Commercial Route Research and Development for SGLT2 Inhibitor Candidate Ertugliflozin von Bowles, Paul, Brenek, Steven J, Caron, Stéphane, Do, Nga M, Drexler, Michele T, Duan, Shengquan, Dubé, Pascal, Hansen, Eric C, Jones, Brian P, Jones, Kris N, Ljubicic, Tomislav A, Makowski, Teresa W, Mustakis, Jason, Nelson, Jade D, Olivier, Mark, Peng, Zhihui, Perfect, Hahdi H, Place, David W, Ragan, John A, Salisbury, John J, Stanchina, Corey L, Vanderplas, Brian C, Webster, Mark E, Weekly, R. Matt

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Development of the Commercial Route for the Manufacture of a 5‑Lipoxygenase Inhibitor PF-04191834 von Chekal, Brian, Damon, David, LaFrance, Danny, Leeman, Kyle, Mojica, Carlos, Palm, Andrew, St. Pierre, Michael, Sieser, Janice, Sutherland, Karen, Vaidyanathan, Rajappa, Van Alsten, John, Vanderplas, Brian, Wager, Carrie, Weisenburger, Gerald, Withbroe, Gregory, Yu, Shu

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A Robust, Streamlined Approach to Bosutinib Monohydrate von Withbroe, Gregory J, Seadeek, Chris, Girard, Kevin P, Guinness, Steven M, Vanderplas, Brian C, Vaidyanathan, Rajappa

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Synthesis of Filibuvir. Part II. Second-Generation Synthesis of a 6,6-Disubstituted 2H‑Pyranone via Dieckmann Cyclization of a β‑Acetoxy Ester von Peng, Zhihui, Ragan, John A, Colon-Cruz, Roberto, Conway, Brian G, Cordi, Eric M, Leeman, Kyle, Letendre, Leo J, Ping, Li-Jen, Sieser, Janice E, Singer, Robert A, Sluggett, Gregory W, Strohmeyer, Holly, Vanderplas, Brian C, Blunt, Jon, Mawby, Nicola, Meldrum, Kevin, Taylor, Stuart

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Development of a Practical and Efficient Synthesis of Chloromethyl 2-Ethoxy-2-methylpropanoate von Ragan, John A, Ide, Nathan D, Cai, Weiling, Cawley, James J, Colon-Cruz, Roberto, Kumar, Rajesh, Peng, Zhihui, Vanderplas, Brian C

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Regioselective Addition of Mesitol to a 2,4-Dichloropyridine von Ruggeri, Sally Gut, Vanderplas, Brian C, Anderson, Bruce G, Breitenbach, Ralph, Urban, Frank J, Stewart, III, A. Morgan, Young, Gregory R

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LARGE SCALE, GREEN SYNTHESIS OF A GENERATION-1 MELAMINE (TRIAZINE) DENDRIMER von Chouai, Abdellatif, Venditto, Vincent J, Simanek, Eric E, Vanderplas, Brian C, Ragan, John A

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Development of a Practical and Efficient Synthesis of CP-945,598-01, a CB1 Antagonist for the Treatment of Obesity von Ragan, John A, Bourassa, Dennis E, Blunt, Jon, Breen, Darragh, Busch, Frank R, Cordi, Eric M, Damon, David B, Do, Nga, Engtrakul, Alanya, Lynch, Denis, McDermott, Ruth E, Mongillo, Joseph A, O’Sullivan, Maria M, Rose, Peter R, Vanderplas, Brian C

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A Chemoenzymatic Route to Chiral Intermediates Used in the Multikilogram Synthesis of a Gamma Secretase Inhibitor von Burns, Michael, Martinez, Carlos A, Vanderplas, Brian, Wisdom, Richard, Yu, Shu, Singer, Robert A

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Safe Execution of a Large-Scale Ozonolysis:  Preparation of the Bisulfite Adduct of 2-Hydroxyindan-2-carboxaldehyde and Its Utility in a Reductive Amination von Ragan, John A, am Ende, David J, Brenek, Steven J, Eisenbeis, Shane A, Singer, Robert A, Tickner, Derek L, Teixeira, John J, Vanderplas, Brian C, Weston, Neil

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Oxidation of carbamate-protected alkylhydrazines to the corresponding hydrazones under Swern conditions von Dupont, Joseph, Bemish, R.J, McCarthy, Keith E, Payne, Emily R, Pollard, Ernest B, Ripin, David H.B, Vanderplas, Brian C, Watrous, Richard M

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Development of two synthetic routes to CE-178,253, a CB1 antagonist for the treatment of obesity von Brandt, Thomas A., Caron, Stéphane, Damon, David B., DiBrino, Joseph, Ghosh, Arun, Griffith, David A., Kedia, Sandeep, Ragan, John A., Rose, Peter R., Vanderplas, Brian C., Wei, Lulin

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Process Research and Scale-up of the κ-Opioid Receptor Agonist CJ-15,161 Drug Candidate von Brian M. Andresen, Brian C. Vanderplas, John L. Tucker, Janice E. Sieser, Maxime Riou, Teresa M. Makowski, Joel M. Hawkins, Melina Girardin, Arun Ghosh, Kristina Dupont-Gaudet, Nga M. Do, Keith M. DeVries, Michel Couturier, Stéphane Caron, Timothy J.N. Watson

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Synthesis of Filibuvir. Part II. Second-Generation Synthesis of a 6,6-Disubstituted 2 H -Pyranone via Dieckmann Cyclization of a β-Acetoxy Ester von Peng, Zhihui, Ragan, John A., Colon-Cruz, Roberto, Conway, Brian G., Cordi, Eric M., Leeman, Kyle, Letendre, Leo J., Ping, Li-Jen, Sieser, Janice E., Singer, Robert A., Sluggett, Gregory W., Strohmeyer, Holly, Vanderplas, Brian C., Blunt, Jon, Mawby, Nicola, Meldrum, Kevin, Taylor, Stuart

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Development of two synthetic routes to CE-178,253, a CB1 antagonist for the treatment of obesity: Recent Advances in Synthetic Methodology: Development and Applications von BRANDT, Thomas A, CARON, Stéphane, LULIN WEI, DAMON, David B, DIBRINO, Joseph, GHOSH, Arun, GRIFFITH, David A, KEDIA, Sandeep, RAGAN, John A, ROSE, Peter R, VANDERPLAS, Brian C

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Synthesis of an optically active octahydro-2H-pyrido[1,2-a]pyrazine based CNS agent von Urban, Frank J, Breitenbach, Ralph, Murtiashaw, Charles W, Vanderplas, Brian C

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Development of a Practical and Efficient Synthesis of CP-945,598-01, a CB 1 Antagonist for the Treatment of Obesity von Ragan, John A., Bourassa, Dennis E., Blunt, Jon, Breen, Darragh, Busch, Frank R., Cordi, Eric M., Damon, David B., Do, Nga, Engtrakul, Alanya, Lynch, Denis, McDermott, Ruth E., Mongillo, Joseph A., O’Sullivan, Maria M., Rose, Peter R., Vanderplas, Brian C.

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Efficient synthesis of the κ-opioid receptor agonist CJ-15,161: four stereospecific inversions at a single aziridinium stereogenic center von Couturier, Michel, Tucker, John L., Andresen, Brian M., DeVries, Keith M., Vanderplas, Brian C., Ito, Fumitaka

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Process Research and Scale-Up for a β-3 Adrenergic Receptor Agonist von Vanderplas, Brian C., DeVries, Keith M., Fox, Darrell E., Raggon, Jeffrey W., Snyder, Michael W., Urban, Frank J.

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The preparation of β-substituted amines from mixtures of epoxide opening products via a common aziridinium ion intermediate von Anderson, Shelby R., Ayers, Joshua T., DeVries, Keith M., Fumitaka Ito, Mendenhall, Debra, Vanderplas, Brian C.

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