CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial von Cordoba, Shaun, Onuoha, Shimobi, Thomas, Simon, Pignataro, Daniela Soriano, Hough, Rachael, Ghorashian, Sara, Vora, Ajay, Bonney, Denise, Veys, Paul, Rao, Kanchan, Lucchini, Giovanna, Chiesa, Robert, Chu, Jan, Clark, Liz, Fung, Mei Mei, Smith, Koval, Peticone, Carlotta, Al-Hajj, Muhammad, Baldan, Vania, Ferrari, Mathieu, Srivastava, Saket, Jha, Ram, Arce Vargas, Frederick, Duffy, Kevin, Day, William, Virgo, Paul, Wheeler, Lucy, Hancock, Jeremy, Farzaneh, Farzin, Domning, Sabine, Zhang, Yiyun, Khokhar, Nushmia Z., Peddareddigari, Vijay G. R., Wynn, Robert, Pule, Martin, Amrolia, Persis J.

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The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2 von Hartwig, Torsten, Montinaro, Antonella, von Karstedt, Silvia, Sevko, Alexandra, Surinova, Silvia, Chakravarthy, Ankur, Taraborrelli, Lucia, Draber, Peter, Lafont, Elodie, Arce Vargas, Frederick, El-Bahrawy, Mona A., Quezada, Sergio A., Walczak, Henning

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Dual targeting of CD19 and CD22 with bicistronic CAR-T cells in patients with relapsed/refractory large B-cell lymphoma von Roddie, Claire, Lekakis, Lazaros J., Marzolini, Maria A. V., Ramakrishnan, Aravind, Zhang, Yiyun, Hu, Yanqing, Peddareddigari, Vijay G. R., Khokhar, Nushmia, Chen, Robert, Basilico, Silvia, Raymond, Meera, Vargas, Frederick Arce, Duffy, Kevin, Brugger, Wolfram, O’Reilly, Maeve A., Wood, Leigh, Linch, David C., Peggs, Karl S., Bachier, Carlos, Budde, Elizabeth Lihua, Lee Batlevi, Connie, Bartlett, Nancy, Irvine, David, Tholouli, Eleni, Osborne, Wendy, Ardeshna, Kirit M., Pule, Martin A.

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Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells von Śledzińska, Anna, Vila de Mucha, Maria, Bergerhoff, Katharina, Hotblack, Alastair, Demane, Dafne Franz, Ghorani, Ehsan, Akarca, Ayse U., Marzolini, Maria A.V., Solomon, Isabelle, Vargas, Frederick Arce, Pule, Martin, Ono, Masahiro, Seddon, Benedict, Kassiotis, George, Ariyan, Charlotte E., Korn, Thomas, Marafioti, Teresa, Lord, Graham M., Stauss, Hans, Jenner, Richard G., Peggs, Karl S., Quezada, Sergio A.

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CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity von Solomon, Isabelle, Amann, Maria, Goubier, Anne, Arce Vargas, Frederick, Zervas, Dimitrios, Qing, Chen, Henry, Jake Y., Ghorani, Ehsan, Akarca, Ayse U., Marafioti, Teresa, Śledzińska, Anna, Werner Sunderland, Mariana, Franz Demane, Dafne, Clancy, Joanne Ruth, Georgiou, Andrew, Salimu, Josephine, Merchiers, Pascal, Brown, Mark Adrian, Flury, Reto, Eckmann, Jan, Murgia, Claudio, Sam, Johannes, Jacobsen, Bjoern, Marrer-Berger, Estelle, Boetsch, Christophe, Belli, Sara, Leibrock, Lea, Benz, Joerg, Koll, Hans, Sutmuller, Roger, Peggs, Karl S., Quezada, Sergio A.

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Resolution of acute inflammation bridges the gap between innate and adaptive immunity von Newson, Justine, Stables, Melanie, Karra, Efthimia, Arce-Vargas, Frederick, Quezada, Sergio, Motwani, Madhur, Mack, Matthias, Yona, Simon, Audzevich, Tatsiana, Gilroy, Derek W.

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Fcγ-receptor tag team boosts anti-tumor immunity von Arce Vargas, Frederick, Quezada, Sergio A

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Molecular Recalibration of PD-1+ Antigen-Specific T Cells from Blood and Liver von Otano, Itziar, Escors, David, Schurich, Anna, Singh, Harsimran, Robertson, Francis, Davidson, Brian R., Fusai, Giuseppe, Vargas, Frederick A., Tan, Zhi M.D., Aw, Jia Y.J., Hansi, Navjyot, Kennedy, Patrick T.F., Xue, Shao-An, Stauss, Hans J., Bertoletti, Antonio, Pavesi, Andrea, Maini, Mala K.

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A compact and simple method of achieving differential transgene expression by exploiting translational readthrough von Sillibourne, James E, Agliardi, Giulia, Righi, Matteo, Smetanova, Katerina, Rowley, Grant, Speller, Simon, Dolor, Abigail, Lamb, Katarina, Allen, Christopher, Karattil, Rajeev, Parekh, Farhaan, Vargas, Frederick Arce, Thomas, Simon, Cordoba, Shaun, Pule, Martin

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Immunomodulatory antibodies for the treatment of lymphoma: Report on the CALYM Workshop von Houot, Roch, Gaulard, Philippe, Schreiber, Robert, Mellman, Ira, Lambotte, Olivier, Coulie, Pierre G, Fest, Thierry, Korman, Alan, Levy, Ronald, Shipp, Margaret, Tarte, Karin, Kohrt, Holbrook, Marabelle, Aurélien, Ansell, Stephen, Watier, Hervé, van Elsas, Andrea, Balakumaran, Arun, Arce Vargas, Frederick, Quezada, Sergio A, Salles, Gilles, Olive, Daniel

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Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors von Lesko, Marta H., Miranda Rota, Enrique, Dahan, Rony, Georgiou, Andrew, Sledzinska, Anna, Werner Sunderland, Mariana, Nicol, David, Beers, Stephen A., Wotherspoon, Andrew, Hayes, Andrew, Stares, Mark, Pickering, Lisa, Rudman, Sarah, Veeriah, Selvaraju, Shafi, Seema, Laycock, Joanne, Bosshard-Carter, Leticia, Goh, Gerald, Rosenthal, Rachel, Hynds, Robert E., Birkbak, Nicolai J., McGranahan, Nicholas, Mitter, Richard, Stewart, Aengus, Rowan, Andrew, Turajlic, Samra, Abbosh, Christopher, Goldman, Jacki, Denner, Tamara, Ward, Sophia, Costa, Marta, Lowe, Helen L., Lawrence, David, Kolvekar, Shyam, Falzon, Mary, Simeon, Celia, Hector, Gemma, Novelli, Marco, Forster, Martin, Papadatos-Pastos, Dionysis, Carnell, Dawn, Navani, Neal, Ahmed, Asia, Taylor, Magali, Choudhary, Junaid, Taylor, Paul, Rammohan, Kendadai, Fontaine, Eustace, Booton, Richard, Moss, Stuart, Idries, Faiza, Joseph, Leena, Moore, Katrina, Waddington, Rachael, Novasio, Juliette, Blackhall, Fiona, Rogan, Jane, Tugwood, Jonathan, Rothwell, Dominic G., Pierce, Jackie, Gulati, Sakshi, Kerr, Amy, Webb, Joanne, Moore, David, Monteiro, William, Marshall, Hilary, Nelson, Louise, Amadi, Anita, Remmen, Hardy, Miller, Joy, Morgan, Fiona, Kornaszewska, Malgorzata, Bell, Harriet, Smith, Sean, Johnson, Benjamin, Lim, Eric, Barbosa, Monica Tavares, Bowman, Alex, Ronquillo, John Carlo, Bhayani, Harshil, Hamilton, Morag, Bakar, Yusura, Mensah, Natalie, Buderi, Silviu, Finch, Jonathan, Green, Sophie, Nicholson, Andrew G., Lau, Kelvin, Schmid, Peter, Conibear, John, Ezhil, Veni, Ismail, Babikir, Prakash, Vineet, Horey, Tracey, Swanton, Charles, Chester, Kerry A., Ravetch, Jeffrey V., Marafioti, Teresa, Peggs, Karl S., Quezada, Sergio A.

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TALEN-Mediated Inactivation of PD-1 in Tumor-Reactive Lymphocytes Promotes Intratumoral T-cell Persistence and Rejection of Established Tumors von Menger, Laurie, Sledzinska, Anna, Bergerhoff, Katharina, Vargas, Frederick Arce, Smith, Julianne, Poirot, Laurent, Pule, Martin, Hererro, Javier, Peggs, Karl S, Quezada, Sergio A

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Abstract 2661: AUTO6NG overcomes immune suppressive mechanisms in the TME and demonstrate preclinical anti-tumor activity in GD2-expressing solid tumors von Neves, Margarida, Stanczuk, Lukas, Alavi, Alireza, Czapiga, Meggan, Moore, Rebecca, Vargas, Frederick, Al-Hajj, Muhammad A.

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Fc[gamma]-receptor tag team boosts anti-tumor immunity von Arce Vargas, Frederick, Quezada, Sergio A

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Impact of tumour microenvironment and Fc receptors on the activity of immunomodulatory antibodies von Furness, Andrew J.S, Vargas, Frederick Arce, Peggs, Karl S, Quezada, Sergio A

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Industrialization of an Academic Miltenyi Prodigy-Based CAR T Process von Culshaw, Abigail, Arce Vargas, Frederick, Santiago Toledo, Gerardo, Roddie, Claire, Shaughnessy, Paul, Cerec, Virginie, Duffy, Kevin, Perna, Serena, Brugger, Wolfram, Merges, Michael, Pule, Martin

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CD25-T reg -depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity von Solomon, Isabelle, Amann, Maria, Goubier, Anne, Arce Vargas, Frederick, Zervas, Dimitrios, Qing, Chen, Henry, Jake Y, Ghorani, Ehsan, Akarca, Ayse U, Marafioti, Teresa, Śledzińska, Anna, Werner Sunderland, Mariana, Franz Demane, Dafne, Clancy, Joanne Ruth, Georgiou, Andrew, Salimu, Josephine, Merchiers, Pascal, Brown, Mark Adrian, Flury, Reto, Eckmann, Jan, Murgia, Claudio, Sam, Johannes, Jacobsen, Bjoern, Marrer-Berger, Estelle, Boetsch, Christophe, Belli, Sara, Leibrock, Lea, Benz, Joerg, Koll, Hans, Sutmuller, Roger, Peggs, Karl S, Quezada, Sergio A

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Abstract 3143: A novel approach to deplete Treg cells using non-IL-2 blocking anti-CD25-targeting antibodies leads to complete rejection of established tumors von Solomon, Isabelle, Vargas, Frederick Arce, Zervas, Dimitrios, Qing, Chen, Salimu, Josephine, Brown, Mark, Merchiers, Pascal, Boughetane, Aghiles, Peggs, Karl S., Goubier, Anne, Quezada, Sergio A.

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Abstract 2787: Generation of first-in-class anti-CD25 antibodies depleting Treg without interfering with IL2 signalling for cancer therapies von Salimu, Josephine C., Brown, Mark, Merchiers, Pascal, Goyenechea, Beatriz, Moulder, Kevin, Dejonge, Robert, Boughetane, Aghiles, Solomon, Isabelle, Vargas, Frederick Arce, Peggs, Karl S., Goubier, Anne, Quezada, Sergio A.

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CMV promotes recipient T-cell immunity following reduced-intensity T-cell–depleted HSCT, significantly modulating chimerism status von Sellar, Rob S., Vargas, Frederick Arce, Henry, Jake Y., Verfuerth, Stephanie, Charrot, Sarah, Beaton, Brendan, Chakraverty, Ronjon, Quezada, Sergio A., Mackinnon, Stephen, Thomson, Kirsty J., Peggs, Karl S.

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