Cooperativity of RUNX1 and CSF3R mutations in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis von Skokowa, Julia, Steinemann, Doris, Katsman-Kuipers, Jenny E., Zeidler, Cornelia, Klimenkova, Olga, Klimiankou, Maksim, Ünalan, Murat, Kandabarau, Siarhei, Makaryan, Vahagn, Beekman, Renee, Behrens, Kira, Stocking, Carol, Obenauer, Julia, Schnittger, Susanne, Kohlmann, Alexander, Valkhof, Marijke G., Hoogenboezem, Remco, Göhring, Gudrun, Reinhardt, Dirk, Schlegelberger, Brigitte, Stanulla, Martin, Vandenberghe, Peter, Donadieu, Jean, Zwaan, C. Michel, Touw, Ivo P., van den Heuvel-Eibrink, Marry M., Dale, David C., Welte, Karl

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Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia von Beekman, Renée, Valkhof, Marijke G., Sanders, Mathijs A., van Strien, Paulette M.H., Haanstra, Jurgen R., Broeders, Lianne, Geertsma-Kleinekoort, Wendy M., Veerman, Anjo J.P., Valk, Peter J.M., Verhaak, Roel G., Löwenberg, Bob, Touw, Ivo P.

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Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes von Zambetti, Noemi A, Bindels, Eric M J, Van Strien, Paulina M H, Valkhof, Marijke G, Adisty, Maria N, Hoogenboezem, Remco M, Sanders, Mathijs A, Rommens, Johanna M, Touw, Ivo P, Raaijmakers, Marc H G P

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Prevalence of a new auto-activating colony stimulating factor 3 receptor mutation (CSF3R-T595I) in acute myeloid leukemia and severe congenital neutropenia von Beekman, Renée, Valkhof, Marijke, van Strien, Paulette, Valk, Peter J M, Touw, Ivo P

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Large-scale in vitro production of red blood cells from human peripheral blood mononuclear cells von Heshusius, Steven, Heideveld, Esther, Burger, Patrick, Thiel-Valkhof, Marijke, Sellink, Erica, Varga, Eszter, Ovchynnikova, Elina, Visser, Anna, Martens, Joost H.A., von Lindern, Marieke, van den Akker, Emile

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Retroviral integration mutagenesis in mice and comparative analysis in human AML identify reduced PTP4A3 expression as a prognostic indicator von Beekman, Renée, Valkhof, Marijke, Erkeland, Stefan J, Taskesen, Erdogan, Rockova, Veronika, Peeters, Justine K, Valk, Peter J M, Löwenberg, Bob, Touw, Ivo P

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The gene encoding thioredoxin-interacting protein (TXNIP) is a frequent virus integration site in virus-induced mouse leukemia and is overexpressed in a subset of AML patients von Erkeland, Stefan J, Palande, Karishma K, Valkhof, Marijke, Gits, Judith, Oorschot, Astrid Danen-van, Touw, Ivo P

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IFNγ induces monopoiesis and inhibits neutrophil development during inflammation von de Bruin, Alexander M., Libregts, Sten F., Valkhof, Marijke, Boon, Louis, Touw, Ivo P., Nolte, Martijn A.

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Large-Scale Identification of Disease Genes Involved in Acute Myeloid Leukemia von Erkeland, Stefan J., Valkhof, Marijke, Heijmans-Antonissen, Claudia, van Hoven-Beijen, Antoinette, Delwel, Ruud, Hermans, Mirjam H. A., Touw, Ivo P.

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Loss of Ercc1 Results in a Time- and Dose-Dependent Reduction of Proliferating Early Hematopoietic Progenitors von Verhagen-Oldenampsen, Judith H. E., Haanstra, Jurgen R., van Strien, Paulina M. H., Valkhof, Marijke, Touw, Ivo P., von Lindern, Marieke

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Large Scale Culture and Differentiation of Erythroblasts from PBMC and iPSC von Claessen, Maria, Varga, Eszter, Heshusius, Steven, Heideveld, Esther, Hansen, Martin, Visser, Anna, Thiel-Valkhof, Marijke, Sellink, Erica, Burger, Patrick, Zeerleder, Sacha, Kersten, Marie Jose, van den Akker, Emile, von Lindern, Marieke

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Lineage-instructive function of C/EBPα in multipotent hematopoietic cells and early thymic progenitors von Wölfler, Albert, Danen-van Oorschot, Astrid A., Haanstra, Jurgen R., Valkhof, Marijke, Bodner, Claudia, Vroegindeweij, Eric, van Strien, Paulette, Novak, Alexandra, Cupedo, Tom, Touw, Ivo P.

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A Homozygous Mutation on the HBA1 Gene Coding for Hb Charlieu (HBA1: c.320T>C) Together with β-Thalassemia Trait Results in Severe Hemolytic Anemia von Klei, Thomas R L, Kheradmand Kia, Sima, Veldthuis, Martijn, Dehbozorgian, Javad, Karimi, Mehran, Geissler, Judy, Sellink, Erica, Thiel-Valkhof, Marijke, Burger, Patrick, van Alphen, Floris, Meijer, Alexander B, van Bruggen, Robin, van Zwieten, Rob

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Deletion of Sbds from Hematopoietic Progenitors Causes Neutropenia in a Mouse Model of Shwachman-Diamond Syndrome By Specifically Blocking Myeloid Lineage Progression at Late Diffe... von Zambetti, Noemi A., Van Strien, Paulina M.H., Valkhof, Marijke G., Adisty, Maria N., Bindels, Eric M.J., Hoogenboezem, Remco M., Sanders, Mathijs A., Rommens, Johanna M., Touw, Ivo P., Raaijmakers, Marc H.G.P.

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Interferon-Gamma Induces Monopoiesis and Inhibits Neutrophil Development During Inflammation von de Bruin, Alexander M., Valkhof, Marijke G., Boon, Louis, Touw, Ivo P., Nolte, Martijn A.

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Methylated Retroviral Integration Mutagenesis (MRIM) in Mice and Comparative Analysis in Human AML Identify Reduced PTP4A3 Expression As a Prognostic Indicator von Beekman, Renee, Valkhof, Marijke G., Erkeland, Stefan J., Taskesen, Erdogan, Rockova, Veronika, Peeters, Justine K., Valk, Peter, Touw, Ivo P.

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Cooperativity of RUNX1 and CSF3R mutations in the development of leukemia in severe congenital neutropenia: a unique pathway in myeloid leukemogenesis von Skokowa, Julia, Steinemann, Doris, Katsman-Kuipers, Jenny E, Zeidler, Cornelia, Klimenkova, Olga, Klimiankou, Maksim, Unalan, Murat, Kandabarau, Siarhei, Makaryan, Vahagn, Beekman, Renee, Behrens, Kira, Stocking, Carol, Obenauer, Julia, Schnittger, Susanne, Kohlmann, Alexander, Valkhof, Marijke G, Hoogenboezem, Remco, Göhring, Gudrun, Reinhardt, Dirk, Schlegelberger, Brigitte, Stanulla, Martin, Vandenberghe, Peter, Donadieu, Jean, Zwaan, C. Michel, Touw, Ivo P, van den Heuvel-Eibrink, Marry M, Dale, David C, Welte, Karl

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Janus kinases promote cell-surface expression and provoke autonomous signalling from routing-defective G-CSF receptors von Meenhuis, Annemarie, Irandoust, Mahban, Wölfler, Albert, Roovers, Onno, Valkhof, Marijke, Touw, Ivo P

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A functional single-nucleotide polymorphism of the G-CSF receptor gene predisposes individuals to high-risk myelodysplastic syndrome von Wölfler, Albert, Erkeland, Stefan J., Bodner, Claudia, Valkhof, Marijke, Renner, Wilfried, Leitner, Christina, Olipitz, Werner, Pfeilstöcker, Michael, Tinchon, Christoph, Emberger, Werner, Linkesch, Werner, Touw, Ivo P., Sill, Heinz

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Lineage Instructive Function of C/EBPα in Multipotent Hematopoietic Progenitor Cells Revealed in a Novel Cebpa-Cre Knock-in Model von Wolfler, Albert, Oorschot, Astrid A Danen-van, Haanstra, Jurgen, Valkhof, Marijke, van Strien, Paulette, Rombouts, Elwin, Touw, Ivo P

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