WGS/WES-RNAseq compared to targeted NGS in oncology: is there something to unlock? von Aldea, M., Vasseur, D., Italiano, A., Nikolaev, S.I.

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Liquid versus tissue biopsy for detecting actionable alterations according to the ESMO Scale for Clinical Actionability of molecular Targets in patients with advanced cancer: a stu... von Bayle, A., Peyraud, F., Belcaid, L., Brunet, M., Aldea, M., Clodion, R., Dubos, P., Vasseur, D., Nicotra, C., Geraud, A., Sakkal, M., Cerbone, L., Blanc-Durand, F., Mosele, F., Martin Romano, P., Ngo Camus, M., Soubeyran, I., Khalifa, E., Alame, M., Blouin, L., Dinart, D., Bellera, C., Hollebecque, A., Ponce, S., Loriot, Y., Besse, B., Lacroix, L., Rouleau, E., Barlesi, F., Andre, F., Italiano, A.

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Single-cell DNA-seq depicts clonal evolution of multiple driver alterations in osimertinib-resistant patients von Chen, J., Facchinetti, F., Braye, F., Yurchenko, A.A., Bigot, L., Ponce, S., Planchard, D., Gazzah, A., Nikolaev, S., Michiels, S., Vasseur, D., Lacroix, L., Tselikas, L., Nobre, C., Olaussen, K.A., Andre, F., Scoazec, J.Y., Barlesi, F., Soria, J.C., Loriot, Y., Besse, B., Friboulet, L.

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Clinical utility of circulating tumor DNA sequencing with a large panel: a National Center for Precision Medicine (PRISM) study von Bayle, A., Belcaid, L., Aldea, M., Vasseur, D., Peyraud, F., Nicotra, C., Geraud, A., Sakkal, M., Seknazi, L., Cerbone, L., Blanc-Durand, F., Hadoux, J., Mosele, F., Tagliamento, M., Bernard-Tessier, A., Verret, B., Smolenschi, C., Clodion, R., Auger, N., Romano, P.M., Gazzah, A., Camus, M.N., Micol, J., Caron, O., Hollebecque, A., Loriot, Y., Besse, B., Lacroix, L., Rouleau, E., Ponce, S., Soria, J.C., Barlesi, F., Andre, F., Italiano, A.

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Detection of additional occult malignancy through profiling of ctDNA in late-stage cancer patients von Aldea, M., Cerbone, L., Bayle, A., Parisi, C., Sarkozy, C., Vasseur, D., Verlingue, L., Blanc-Durand, F., Mosele, F., Sakkal, M., Ponce, S., Lavaud, P., Loriot, Y., Hollebecque, A., Massard, C., Soria, J.-C., Lacroix, L., Rouleau, E., Italiano, A.

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Concomitant GNA11 and SF3B1 mutations in two cases of melanoma associated with blue naevus von Danset, M., Milley, S., Harou, O., Vasseur, D., Amini‐Adle, M., Thomas, L., Dalle, S., Balme, B., Lopez, J.

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International survey on PSA figures of merit von Vasseur, D., Llory, M.

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865P Molecular analysis of surgical margins in early oral carcinomas (OSCC) von Moya-Plana, A., Vasseur, D., Auperin, A., Casiraghi, O., André, F., Lacroix, L., Temam, S.

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Les nouveaux paradigmes de l'archive von Scopsi, Claire, Roullier, Clothilde, Sin Blima-Barru, Martine, Vasseur, Édouard

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922P Genomic instability as a biomarker for advanced cancer of the head and neck von Dall'Olio, F.G., Zrafi, W.S., Al Burshaid, D., Bassil, J., Pop, V.V., Vasseur, D., lacroix, L., Kannouche, P., Benihoud, K., Breuskin, I., Even, C.

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71P Usefulness of circulating mitochondrial DNA copy number as a prognostic biomarker in metastatic patients von Moreau, M., Nélo, V., Pata-Merci, N., Stourm, A., Saulnier, P., Rouleau, E., Lacroix, L., Vasseur, D.

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Qui suis-je ? Dis-moi qui tu es: L’identification des différents aspects juridiques de l’identité von Vasseur-Lambry, Fanny, Mutelet, Valerie

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705P TIMES: A ctDNA tumor fraction based and externally validated nomogram to predict survival in cancer patients referred for early phase trials von Italiano, A., Belcaid, L., Cousin, S., Trin, K., Bayle, A., Soubeyran, I., Alamé, M., Blouin, L., Rouleau, E., Lacroix, L., Vasseur, D., Bellera, C.

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191P Understanding and overcoming resistance to selective FGFR inhibitors across FGFR2-driven tumors von Facchinetti, F., Loriot, Y., Brayé, F., Vasseur, D., Bahleda, R., Bigot, L., Barbe, R., Nobre, C., Combarel, D., Michiels, S., Italiano, A., Smolenschi, C., Tselikas, L., Scoazec, J., Aix, S. Ponce, Besse, B., André, F., Olaussen, K.A., Hollebecque, A., Friboulet, L.

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230TiP Exploring mechanisms of action and resistance in innovate cancer therapies: The UNLOCK program von Alonso de Castro, B., Rodriguez, J.E., Mosele, M.F., Nicotra, C., Camus, M. Ngo, Scoazec, J., Vasseur, D., Bigot, L., Nikolaev, S., Wang, J., Gerome, J-C., Brayé, F., André, F., Aix, S. Ponce, Massard, C.P., Italiano, A., Loriot, Y., Friboulet, L.

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1705P Association between baseline radiological tumor burden (BRTB) and outcomes in metastatic clear cell renal cell carcinoma (mccRCC) treated with first line (1L) immunotherapy (... von Nawfal, R., Semaan, K., Eid, M., Paul, M., Saliby, R.M., El Hajj Chehade, R., Machaalani, M., Saad, E., Phillips, N., Canniff, J., Vasseur, D., El Zarif, T., Yekeduz, E., Sun, M., Baca, S., Braun, D.A., Xie, W., Krajewski, K., Choueiri, T.K.

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111P Leveraging circulating tumor DNA sequencing for first-line cancer treatment: Insights from two prospective precision medicine studies von Debien, V., Taleb, S., Cousin, S., Belcaid, L., Bayle, A., Taleb, I., Besson, A., El Ghazzi, N., Moreau, A., Laizet, Y., Alamé, M., Vasseur, D., Blouin, L., Khalifa, E., Lacroix, L., Soubeyran, I., Rouleau, E., Massard, C.P., Italiano, A.

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234P Do we need molecular profiling in patients with squamous anal carcinoma? von Smolenschi, C., Sharaf, R., Hollebecque, A., Facchinetti, F., Dallolio, F., Ouali, K., Italiano, A., Boileve, A., Valery, M., Pudlarz, T., Tarabay, A., Boige, V., Fuerea, A.C., Ducreux, M.P., Cheaib, B., Rodriguez, J.E., Massard, C.P., Gjoerup, O., Fine, A., Vasseur, D.

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Clinical utility of plasma ctDNA sequencing in metastatic urothelial cancer von Helal, Clara, Pobel, Cédric, Bayle, Arnaud, Vasseur, Damien, Nicotra, Claudio, Blanc-Durand, Félix, Naoun, Natacha, Bernard-Tessier, Alice, Patrikidou, Anna, Colomba, Emeline, Flippot, Ronan, Fuerea, Alina, Auger, Nathalie, Ngo Camus, Maud, Besse, Benjamin, Lacroix, Ludovic, Rouleau, Etienne, Ponce, Santiago, Italiano, Antoine, Loriot, Yohann

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587P Sequential approach to determine the HRD status with BRCA1 promotor methylation status and shallow whole genome sequencing (sWGS) von Rouleau, E., Blanc-Durand, F., Nashvi, M., Cotteret, S., Genestie, C., Le Formal, A., Pommier, M., Vasseur, D., Adnani, Y., Lacroix, L., Leary, A., Tang, R.

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