Characterization of a novel KDM1A/LSD1 inhibitor DDP_38003 in preclinical models of human and murine acute myeloid leukemia von Mercurio, C, Botrugno, O.A, Brambillasca, S, Cera, M, Cappa, A, Dal Zuffo, R, Dessanti, P, Meroni, G, Thaler, F, Trifirò, P, Villa, M, Minucci, S, So, E.C.W, Varasi, M, Vianello, P

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New reversible inhibitors of histone lysine demethylase (KDM1A/LSD1). From high throughput screening to the identification of low nanomolar inhibitors with cellular activity von Vianello, P, Sartori, L, Amigoni, F, Cappa, A, Faga', G, Mattevi, A, Meroni, G, Moretti, L, Pasqualato, S, Cecatiello, V, Romussi, A, Trifiro', P, Varasi, M, Villa, M, Minucci, S, Vultaggio, S, Zagarri, E, Mercurio, C

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571 Novel potent inhibitors of the Histone Demethylase KDM1A: Synthesis, pharmacological evaluation and in vivo activity von Varasi, M, Botrugno, O, Cappa, A, Dal Zuffo, R, Dessanti, P, Mai, A, Mattevi, A, Mercurio, C, Meroni, G, Minucci, S, Thaler, F, Trifiro', P, Valente, S, Vianello, P, Villa, M

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Effectiveness of anthracycline against experimental prion disease in Syrian hamsters von Tagliavini, F. (Istituto Nazionale Neurologico Carlo Besta, Milano, Italy.), McArthur, R.A, Canciani, B, Giaccone, G, Porro, M, Bugiani, M, Lievens, P.M.J, Bugiani, O, Peri, E, Dall'Ara, P

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Pharmacological screening identified promising combination partners in marginal zone lymphoma models with secondary resistance to BTK and PI3K inhibitors von Arribas, A., Vultaggio, S., Andronache, A., Robusto, M., Fancelli, D., Cannas, E., Spriano, F., Tarantelli, C., Rossi, D., Zucca, E., Stathis, A., Varasi, M., Mercurio, C., Bertoni, F.

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Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo von Wu, H.-Q, Guidetti, P, Goodman, J.H, Varasi, M, Ceresoli-Borroni, G, Speciale, C, Scharfman, H.E, Schwarcz, R

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3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 1. Lead Finding von Pevarello, Paolo, Brasca, Maria Gabriella, Amici, Raffaella, Orsini, Paolo, Traquandi, Gabriella, Corti, Luca, Piutti, Claudia, Sansonna, Pietro, Villa, Manuela, Pierce, Betsy S, Pulici, Maurizio, Giordano, Patrizia, Martina, Katia, Fritzen, Edward L, Nugent, Richard A, Casale, Elena, Cameron, Alexander, Ciomei, Marina, Roletto, Fulvia, Isacchi, Antonella, Fogliatto, GianPaolo, Pesenti, Enrico, Pastori, Wilma, Marsiglio, Aurelio, Leach, Karen L, Clare, Paula M, Fiorentini, Francesco, Varasi, Mario, Vulpetti, Anna, Warpehoski, Martha A

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Potent and Selective Aurora Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition von Fancelli, Daniele, Berta, Daniela, Bindi, Simona, Cameron, Alexander, Cappella, Paolo, Carpinelli, Patrizia, Catana, Cornel, Forte, Barbara, Giordano, Patrizia, Giorgini, Maria Laura, Mantegani, Sergio, Marsiglio, Aurelio, Meroni, Maurizio, Moll, Juergen, Pittalà, Valeria, Roletto, Fulvia, Severino, Dino, Soncini, Chiara, Storici, Paola, Tonani, Roberto, Varasi, Mario, Vulpetti, Anna, Vianello, Paola

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3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 2. Lead Optimization von Pevarello, Paolo, Brasca, Maria Gabriella, Orsini, Paolo, Traquandi, Gabriella, Longo, Antonio, Nesi, Marcella, Orzi, Fabrizio, Piutti, Claudia, Sansonna, Pietro, Varasi, Mario, Cameron, Alexander, Vulpetti, Anna, Roletto, Fulvia, Alzani, Rachele, Ciomei, Marina, Albanese, Clara, Pastori, Wilma, Marsiglio, Aurelio, Pesenti, Enrico, Fiorentini, Francesco, Bischoff, Jim R, Mercurio, Ciro

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259 - Characterization of a novel KDM1A/LSD1 inhibitor DDP_38003 in preclinical models of human and murine acute myeloid leukemia von Mercurio, C., Botrugno, O.A., Brambillasca, S., Cera, M., Cappa, A., Dal Zuffo, R., Dessanti, P., Meroni, G., Thaler, F., Trifirò, P., Villa, M., Minucci, S., So, E.C.W., Varasi, M., Vianello, P.

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High-Throughput NMR-Based Screening with Competition Binding Experiments von Dalvit, Claudio, Flocco, Maria, Knapp, Stefan, Mostardini, Marina, Perego, Rita, Stockman, Brian J, Veronesi, Marina, Varasi, Mario

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A New Glycociamidine Ring Precursor:  Syntheses of (Z)-Hymenialdisine, (Z)-2-Debromohymenialdisine, and (±)-endo-2-Debromohymenialdisine von Papeo, Gianluca, Posteri, Helena, Borghi, Daniela, Varasi, Mario

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260 - New reversible inhibitors of histone lysine demethylase (KDM1A/LSD1). From high throughput screening to the identification of low nanomolar inhibitors with cellular activity von Vianello, P., Sartori, L., Amigoni, F., Cappa, A., Faga', G., Mattevi, A., Meroni, G., Moretti, L., Pasqualato, S., Cecatiello, V., Romussi, A., Trifiro', P., Varasi, M., Villa, M., Minucci, S., Vultaggio, S., Zagarri, E., Mercurio, C.

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Study of indium bumps for the ATLAS pixel detector von Gemme, C., Fiorello, A.M., Gagliardi, G., Gilchriese, M., Netchaeva, P., Rossi, L., Ruscino, E., Vernocchi, F., Varasi, M.

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Targeting the scaffolding role of LSD1 (KDM1A) poises acute myeloid leukemia cells for retinoic acid–induced differentiation von Ravasio, R, Ceccacci, E, Nicosia, L, Hosseini, A, Rossi, PL, Barozzi, I, Fornasari, L, Zuffo, RD, Valente, S, Fioravanti, R, Mercurio, C, Varasi, M, Mattevi, A, Mai, A, Pavesi, G, Bonaldi, T, Minucci, S

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3-Amino-1,4,5,6-tetrahydropyrrolo[3,4- c]pyrazoles: A new class of CDK2 inhibitors von Pevarello, Paolo, Fancelli, Daniele, Vulpetti, Anna, Amici, Raffaella, Villa, Manuela, Pittalà, Valeria, Vianello, Paola, Cameron, Alexander, Ciomei, Marina, Mercurio, Ciro, Bischoff, James R., Roletto, Fulvia, Varasi, Mario, Brasca, Maria Gabriella

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Total synthesis of (±)-cyclooroidin von Papeo, Gianluca, Frau, María Antonia Gómez-Zurita, Borghi, Daniela, Varasi, Mario

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Synthesis of dihydrolysergol analogues von Mantegani, Sergio, Traquandi, Gabriella, Varasi, Mario

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Nicotinoyl Azide (NCA)-Mediated Mitsunobu Reaction: An Expedient One-Pot Transformation of Alcohols into Azides von Papeo, Gianluca, Posteri, Helena, Vianello, Paola, Varasi, Mario

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An Easy Entry to (1S, 2S) and (1R, 2R)-Threo-Ifenprodil von Mantegani, Sergio, Arlandini, Emanuele, Brambilla, Enzo, Cremonesi, Paolo, Varasi, Mario

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