellore, Nadeem A

Volltext

A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with ROS1-Rearranged Lung Cancer von Drilon, Alexander, Somwar, Romel, Wagner, Jacob P, Vellore, Nadeem A, Eide, Christopher A, Zabriskie, Matthew S, Arcila, Maria E, Hechtman, Jaclyn F, Wang, Lu, Smith, Roger S, Kris, Mark G, Riely, Gregory J, Druker, Brian J, O'Hare, Thomas, Ladanyi, Marc, Davare, Monika A

Volltext

Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors von Davare, Monika A., Vellore, Nadeem A., Wagner, Jacob P., Eide, Christopher A., Goodman, James R., Drilon, Alexander, Deininger, Michael W., O’Hare, Thomas, Druker, Brian J.

Volltext

Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin von Robertson, James C, Hurley, Nate C, Tortorici, Marcello, Ciossani, Giuseppe, Borrello, Maria Teresa, Vellore, Nadeem A, Ganesan, A, Mattevi, Andrea, Baron, Riccardo

Volltext

Molecular docking of bisphenol A and its nitrated and chlorinated metabolites onto human estrogen-related receptor-gamma von Babu, Sainath, Vellore, Nadeem A., Kasibotla, Agasthya V., Dwayne, Harlan J., Stubblefield, Michael A., Uppu, Rao M.

Volltext

Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities von Ali, Ahmed M., Gómez-Biagi, Rodolfo F., Rosa, David A., Lai, Ping-Shan, Heaton, William L., Park, Ji Sung, Eiring, Anna M., Vellore, Nadeem A., de Araujo, Elvin D., Ball, Dan P., Shouksmith, Andrew E., Patel, Ami B., Deininger, Michael W., O'Hare, Thomas, Gunning, Patrick T.

Volltext

Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 Mutants von Eide, Christopher A., Zabriskie, Matthew S., Savage Stevens, Samantha L., Antelope, Orlando, Vellore, Nadeem A., Than, Hein, Schultz, Anna Reister, Clair, Phillip, Bowler, Amber D., Pomicter, Anthony D., Yan, Dongqing, Senina, Anna V., Qiang, Wang, Kelley, Todd W., Szankasi, Philippe, Heinrich, Michael C., Tyner, Jeffrey W., Rea, Delphine, Cayuela, Jean-Michel, Kim, Dong-Wook, Tognon, Cristina E., O'Hare, Thomas, Druker, Brian J., Deininger, Michael W.

Volltext

BCR-ABL1 Compound Mutations Combining Key Kinase Domain Positions Confer Clinical Resistance to Ponatinib in Ph Chromosome-Positive Leukemia von Zabriskie, Matthew S., Eide, Christopher A., Tantravahi, Srinivas K., Vellore, Nadeem A., Estrada, Johanna, Nicolini, Franck E., Khoury, Hanna J., Larson, Richard A., Konopleva, Marina, Cortes, Jorge E., Kantarjian, Hagop, Jabbour, Elias J., Kornblau, Steven M., Lipton, Jeffrey H., Rea, Delphine, Stenke, Leif, Barbany, Gisela, Lange, Thoralf, Hernández-Boluda, Juan-Carlos, Ossenkoppele, Gert J., Press, Richard D., Chuah, Charles, Goldberg, Stuart L., Wetzler, Meir, Mahon, Francois-Xavier, Etienne, Gabriel, Baccarani, Michele, Soverini, Simona, Rosti, Gianantonio, Rousselot, Philippe, Friedman, Ran, Deininger, Marie, Reynolds, Kimberly R., Heaton, William L., Eiring, Anna M., Pomicter, Anthony D., Khorashad, Jamshid S., Kelley, Todd W., Baron, Riccardo, Druker, Brian J., Deininger, Michael W., O’Hare, Thomas

Volltext

LSD1/CoREST Reversible Opening–Closing Dynamics: Discovery of a Nanoscale Clamp for Chromatin and Protein Binding von Baron, Riccardo, Vellore, Nadeem A

Volltext

BCR-ABL1 tyrosine kinase inhibitor K0706 exhibits preclinical activity in Philadelphia chromosome-positive leukemia von Antelope, Orlando, Vellore, Nadeem A., Pomicter, Anthony D., Patel, Ami B., Van Scoyk, Alexandria, Clair, Phillip M., Deininger, Michael W., O'Hare, Thomas

Volltext

SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA von Yan, Dongqing, Franzini, Anca, Pomicter, Anthony D, Halverson, Brayden J, Antelope, Orlando, Mason, Clinton C, Ahmann, Jonathan M, Senina, Anna V, Vellore, Nadeem A, Jones, Courtney L, Zabriskie, Matthew S, Than, Hein, Xiao, Michael J, van Scoyk, Alexandria, Patel, Ami B, Clair, Phillip M, Heaton, William L, Owen, Shawn C, Andersen, Joshua L, Egbert, Christina M, Reisz, Julie A, D'Alessandro, Angelo, Cox, James E, Gantz, Kevin C, Redwine, Hannah M, Iyer, Siddharth M, Khorashad, Jamshid S, Rajabi, Nima, Olsen, Christian A, O'Hare, Thomas, Deininger, Michael W

Volltext

New Strategies in Myeloproliferative Neoplasms: The Evolving Genetic and Therapeutic Landscape von Patel, Ami B, Vellore, Nadeem A, Deininger, Michael W

Volltext

Identification of small-molecule protein-protein interaction inhibitors for NKG2D von Thompson, Aaron A, Harbut, Michael B, Kung, Pei-Pei, Karpowich, Nathan K, Branson, Jeffrey D, Grant, Joanna C, Hagan, Deborah, Pascual, Heather A, Bai, Guoyun, Zavareh, Reza Beheshti, Coate, Heather R, Collins, Bernard C, Côte, Marjorie, Gelin, Christine F, Damm-Ganamet, Kelly L, Gholami, Hadi, Huff, Adam R, Limon, Luis, Lumb, Kevin J, Mak, Puiying A, Nakafuku, Kohki M, Price, Edmund V, Shih, Amy Y, Tootoonchi, Mandana, Vellore, Nadeem A, Wang, Jocelyn, Wei, Na, Ziff, Jeannie, Berger, Scott B, Edwards, James P, Gardet, Agnès, Sun, Siquan, Towne, Jennifer E, Venable, Jennifer D, Shi, Zhicai, Venkatesan, Hariharan, Rives, Marie-Laure, Sharma, Sujata, Shireman, Brock T, Allen, Samantha J

Volltext

Assessment of the Transferability of a Protein Force Field for the Simulation of Peptide-Surface Interactions von Vellore, Nadeem A, Yancey, Jeremy A, Collier, Galen, Latour, Robert A, Stuart, Steven J

Volltext

Epigenetic Molecular Recognition: A Biomolecular Modeling Perspective von Vellore, Nadeem A., Baron, Riccardo

Volltext

Protein Recognition by Short Peptide Reversible Inhibitors of the Chromatin-Modifying LSD1/CoREST Lysine Demethylase von Tortorici, Marcello, Borrello, Maria Teresa, Tardugno, Maria, Chiarelli, Laurent R, Pilotto, Simona, Ciossani, Giuseppe, Vellore, Nadeem A, Bailey, Sarah G, Cowan, Jonathan, O’Connell, Maria, Crabb, Simon J, Packham, Graham, Mai, Antonello, Baron, Riccardo, Ganesan, A, Mattevi, Andrea

Volltext

Molecular dynamics simulations indicate an induced-fit mechanism for LSD1/CoREST-H3-histone molecular recognition von Vellore, Nadeem A, Baron, Riccardo

Volltext

Development of molecular simulation methods to accurately represent protein-surface interactions: Method assessment for the calculation of electrostatic effects von Collier, Galen, Vellore, Nadeem A, Latour, Robert A, Stuart, Steven J

Volltext

Comparison Between Empirical Protein Force Fields for the Simulation of the Adsorption Behavior of Structured LK Peptides on Functionalized Surfaces von Collier, Galen, Vellore, Nadeem A., Yancey, Jeremy A., Stuart, Steven J., Latour, Robert A.

Volltext

A marine analgesic peptide, Contulakin-G, and neurotensin are distinct agonists for neurotensin receptors: uncovering structural determinants of desensitization properties von Lee, Hee-Kyoung, Zhang, Liuyin, Smith, Misty D, Walewska, Aleksandra, Vellore, Nadeem A, Baron, Riccardo, McIntosh, J Michael, White, H Steve, Olivera, Baldomero M, Bulaj, Grzegorz

Volltext