ABT-199, a new Bcl-2–specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia von Vandenberg, Cassandra J., Cory, Suzanne

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DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa von Kerr, Jeffrey B., Hutt, Karla J., Michalak, Ewa M., Cook, Michele, Vandenberg, Cassandra J., Liew, Seng H., Bouillet, Philippe, Mills, Alea, Scott, Clare L., Findlay, Jock K., Strasser, Andreas

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Acquired RAD51C Promoter Methylation Loss Causes PARP Inhibitor Resistance in High-Grade Serous Ovarian Carcinoma von Nesic, Ksenija, Kondrashova, Olga, Hurley, Rachel M, McGehee, Cordelia D, Vandenberg, Cassandra J, Ho, Gwo-Yaw, Lieschke, Elizabeth, Dall, Genevieve, Bound, Nirashaa, Shield-Artin, Kristy, Radke, Marc, Musafer, Ashan, Chai, Zi Qing, Ghamsari, Mohammad Reza Eftekhariyan, Harrell, Maria I, Kee, Damien, Olesen, Inger, McNally, Orla, Traficante, Nadia, Australian Ovarian Cancer Study, DeFazio, Anna, Bowtell, David D L, Swisher, Elizabeth M, Weroha, S John, Nones, Katia, Waddell, Nicola, Kaufmann, Scott H, Dobrovic, Alexander, Wakefield, Matthew J, Scott, Clare L

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Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells von Sathe, Priyanka, Delconte, Rebecca B., Souza-Fonseca-Guimaraes, Fernando, Seillet, Cyril, Chopin, Michael, Vandenberg, Cassandra J., Rankin, Lucille C., Mielke, Lisa A., Vikstrom, Ingela, Kolesnik, Tatiana B., Nicholson, Sandra E., Vivier, Eric, Smyth, Mark J., Nutt, Stephen L., Glaser, Stefan P., Strasser, Andreas, Belz, Gabrielle T., Carotta, Sebastian, Huntington, Nicholas D.

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized von van Delft, Mark F., Wei, Andrew H., Mason, Kylie D., Vandenberg, Cassandra J., Chen, Lin, Czabotar, Peter E., Willis, Simon N., Scott, Clare L., Day, Catherine L., Cory, Suzanne, Adams, Jerry M., Roberts, Andrew W., Huang, David C.S.

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Targeting homologous recombination deficiency in uterine leiomyosarcoma von Dall, Genevieve, Vandenberg, Cassandra J, Nesic, Ksenija, Ratnayake, Gayanie, Zhu, Wenying, Vissers, Joseph H A, Bedő, Justin, Penington, Jocelyn, Wakefield, Matthew J, Kee, Damien, Carmagnac, Amandine, Lim, Ratana, Shield-Artin, Kristy, Milesi, Briony, Lobley, Amanda, Kyran, Elizabeth L, O'Grady, Emily, Tram, Joshua, Zhou, Warren, Nugawela, Devindee, Stewart, Kym Pham, Caldwell, Reece, Papadopoulos, Lia, Ng, Ashley P, Dobrovic, Alexander, Fox, Stephen B, McNally, Orla, Power, Jeremy D, Meniawy, Tarek, Tan, Teng Han, Collins, Ian M, Klein, Oliver, Barnett, Stephen, Olesen, Inger, Hamilton, Anne, Hofmann, Oliver, Grimmond, Sean, Papenfuss, Anthony T, Scott, Clare L, Barker, Holly E

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Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis von Grabow, Stephanie, Delbridge, Alex R.D., Aubrey, Brandon J., Vandenberg, Cassandra J., Strasser, Andreas

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Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance von Campbell, Kirsteen J., Bath, Mary L., Turner, Marian L., Vandenberg, Cassandra J., Bouillet, Philippe, Metcalf, Donald, Scott, Clare L., Cory, Suzanne

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Improving PARP inhibitor efficacy in high-grade serous ovarian carcinoma: A focus on the immune system von Bound, Nirashaa T., Vandenberg, Cassandra J., Kartikasari, Apriliana E. R., Plebanski, Magdalena, Scott, Clare L.

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In vivo Efficacy of the Bcl-2 Antagonist ABT-737 against Aggressive Myc-Driven Lymphomas von Mason, Kylie D., Vandenberg, Cassandra J., Scott, Clare L., Wei, Andrew H., Cory, Suzanne, Huang, David C. S., Roberts, Andrew W.

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The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair von Bridge, Wendy L, Vandenberg, Cassandra J, Franklin, Roger J, Hiom, Kevin

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BRCA1 Is Required for Maintenance of Phospho-Chk1 and G2/M Arrest during DNA Cross-Link Repair in DT40 Cells von Draga, Margarethe, Madgett, Elizabeth B., Vandenberg, Cassandra J., du Plessis, David, Kaufmann, Aisling, Werler, Petra, Chakraborty, Prasun, Lowndes, Noel F., Hiom, Kevin

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RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice von Delbridge, Alex R D, Pang, Swee Heng Milon, Vandenberg, Cassandra J, Grabow, Stephanie, Aubrey, Brandon J, Tai, Lin, Herold, Marco J, Strasser, Andreas

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CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer von Xu, Haineng, Gitto, Sarah B., Ho, Gwo-Yaw, Medvedev, Sergey, Shield-Artin, Kristy, Kim, Hyoung, Beard, Sally, Kinose, Yasuto, Wang, Xiaolei, Barker, Holly E., Ratnayake, Gayanie, Hwang, Wei-Ting, Hansen, Ryan J., Strouse, Bryan, Milutinovic, Snezana, Hassig, Christian, Wakefield, Matthew J., Vandenberg, Cassandra J., Scott, Clare L., Simpkins, Fiona

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The microtubule inhibitor eribulin demonstrates efficacy in platinum-resistant and refractory high-grade serous ovarian cancer patient-derived xenograft models von Ho, Gwo Yaw, Vandenberg, Cassandra J., Lim, Ratana, Christie, Elizabeth L., Garsed, Dale W., Lieschke, Elizabeth, Nesic, Ksenija, Kondrashova, Olga, Ratnayake, Gayanie, Radke, Marc, Penington, Jocelyn S., Carmagnac, Amandine, Heong, Valerie, Kyran, Elizabeth L., Zhang, Fan, Traficante, Nadia, Huang, Ruby, Dobrovic, Alexander, Swisher, Elizabeth M., McNally, Orla, Kee, Damien, Wakefield, Matthew J., Papenfuss, Anthony T., Bowtell, David D. L., Barker, Holly E., Scott, Clare L.

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DNA repair processes are critical mediators of p53-dependent tumor suppression von Janic, Ana, Valente, Liz J., Wakefield, Matthew J., Di Stefano, Leon, Milla, Liz, Wilcox, Stephen, Yang, Haoyu, Tai, Lin, Vandenberg, Cassandra J., Kueh, Andrew J., Mizutani, Shinsuke, Brennan, Margs S., Schenk, Robyn L., Lindqvist, Lisa M., Papenfuss, Anthony T., O’Connor, Liam, Strasser, Andreas, Herold, Marco J.

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MNT suppresses T cell apoptosis via BIM and is critical for T lymphomagenesis von Nguyen, Hai Vu, Vandenberg, Cassandra J., Robati, Mikara R., Ng, Ashley P., Cory, Suzanne

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CHK2 Inhibition Provides a Strategy to Suppress Hematologic Toxicity from PARP Inhibitors von Xu, Zhen, Vandenberg, Cassandra J, Lieschke, Elizabeth, Di Rago, Ladina, Scott, Clare L, Majewski, Ian J

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Impact of elevated anti-apoptotic MCL-1 and BCL-2 on the development and treatment of MLL-AF9 AML in mice von Anstee, Natasha S., Bilardi, Rebecca A., Ng, Ashley P., Xu, Zhen, Robati, Mikara, Vandenberg, Cassandra J., Cory, Suzanne

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Development and survival of MYC-driven lymphomas require the MYC antagonist MNT to curb MYC-induced apoptosis von Nguyen, Hai Vu, Vandenberg, Cassandra J., Ng, Ashley P., Robati, Mikara R., Anstee, Natasha S., Rimes, Joel, Hawkins, Edwin D., Cory, Suzanne

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