Cell membranes… and how long drugs may exert beneficial pharmacological activity in vivo von Vauquelin, Georges

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Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands von Vauquelin, Georges, Charlton, Steven J

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Long‐lasting target binding and rebinding as mechanisms to prolong in vivo drug action von Vauquelin, Georges, Charlton, Steven J

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Distinct In Vitro Binding Profile of the Somatostatin Receptor Subtype 2 Antagonist [Lu-177]Lu-OPS201 Compared to the Agonist [Lu-177]Lu-DOTA-TATE von Mansi, Rosalba, Plas, Pascale, Vauquelin, Georges, Fani, Melpomeni

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Induced fit versus conformational selection: From rate constants to fluxes… and back to rate constants von Vauquelin, Georges, Maes, Dominique

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Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets von Erlendsson, Simon, Thorsen, Thor Seneca, Vauquelin, Georges, Ammendrup-Johnsen, Ina, Wirth, Volker, Martinez, Karen L, Teilum, Kaare, Gether, Ulrik, Madsen, Kenneth Lindegaard

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Distinct in vivo target occupancy by bivalent‐ and induced‐fit‐like binding drugs von Vauquelin, Georges

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A study of the molecular mechanism of binding kinetics and long residence times of human CCR5 receptor small molecule allosteric ligands von Swinney, David C, Beavis, Paul, Chuang, Kai‐Ting, Zheng, Yue, Lee, Ina, Gee, Peter, Deval, Jerome, Rotstein, David M, Dioszegi, Marianna, Ravendran, Palani, Zhang, Jun, Sankuratri, Surya, Kondru, Rama, Vauquelin, Georges

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Link between a high k on for drug binding and a fast clinical action: to be or not to be? von Vauquelin, Georges

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Link between a high kon for drug binding and a fast clinical action: to be or not to be? von Vauquelin, Georges

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Competition in drug binding and … the race to equilibrium von Vauquelin, Georges, Maes, Dominique

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Effects of target binding kinetics on in vivo drug efficacy: k off , k on and rebinding von Vauquelin, Georges

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Effects of target binding kinetics on in vivo drug efficacy: koff, kon and rebinding von Vauquelin, Georges

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Simplified models for heterobivalent ligand binding: when are they applicable and which are the factors that affect their target residence time von Vauquelin, Georges

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Molecular Mechanisms of Corticotropin-Releasing Factor Receptor-Induced Calcium Signaling von Gutknecht, Eric, Van der Linden, Ilse, Van Kolen, Kristof, Verhoeven, Kim F C, Vauquelin, Georges, Dautzenberg, Frank M

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Link between a high kon for drug binding and a fast clinical action: to be or not to be?Electronic supplementary information (ESI) available. See DOI: 10.1039/c8md00296g von Vauquelin, Georges

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Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent von Yang, Rui, Smolders, Ilse, Vanderheyden, Patrick, Demaegdt, Heidi, Van Eeckhaut, Ann, Vauquelin, Georges, Lukaszuk, Aneta, Tourwé, Dirk, Chai, Siew Yeen, Albiston, Anthony L, Nahmias, Clara, Walther, Thomas, Dupont, Alain G

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Radioligand binding to intact cells as a tool for extended drug screening in a representative physiological context von Vauquelin, Georges, Van Liefde, Isabelle, Swinney, David C.

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Induced fit versus conformational selection: From rate constants to fluxes horizontal ellipsis and back to rate constants von Vauquelin, Georges, Maes, Dominique

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Ligands to the (IRAP)/AT4 receptor encompassing a 4-hydroxydiphenylmethane scaffold replacing Tyr2 von ANDERSSON, Hanna, DEMAEGDT, Heidi, VAUQUELIN, Georges, LINDEBERG, Gunnar, KARLEN, Anders, HALLBERG, Mathias

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