CONTROL: A randomized phase 2 study of obeticholic acid and atorvastatin on lipoproteins in nonalcoholic steatohepatitis patients von Pockros, Paul J., Fuchs, Michael, Freilich, Bradley, Schiff, Eugene, Kohli, Anita, Lawitz, Eric J., Hellstern, Paul A., Owens‐Grillo, Janet, Van Biene, Courtney, Shringarpure, Reshma, MacConell, Leigh, Shapiro, David, Cohen, David E.

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Randomised clinical trial: a phase 1b study of GB004, an oral HIF‐1α stabiliser, for treatment of ulcerative colitis von Danese, Silvio, Levesque, Barrett G., Feagan, Brian G., Jucov, Alina, Bhandari, Bal Raj, Pai, Rish K., Taylor Meadows, Kristen, Kirby, Brian J., Bruey, Jean‐Marie, Olson, Allan, Osterhout, Robin, Van Biene, Courtney, Ford, Julia, Aranda, Richard, Raghupathi, Kartik, Sandborn, William J.

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Editorial: protecting hypoxia‐inducible factor 1a and gut integrity with GB004—a promising therapeutic approach for ulcerative colitis? Authors' reply von Danese, Silvio, Levesque, Barrett G., Feagan, Brian G., Jucov, Alina, Bhandari, B. R., Pai, Rish K., Meadows, Kristen Taylor, Kirby, Brian J., Bruey, Jean‐Marie, Olson, Allan, Osterhout, Robin, Van Biene, Courtney, Ford, Julia, Aranda, Richard, Raghupathi, Kartik, Sandborn, William J.

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Editorial: protecting hypoxia‐inducible factor 1a and gut integrity with GB 004—a promising therapeutic approach for ulcerative colitis? Authors' reply von Danese, Silvio, Levesque, Barrett G., Feagan, Brian G., Jucov, Alina, Bhandari, B. R., Pai, Rish K., Meadows, Kristen Taylor, Kirby, Brian J., Bruey, Jean‐Marie, Olson, Allan, Osterhout, Robin, Van Biene, Courtney, Ford, Julia, Aranda, Richard, Raghupathi, Kartik, Sandborn, William J.

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Cover Image von Danese, Silvio, Levesque, Barrett G., Feagan, Brian G., Jucov, Alina, Bhandari, Bal Raj, Pai, Rish K., Taylor Meadows, Kristen, Kirby, Brian J., Bruey, Jean‐Marie, Olson, Allan, Osterhout, Robin, Van Biene, Courtney, Ford, Julia, Aranda, Richard, Raghupathi, Kartik, Sandborn, William J.

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P066 GB004, A NOVEL GUT-TARGETED PROLYL HYDROXYLASE INHIBITOR FOR INFLAMMATORY BOWEL DISEASE: FIRST-IN-HUMAN, MUTLIPLE-DOSE STUDY IN HEALTHY SUBJECTS WITH GUT BIOPSIES von Levesque, Barrett, Meadows, Kristen Taylor, Buch, Akshay, Flynn, Michael, Peters, Kevin, Olson, Allan, Shen, Jinshan, Sergeeva, Masha, Slee, Debbie, Van Biene, Courtney, Aranda, Richard, Opiteck, Greg

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P066 GB004, A NOVEL GUT-TARGETED PROLYL HYDROXYLASE INHIBITOR FOR INFLAMMATORY BOWEL DISEASE: FIRST-IN-HUMAN, MUTLIPLE-DOSE STUDY IN HEALTHY SUBJECTS WITH GUT BIOPSIES von Levesque, Barrett, Meadows, Kristen Taylor, Buch, Akshay, Flynn, Michael, Peters, Kevin, Olson, Allan, Shen, Jinshan, Sergeeva, Masha, Slee, Debbie, Van Biene, Courtney, Aranda, Richard, Opiteck, Greg

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Tu1882 GB004, A NOVEL PROLYL HYDROXYLASE INHIBITOR FOR INFLAMMATOYR BOWEL DISEASE, LEADS TO GUT-TARGETED HIF-1ALPHA PATHWAY ENGAGEMENT IN A MULTIPLE DOSE STUDY IN HEATHY SUBJECTS von Levesque, Barrett G., Meadows, Kristen Taylor, Buch, Akshay, Flynn, Michael, Peters, Kevin, Olson, Allan, Shen, Jinshan, Slee, Debbie, Van Biene, Courtney, Aranda, Richard, Casteele, Niels Vande, Opiteck, Gregory J.

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