Animal models in translational medicine: Validation and prediction von Denayer, Tinneke, Stöhr, Thomas, Van Roy, Maarten

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The preclinical pharmacology of the high affinity anti-IL-6R Nanobody® ALX-0061 supports its clinical development in rheumatoid arthritis von Van Roy, Maarten, Ververken, Cedric, Beirnaert, Els, Hoefman, Sven, Kolkman, Joost, Vierboom, Michel, Breedveld, Elia, 't Hart, Bert, Poelmans, Sofie, Bontinck, Lieselot, Hemeryck, Alex, Jacobs, Sandy, Baumeister, Judith, Ulrichts, Hans

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Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist von Fontaine, Thomas, Busch, Andreas, Laeremans, Toon, De Cesco, Stéphane, Liang, Yi-Lynn, Jaakola, Veli-Pekka, Sands, Zara, Triest, Sarah, Masiulis, Simonas, Dekeyzer, Lies, Samyn, Noor, Loeys, Nicolas, Perneel, Lisa, Debaere, Melanie, Martini, Murielle, Vantieghem, Charlotte, Virmani, Richa, Skieterska, Kamila, Staelens, Stephanie, Barroco, Rosa, Van Roy, Maarten, Menet, Christel

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Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine-Nanobody Complex von Desmyter, Aline, Spinelli, Silvia, Boutton, Carlo, Saunders, Michael, Blachetot, Christophe, de Haard, Hans, Denecker, Geertrui, Van Roy, Maarten, Cambillau, Christian, Rommelaere, Heidi

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Protection of zinc against tumor necrosis factor-induced lethal inflammation depends on heat shock protein 70 and allows safe antitumor therapy von VAN MOLLE, Wim, VAN ROY, Maarten, VAN BOGAERT, Tom, DEJAGER, Lien, VAN LINT, Philippe, VANLAERE, Ineke, SEKIKAWA, Kenji, KOLLIAS, George, LIBERTL, Claude

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Reperfusion of cerebral artery thrombosis by the GPIb–VWF blockade with the Nanobody ALX-0081 reduces brain infarct size in guinea pigs von Momi, Stefania, Tantucci, Michela, Van Roy, Maarten, Ulrichts, Hans, Ricci, Giovanni, Gresele, Paolo

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Llama-derived Single Variable Domains (Nanobodies) Directed against Chemokine Receptor CXCR7 Reduce Head and Neck Cancer Cell Growth in Vivo von Maussang, David, Mujić-Delić, Azra, Descamps, Francis J., Stortelers, Catelijne, Vanlandschoot, Peter, Stigter-van Walsum, Marijke, Vischer, Henry F., van Roy, Maarten, Vosjan, Maria, Gonzalez-Pajuelo, Maria, van Dongen, Guus A.M.S., Merchiers, Pascal, van Rompaey, Philippe, Smit, Martine J.

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Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNγ–based cancer therapy in mice von Van Roy, Maarten, Van Lint, Philippe, Van Laere, Ineke, Wielockx, Ben, Wilson, Carole, López-Otin, Carlos, Shapiro, Stephen, Libert, Claude

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Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium von Van Hauwermeiren, Filip, Armaka, Marietta, Karagianni, Niki, Kranidioti, Ksanthi, Vandenbroucke, Roosmarijn E, Loges, Sonja, Van Roy, Maarten, Staelens, Jan, Puimège, Leen, Palagani, Ajay, Berghe, Wim Vanden, Victoratos, Panayiotis, Carmeliet, Peter, Libert, Claude, Kollias, George

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Human Epidermal Growth Factor Receptor 3-Specific Tumor Uptake and Biodistribution of ^sup 89^Zr-MSB0010853 Visualized by Real-Time and Noninvasive PET Imaging von Warnders, Frank J, van Scheltinga, Anton GT Terwisscha, Knuehl, Christine, van Roy, Maarten, de Vries, Eirk FJ, W Kosterink, Jos G, de Vries, Elisabeth GE, N Lub-de Hooge, Marjolijn

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Human Epidermal Growth Factor Receptor 3-Specific Tumor Uptake and Biodistribution of 89 Zr-MSB0010853 Visualized by Real-Time and Noninvasive PET Imaging von Warnders, Frank J, Terwisscha van Scheltinga, Anton G T, Knuehl, Christine, van Roy, Maarten, de Vries, Erik F J, Kosterink, Jos G W, de Vries, Elisabeth G E, Lub-de Hooge, Marjolijn N

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Nonclinical safety assessment of the RANK-L targeting Nanobody® ALX-0141 von Jacobs, Sandy, Van Roy, Maarten, Hemeryck, Alex, Ottevaere, Ingrid, Baumeister, Judith

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Human Epidermal Growth Factor Receptor 3-Specific Tumor Uptake and Biodistribution of 89Zr-MSB0010853 Visualized by Real-Time and Noninvasive PET Imaging von Warnders, Frank J, Terwisscha van Scheltinga, Anton G T, Knuehl, Christine, van Roy, Maarten, de Vries, Erik F J, Kosterink, Jos G W, de Vries, Elisabeth G E, Lub-de Hooge, Marjolijn N

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Involvement of specific matrix metalloproteinases during tumor necrosis factor/IFNgamma-based cancer therapy in mice von Van Roy, Maarten, Van Lint, Philippe, Van Laere, Ineke, Wielockx, Ben, Wilson, Carole, López-Otin, Carlos, Shapiro, Stephen, Libert, Claude

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Description and Mapping of the Resistance of DBA/2 Mice to TNF-Induced Lethal Shock von Wielockx, Ben, Staelens, Jan, Puimege, Leen, Vanlaere, Ineke, Van Roy, Maarten, van Lint, Philippe, Van Roy, Frans, Libert, Claude

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Structure elucidation of a human melanocortin-4 receptor specific orthosteric nanobody agonist von Menet, Christel, Fontaine, Thomas, Busch, Andreas, Laeremans, Toon, De Cesco, Stephane, Liang, Yi-Lynn, Jaakola, Veli-Pekka, Sands, Zara A., Triest, Sarah, Masiulis, Simonas, Dekeyzer, Lies, Samyn, Noortje, Loeys, Nicolas, Perneel, Lisa, Debaere, Melanie, Martini, Murielle, Vantieghem, Charlotte, Virmani, Richa, Skieterska, Kamila, Staelens, Stephanie, Barroco, Rosa, Van Roy, Maarten

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Methods for the preparation of compounds directed against interleukin-6 receptor (IL-6R) von Kolkman, Joost Alexander, Beirnaert, Els Anna Alice, Van Roy, Maarten, Ververken, Cedric Jozef Neotere

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IMPROVED AMINO ACID SEQUENCES DIRECTED AGAINST IL-6R AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF IL-6R RELATED DISEASES AND DISORDERS von Ververken, Cedric Jozef Néotére, Kolkman, Joost Alexander, Beirnaert, Els Anna Alice, van Roy, Maarten

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IMPROVED AMINO ACID SEQUENCES DIRECTED AGAINST IL-6R AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF IL-6R RELATED DISEASES AND DISORDERS von Ververken, Cedric Jozef Néotére, Kolkman, Joost Alexander, Beirnaert, Els Anna Alice, van Roy, Maarten

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IMPROVED AMINO ACID SEQUENCES DIRECTED AGAINST IL-6R AND POLYPEPTIDES COMPRISING THE SAME FOR THE TREATMENT OF IL-6R RELATED DISEASES AND DISORDERS von KOLKMAN, Joost Alexander, BEIRNAERT, Els, Anna Alice, VAN ROY, Maarten, VERVERKEN, Cedric Jozef Néotère

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