Abstract PS4-25: Comprehensive genomic analysis reveals molecular correlates of response to immune checkpoint inhibitors (ICI) in metastatic triple-negative breast cancer (mTNBC) von Barroso-Sousa, Romualdo, Forman, Juliet, Weber, Zachary T., Collier, Katherine, Kao, Katrina Z., Richardson, Edward T., Keenan, Tanya, Cohen, Ofir, Manos, Michael P., Brennick, Ryan C., Ott, Patrick, Hodi, F. Steve, Dillon, Deborah A., Lin, Nancy U., Van Allen, Eliezer E., Rodig, Scott, Winer, Eric P., Mittendorf, Elizabeth A., Wu, Catherine J., Stover, Daniel, Wagle, Nikhil, Shukla, Sachet, Tolaney, Sara

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Genomic correlates of response to immune checkpoint blockade von Keenan, Tanya E., Burke, Kelly P., Van Allen, Eliezer M.

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Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma von Miao, Diana, Margolis, Claire A, Gao, Wenhua, Voss, Martin H, Li, Wei, Martini, Dylan J, Norton, Craig, Bossé, Dominick, Wankowicz, Stephanie M, Cullen, Dana, Horak, Christine, Wind-Rotolo, Megan, Tracy, Adam, Giannakis, Marios, Hodi, Frank Stephen, Drake, Charles G, Ball, Mark W, Allaf, Mohamad E, Snyder, Alexandra, Hellmann, Matthew D, Ho, Thai, Motzer, Robert J, Signoretti, Sabina, Kaelin, Jr, William G, Choueiri, Toni K, Van Allen, Eliezer M

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Biologically informed deep neural network for prostate cancer discovery von Elmarakeby, Haitham A., Hwang, Justin, Arafeh, Rand, Crowdis, Jett, Gang, Sydney, Liu, David, AlDubayan, Saud H., Salari, Keyan, Kregel, Steven, Richter, Camden, Arnoff, Taylor E., Park, Jihye, Hahn, William C., Van Allen, Eliezer M.

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Tumor Mutational Burden and PTEN Alterations as Molecular Correlates of Response to PD-1/L1 Blockade in Metastatic Triple-Negative Breast Cancer von Barroso-Sousa, Romualdo, Keenan, Tanya E, Pernas, Sonia, Exman, Pedro, Jain, Esha, Garrido-Castro, Ana C, Hughes, Melissa, Bychkovsky, Brittany, Umeton, Renato, Files, Janet L, Lindeman, Neal I, MacConaill, Laura E, Hodi, F Stephen, Krop, Ian E, Dillon, Deborah, Winer, Eric P, Wagle, Nikhil, Lin, Nancy U, Mittendorf, Elizabeth A, Van Allen, Eliezer M, Tolaney, Sara M

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Compound Genomic Alterations of TP53, PTEN, and RB1 Tumor Suppressors in Localized and Metastatic Prostate Cancer von Hamid, Anis A., Gray, Kathryn P., Shaw, Grace, MacConaill, Laura E., Evan, Carolyn, Bernard, Brandon, Loda, Massimo, Corcoran, Niall M., Van Allen, Eliezer M., Choudhury, Atish D., Sweeney, Christopher J.

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Integrative Molecular Characterization of Resistance to Neoadjuvant Chemoradiation in Rectal Cancer von Kamran, Sophia C, Lennerz, Jochen K, Margolis, Claire A, Liu, David, Reardon, Brendan, Wankowicz, Stephanie A, Van Seventer, Emily E, Tracy, Adam, Wo, Jennifer Y, Carter, Scott L, Willers, Henning, Corcoran, Ryan B, Hong, Theodore S, Van Allen, Eliezer M

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A phase II trial of AS1411 (a novel nucleolin-targeted DNA aptamer) in metastatic renal cell carcinoma von Rosenberg, Jonathan E., Bambury, Richard M., Van Allen, Eliezer M., Drabkin, Harry A., Lara, Primo N., Harzstark, Andrea L., Wagle, Nikhil, Figlin, Robert A., Smith, Gregory W., Garraway, Levi A., Choueiri, Toni, Erlandsson, Fredrik, Laber, Damian A.

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Tumor immune microenvironment characterization in clear cell renal cell carcinoma identifies prognostic and immunotherapeutically relevant messenger RNA signatures von Şenbabaoğlu, Yasin, Gejman, Ron S, Winer, Andrew G, Liu, Ming, Van Allen, Eliezer M, de Velasco, Guillermo, Miao, Diana, Ostrovnaya, Irina, Drill, Esther, Luna, Augustin, Weinhold, Nils, Lee, William, Manley, Brandon J, Khalil, Danny N, Kaffenberger, Samuel D, Chen, Yingbei, Danilova, Ludmila, Voss, Martin H, Coleman, Jonathan A, Russo, Paul, Reuter, Victor E, Chan, Timothy A, Cheng, Emily H, Scheinberg, David A, Li, Ming O, Choueiri, Toni K, Hsieh, James J, Sander, Chris, Hakimi, A Ari

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Genomic evolution and chemoresistance in germ-cell tumours von Taylor-Weiner, Amaro, Zack, Travis, O’Donnell, Elizabeth, Guerriero, Jennifer L., Bernard, Brandon, Reddy, Anita, Han, G. Celine, AlDubayan, Saud, Amin-Mansour, Ali, Schumacher, Steven E., Litchfield, Kevin, Turnbull, Clare, Gabriel, Stacey, Beroukhim, Rameen, Getz, Gad, Carter, Scott L., Hirsch, Michelle S., Letai, Anthony, Sweeney, Christopher, Van Allen, Eliezer M

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Molecular correlates of response to eribulin and pembrolizumab in hormone receptor-positive metastatic breast cancer von Keenan, Tanya E., Guerriero, Jennifer L., Barroso-Sousa, Romualdo, Li, Tianyu, O’Meara, Tess, Giobbie-Hurder, Anita, Tayob, Nabihah, Hu, Jiani, Severgnini, Mariano, Agudo, Judith, Vaz-Luis, Ines, Anderson, Leilani, Attaya, Victoria, Park, Jihye, Conway, Jake, He, Meng Xiao, Reardon, Brendan, Shannon, Erin, Wulf, Gerburg, Spring, Laura M., Jeselsohn, Rinath, Krop, Ian, Lin, Nancy U., Partridge, Ann, Winer, Eric P., Mittendorf, Elizabeth A., Liu, David, Van Allen, Eliezer M., Tolaney, Sara M.

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A Functional Landscape of Resistance to ALK Inhibition in Lung Cancer von Wilson, Frederick H., Johannessen, Cory M., Piccioni, Federica, Tamayo, Pablo, Kim, Jong Wook, Van Allen, Eliezer M., Corsello, Steven M., Capelletti, Marzia, Calles, Antonio, Butaney, Mohit, Sharifnia, Tanaz, Gabriel, Stacey B., Mesirov, Jill P., Hahn, William C., Engelman, Jeffrey A., Meyerson, Matthew, Root, David E., Jänne, Pasi A., Garraway, Levi A.

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Mutations in TSC1, TSC2, and MTOR Are Associated with Response to Rapalogs in Patients with Metastatic Renal Cell Carcinoma von Kwiatkowski, David J, Choueiri, Toni K, Fay, André P, Rini, Brian I, Thorner, Aaron R, de Velasco, Guillermo, Tyburczy, Magdalena E, Hamieh, Lana, Albiges, Laurence, Agarwal, Neeraj, Ho, Thai H, Song, Jiaxi, Pignon, Jean-Christophe, Barrios, Pablo M, Michaelson, M Dror, Van Allen, Eliezer, Krajewski, Katherine M, Porta, Camillo, Pal, Sumanta, Bellmunt, Joaquim, McDermott, David F, Heng, Daniel Y C, Gray, Kathryn P, Signoretti, Sabina

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Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma von Zavidij, Oksana, Haradhvala, Nicholas J, Mouhieddine, Tarek H, Sklavenitis-Pistofidis, Romanos, Cai, Songjie, Reidy, Mairead, Rahmat, Mahshid, Flaifel, Abdallah, Ferland, Benjamin, Su, Nang K, Agius, Michael P, Park, Jihye, Manier, Salomon, Bustoros, Mark, Huynh, Daisy, Capelletti, Marzia, Berrios, Brianna, Liu, Chia-Jen, He, Meng Xiao, Braggio, Esteban, Fonseca, Rafael, Maruvka, Yosef E, Guerriero, Jennifer L, Goldman, Melissa, Van Allen, Eliezer M, McCarroll, Steven A, Azzi, Jamil, Getz, Gad, Ghobrial, Irene M

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Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma von Gopal, Raj K., Calvo, Sarah E., Shih, Angela R., Chaves, Frances L., McGuone, Declan, Mick, Eran, Pierce, Kerry A., Li, Yang, Garofalo, Andrea, Van Allen, Eliezer M., Clish, Clary B., Oliva, Esther, Mootha, Vamsi K.

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A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade von Jerby-Arnon, Livnat, Shah, Parin, Cuoco, Michael S., Rodman, Christopher, Su, Mei-Ju, Melms, Johannes C., Leeson, Rachel, Kanodia, Abhay, Mei, Shaolin, Lin, Jia-Ren, Wang, Shu, Rabasha, Bokang, Liu, David, Zhang, Gao, Margolais, Claire, Ashenberg, Orr, Ott, Patrick A., Buchbinder, Elizabeth I., Haq, Rizwan, Hodi, F. Stephen, Boland, Genevieve M., Sullivan, Ryan J., Frederick, Dennie T., Miao, Benchun, Moll, Tabea, Flaherty, Keith T., Herlyn, Meenhard, Jenkins, Russell W., Thummalapalli, Rohit, Kowalczyk, Monika S., Cañadas, Israel, Schilling, Bastian, Cartwright, Adam N.R., Luoma, Adrienne M., Malu, Shruti, Hwu, Patrick, Bernatchez, Chantale, Forget, Marie-Andrée, Barbie, David A., Shalek, Alex K., Tirosh, Itay, Sorger, Peter K., Wucherpfennig, Kai, Van Allen, Eliezer M., Schadendorf, Dirk, Johnson, Bruce E., Rotem, Asaf, Rozenblatt-Rosen, Orit, Garraway, Levi A., Yoon, Charles H., Izar, Benjamin, Regev, Aviv

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Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer von Liu, David, Abbosh, Philip, Keliher, Daniel, Reardon, Brendan, Miao, Diana, Mouw, Kent, Weiner-Taylor, Amaro, Wankowicz, Stephanie, Han, Garam, Teo, Min Yuen, Cipolla, Catharine, Kim, Jaegil, Iyer, Gopa, Al-Ahmadie, Hikmat, Dulaimi, Essel, Chen, David Y. T., Alpaugh, R. Katherine, Hoffman-Censits, Jean, Garraway, Levi A., Getz, Gad, Carter, Scott L., Bellmunt, Joaquim, Plimack, Elizabeth R., Rosenberg, Jonathan E., Van Allen, Eliezer M.

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Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors von Kim, Jaegil, Mouw, Kent W, Polak, Paz, Braunstein, Lior Z, Kamburov, Atanas, Tiao, Grace, Kwiatkowski, David J, Rosenberg, Jonathan E, Van Allen, Eliezer M, D'Andrea, Alan D, Getz, Gad

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Genomic Evolution after Chemoradiotherapy in Anal Squamous Cell Carcinoma von Mouw, Kent W, Cleary, James M, Reardon, Brendan, Pike, Jonathan, Braunstein, Lior Z, Kim, Jaegil, Amin-Mansour, Ali, Miao, Diana, Damish, Alexis, Chin, Joanna, Ott, Patrick A, Fuchs, Charles S, Martin, Neil E, Getz, Gad, Carter, Scott, Mamon, Harvey J, Hornick, Jason L, Van Allen, Eliezer M, D'Andrea, Alan D

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A Phase I Study of Combination Olaparib and Radium-223 in Men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) with Bone Metastases (COMRADE) von Pan, Elizabeth, Xie, Wanling, Ajmera, Archana, Araneta, Arlene, Jamieson, Christina, Folefac, Edmund, Hussain, Arif, Kyriakopoulos, Christos E, Olson, Adam, Parikh, Mamta, Parikh, Rahul, Saraiya, Biren, Ivy, S Percy, Van Allen, Eliezer M, Lindeman, Neal I, Kochupurakkal, Bose S, Shapiro, Geoffrey I, McKay, Rana R

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