Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development von Wittman, Mark D, Carboni, Joan M, Yang, Zheng, Lee, Francis Y, Antman, Melissa, Attar, Ricardo, Balimane, Praveen, Chang, Chiehying, Chen, Cliff, Discenza, Lorell, Frennesson, David, Gottardis, Marco M, Greer, Ann, Hurlburt, Warren, Johnson, Walter, Langley, David R, Li, Aixin, Li, Jianqing, Liu, Peiying, Mastalerz, Harold, Mathur, Arvind, Menard, Krista, Patel, Karishma, Sack, John, Sang, Xiaopeng, Saulnier, Mark, Smith, Daniel, Stefanski, Kevin, Trainor, George, Velaparthi, Upender, Zhang, Guifen, Zimmermann, Kurt, Vyas, Dolatrai M

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New dual inhibitors of EGFR and HER2 protein tyrosine kinases von Fink, Brian E., Vite, Gregory D., Mastalerz, Harold, Kadow, John F., Kim, Soong-Hoon, Leavitt, Kenneth J., Du, Karen, Crews, Donald, Mitt, Toomas, Wong, Tai W., Hunt, John T., Vyas, Dolatrai M., Tokarski, John S.

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The discovery of BMS-275183: an orally efficacious novel taxane von Mastalerz, Harold, Cook, Donald, Fairchild, Craig R, Hansel, Steven, Johnson, Walter, Kadow, John F, Long, Byron H, Rose, William C, Tarrant, James, Wu, Mu-Jen, Xue, May Quifen, Zhang, Guifen, Zoeckler, Mary, Vyas, Dolatrai M

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Synthesis and Antitumor Activity of Novel C-7 Paclitaxel Ethers:  Discovery of BMS-184476 von Altstadt, Thomas J, Fairchild, Craig R, Golik, Jerzy, Johnston, Kathy A, Kadow, John F, Lee, Francis Y, Long, Byron H, Rose, William C, Vyas, Dolatrai M, Wong, Henry, Wu, Mu-Jen, Wittman, Mark D

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Discovery and Preclinical Evaluation of [4-[[1-(3-fluorophenyl)methyl]-1H-indazol-5-ylamino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamic Acid, (3S)-3-Morpholinylmethyl Ester... von Gavai, Ashvinikumar V, Fink, Brian E, Fairfax, David J, Martin, Gregory S, Rossiter, Lana M, Holst, Christian L, Kim, Soong-Hoon, Leavitt, Kenneth J, Mastalerz, Harold, Han, Wen-Ching, Norris, Derek, Goyal, Bindu, Swaminathan, Shankar, Patel, Bharat, Mathur, Arvind, Vyas, Dolatrai M, Tokarski, John S, Yu, Chiang, Oppenheimer, Simone, Zhang, Hongjian, Marathe, Punit, Fargnoli, Joseph, Lee, Francis Y, Wong, Tai W, Vite, Gregory D

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Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2- f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase von Sampognaro, Anthony J., Wittman, Mark D., Carboni, Joan M., Chang, Chiehying, Greer, Ann F., Hurlburt, Warren W., Sack, John S., Vyas, Dolatrai M.

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Nucleophilic Capture of the Imino-Quinone Methide Type Intermediates Generated from 2-Aminothiazol-5-yl Carbinols von Saulnier, Mark G, Dodier, Marco, Frennesson, David B, Langley, David R, Vyas, Dolatrai M

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Synthesis and structure–activity relationship of imidazo(1,2- a)thieno(3,2- e)pyrazines as IKK-β inhibitors von Belema, Makonen, Bunker, Amy, Nguyen, Van N., Beaulieu, Francis, Ouellet, Carl, Qiu, Yuping, Zhang, Yunhui, Martel, Alain, Burke, James R., McIntyre, Kim W., Pattoli, Mark A., Daloisio, Connie, Gillooly, Kathleen M., Clarke, Wendy J., Brassil, Patrick J., Zusi, F. Chris, Vyas, Dolatrai M.

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2-Aryl-2,2-difluoroacetamide FKBP12 Ligands:  Synthesis and X-ray Structural Studies von Dubowchik, Gene M, Vrudhula, Vivekananda M, Dasgupta, Bireshwar, Ditta, Jonathan, Chen, Ti, Sheriff, Steven, Sipman, Karin, Witmer, Mark, Tredup, Jeffrey, Vyas, Dolatrai M, Verdoorn, Todd A, Bollini, Sagarika, Vinitsky, Alexander

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Novel C-5 aminomethyl pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases von Mastalerz, Harold, Chang, Ming, Gavai, Ashvinikumar, Johnson, Walter, Langley, David, Lee, Francis Y., Marathe, Punit, Mathur, Arvind, Oppenheimer, Simone, Tarrant, James, Tokarski, John S., Vite, Gregory D., Vyas, Dolatrai M., Wong, Henry, Wong, Tai W., Zhang, Hongjian, Zhang, Guifen

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New C-5 substituted pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases von Mastalerz, Harold, Chang, Ming, Chen, Ping, Dextraze, Pierre, Fink, Brian E., Gavai, Ashvinikumar, Goyal, Bindu, Han, Wen-Ching, Johnson, Walter, Langley, David, Lee, Francis Y., Marathe, Punit, Mathur, Arvind, Oppenheimer, Simone, Ruediger, Edward, Tarrant, James, Tokarski, John S., Vite, Gregory D., Vyas, Dolatrai M., Wong, Henry, Wong, Tai W., Zhang, Hongjian, Zhang, Guifen

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5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases von Mastalerz, Harold, Chang, Ming, Chen, Ping, Fink, Brian E., Gavai, Ashvinikumar, Han, Wen-Ching, Johnson, Walter, Langley, David, Lee, Francis Y., Leavitt, Kenneth, Marathe, Punit, Norris, Derek, Oppenheimer, Simone, Sleczka, Bogdan, Tarrant, James, Tokarski, John S., Vite, Gregory D., Vyas, Dolatrai M., Wong, Henry, Wong, Tai W., Zhang, Hongjian, Zhang, Guifen

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Novel 1H -(benzimidazol -2 -yl ) -1H -pyridin -2 -one inhibitors of insulin-like growth factor I (IGF-1R) kinase von WITTMAN, Mark D, BALASUBRAMANIAN, Balu, GOTTARDIS, Marco, CHIEHYING CHANG, JACOBSON, Bruce, SUN, Yax, HANSEL, Steven, ZOECKLER, Mary, VYAS, Dolatrai M, STOFFAN, Karen, VELAPARTHI, Upender, PIEYING LIU, KRISHNANATHAN, Subramaniam, CARBONI, Joan, AIXIN LI, GREER, Ann, ATTAR, Ricardo

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Discovery of a Fluoroindolo[2,3-a]carbazole Clinical Candidate with Broad Spectrum Antitumor Activity in Preclinical Tumor Models Superior to the Marketed Oncology Drug, CPT-11 von Saulnier, Mark G, Balasubramanian, Balu N, Long, Byron H, Frennesson, David B, Ruediger, Edward, Zimmermann, Kurt, Eummer, Jeffrey T, St. Laurent, Denis R, Stoffan, Karen M, Naidu, B. Narasimhulu, Mahler, Mikael, Beaulieu, Francis, Bachand, Carol, Lee, Frank Y, Fairchild, Craig R, Stadnick, Linda K, Rose, William C, Solomon, Carola, Wong, Henry, Martel, Alain, Wright, John J, Kramer, Robert, Langley, David R, Vyas, Dolatrai M

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Sordaricin antifungal agents von Quesnelle, Claude A, Gill, Patrice, Dodier, Marco, St. Laurent, Denis, Serrano-Wu, Michael, Marinier, Anne, Martel, Alain, Mazzucco, Charles E, Stickle, Terry M, Barrett, John F, Vyas, Dolatrai M, Balasubramanian, Balu N

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Design and Synthesis of a Fluoroindolocarbazole Series as Selective Topoisomerase I Active Agents. Discovery of Water-Soluble 3,9-Difluoro-12,13-dihydro-13-[6-amino-β- d-glucopyran... von Balasubramanian, Balu N, St. Laurent, Denis R, Saulnier, Mark G, Long, Byron H, Bachand, Carol, Beaulieu, Francis, Clarke, Wendy, Deshpande, Milind, Eummer, Jeffrey, Fairchild, Craig R, Frennesson, David B, Kramer, Robert, Lee, Frank Y, Mahler, Mikael, Martel, Alain, Naidu, B. Narasimhulu, Rose, William C, Russell, John, Ruediger, Edward, Solomon, Carola, Stoffan, Karen M, Wong, Henry, Zimmermann, Kurt, Vyas, Dolatrai M

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Pyrrolotriazine-5-carboxylate ester inhibitors of EGFR and HER2 protein tyrosine kinases and a novel one-pot synthesis of C-4 subsitituted pyrrole-2,3-dicarboxylate diesters von Mastalerz, Harold, Gavai, Ashvinikumar V, Fink, Brian, Struzynski, Charles, Tarrant, James, Vite, Gregory D, Wong, Tai W, Zhang, Guifen, Vyas, Dolatrai M

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Oxime derivatives of sordaricin as potent antifungal agents von SERRANO-WU, Michael H, LAURENT, Denis R. St, MAZZUCCO, Charles E, STICKLE, Terry M, BARRETT, John F, VYAS, Dolatrai M, BALASUBRAMANIAN, Balu N

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Sordarin Oxazepine Derivatives as Potent Antifungal Agents von Serrano-Wu, Michael H., St. Laurent, Denis R., Chen, Yijun, Huang, Stella, Lam, Kin-Ray, Matson, James A., Mazzucco, Charles E., Stickle, Terry M., Tully, Thomas P., Wong, Henry S., Vyas, Dolatrai M., Balasubramanian, Balu N.

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Synthesis of a hybrid analog of the esperamicin and dynemicin cores von Mastalerz, Harold, Doyle, Terrence W, Kadow, John F, Vyas, Dolatrai M

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