Molecular Determinants of the Early Life Immune Response to COVID-19 Infection and Immunization von Beijnen, Elisabeth M S, Odumade, Oludare A, Haren, Simon D van

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Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain von Herczenik, Eszter, PhD, van Haren, Simon D., MSc, Wroblewska, Aleksandra, MSc, Kaijen, Paul, MSc, van den Biggelaar, Maartje, PhD, Meijer, Alexander B., PhD, Martinez-Pomares, Luisa, PhD, ten Brinke, Anja, PhD, Voorberg, Jan, PhD

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Human In vitro Modeling Identifies Adjuvant Combinations that Unlock Antigen Cross-presentation and Promote T-helper 1 Development in Newborns, Adults and Elders von Thomas, Sanya, Pak, Jensen, Doss-Gollin, Simon, Ryff, Kevin, Beijnen, Elisabeth, Pedersen, Gabriel K., Christensen, Dennis, Levy, Ofer, van Haren, Simon D.

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Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses von Dowling, David J., PhD, Scott, Evan A., PhD, Scheid, Annette, MD, Bergelson, Ilana, BSc, Joshi, Sweta, PhD, Pietrasanta, Carlo, MD, Brightman, Spencer, BA, Sanchez-Schmitz, Guzman, MSc, PhD, Van Haren, Simon D., PhD, Ninković, Jana, PhD, Kats, Dina, BSc, Guiducci, Cristiana, PhD, de Titta, Alexandre, PhD, Bonner, Daniel K., PhD, Hirosue, Sachiko, PhD, Swartz, Melody A., PhD, Hubbell, Jeffrey A., PhD, Levy, Ofer, MD, PhD

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Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization von van Haren, Simon D, Dowling, David J, Foppen, Willemina, Christensen, Dennis, Andersen, Peter, Reed, Steven G, Hershberg, Robert M, Baden, Lindsey R, Levy, Ofer

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Vaccine-Induced CD8(+) T Cell Responses in Children: A Review of Age-Specific Molecular Determinants Contributing to Antigen Cross-Presentation von Beijnen, Elisabeth M. S., van Haren, Simon D.

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CAF08 adjuvant enables single dose protection against respiratory syncytial virus infection in murine newborns von van Haren, Simon D., Pedersen, Gabriel K., Kumar, Azad, Ruckwardt, Tracy J., Moin, Syed, Moore, Ian N., Minai, Mahnaz, Liu, Mark, Pak, Jensen, Borriello, Francesco, Doss-Gollin, Simon, Beijnen, Elisabeth M. S., Ahmed, Saima, Helmel, Michaela, Andersen, Peter, Graham, Barney S., Steen, Hanno, Christensen, Dennis, Levy, Ofer

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Bacille Calmette-Guérin vaccine reprograms human neonatal lipid metabolism in vivo and in vitro von Diray-Arce, Joann, Angelidou, Asimenia, Jensen, Kristoffer Jarlov, Conti, Maria Giulia, Kelly, Rachel S., Pettengill, Matthew A., Liu, Mark, van Haren, Simon D., McCulloch, Scott D., Michelloti, Greg, Idoko, Olubukola, Kollmann, Tobias R., Kampmann, Beate, Steen, Hanno, Ozonoff, Al, Lasky-Su, Jessica, Benn, Christine S., Levy, Ofer

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Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference von Soni, Dheeraj, Van Haren, Simon D., Idoko, Olubukola T., Evans, Jay T., Diray-Arce, Joann, Dowling, David J., Levy, Ofer

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Cyclic AMP in human preterm infant blood is associated with increased TLR-mediated production of acute-phase and anti-inflammatory cytokines in vitro von Strunk, Tobias, van Haren, Simon D., Hibbert, Julie, Pettengill, Matthew, Ozonoff, Al, Jans, Jop, Schüller, Simone S., Burgner, David, Levy, Ofer, Currie, Andrew J.

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Human Newborn Monocytes Demonstrate Distinct BCG-Induced Primary and Trained Innate Cytokine Production and Metabolic Activation In Vitro von Angelidou, Asimenia, Diray-Arce, Joann, Conti, Maria-Giulia, Netea, Mihai G., Blok, Bastiaan A., Liu, Mark, Sanchez-Schmitz, Guzman, Ozonoff, Al, van Haren, Simon D., Levy, Ofer

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Respiratory infection- and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathways von Martino, David, Schultz, Nikki, Kaur, Ravinder, van Haren, Simon D, Kresoje, Nina, Hoch, Annmarie, Diray-Arce, Joann, Su, Jessica Lasky, Levy, Ofer, Pichichero, Michael

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Preparing for Life: Plasma Proteome Changes and Immune System Development During the First Week of Human Life von Bennike, Tue Bjerg, Fatou, Benoit, Angelidou, Asimenia, Diray-Arce, Joann, Falsafi, Reza, Ford, Rebecca, Gill, Erin E., van Haren, Simon D., Idoko, Olubukola T., Lee, Amy H., Ben-Othman, Rym, Pomat, William S., Shannon, Casey P., Smolen, Kinga K., Tebbutt, Scott J., Ozonoff, Al, Richmond, Peter C., van den Biggelaar, Anita H. J., Hancock, Robert E. W., Kampmann, Beate, Kollmann, Tobias R., Levy, Ofer, Steen, Hanno

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Implications of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pandemic on the Epidemiology of Pediatric Respiratory Syncytial Virus Infection von Odumade, Oludare A, van Haren, Simon D, Angelidou, Asimenia

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Human in vitro modeling of adjuvant formulations demonstrates enhancement of immune responses to SARS-CoV-2 antigen von Doss-Gollin, Simon, Thomas, Sanya, Brook, Byron, Abedi, Kimia, Lebas, Célia, Auderset, Floriane, Lugo-Rodriguez, Yamile, Sanchez-Schmitz, Guzman, Dowling, David J., Levy, Ofer, van Haren, Simon D.

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Limited promiscuity of HLA-DRB1 presented peptides derived of blood coagulation factor VIII von van Haren, Simon D, Wroblewska, Aleksandra, Herczenik, Eszter, Kaijen, Paul H, Ruminska, Aleksandra, ten Brinke, Anja, Meijer, Alexander B, Voorberg, Jan

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First International Precision Vaccines Conference: Multidisciplinary Approaches to Next-Generation Vaccines von Borriello, Francesco, van Haren, Simon D, Levy, Ofer

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The BNT162b2 mRNA vaccine demonstrates reduced age-associated TH1 support in vitro and in vivo von Brook, Byron, Checkervarty, Abhinav Kumar, Barman, Soumik, Sweitzer, Cali, Bosco, Anna-Nicole, Sherman, Amy C., Baden, Lindsey R., Morrocchi, Elena, Sanchez-Schmitz, Guzman, Palma, Paolo, Nanishi, Etsuro, O’Meara, Timothy R., McGrath, Marisa E., Frieman, Matthew B., Soni, Dheeraj, van Haren, Simon D., Ozonoff, Al, Diray-Arce, Joann, Steen, Hanno, Dowling, David J., Levy, Ofer

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TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth von Dowling, David J, van Haren, Simon D, Scheid, Annette, Bergelson, Ilana, Kim, Dhohyung, Mancuso, Christy J, Foppen, Willemina, Ozonoff, Al, Fresh, Lynn, Theriot, Terese B, Lackner, Andrew A, Fichorova, Raina N, Smirnov, Dmitri, Vasilakos, John P, Beaurline, Joe M, Tomai, Mark A, Midkiff, Cecily C, Alvarez, Xavier, Blanchard, James L, Gilbert, Margaret H, Aye, Pyone Pyone, Levy, Ofer

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Co-adjuvanting DDA/TDB liposomes with a TLR7 agonist allows for IgG2a/c class-switching in the absence of Th1 cells von Zimmermann, Julie, van Haren, Simon D., Diray-Arce, Joann, Adriawan, Ignatius Ryan, Wørzner, Katharina, Krog, Ricki T., Guleed, Safia, Hu, Tu, Mortensen, Rasmus, Dietrich, Jes, Solbak, Sara M. Ø., Levy, Ofer, Christensen, Dennis, Pedersen, Gabriel K.

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