Tumor suppressors BTG1 and BTG2: Beyond growth control von Yuniati, Laurensia, Scheijen, Blanca, Meer, Laurens T., Leeuwen, Frank N.

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Amino Acid Depletion Therapies: Starving Cancer Cells to Death von Butler, Miriam, van der Meer, Laurens T., van Leeuwen, Frank N.

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Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells von Wortel, Inge M.N., van der Meer, Laurens T., Kilberg, Michael S., van Leeuwen, Frank N.

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The origin and nature of tightly clustered BTG1 deletions in precursor B-cell acute lymphoblastic leukemia support a model of multiclonal evolution von Waanders, Esmé, Scheijen, Blanca, van der Meer, Laurens T, van Reijmersdal, Simon V, van Emst, Liesbeth, Kroeze, Yvet, Sonneveld, Edwin, Hoogerbrugge, Peter M, van Kessel, Ad Geurts, van Leeuwen, Frank N, Kuiper, Roland P

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Histone deacetylase inhibition sensitizes p53-deficient B-cell precursor acute lymphoblastic leukemia to chemotherapy von Cox, Willem P J, Evander, Nils, Van Ingen Schenau, Dorette S, Stoll, Gawin R, Anderson, Nadia, De Groot, Lieke, Grünewald, Kari J T, Hagelaar, Rico, Butler, Miriam, Kuiper, Roland P, Van der Meer, Laurens T, Van Leeuwen, Frank N

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IKZF1 gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia von Vervoort, Britt M T, Butler, Miriam, Grünewald, Kari J T, Schenau, Dorette S van Ingen, Tee, Trisha M, Lucas, Luc, Huitema, Alwin D R, Boer, Judith M, Bornhauser, Beat C, Bourquin, Jean-Pierre, Hoogerbrugge, Peter M, Van der Velden, Vincent H J, Kuiper, Roland P, Van der Meer, Laurens T, Van Leeuwen, Frank N

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Reversal of IKZF1-induced glucocorticoid resistance by dual targeting of AKT and ERK signaling pathways von Butler, Miriam, Vervoort, Britt M.T., van Ingen Schenau, Dorette S., Jongeneel, Lieneke, van der Zwet, Jordy C.G., Marke, René, Meijerink, Jules P.P., Scheijen, Blanca, van der Meer, Laurens T., van Leeuwen, Frank N.

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Tumor suppressors BTG1 and IKZF1 cooperate during mouse leukemia development and increase relapse risk in B-cell precursor acute lymphoblastic leukemia patients von Scheijen, Blanca, Boer, Judith M, Marke, René, Tijchon, Esther, van Ingen Schenau, Dorette, Waanders, Esmé, van Emst, Liesbeth, van der Meer, Laurens T, Pieters, Rob, Escherich, Gabriele, Horstmann, Martin A, Sonneveld, Edwin, Venn, Nicola, Sutton, Rosemary, Dalla-Pozza, Luciano, Kuiper, Roland P, Hoogerbrugge, Peter M, den Boer, Monique L, van Leeuwen, Frank N

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BTK inhibition sensitizes acute lymphoblastic leukemia to asparaginase by suppressing the amino acid response pathway von Butler, Miriam, van Ingen Schenau, Dorette S., Yu, Jiangyan, Jenni, Silvia, Dobay, Maria P., Hagelaar, Rico, Vervoort, Britt M.T., Tee, Trisha M., Hoff, Fieke W., Meijerink, Jules P., Kornblau, Steven M., Bornhauser, Beat, Bourquin, Jean-Pierre, Kuiper, Roland P., van der Meer, Laurens T., van Leeuwen, Frank N.

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Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1 von Marteijn, Jurgen A.F., van der Meer, Laurens T., van Emst, Liesbeth, van Reijmersdal, Simon, Wissink, Willemijn, de Witte, Theo, Jansen, Joop H., Van der Reijden, Bert A.

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Diminished proteasomal degradation results in accumulation of Gfi1 protein in monocytes von Marteijn, Jurgen A.F., van der Meer, Laurens T., Van Emst, Liesbeth, de Witte, Theo, Jansen, Joop H., van der Reijden, Bert A.

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In Vivo Imaging of Antileukemic Drug Asparaginase Reveals a Rapid Macrophage-Mediated Clearance from the Bone Marrow von van der Meer, Laurens T, Terry, Samantha Y A, van Ingen Schenau, Dorette S, Andree, Kiki C, Franssen, Gerben M, Roeleveld, Debbie M, Metselaar, Josbert M, Reinheckel, Thomas, Hoogerbrugge, Peter M, Boerman, Otto C, van Leeuwen, Frank N

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Tumor suppressor BTG1 promotes PRMT1-mediated ATF4 function in response to cellular stress von Yuniati, Laurensia, van der Meer, Laurens T, Tijchon, Esther, van Ingen Schenau, Dorette, van Emst, Liesbeth, Levers, Marloes, Palit, Sander A L, Rodenbach, Caroline, Poelmans, Geert, Hoogerbrugge, Peter M, Shan, Jixiu, Kilberg, Michael S, Scheijen, Blanca, van Leeuwen, Frank N

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Tumor suppressor BTG1 limits activation of BCL6 expression downstream of ETV6-RUNX1 von Tijchon, Esther, van Emst, Liesbeth, Yuniati, Laurensia, van Ingen Schenau, Dorette, Gerritsen, Mylène, van der Meer, Laurens T., Williams, Owen, Hoogerbrugge, Peter M., Scheijen, Blanca, van Leeuwen, Frank N.

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Loss of p53 impairs death receptor expression and confers resistance to CD19 CAR T-cell therapy in BCP-ALL von Cox, Willem P. J., Dautzenberg, Noël M. M., Dekker, Linde, Klenovsek, Tesa, Cornel, Annelisa M., van Hoesel, Marliek, van Ingen Schenau, Dorette S., Bladergroen, Reno S., Kuiper, Roland P., van der Meer, Laurens T., Calkoen, Friso G., Nierkens, Stefan, van Leeuwen, Frank N.

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A germ line mutation in cathepsin B points toward a role in asparaginase pharmacokinetics von van der Meer, Laurens T., Waanders, Esmé, Levers, Marloes, Venselaar, Hanka, Roeleveld, Debbie, Boos, Joachim, Lanvers, Claudia, Brüggemann, Roger J., Kuiper, Roland P., Hoogerbrugge, Peter M., van Leeuwen, Frank N., te Loo, D. Maroeska

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TP53 Aberrant B-Cell Precursor Acute Lymphoblastic Leukemia (BCP-ALL) Are Uniquely Sensitive to a Combination of Pyrimidine De Novo Synthesis Blockade and Replication Checkpoint In... von Stoll, Gawin R., Van Ingen Schenau, Dorette, Cox, Willem P. J., Tang, Ziqin, Wagener, Emmely M., van der Meer, Laurens T., van Leeuwen, Frank N.

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MLL (KMT2A)-rearranged Acute Lymphoblastic Leukemias Are Addicted to S-Adenosyl Methionine (SAM): Implications for Therapy von Tee, Trisha, Ruiter, Titine, Wajon, Danique, Wu, Shuiyan, Dahaoui, Ahmed, van Ingen Schenau, Dorette S, van der Meer, Laurens T, van Leeuwen, Frank N

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Histone Deacetylase Inhibition Restores Therapy Response in TP53mutated Acute Lymphoblastic Leukemia to Chemotherapy von Cox, Willem, Butler, Miriam, van Ingen Schenau, Dorette S, Anderson, Nadia, de Groot, Lieke, van der Meer, Laurens T, van Leeuwen, Frank N

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Loss of p53 Impairs Death Receptor Expression and Confers Resistance to CD19-Directed CAR T-Cell Therapy in B-Cell Precursor Acute Lymphoblastic Leukemia von Cox, Willem P. J., Dautzenberg, Noel M. M., Dekker, Linde, Klenovšek, Tesa, van Hoesel, Marliek, Stoll, Gawin R., Kuiper, Roland P., van der Meer, Laurens T., Calkoen, Friso G. J., Nierkens, Stefan, van Leeuwen, Frank N.

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