Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens von Carette, Jan E, Guimaraes, Carla P, Varadarajan, Malini, Park, Annie S, Wuethrich, Irene, Godarova, Alzbeta, Kotecki, Maciej, Cochran, Brent H, Spooner, Eric, Ploegh, Hidde L, Brummelkamp, Thijn R

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Generation of iPSCs from cultured human malignant cells von Carette, Jan E., Pruszak, Jan, Varadarajan, Malini, Blomen, Vincent A., Gokhale, Sumita, Camargo, Fernando D., Wernig, Marius, Jaenisch, Rudolf, Brummelkamp, Thijn R.

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haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin von Reiling, Jan H, Clish, Clary B, Carette, Jan E, Varadarajan, Malini, Brummelkamp, Thijn R, Sabatini, David M

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CRISPR screening identifies T cell-intrinsic regulators of CD3-bispecific antibody responses von Molony, Ryan D., Funk, Theresa, Trabucco, Gina, Corcoran, Erik, Ruddy, David, Varadarajan, Malini, Elliot, GiNell, Piquet, Michelle, Lam, Joni, Meyer, Matthew J., Wang, Hui Qin, Kurtulus, Sema, Lu, Haihui

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Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome von Tsvetkov, Peter, Mendillo, Marc L, Zhao, Jinghui, Carette, Jan E, Merrill, Parker H, Cikes, Domagoj, Varadarajan, Malini, van Diemen, Ferdy R, Penninger, Josef M, Goldberg, Alfred L, Brummelkamp, Thijn R, Santagata, Sandro, Lindquist, Susan

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Identification of host cell factors required for intoxication through use of modified cholera toxin von Guimaraes, Carla P, Carette, Jan E, Varadarajan, Malini, Antos, John, Popp, Maximilian W, Spooner, Eric, Brummelkamp, Thijn R, Ploegh, Hidde L

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Genome-wide CRISPR screen identifies protein pathways modulating tau protein levels in neurons von Sanchez, Carlos G., Acker, Christopher M., Gray, Audrey, Varadarajan, Malini, Song, Cheng, Cochran, Nadire R., Paula, Steven, Lindeman, Alicia, An, Shaojian, McAllister, Gregory, Alford, John, Reece-Hoyes, John, Russ, Carsten, Craig, Lucas, Capre, Ketthsy, Doherty, Christian, Hoffman, Gregory R., Luchansky, Sarah J., Polydoro, Manuela, Dolmetsch, Ricardo, Elwood, Fiona

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Identification of a novel NAMPT inhibitor by CRISPR/Cas9 chemogenomic profiling in mammalian cells von Estoppey, David, Hewett, Jeffrey W., Guy, Chantale T., Harrington, Edmund, Thomas, Jason R., Schirle, Markus, Cuttat, Rachel, Waldt, Annick, Gerrits, Bertran, Yang, Zinger, Schuierer, Sven, Pan, Xuewen, Xie, Kevin, Carbone, Walter, Knehr, Judith, Lindeman, Alicia, Russ, Carsten, Frias, Elizabeth, Hoffman, Gregory R., Varadarajan, Malini, Ramadan, Nadire, Reece-Hoyes, John S., Wang, Qiong, Chen, Xin, McAllister, Gregory, Roma, Guglielmo, Bouwmeester, Tewis, Hoepfner, Dominic

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Global gene disruption in human cells to assign genes to phenotypes by deep sequencing von Ploegh, Hidde L, Brummelkamp, Thijn R, Carette, Jan E, Guimaraes, Carla P, Wuethrich, Irene, Blomen, Vincent A, Varadarajan, Malini, Sun, Chong, Bell, George, Yuan, Bingbing, Muellner, Markus K, Nijman, Sebastian M

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SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms von Wang, Ye, Mohseni, Morvarid, Grauel, Angelo, Diez, Javier Estrada, Guan, Wei, Liang, Simon, Choi, Jiyoung Elizabeth, Pu, Minying, Chen, Dongshu, Laszewski, Tyler, Schwartz, Stephanie, Gu, Jane, Mansur, Leandra, Burks, Tyler, Brodeur, Lauren, Velazquez, Roberto, Kovats, Steve, Pant, Bhavesh, Buruzula, Giri, Deng, Emily, Chen, Julie T., Sari-Sarraf, Farid, Dornelas, Christina, Varadarajan, Malini, Yu, Haiyan, Liu, Chen, Lim, Joanne, Hao, Huai-Xiang, Jiang, Xiaomo, Malamas, Anthony, LaMarche, Matthew J., Geyer, Felipe Correa, McLaughlin, Margaret, Costa, Carlotta, Wagner, Joel, Ruddy, David, Jayaraman, Pushpa, Kirkpatrick, Nathaniel D., Zhang, Pu, Iartchouk, Oleg, Aardalen, Kimberly, Cremasco, Viviana, Dranoff, Glenn, Engelman, Jeffrey A., Silver, Serena, Wang, Hongyun, Hastings, William D., Goldoni, Silvia

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Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome von Tsvetkov, Peter, Mendillo, Marc L, Zhao, Jinghui, Carette, Jan E, Merrill, Parker H, Cikes, Domagoj, Varadarajan, Malini, van Diemen, Ferdy R, Penninger, Josef M, Goldberg, Alfred L, Brummelkamp, Thijn R, Santagata, Sandro, Lindquist, Susan

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Global gene disruption in human cells to assign genes to phenotypes von Carette, Jan E., Guimaraes, Carla P., Wuethrich, Irene, Blomen, Vincent A., Varadarajan, Malini, Sun, Chong, Bell, George, Yuan, Bingbing, Muellner, Markus K., Nijman, Sebastian M., Ploegh, Hidde L., Brummelkamp, Thijn R.

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Alternative splicing of an rnp-4f mRNA isoform retaining an evolutionarily-conserved 5′-UTR intronic element is developmentally regulated and shown via RNAi to be essential for nor... von Chen, Jing, Concel, Vincent J., Bhatla, Sunetra, Rajeshwaran, Rajkumar, Smith, Darcey L.H., Varadarajan, Malini, Backscheider, Kimberly L., Bockrath, Robyn A., Petschek, Jane P., Vaughn, Jack C.

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Effect of the killing style of individual CAR T cells on the clinicopathological behavior of therapeutic products in the clinic von Gad, Ahmed Z, Morris, Jessica S, Godret-Miertschin, Lea, Montalvo, Melisa J, Berger, Harrison, Brock, Rebecca M, Fousek, Kristen, Srinivasan, Madhuwanti, Saeedi, Arash, Levental, Kandice, Mamonkin, Maksim, Carisey, Alexandre, Varadarajan, Navin, Hegde, Meenakshi, Joseph, Sujith, Levental, Ilya, Mukherjee, Malini, Ahmed, Nabil

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Predictive modeling for healthcare worker well-being with cloud computing and machine learning for stress management von Sudha, Muthukathan Rajendran, Malini, Gnanamuthu Bai Hema, Sankar, Rangasamy, Mythily, Murugaaboopathy, Kumaresh, Piskala Sathiyamurthy, Varadarajan, Mageshkumar Naarayanasamy, Sujatha, Shanmugam

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