Dual melanocortin‐4 receptor and GLP‐1 receptor agonism amplifies metabolic benefits in diet‐induced obese mice von Clemmensen, Christoffer, Finan, Brian, Fischer, Katrin, Tom, Robby Zachariah, Legutko, Beata, Sehrer, Laura, Heine, Daniela, Grassl, Niklas, Meyer, Carola W, Henderson, Bart, Hofmann, Susanna M, Tschöp, Matthias H, Van der Ploeg, Lex HT, Müller, Timo D

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neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice von Ishihara, A, Kanatani, A, Mashiko, S, Tanaka, T, Hidaka, M, Gomori, A, Iwaasa, H, Murai, N, Egashira, S, Murai, T

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Effects of a Novel Y5 Antagonist in Obese Mice: Combination With Food Restriction or Sibutramine von Mashiko, Satoshi, Ishihara, Akane, Iwaasa, Hisashi, Moriya, Ryuichi, Kitazawa, Hidefumi, Mitobe, Yuko, Ito, Junko, Gomori, Akira, Matsushita, Hiroko, Takahashi, Toshiyuki, MacNeil, Douglas J., Ploeg, Lex H.T., Fukami, Takehiro, Kanatani, Akio

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A Pair-Feeding Study Reveals That a Y5 Antagonist Causes Weight Loss in Diet-Induced Obese Mice by Modulating Food Intake and Energy Expenditure von Mashiko, Satoshi, Ishihara, Akane, Iwaasa, Hisashi, Sano, Hideki, Ito, Junko, Gomori, Akira, Oda, Zenjun, Moriya, Ryuichi, Matsushita, Hiroko, Jitsuoka, Makoto, Okamoto, Osamu, MacNeil, Douglas J, Van der Ploeg, Lex H T, Fukami, Takehiro, Kanatani, Akio

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2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists von Jiang, Jinlong, Hoang, Myle, Young, Jonathan R., Chaung, Danny, Eid, Ronsar, Turner, Cherilyn, Lin, Peter, Tong, Xinchun, Wang, Junying, Tan, Carina, Feighner, Scott, Palyha, Oksana, Hreniuk, Donna L., Pan, Jie, Sailer, Andreas W., MacNeil, Douglas J., Howard, Andrew, Shearman, Lauren, Stribling, Sloan, Camacho, Ramon, Strack, Alison, Van der Ploeg, Lex H.T., Goulet, Mark T., DeVita, Robert J.

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Obesity: an epidemic in need of therapeutics von Van der Ploeg, Lex HT

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Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators von Guo, Liangqin, Ye, Zhixiong, Ujjainwalla, Feroze, Sings, Heather L., Sebhat, Iyassu K., Huber, John, Weinberg, David H., Tang, Rui, MacNeil, Tanya, Tamvakopoulos, Constantin, Peng, Qianping, MacIntyre, Euan, van der Ploeg, Lex H.T., Goulet, Mark T., Wyvratt, Matthew J., Nargund, Ravi P.

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Role of the melanocortin-4 receptor in metabolic rate and food intake in mice von CHEN, A. S, METZGER, J. M, CAMACHO, R. E, STRACK, A. M, MELLIN, T. N, MACINTYRE, D. E, CHEN, H. Y, VAN DER PLOEG, L. H. T, TRUMBAUER, M. E, GUAN, X.-M, HONG YU, FRAZIER, E. G, MARSH, D. J, FORREST, M. J, GOPAL-TRUTER, S, FISHER, J

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Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands von Hong, Qingmei, Bakshi, Raman K., Dellureficio, James, He, Shuwen, Ye, Zhixiong, Dobbelaar, Peter H., Sebhat, Iyassu K., Guo, Liangqin, Liu, Jian, Jian, Tianying, Tang, Rui, Kalyani, Rubana N., MacNeil, Tanya, Vongs, Aurawan, Rosenblum, Charles I., Weinberg, David H., Peng, Qingping, Tamvakopoulos, Constantin, Miller, Randy R., Stearns, Ralph A., Cashen, Doreen, Martin, Willian J., Chen, Airu S., Metzger, Joseph M., Chen, Howard Y., Strack, Allison M., Fong, Tung M., Maclntyre, Euan, Van der Ploeg, Lex H.T., Wyvratt, Matthew J., Nargund, Ravi P.

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Molecular cloning and characterization of a new receptor for galanin von Howard, Andrew D, Tan, Carina, Shiao, Lin-Lin, Palyha, Oksana C, McKee, Karen Kulju, Weinberg, David H, Feighner, Scott D, Cascieri, Margaret A, Smith, Roy G, Van Der Ploeg, Lex H.T, Sullivan, Kathleen A

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Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands von Bakshi, Raman K., Hong, Qingmei, Tang, Rui, Kalyani, Rubana N., MacNeil, Tanya, Weinberg, David H., Van der Ploeg, Lex H.T., Patchett, Arthur A., Nargund, Ravi P.

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4-Aminoquinoline melanin-concentrating hormone 1-receptor (MCH1R) antagonists von Jiang, Jinlong, Lin, Peter, Hoang, Myle, Chang, Lehua, Tan, Carina, Feighner, Scott, Palyha, Oksana C., Hreniuk, Donna L., Pan, Jie, Sailer, Andreas W., Morin, Nancy R., MacNeil, Douglas J., Howard, Andrew D., Van der Ploeg, Lex H.T., Goulet, Mark T., DeVita, Robert J.

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Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists von Madsen-Duggan, Christina B., Debenham, John S., Walsh, Thomas F., Toupence, Richard B., Huang, Song X., Wang, Junying, Tong, Xinchun, Lao, Julie, Fong, Tung M., Schaeffer, Marie-Therese, Xiao, Jing Chen, Huang, Cathy R.-R.C., Shen, Chun-Pyn, Stribling, D. Sloan, Shearman, Lauren P., Strack, Alison M., MacIntyre, D. Euan, Van der Ploeg, Lex H.T., Goulet, Mark T.

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Increased Melanin Concentrating Hormone Receptor Type I in the Human Hypothalamic Infundibular Nucleus in Cachexia von Unmehopa, Unga A., van Heerikhuize, Joop J., Spijkstra, Wenda, Woods, John W., Howard, Andrew D., Zycband, Emanuel, Feighner, Scott D., Hreniuk, Donna L., Palyha, Oksana C., Guan, Xiao-Ming, MacNeil, Douglas J., Van der Ploeg, Lex H. T., Swaab, Dick F.

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Evolutionary relationship of the ligand-gated ion channels and the avermectin-sensitive, glutamate-gated chloride channels von Vassilatis, D K, Elliston, K O, Paress, P S, Hamelin, M, Arena, J P, Schaeffer, J M, Van der Ploeg, L H, Cully, D F

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