Post-Transcriptional Regulation of Homeostatic, Stressed, and Malignant Stem Cells von Chua, Bernadette A., Van Der Werf, Inge, Jamieson, Catriona, Signer, Robert A.J.

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Targeting Tumor Vascular CD99 Inhibits Tumor Growth von Huijbers, Elisabeth J M, van der Werf, Inge M, Faber, Lisette D, Sialino, Lena D, van der Laan, Pia, Holland, Hanna A, Cimpean, Anca M, Thijssen, Victor L J L, van Beijnum, Judy R, Griffioen, Arjan W

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SF3B1 as therapeutic target in FLT3/ITD positive acute myeloid leukemia von van der Werf, Inge, Wojtuszkiewicz, Anna, Yao, Huilan, Sciarrillo, Rocco, Meggendorfer, Manja, Hutter, Stephan, Walter, Wencke, Janssen, Jeroen, Kern, Wolfgang, Haferlach, Claudia, Haferlach, Torsten, Jansen, Gerrit, Kaspers, Gertjan J. L., Groen, Richard, Ossenkoppele, Gert, Cloos, Jacqueline

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Splicing factor gene mutations in acute myeloid leukemia offer additive value if incorporated in current risk classification von van der Werf, Inge, Wojtuszkiewicz, Anna, Meggendorfer, Manja, Hutter, Stephan, Baer, Constance, Heymans, Martijn, Valk, Peter J.M., Kern, Wolfgang, Haferlach, Claudia, Janssen, Jeroen J.W.M., Ossenkoppele, Gert J., Cloos, Jacqueline, Haferlach, Torsten

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P425: A MULTIDIMENSIONAL AND SPATIAL ANALYSIS REVEALS DISTINCT IMMUNE PHENOTYPES AND SECONDARY LYMPHOID ORGAN‐RESEMBLING STRUCTURES IN THE BONE MARROW OF PEDIATRIC ACUTE MYELOID LE... von Koedijk, Joost, Werf, Inge, Vermeulen, Marijn, Perzolli, Alicia, Fiocco, Marta, Groot‐Kruseman, Hester, Moeniralam, Rubina, Nierkens, Stefan, Belderbos, Mirjam, Zwaan, Michel, Heidenreich, Olaf

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Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox von Middelkamp, Sjors, Manders, Freek, Peci, Flavia, van Roosmalen, Markus J., González, Diego Montiel, Bertrums, Eline J.M., van der Werf, Inge, Derks, Lucca L.M., Groenen, Niels M., Verheul, Mark, Trabut, Laurianne, Pleguezuelos-Manzano, Cayetano, Brandsma, Arianne M., Antoniou, Evangelia, Reinhardt, Dirk, Bierings, Marc, Belderbos, Mirjam E., van Boxtel, Ruben

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RNA Modifications Shape Hematopoietic Stem Cell Aging: Beyond the Code von Werf, Inge, Sneifer, Jenna, Jamieson, Catriona

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The Yin and Yang of RNA Methylation: An Imbalance of Erasers Enhances Sensitivity to FTO Demethylase Small-Molecule Targeting in Leukemia Stem Cells von Van Der Werf, Inge, Jamieson, Catriona

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Single-Cell Whole-Genome Sequencing after Chemotherapeutic Treatment Reveals Cell Type-Specific Mutational Burdens von Derks, Lucca L.M., Van Der Werf, Inge, Trabut, Laurianne, Bertrums, Eline, De Kanter, Jurrian, Rosendahl Huber, Axel, Van Boxtel, Ruben

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Spatial Technologies Reveal the Immune Landscape of Pediatric Acute Myeloid Leukemia von Koedijk, Joost B., Van Der Werf, Inge, Vermeulen, Marijn A., Perzolli, Alicia, Fiocco, Marta F., de Groot-Kruseman, Hester A., Moeniralam, Rubina, Christensen, Kristina B., Hasle, Henrik, Nierkens, Stefan, Belderbos, Mirjam E., Zwaan, Michel C., Heidenreich, Olaf

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Retrospective Lineage Tracing of Pediatric Acute Myeloid Leukemia Using Single-Cell Whole Genome Sequencing von Bertrums, Eline J.M., Middelkamp, Sjors, van der Werf, Inge M., Manders, Freek, Brandsma, Arianne M., Groenen, Niels M., Verheul, Mark, van Roosmalen, Markus J., Zwaan, C. Michel, van den Heuvel-Eibrink, Marry M., Goemans, Bianca F., Van Boxtel, Ruben

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Decreased Embryonic Splicing Repressor Expression Enhances Splicing Modulator Sensitivity in Pediatric Acute Myeloid Leukemia Stem Cells von Van Der Werf, Inge, Steel, Kathleen, Mondala, Phoebe, Balaian, Larissa, Cloos, Jacqueline, Kaspers, Gertjan J.L., La Clair, James, Wentworth, Peggy, Fisch, Kathleen, Crews, Leslie, Whisenant, Thomas, Burkart, Michael, Donohoe, Mary, Jamieson, Catriona

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Cirmtuzumab (Zilovertamab) Eliminates ROR1 Positive Leukemia Stem Cells By Blocking Niche Dependent ROR1/WNT5a Signaling von Balaian, Larissa, Donohoe, Mary, Mondala, Phoebe, Widhopf II, George F., Ghia, Emanuela M., Ball, Edward D., Kulidjian, Anna, Van Der Werf, Inge, Kipps, Thomas J., Jamieson, Catriona

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Reversal of malignant ADAR1 splice isoform switching with Rebecsinib von Crews, Leslie A., Ma, Wenxue, Ladel, Luisa, Pham, Jessica, Balaian, Larisa, Steel, S. Kathleen, Mondala, Phoebe K., Diep, Raymond H., Wu, Christina N., Mason, Cayla N., van der Werf, Inge, Oliver, Isabelle, Reynoso, Eduardo, Pineda, Gabriel, Whisenant, Thomas C., Wentworth, Peggy, La Clair, James J., Jiang, Qingfei, Burkart, Michael D., Jamieson, Catriona H.M.

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A multidimensional analysis reveals distinct immune phenotypes and the composition of immune aggregates in pediatric acute myeloid leukemia von Koedijk, Joost B., van der Werf, Inge, Penter, Livius, Vermeulen, Marijn A., Barneh, Farnaz, Perzolli, Alicia, Meesters-Ensing, Joyce I., Metselaar, Dennis S., Margaritis, Thanasis, Fiocco, Marta, de Groot-Kruseman, Hester A., Moeniralam, Rubina, Bang Christensen, Kristina, Porter, Billie, Pfaff, Kathleen, Garcia, Jacqueline S., Rodig, Scott J., Wu, Catherine J., Hasle, Henrik, Nierkens, Stefan, Belderbos, Mirjam E., Zwaan, C. Michel, Heidenreich, Olaf

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Deregulation of Splicing in Pediatric Acute Myeloid Stem and Progenitor Cells von Mondala, Phoebe, Van Der Werf, Inge, Balaian, Larisa, Steel, Kathleen, Ladel, Luisa, Mason, Cayla, Diep, Raymond, Cloos, Jacqueline, Kaspers, Gertjan, van Roosmalen, Markus J, Van Boxtel, Ruben, Chan, Warren, Mark, Adam, Donohoe, Mary, La Clair, James, Wentworth, Peggy, Fisch, Kathleen, Crews, Leslie A, Whisenant, Thomas, Burkart, Michael, Jamieson, Catriona

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Selective Targeting of Alternative Splicing Deregulation in Pediatric Acute Myeloid Stem and Progenitor Cells von Van Der Werf, Inge, Mondala, Phoebe, Diep, Raymond, Balaian, Larissa, Mason, Cayla, Cloos, Jacqueline, Kaspers, Gertjan J.L., La Clair, Jim, Wentworth, Peggy, Crews, Leslie A, Whisenant, Thomas, Fisch, Kathleen, Burkart, Michael, Jamieson, Catriona

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Abstract 469: Selective targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells von Van der Werf, Inge, Mondala, Phoebe, Diep, Raymond, Balaian, Larisa, Mason, Cayla, Kaspers, Gertjan, Cloos, Jacqueline, La Clair, Jim, Wentworth, Peggy, Whisenant, Tom, Fisch, Katie, Burkart, Michael, Jamieson, Catriona

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Paving the way for immunotherapy in pediatric acute myeloid leukemia: Current knowledge and the way forward von Koedijk, Joost B, van der Werf, Inge, Calkoen, Friso G, Nierkens, Stefan, Kaspers, Gertjan J.L, Zwaan, Christian Michel, Heidenreich, Olaf

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Author Correction: SF3B1 as therapeutic target in FLT3/ITD positive acute myeloid leukemia von van der Werf, Inge, Wojtuszkiewicz, Anna, Yao, Huilan, Sciarrillo, Rocco, Meggendorfer, Manja, Hutter, Stephan, Walter, Wencke, Janssen, Jeroen, Kern, Wolfgang, Haferlach, Claudia, Haferlach, Torsten, Jansen, Gerrit, Kaspers, Gertjan J. L., Groen, Richard, Ossenkoppele, Gert, Cloos, Jacqueline

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