Synthesis, Crystallization, and Biological Evaluation of an Orally Active Prodrug of Gemcitabine von Bender, David M, Bao, Jingqi, Dantzig, Anne H, Diseroad, William D, Law, Kevin L, Magnus, Nicholas A, Peterson, Jeffrey A, Perkins, Everett J, Pu, Yangwei J, Reutzel-Edens, Susan M, Remick, David M, Starling, James J, Stephenson, Gregory A, Vaid, Radhe K, Zhang, Deyi, McCarthy, James R

Volltext

Rapid Development and Scale-Up of a 1H-4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors von May, Scott A, Johnson, Martin D, Braden, Timothy M, Calvin, Joel R, Haeberle, Brian D, Jines, Amy R, Miller, Richard D, Plocharczyk, Edward F, Rener, Gregory A, Richey, Rachel N, Schmid, Christopher R, Vaid, Radhe K, Yu, Hannah

Volltext

A Practical Method for Functionalized Peptide or Amide Bond Formation in Aqueous−Ethanol Media with EDC as Activator von Pu, Yangwei John, Vaid, Radhe K, Boini, Sathish K, Towsley, Robert W, Doecke, Christopher W, Mitchell, David

Volltext

An Asymmetric Synthesis of a Chiral Sulfone Acid with Concomitant Hydrolysis and Oxidation to Enable the Preparation of a Glucokinase Activator von DeBaillie, Amy C, Magnus, Nicholas A, Laurila, Michael E, Wepsiec, James P, Ruble, J. Craig, Petkus, Jeffrey J, Vaid, Radhe K, Niemeier, Jeffry K, Mick, Joseph F, Gunter, Thomas Z

Volltext

Development of a Manufacturing Process for 1-(1-Pyridin-2-yl methyl-piperidin-4-yl)-1H-indole:  A Key Intermediate for Protein Kinase C Inhibitor LY317615 von Boini, Sathish, Moder, Kenneth P, Vaid, Radhe K, Kopach, Micheal, Kobierski, M

Volltext

Carbon-Carbon Bond Formation Via Hypervalent Iodine Oxidations von Moriarty, Robert M., Vaid, Radhe K.

Volltext

Development and Production of an Enantioselective Tetrahydroisoquinoline Synthesis Enabled by Continuous Cryogenic Lithium-Halogen Exchange von Cole, Kevin P., Argentine, Mark D., Conder, Edward W., Vaid, Radhe K., Feng, Pengyao, Jia, Mo, Huang, Ping, Liu, Peng, Sun, Baoquan, Tadayon, Sam, Zhu, Cheng, Zhu, Ruiheng

Volltext

Process Development of (1S,2S,5R,6S)- Spiro[bicyclo[3.1.0]hexane-2‘,5‘-dioxo-2,4‘-imidazolidine]-6-carboxylic Acid, (R)-α-Methylbenzenemethanamine Salt (LSN344309) von Rasmy, Ossama M, Vaid, Radhe K, Semo, Michael J, Chelius, Erik C, Robey, Roger L, Alt, Charles A, Rhodes, Gary A, Vicenzi, Jeffery T

Volltext

Hypervalent iodine oxidation of silyl enol ethers under Lewis-acid conditions in methanol. A general route to .alpha.-methoxy ketones von Moriarty, Robert M, Prakash, Om, Duncan, Michael P, Vaid, Radhe K, Musallam, Hikmat A

Volltext

Rapid Development and Scale-Up of a 1 H -4-Substituted Imidazole Intermediate Enabled by Chemistry in Continuous Plug Flow Reactors von May, Scott A., Johnson, Martin D., Braden, Timothy M., Calvin, Joel R., Haeberle, Brian D., Jines, Amy R., Miller, Richard D., Plocharczyk, Edward F., Rener, Gregory A., Richey, Rachel N., Schmid, Christopher R., Vaid, Radhe K., Yu, Hannah

Volltext

Synthesis of Methyl 7,9-Dimethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carboxylate and Its Analogues von Vaid, Radhe K., Boini, Sathish K., Alt, Charles A., Spitler, Jeremy T., Hadden, Chad E., Frank, Scott A., Moher, Eric D.

Volltext

A novel intramolecular cyclopropanation using iodonium ylides von Moriarty, Robert M, Prakash, Om, Vaid, Radhe K, Zhao, Lei

Volltext

Counterion effects in the preparation of aldehyde–bisulfite adducts von Kissane, Marie G., Frank, Scott A., Rener, Gregory A., Ley, Christopher P., Alt, Charles A., Stroud, Paul A., Vaid, Radhe K., Boini, Sathish K., McKee, Laura A., Vicenzi, Jeffrey T., Stephenson, Gregory A.

Volltext

Oxidative rearrangement of alkynes to carboxylic acid esters by [Hydroxy(tosyloxy)iodo]benzene in methanol von Moriarty, Robert M, Vaid, Radhe K, Duncan, Michael P, Vaid, Beena K

Volltext

Hypervalent iodine oxidation of amines using iodosobenzene: Synthesis of nitriles, ketones and lactams von Moriarty, Robert M, Vaid, Radhe K, Duncan, Michael P, Ochiai, Masahito, Inenaga, Minako, Nagao, Yoshimitsu

Volltext

ChemInform Abstract: Synthesis of Methyl 7,9-Dimethyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carboxylate and Its Analogues von Vaid, Radhe K., Boini, Sathish K., Alt, Charles A., Spitler, Jeremy T., Hadden, Chad E., Frank, Scott A., Moher, Eric D.

Volltext

Use of Silyl Ester and Enamine Protection for an Efficient Alternate Synthesis of (1S,2S,5R,6S)-2-[(2′S)-(2′-Amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydroch... von Fennell, Jared W., Semo, Michael J., Wirth, David D., Vaid, Radhe K.

Volltext

An efficient synthesis of LY544344·HCl: a prodrug of mGluR2 agonist LY354740 von Coffey, D. Scott, Hawk, Mai Khanh, Pedersen, Steven W., Vaid, Radhe K.

Volltext

Oxidative decarboxylation of cyclic amino acids and dehydrogenation of cyclic secondary amines with iodosobenzene von Ochiai, Masahito, Inenaga, Minako, Nagao, Yoshimitsu, Moriarty, Robert M., Vaid, Radhe K, Duncan, Michael P.

Volltext

[Hydroxy(organosulfonyloxy)iodo]arenes in Organic Synthesis von Moriarty, Robert M., Vaid, Radhe K., Koser, Gerald F.

Volltext