Polycomb silencers control cell fate, development and cancer von Sparmann, Anke, van Lohuizen, Maarten

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Chromatin landscapes of retroviral and transposon integration profiles von de Jong, Johann, Akhtar, Waseem, Badhai, Jitendra, Rust, Alistair G, Rad, Roland, Hilkens, John, Berns, Anton, van Lohuizen, Maarten, Wessels, Lodewyk F A, de Ridder, Jeroen

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Multiplexed Cas9 targeting reveals genomic location effects and gRNA-based staggered breaks influencing mutation efficiency von Gisler, Santiago, Gonçalves, Joana P., Akhtar, Waseem, de Jong, Johann, Pindyurin, Alexey V., Wessels, Lodewyk F. A., van Lohuizen, Maarten

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Epigenetics and cancer von Lund, Anders H, van Lohuizen, Maarten

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In Vivo RNAi Screen for BMI1 Targets Identifies TGF-β/BMP-ER Stress Pathways as Key Regulators of Neural- and Malignant Glioma-Stem Cell Homeostasis von Gargiulo, Gaetano, Cesaroni, Matteo, Serresi, Michela, de Vries, Nienke, Hulsman, Danielle, Bruggeman, Sophia W., Lancini, Cesare, van Lohuizen, Maarten

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Combined deletion of Bap1, Nf2, and Cdkn2ab causes rapid onset of malignant mesothelioma in mice von Badhai, Jitendra, Pandey, Gaurav Kumar, Song, Ji-Ying, Krijgsman, Oscar, Bhaskaran, Rajith, Chandrasekaran, Gayathri, Kwon, Min-Chul, Bombardelli, Lorenzo, Monkhorst, Kim, Grasso, Cristoforo, Zevenhoven, John, van der Vliet, Jan, Cozijnsen, Miranda, Krimpenfort, Paul, Peeper, Daniel, van Lohuizen, Maarten, Berns, Anton

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Molecular Maps of the Reorganization of Genome-Nuclear Lamina Interactions during Differentiation von Peric-Hupkes, Daan, Meuleman, Wouter, Pagie, Ludo, Bruggeman, Sophia W.M., Solovei, Irina, Brugman, Wim, Gräf, Stefan, Flicek, Paul, Kerkhoven, Ron M., van Lohuizen, Maarten, Reinders, Marcel, Wessels, Lodewyk, van Steensel, Bas

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PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos von Puschendorf, Mareike, Terranova, Rémi, Boutsma, Erwin, Mao, Xiaohong, Isono, Kyo-ichi, Brykczynska, Urszula, Kolb, Carolin, Otte, Arie P, Koseki, Haruhiko, Orkin, Stuart H, van Lohuizen, Maarten, Peters, Antoine H F M

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Polycomb function during oogenesis is required for mouse embryonic development von Posfai, Eszter, Kunzmann, Rico, Brochard, Vincent, Salvaing, Juliette, Cabuy, Erik, Roloff, Tim C, Liu, Zichuan, Tardat, Mathieu, van Lohuizen, Maarten, Vidal, Miguel, Beaujean, Nathalie, Peters, Antoine H F M

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Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster von Tolhuis, Bas, Muijrers, Inhua, de Wit, Elzo, Teunissen, Hans, Talhout, Wendy, van Steensel, Bas, van Lohuizen, Maarten

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The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation von Sparmann, Anke, Xie, Yunli, Verhoeven, Els, Vermeulen, Michiel, Lancini, Cesare, Gargiulo, Gaetano, Hulsman, Danielle, Mann, Matthias, Knoblich, Juergen A, van Lohuizen, Maarten

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Stem cell regulation by polycomb repressors: postponing commitment von Pietersen, Alexandra M, van Lohuizen, Maarten

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Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression von de Vries, Nienke A., Hulsman, Danielle, Akhtar, Waseem, de Jong, Johann, Miles, Denise C., Blom, Marleen, van Tellingen, Olaf, Jonkers, Jos, van Lohuizen, Maarten

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BMI1 Is Recruited to DNA Breaks and Contributes to DNA Damage-Induced H2A Ubiquitination and Repair von Ginjala, Vasudeva, Nacerddine, Karim, Kulkarni, Atul, Oza, Jay, Hill, Sarah J., Yao, Ming, Citterio, Elisabetta, van Lohuizen, Maarten, Ganesan, Shridar

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Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice von Bruggeman, Sophia W M, Valk-Lingbeek, Merel E, van der Stoop, Petra P M, Jacobs, Jacqueline J L, Kieboom, Karin, Tanger, Ellen, Hulsman, Danielle, Leung, Carly, Arsenijevic, Yvan, Marino, Silvia, van Lohuizen, Maarten

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Enhanced Self-Renewal of Hematopoietic Stem Cells Mediated by the Polycomb Gene Product Bmi-1 von Iwama, Atsushi, Oguro, Hideyuki, Negishi, Masamitsu, Kato, Yuko, Morita, Youhei, Tsukui, Hiroko, Ema, Hideo, Kamijo, Takehiko, Katoh-Fukui, Yuko, Koseki, Haruhiko, van Lohuizen, Maarten, Nakauchi, Hiromitsu

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Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells von Lancini, Cesare, van den Berk, Paul C M, Vissers, Joseph H A, Gargiulo, Gaetano, Song, Ji-Ying, Hulsman, Danielle, Serresi, Michela, Tanger, Ellen, Blom, Marleen, Vens, Conchita, van Lohuizen, Maarten, Jacobs, Heinz, Citterio, Elisabetta

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TRIM28 Is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming von Miles, Denise Catherine, de Vries, Nienke Alexandra, Gisler, Santiago, Lieftink, Cor, Akhtar, Waseem, Gogola, Ewa, Pawlitzky, Inka, Hulsman, Danielle, Tanger, Ellen, Koppens, Martijn, Beijersbergen, Roderick Leonardus, van Lohuizen, Maarten

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Enhancer of Zeste Homolog 2 (EZH2) Contributes to Rod Photoreceptor Death Process in Several Forms of Retinal Degeneration and Its Activity Can Serve as a Biomarker for Therapy Eff... von Mbefo, Martial, Berger, Adeline, Schouwey, Karine, Gérard, Xavier, Kostic, Corinne, Beryozkin, Avigail, Sharon, Dror, Dolfuss, Hélène, Munier, Francis, Tran, Hoai Viet, van Lohuizen, Maarten, Beltran, William A., Arsenijevic, Yvan

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Rnf2 (Ring1b) Deficiency Causes Gastrulation Arrest and Cell Cycle Inhibition von Voncken, Jan Willem, Bernard A. J. Roelen, Roefs, Mieke, de Vries, Stijn, Verhoeven, Els, Marino, Silvia, Deschamps, Jacqueline, van Lohuizen, Maarten

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